{"id":"https://openalex.org/W2109138228","doi":"https://doi.org/10.1186/s12941-014-0052-2","title":"Regional and global antimicrobial susceptibility among isolates of Streptococcus pneumoniae and Haemophilus influenzae collected as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) from 2009 to 2012 and comparison with previous years of T.E.S.T. (2004-2008)","display_name":"Regional and global antimicrobial susceptibility among isolates of Streptococcus pneumoniae and Haemophilus influenzae collected as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) from 2009 to 2012 and comparison with previous years of T.E.S.T. (2004-2008)","publication_year":2014,"publication_date":"2014-11-06","ids":{"openalex":"https://openalex.org/W2109138228","doi":"https://doi.org/10.1186/s12941-014-0052-2","mag":"2109138228","pmid":"https://pubmed.ncbi.nlm.nih.gov/25376749","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4239395"},"language":"en","primary_location":{"id":"doi:10.1186/s12941-014-0052-2","doi":"https://doi.org/10.1186/s12941-014-0052-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12941-014-0052-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12941-014-0052-2.pdf","source":{"id":"https://openalex.org/S14661945","display_name":"Annals of Clinical Microbiology and Antimicrobials","issn_l":"1476-0711","issn":["1476-0711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Microbiology and Antimicrobials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12941-014-0052-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064661348","display_name":"Viktorija Tomi\u010d","orcid":"https://orcid.org/0000-0003-4806-1024","observed_orcids":["https://orcid.org/0000-0003-4806-1024"]},"institutions":[{"id":"https://openalex.org/I4210113670","display_name":"University Clinic of Pulmonary and Allergic Diseases Golnik","ror":"https://ror.org/01yxj7x74","country_code":"SI","type":"healthcare","lineage":["https://openalex.org/I4210113670"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Viktorija Tomic","raw_affiliation_strings":["University Clinic of Respiratory and Allergic Diseases, Golnik 36, 4204, Golnik, Slovenia. viktorija.tomic@klinika-golnik.si","University Clinic of Respiratory and Allergic Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Clinic of Respiratory and Allergic Diseases, Golnik 36, 4204, Golnik, Slovenia. viktorija.tomic@klinika-golnik.si","institution_ids":["https://openalex.org/I4210113670"]},{"raw_affiliation_string":"University Clinic of Respiratory and Allergic Diseases","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113566843","display_name":"Michael J. Dowzicky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J Dowzicky","raw_affiliation_strings":["Pfizer Inc, Collegeville, PA, USA. Michael.Dowzicky@pfizer.com","Pfizer Inc.,;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, Collegeville, PA, USA. Michael.Dowzicky@pfizer.com","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Inc.,;","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064661348"],"corresponding_institution_ids":["https://openalex.org/I4210113670"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":3.1525,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.90891317,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"52","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.7064999938011169,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.22630000114440918,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.9399999976158142},{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":1.0},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.6510000228881836},{"id":"https://openalex.org/keywords/penicillin-resistance","display_name":"penicillin resistance","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tigecycline","display_name":"tigecycline","score":0.8820000290870667},{"id":"https://openalex.org/keywords/levofloxacin","display_name":"levofloxacin","score":0.902999997138977},{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":0.8149999976158142},{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ampicillin-resistance","display_name":"ampicillin resistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/global-surveillance","display_name":"global surveillance","score":0.5080000162124634},{"id":"https://openalex.org/keywords/regional-variation","display_name":"regional variation","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2777027569","wikidata":"https://www.wikidata.org/wiki/Q420595","display_name":"Tigecycline","level":3,"score":0.916895866394043},{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.7061969637870789},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.6893505454063416},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6812775731086731},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.6411632299423218},{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.5952637195587158},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.5722286701202393},{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.564671516418457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48678871989250183},{"id":"https://openalex.org/C174802600","wikidata":"https://www.wikidata.org/wiki/Q12190","display_name":"Penicillin","level":3,"score":0.46970316767692566},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.37118691205978394},{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.3482348620891571},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3302157521247864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28991228342056274},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2887378931045532},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.16900956630706787},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.1164289116859436},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.07796502113342285},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078304","descriptor_name":"Tigecycline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006192","descriptor_name":"Haemophilus Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014943","descriptor_name":"Global Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12941-014-0052-2","doi":"https://doi.org/10.1186/s12941-014-0052-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12941-014-0052-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12941-014-0052-2.pdf","source":{"id":"https://openalex.org/S14661945","display_name":"Annals