{"id":"https://openalex.org/W2109059809","doi":"https://doi.org/10.1373/clinchem.2014.224816","title":"Usefulness of a Thyroglobulin Liquid Chromatography\u2013Tandem Mass Spectrometry Assay for Evaluation of Suspected Heterophile Interference","display_name":"Usefulness of a Thyroglobulin Liquid Chromatography\u2013Tandem Mass Spectrometry Assay for Evaluation of Suspected Heterophile Interference","publication_year":2014,"publication_date":"2014-05-09","ids":{"openalex":"https://openalex.org/W2109059809","doi":"https://doi.org/10.1373/clinchem.2014.224816","mag":"2109059809","pmid":"https://pubmed.ncbi.nlm.nih.gov/24812415"},"language":"en","primary_location":{"id":"doi:10.1373/clinchem.2014.224816","doi":"https://doi.org/10.1373/clinchem.2014.224816","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2014.224816","pdf_url":"http://clinchem.aaccjnls.org/content/clinchem/60/7/1016.full.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://clinchem.aaccjnls.org/content/clinchem/60/7/1016.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062296545","display_name":"Brian C. Netzel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian C Netzel","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110477023","display_name":"Stefan K. G. Grebe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan K G Grebe","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology","Department of Medicine Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041094047","display_name":"Alicia Algeciras\u2010Schimnich","orcid":"https://orcid.org/0000-0002-4455-6217","observed_orcids":["https://orcid.org/0000-0002-4455-6217"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alicia Algeciras-Schimnich","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041094047"],"corresponding_institution_ids":[],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":{"value":4636,"currency":"USD","value_usd":4636},"fwci":null,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"60","issue":"7","first_page":"1016","last_page":"1018"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.8695999979972839,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.03590000048279762,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.031300000846385956,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroglobulin","display_name":"thyroglobulin","score":0.8339999914169312},{"id":"https://openalex.org/keywords/heterophile-antibodies","display_name":"heterophile antibodies","score":0.7570000290870667},{"id":"https://openalex.org/keywords/anti-thyroglobulin-antibodies","display_name":"thyroglobulin antibodies","score":0.8759999871253967},{"id":"https://openalex.org/keywords/immunoassay-interference","display_name":"immunoassay interference","score":0.796999990940094},{"id":"https://openalex.org/keywords/thyroid-function-tests","display_name":"thyroid function tests","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2778835679","wikidata":"https://www.wikidata.org/wiki/Q412228","display_name":"Thyroglobulin","level":3,"score":0.8065595030784607},{"id":"https://openalex.org/C2777774473","wikidata":"https://www.wikidata.org/wiki/Q5747444","display_name":"Heterophile","level":3,"score":0.7888323664665222},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.7769482135772705},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.7358598709106445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.699717104434967},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.6395731568336487},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5562251210212708},{"id":"https://openalex.org/C119128265","wikidata":"https://www.wikidata.org/wiki/Q900165","display_name":"Detection limit","level":2,"score":0.5216808319091797},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.4964919686317444},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20324179530143738},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16930538415908813},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08543744683265686}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010949","descriptor_name":"Plasma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013954","descriptor_name":"Thyroglobulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1373/clinchem.2014.224816","doi":"https://doi.org/10.1373/clinchem.2014.224816","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2014.224816","pdf_url":"http://clinchem.aaccjnls.org/content/clinchem/60/7/1016.full.