{"id":"https://openalex.org/W2109079761","doi":"https://doi.org/10.1016/j.ijrobp.2004.07.020","title":"Phase I trial of ZD1839 (Iressa\u2122) and radiation in pediatric patients newly diagnosed with brain stem tumors or incompletely resected supratentorial malignant gliomas","display_name":"Phase I trial of ZD1839 (Iressa\u2122) and radiation in pediatric patients newly diagnosed with brain stem tumors or incompletely resected supratentorial malignant gliomas","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2109079761","doi":"https://doi.org/10.1016/j.ijrobp.2004.07.020","mag":"2109079761"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijrobp.2004.07.020","doi":"https://doi.org/10.1016/j.ijrobp.2004.07.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2004.07.020","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.redjournal.org/article/S036030160401291X/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108449378","display_name":"Jeffrey Russell Geyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.R. Geyer","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN","Pediatrics, University of Washington, Seattle, WA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]},{"raw_affiliation_string":"Pediatrics, University of Washington, Seattle, WA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110213508","display_name":"James M. Boyett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Boyett","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113841777","display_name":"James G. Douglas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Douglas","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062483954","display_name":"Penny Phillips","orcid":"https://orcid.org/0009-0005-3268-7155","observed_orcids":["https://orcid.org/0009-0005-3268-7155"]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Phillips","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001841105","display_name":"Tina Young Poussaint","orcid":"https://orcid.org/0000-0002-0814-0791","observed_orcids":["https://orcid.org/0000-0002-0814-0791"]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Young-Poussaint","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025567999","display_name":"Roger J. Packer","orcid":"https://orcid.org/0000-0001-9413-7531","observed_orcids":["https://orcid.org/0000-0001-9413-7531"]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Packer","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109896919","display_name":"H. S. Friedman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Friedman","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046264008","display_name":"Michael D. Prados","orcid":"https://orcid.org/0000-0002-9630-2075","observed_orcids":["https://orcid.org/0000-0002-9630-2075"]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Prados","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060208068","display_name":"Mark W. Kieran","orcid":"https://orcid.org/0000-0003-2184-7692","observed_orcids":["https://orcid.org/0000-0003-2184-7692"]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Kieran","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048354311","display_name":"S. Blaney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Blaney","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025080223","display_name":"Ian Pollack","orcid":"https://orcid.org/0009-0003-2247-2375","observed_orcids":["https://orcid.org/0009-0003-2247-2375"]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. Pollack","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042463331","display_name":"Larry E. Kun","orcid":"https://orcid.org/0000-0003-0386-419X","observed_orcids":["https://orcid.org/0000-0003-0386-419X"]},"institutions":[{"id":"https://openalex.org/I4210093802","display_name":"Pediatric Brain Tumor Consortium","ror":"https://ror.org/00hj21c17","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210093802"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Kun","raw_affiliation_strings":["Pediatric Brain Tumor Consortium, Memphis, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Brain Tumor Consortium, Memphis, TN","institution_ids":["https://openalex.org/I4210093802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.5213,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71233092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"60","issue":"1","first_page":"S251","last_page":"S251"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9580000042915344},{"id":"https://openalex.org/keywords/erlotinib","display_name":"erlotinib","score":0.8429999947547913},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/brainstem-glioma","display_name":"brainstem glioma","score":0.8330000042915344},{"id":"https://openalex.org/keywords/incomplete-resection","display_name":"incomplete resection","score":0.7549999952316284},{"id":"https://openalex.org/keywords/involved-field-radiotherapy","display_name":"involved-field radiotherapy","score":0.7860000133514404},{"id":"https://openalex.org/keywords/pediatric-brain-tumors","display_name":"pediatric brain tumors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/intratumoral-hemorrhage","display_name":"intratumoral hemorrhage","score":0.9819999933242798},{"id":"https://openalex.org/keywords/enzyme-inducing-anticonvulsants","display_name":"enzyme-inducing anticonvulsants","score":0.9620000123977661},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4429999887943268},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6079999804496765},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9390159845352173},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6553997993469238},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5168605446815491},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.47225016355514526},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46457064151763916},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4525619149208069},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3316038250923157},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.1775207817554474}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ijrobp.2004.07.020","doi":"https://doi.org/10.1016/j.ijrobp.2004.07.020","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijrobp.2004.07.020","pdf_url":null,"source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation Oncology*Biology*Physics","raw_type":"journal-article"},{"id":"doi:10.1016/s0360-3016(04)01291-x","doi":"https://doi.org/10.1016/s0360-3016(04)01291-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0360-3016(04)01291-x","pdf_url":"http://www.redjournal.org/article/S036030160401291X/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation OncologyBiologyPhysics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0360-3016(04)01291-x","doi":"https://doi.org/10.1016/s0360-3016(04)01291-x","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0360-3016(04)01291-x","pdf_url":"http://www.redjournal.org/article/S036030160401291X/pdf","source":{"id":"https://openalex.org/S110533041","display_name":"International Journal of Radiation Oncology*Biology*Physics","issn_l":"0360-3016","issn":["0360-3016","1879-355X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Radiation OncologyBiologyPhysics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109079761.pdf","grobid_xml":"https://content.openalex.org/works/W2109079761.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2340024792","https://openalex.org/W1971465436","https://openalex.org/W2605287751","https://openalex.org/W7100162271","https://openalex.org/W2118992609","https://openalex.org/W2107733793","https://openalex.org/W2244520218","https://openalex.org/W2002943210","https://openalex.org/W2061777697","https://openalex.org/W2075789273"],"abstract_inverted_index":null,"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