of Clinical Microbiology and Antimicrobials","issn_l":"1476-0711","issn":["1476-0711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Microbiology and Antimicrobials","raw_type":"journal-article"},{"id":"pmid:25376749","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25376749","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical microbiology and antimicrobials","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4239395","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4239395/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Clin Microbiol Antimicrob","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12941-014-0052-2","doi":"https://doi.org/10.1186/s12941-014-0052-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12941-014-0052-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12941-014-0052-2.pdf","source":{"id":"https://openalex.org/S14661945","display_name":"Annals of Clinical Microbiology and Antimicrobials","issn_l":"1476-0711","issn":["1476-0711"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Clinical Microbiology and Antimicrobials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109138228.pdf","grobid_xml":"https://content.openalex.org/works/W2109138228.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W26641785","https://openalex.org/W611976593","https://openalex.org/W1598844438","https://openalex.org/W1973154379","https://openalex.org/W1992766213","https://openalex.org/W2008846329","https://openalex.org/W2010410350","https://openalex.org/W2011867843","https://openalex.org/W2023671201","https://openalex.org/W2063394772","https://openalex.org/W2098920479","https://openalex.org/W2103158733","https://openalex.org/W2104051878","https://openalex.org/W2107722421","https://openalex.org/W2107932739","https://openalex.org/W2107996101","https://openalex.org/W2111959328","https://openalex.org/W2114827863","https://openalex.org/W2115070538","https://openalex.org/W2116559313","https://openalex.org/W2117486940","https://openalex.org/W2128396188","https://openalex.org/W2129710210","https://openalex.org/W2130141864","https://openalex.org/W2133440505","https://openalex.org/W2133979383","https://openalex.org/W2157819951","https://openalex.org/W2464417828","https://openalex.org/W2588737010"],"related_works":["https://openalex.org/W2943894404","https://openalex.org/W2111959328","https://openalex.org/W2015979923","https://openalex.org/W2135036032","https://openalex.org/W2085226831","https://openalex.org/W2034434216","https://openalex.org/W2145517870","https://openalex.org/W2356352517","https://openalex.org/W1977219392","https://openalex.org/W2011489517"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1],"report":[2],"here":[3],"on":[4,145],"14438":[5],"Streptococcus":[6],"pneumoniae":[7,77,96,110,125,176],"and":[8,20,29,47,57,97,104,131,184],"14770":[9],"Haemophilus":[10],"influenzae":[11,140,165,188],"isolates":[12,78,111,169],"collected":[13],"from":[14],"560":[15],"centres":[16],"globally":[17,79],"between":[18,129],"2004":[19],"2012":[21],"as":[22,42,65],"a":[23],"part":[24],"of":[25,75,94,108,163,168],"the":[26,45,146,196],"Tigecycline":[27],"Evaluation":[28],"Surveillance":[30],"Trial":[31],"(T.E.S.T.).":[32],"METHODS:":[33],"MIC":[34],"testing":[35,197],"was":[36,90,98,136,159,189],"performed":[37],"using":[38,52],"broth":[39],"microdilution":[40],"methods":[41],"described":[43],"by":[44,127],"Clinical":[46],"Laboratory":[48],"Standards":[49],"Institute":[50],"(CLSI)":[51],"CLSI-approved":[53],"breakpoints;":[54],"US":[55],"Food":[56],"Drug":[58],"Administration":[59],"breakpoints":[60,67],"were":[61,80,112,115,155,170],"used":[62],"for":[63],"tigecycline":[64,85,183],"CLSI":[66],"are":[68],"not":[69],"available.":[70],"RESULTS:":[71],"At":[72],"least":[73],"99%":[74],"S.":[76,95,109,124,175],"susceptible":[81,179,190],"to":[82,141,151,180,191],"levofloxacin,":[83,181],"linezolid,":[84,182],"or":[86],"vancomycin.":[87],"Penicillin":[88],"resistance":[89],"observed":[91,160],"among":[92,123,138,161],"14.8%":[93],"highest":[99],"in":[100,118,195],"Asia/Pacific":[101],"Rim":[102],"(30.1%)":[103],"Africa":[105,119],"(27.6%);":[106],"23.4%":[107],"penicillin-intermediate,":[113],"which":[114,152],"most":[116,192],"common":[117],"(37.6%).":[120],"Minocycline":[121],"susceptibility":[122,135],"decreased":[126],"20%":[128],"2004-2008":[130],"2009-2012.":[132],"High":[133],"(>98.5%)":[134],"reported":[137],"H.":[139,164,187],"all":[142],"antimicrobial":[143,193],"agents":[144,194],"T.E.S.T.":[147],"panel":[148,198],"excluding":[149],"ampicillin,":[150],"only":[153],"78.3%":[154],"susceptible.":[156],"\u03b2-lactamase":[157,171],"production":[158],"20.2%":[162],"isolates;":[166],"1.5%":[167],"negative,":[172],"ampicillin-resistant.":[173],"CONCLUSIONS:":[174],"remained":[177],"highly":[178],"vancomycin":[185],"while":[186],"(excluding":[199],"ampicillin).":[200]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}