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:24812415","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24812415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Letter"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.889.1928","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.889.1928","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.clinchem.org/content/early/2014/04/28/clinchem.2014.224816.full.pdf","raw_type":"text"},{"id":"mag:2978709565","doi":null,"is_oa":false,"landing_page_url":"http://www.siscapa.com/uploads/2/5/7/8/25788380/msacl_2014_netzel_final.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1373/clinchem.2014.224816","doi":"https://doi.org/10.1373/clinchem.2014.224816","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2014.224816","pdf_url":"http://clinchem.aaccjnls.org/content/clinchem/60/7/1016.full.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9502999782562256,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1159597930","display_name":null,"funder_award_id":"R21CA-175542","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3700056219","display_name":null,"funder_award_id":"R21CA-155615","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2109059809.pdf","grobid_xml":"https://content.openalex.org/works/W2109059809.grobid-xml"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W71825053","https://openalex.org/W2121404782","https://openalex.org/W2137904973","https://openalex.org/W2167033601"],"related_works":["https://openalex.org/W7097296565","https://openalex.org/W2978709565","https://openalex.org/W4308134802","https://openalex.org/W2048413452","https://openalex.org/W4413803952","https://openalex.org/W1963582227","https://openalex.org/W2264897583","https://openalex.org/W2775371394","https://openalex.org/W3202499890","https://openalex.org/W1968012134"],"abstract_inverted_index":{"To":[0],"the":[1,27,64,78,94,101,130,168,184,231,255,269,304,325,344,347,358,371,452,470,508,518,526,546,560,566,572,579,588,595,621,631,644,651,687,695,711],"Editor:":[2],"The":[3,213,273,535],"accuracy":[4],"of":[5,66,82,96,103,113,132,135,170,216,218,230,257,268,275,320,343,354,357,474,517,574,585,597,689,708,713,725,760],"human":[6,750],"serum":[7,115,542,751],"thyroglobulin":[8,752],"(Tg)1":[9],"measurement":[10,283],"by":[11,16,38,47,55,63,109,122,163,178,284,303,481,550,578,650,692,701,748],"immunoassays":[12],"can":[13,31,745],"be":[14,301,738,746],"affected":[15],"anti-Tg":[17,753],"autoantibodies":[18,754],"(TgAB)":[19],"(1).":[20],"In":[21,77,160,395,562,583,610],"immunometric":[22,211],"Tg":[23,36,107,120,127,138,208,271,282,326,349,386,410,472,520,523,543,608,624,641,690,709,730],"assays,":[24],"which":[25,117,203,477],"dominate":[26],"market,":[28],"TgAB":[29,61,104,188],"interference":[30,62,323,336,400,599,728],"result":[32,205,267],"in":[33,99,157,186,206,210,253,290,324,427,496,710,729],"false-low":[34],"measurements.":[35],"quantification":[37,108,133,289,707,761],"liquid":[39,755],"chromatography\u2013tandem":[40,756],"mass":[41,493,757],"spectrometry":[42,758],"(LC-MS/MS)":[43],"was":[44,278,298,337,401,406,449,478,569],"first":[45],"described":[46],"Hoofnagle":[48],"et":[49,57,86,172],"al.":[50,58,87,173],"(2)":[51],"and":[52,225,242,377,380,434,436,440,451,511,521,635,655,659,670,674,732],"subsequently":[53],"shown":[54],"Clarke":[56],"to":[59,199,263,279,300,468,603,626,630,740],"overcome":[60,196],"use":[65],"proteotypic":[67,471],"peptide":[68,448,473,510],"quantitation":[69],"after":[70,234],"tryptic":[71],"digestion,":[72],"with":[73,147,220,238,244,292,363,383,421,438,456,529,571,614],"peptide-specific":[74],"immunocapture":[75],"(3).":[76],"June":[79],"2013":[80],"issue":[81],"Clinical":[83],"Chemistry,":[84],"Kushnir":[85,