{"id":"https://openalex.org/W2109199161","doi":null,"title":"Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.","display_name":"Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation.","publication_year":2002,"publication_date":"2002-12-01","ids":{"openalex":"https://openalex.org/W2109199161","mag":"2109199161","pmid":"https://pubmed.ncbi.nlm.nih.gov/12460917"},"language":"en","primary_location":{"id":"pmid:12460917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12460917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015323681","display_name":"Wei\u2010Min Tong","orcid":"https://orcid.org/0000-0002-6240-0267","observed_orcids":["https://orcid.org/0000-0002-6240-0267"]},"institutions":[{"id":"https://openalex.org/I42237331","display_name":"Centre international de recherche sur le cancer","ror":"https://ror.org/00v452281","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210105654","https://openalex.org/I42237331"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Wei-Min Tong","raw_affiliation_strings":["International Agency for Research on Cancer (IARC), 69008 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Agency for Research on Cancer (IARC), 69008 Lyon, France","institution_ids":["https://openalex.org/I42237331"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052448387","display_name":"Ulrich Cortes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrich Cortes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008546813","display_name":"Manoor Prakash Hande","orcid":"https://orcid.org/0000-0002-4511-6256","observed_orcids":["https://orcid.org/0000-0002-4511-6256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Prakash Hande","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103530823","display_name":"Hiroko Ohgaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroko Ohgaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056590283","display_name":"Luciane R. Cavalli","orcid":"https://orcid.org/0000-0001-5619-9037","observed_orcids":["https://orcid.org/0000-0001-5619-9037","https://orcid.org/0000-0003-4477-6233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luciane R Cavalli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056104532","display_name":"Peter M. Lansdorp","orcid":"https://orcid.org/0000-0001-7435-1071","observed_orcids":["https://orcid.org/0000-0001-7435-1071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter M Lansdorp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108491622","display_name":"Bassem R. Haddad","orcid":"https://orcid.org/0000-0003-2679-3371","observed_orcids":["https://orcid.org/0000-0003-2679-3371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bassem R Haddad","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100613095","display_name":"Zhao\u2010Qi Wang","orcid":"https://orcid.org/0000-0002-8336-3485","observed_orcids":["https://orcid.org/0000-0002-8336-3485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhao-Qi Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4948,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.89642907,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"23","first_page":"6990","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.01119999960064888,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ku80","display_name":"Ku80","score":0.996999979019165},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/hepatocellular-adenoma","display_name":"hepatocellular adenoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.8799999952316284},{"id":"https://openalex.org/keywords/non-reciprocal-translocation","display_name":"non-reciprocal translocation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/non-homologous-end-joining","display_name":"non-homologous end joining","score":0.9480000138282776},{"id":"https://openalex.org/keywords/dna-end-processing","display_name":"DNA end processing","score":0.6589999794960022},{"id":"https://openalex.org/keywords/haploinsufficiency","display_name":"haploinsufficiency","score":0.8569999933242798},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8389999866485596},{"id":"https://openalex.org/keywords/ctnnb1-mutation","display_name":"CTNNB1 mutation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.734000027179718},{"id":"https://openalex.org/keywords/liver-cancer-etiology","display_name":"liver cancer etiology","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C193104389","wikidata":"https://www.wikidata.org/wiki/Q18032397","display_name":"Ku80","level":5,"score":0.7700226306915283},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6735784411430359},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6595388054847717},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.6063855290412903},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.575761079788208},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.5028473734855652},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.4977317154407501},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.49447202682495117},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4771232604980469},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.45943281054496765},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4136633574962616},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.4012361466884613},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.3913303017616272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.356486052274704},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.3494802713394165},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32353436946868896},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.19554397463798523},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1910037100315094},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.09537181258201599},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08552715182304382},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000072200","descriptor_name":"Ku Autoantigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034961","descriptor_name":"Antigens, Nuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12460917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12460917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2109199161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12460917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1515564094","https://openalex.org/W1544851750","https://openalex.org/W1546643851","https://openalex.org/W1964699982","https://openalex.org/W1964931568","https://openalex.org/W1971953001","https://openalex.org/W1973046279","https://openalex.org/W1975864013","https://openalex.org/W1975866042","https://openalex.org/W1982362157","https://openalex.org/W1983795887","https://openalex.org/W1985598285","https://openalex.org/W1987850577","https://openalex.org/W1988829501","https://openalex.org/W1990563353","https://openalex.org/W1991964724","https://openalex.org/W1995577291","https://openalex.org/W1998530321","https://openalex.org/W2009650244","https://openalex.org/W2010465993","https://openalex.org/W2011013164","https://openalex.org/W2018609920","https://openalex.org/W2039704215","https://openalex.org/W2041518108","https://openalex.org/W2047425230","https://openalex.org/W2047804529","https://openalex.org/W2053356867","https://openalex.org/W2053994548","https://openalex.org/W2057676980","https://openalex.org/W2060002498","https://openalex.org/W2065169211","https://openalex.org/W2075784029","https://openalex.org/W2076328665","https://openalex.org/W2079043484","https://openalex.org/W2080152855","https://openalex.org/W2101274152","https://openalex.org/W2117351453","https://openalex.org/W2117743516","https://openalex.org/W2127957276","https://openalex.org/W2130728712","https://openalex.org/W2135789299","https://openalex.org/W2136318431","https://openalex.org/W2138882303","https://openalex.org/W2150990082","https://openalex.org/W2151530333","https://openalex.org/W2151797852","https://openalex.org/W2156442575","https://openalex.org/W2158491040","https://openalex.org/W2158820560","https://openalex.org/W2160089420","https://openalex.org/W2165000695","https://openalex.org/W2170970288","https://openalex.org/W2313449389","https://openalex.org/W2316712853","https://openalex.org/W2328854054"],"related_works":["https://openalex.org/W2020376495","https://openalex.org/W1985133321","https://openalex.org/W2012242260","https://openalex.org/W7124822999","https://openalex.org/W3090809699","https://openalex.org/W3195235768","https://openalex.org/W2080152855","https://openalex.org/W2002433066","https://openalex.org/W1988829501","https://openalex.org/W2165000695"],"abstract_inverted_index":{"Liver":[0],"cancer":[1,25,51,211],"is":[2,52,103],"one":[3],"of":[4,47,50,61,90,99,120,128,146,152,175,191,202],"the":[5,10,19,41,45,88,97,126,144,150],"major":[6,20,69],"human":[7,192,226],"tumors":[8,136,170],"in":[9,78,122,163,206,217,225],"world.":[11],"Basic":[12],"and":[13,28,37,58,82,101,131,149,166,182,204,210,213],"epidemiological":[14],"studies":[15],"have":[16],"proposed":[17],"that":[18,73,96,157,167,215],"risk":[21],"factors":[22,224],"for":[23,44,105],"liver":[24,169],"include":[26],"alcohol":[27],"diet":[29],"as":[30,32,85,87],"well":[31,86],"infection":[33],"with":[34,143],"hepatitis":[35],"B":[36],"C":[38],"viruses.":[39],"However,":[40],"mechanistic":[42],"clues":[43],"development":[46,106,127,212],"this":[48],"type":[49],"largely":[53],"unknown.":[54],"Poly(ADP-ribose)":[55],"polymerase":[56],"(PARP-1)":[57],"a":[59,75,138,172,199],"component":[60],"nonhomologous":[62],"end-joining":[63],"(NHEJ)":[64],"machinery,":[65],"Ku80,":[66],"are":[67,189],"two":[68],"DNA":[70,79,218],"end-binding":[71],"molecules":[72,220],"play":[74],"multifunctional":[76],"role":[77],"damage":[80],"signaling":[81],"repair,":[83],"recombination":[84],"maintenance":[89],"genomic":[91],"stability.":[92],"Here":[93],"we":[94],"show":[95],"interaction":[98],"PARP-1":[100,205],"Ku80":[102,121,158,203],"essential":[104],"because":[107],"PARP-1/Ku80":[108],"double":[109],"null":[110],"mice":[111,124],"died":[112],"at":[113],"embryonic":[114],"day":[115],"(E)":[116],"9.5.":[117],"Interestingly,":[118],"haplo-insufficiency":[119],"PARP-1-/-":[123,164],"promotes":[125],"hepatocellular":[129,132],"adenoma":[130],"carcinoma":[133],"(HCC).":[134],"These":[135,187],"exhibited":[137],"multistage":[139],"tumor":[140],"progression":[141],"associated":[142],"loss":[145],"E-cadherin":[147],"expression":[148],"mutation":[151],"beta-catenin.":[153],"Cytogenetic":[154],"analysis":[155],"revealed":[156],"heterozygosity":[159],"elevated":[160],"chromosomal":[161,176],"instability":[162],"cells":[165],"these":[168,196],"harbored":[171],"high":[173],"degree":[174],"aberrations":[177,209],"including":[178],"fragmentations,":[179],"end-to-end":[180],"fusions,":[181],"recurrent":[183],"nonreciprocal":[184],"translocations":[185],"(NRT).":[186],"features":[188],"reminiscent":[190],"HCC.":[193],"Taken":[194],"together,":[195],"data":[197],"implicate":[198],"synergistic":[200],"function":[201],"minimized":[207],"chromosome":[208],"suggest":[214],"defects":[216],"end-processing":[219],"may":[221],"be":[222],"etiological":[223],"HCC":[227],"formation.":[228]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