171],"presented":[88],"a":[89,154,311,384,482,605,627],"study":[90,146,277,297],"that":[91,111,192,686,734,744],"further":[92],"solidified":[93],"usefulness":[95],"using":[97,411],"LC-MS/MS":[98,137,285,522,580,633,693],"overcoming":[100,187],"effects":[102],"on":[105,346,487,559,643],"accurate":[106,266,288,706],"demonstrating":[110],"23%":[112],"TgAB-positive":[114],"samples,":[116,540],"had":[118,126,541,592,601,618],"undetectable":[119],"concentrations":[121,544,642,691],"immunoassay":[123,246,327],"(<0.1":[124],"\u03bcg/L),":[125],"values":[128],"above":[129],"limit":[131,759],"(LOQ)":[134],"their":[136],"assay":[139,350,387,581],"(\u22650.5":[140],"\u03bcg/L)":[141,549],"(4).":[142],"We":[143,684,717],"read":[144],"this":[145,193,249,276,720,735],"great":[148],"interest":[149,475],"because":[150],"we":[151,190],"recently":[152],"implemented":[153],"similar":[155],"methodology":[156,194],"our":[158,165,314],"laboratory.":[159],"TgAB-positive/Tg-negative":[161],"samples":[162,219,291,453,528,637],"immunoassay,":[164],"results":[166,331,372],"matched":[167,524],"findings":[169],"very":[174],"well":[175],"(21%":[176],"positive":[177,497],"LC-MS/MS,":[179,551],"n":[180],"=":[181,432],"115).":[182],"Given":[183],"success":[185],"interferences,":[189],"believed":[191],"would":[195,286],"interferences":[197],"due":[198],"heterophilic":[200,615,762],"antibodies":[201],"(HAB),":[202],"may":[204],"false-high":[207],"measurements":[209],"assays.":[212],"current":[214],"process":[215],"workup":[217,250,532,591,700],"suspected":[221,293,726],"HAB":[222,239,258,294,322,335,364,399,531,590,598,699,715,727],"is":[223],"complex":[224],"costly.":[226],"It":[227],"involves":[228],"remeasurement":[229],"questionable":[232],"sample":[233,345,405],"serial":[235,341],"dilutions,":[236],"pretreatment":[237,362,613],"blocking":[240,365,616],"reagents,":[241],"reassaying":[243],"alternative":[245],"platforms.":[247],"While":[248],"usually":[251],"succeeds":[252],"confirming":[254],"presence":[256,596,712],"interference,":[259],"it":[260],"frequently":[261],"fails":[262],"provide":[264,604],"an":[265,488],"true":[270],"concentration.":[272],"goal":[274],"determine":[280],"whether":[281],"allow":[287],"interference.":[295],"This":[296],"determined":[299],"exempt":[302],"Mayo":[305],"Clinic":[306],"institutional":[307],"review":[308],"board.":[309],"During":[310],"4-month":[312],"period,":[313],"laboratory":[315],"received":[316],"requests":[317],"for":[318,332,409,459,507,525,697,722],"investigation":[319],"potential":[321],"(Access,":[328],"Beckman":[329,652],"Coulter)":[330],"7":[333],"patients.":[334],"excluded":[338],"when":[339],"(a)":[340],"dilutions":[342,355,662,677],"Access":[348,519,623],"were":[351,418,425,454,465,505],"linear":[352],"(recovery":[353],"\u00b115%":[356],"original":[359],"value),":[360],"(b)":[361],"reagents":[366],"did":[367],"not":[368,619,667,682],"substantially":[369],"alter":[370],"(<20%":[373],"difference":[374],"between":[375],"treated":[376],"untreated":[378],"samples),":[379],"(c)":[381],"retesting":[382],"different":[385],"(Immulite,":[388],"Siemens":[389],"Corporation)":[390],"yielded":[391],"similarly":[392],"increased":[393,640],"values.":[394],"all":[396,563,723],"other":[397,536,741],"cases":[398,565,724],"considered":[402],"likely.":[403],"Each":[404],"then":[407,466],"assayed":[408,479],"LC-MS/MS.":[412],"Briefly,":[413],"large":[414],"proteins,":[415],"including":[416],"Tg,":[417],"selectively":[419],"precipitated":[420],"ammonium":[422,428],"sulfate.":[423],"Pellets":[424],"resuspended":[426],"bicarbonate":[429],"buffer":[430],"(pH":[431],"8)":[433],"reduced":[435,620],"alkylated":[437],"dithiothreitol":[439],"iodoacetamide,":[441],"respectively.":[442,665,680],"C13-labeled":[443],"stable":[444],"isotope":[445],"internal":[446,514],"standard":[447],"added,":[450],"digested":[455],"bovine":[457],"trypsin":[458],"16":[460],"h.":[461],"Antibody-labeled":[462],"magnetic":[463],"beads":[464],"added":[467],"capture":[469],"(FSPDDSAGASALLR),":[476],"postelution":[480],"single-reaction":[483],"monitoring\u2013based":[484],"MS/MS":[485],"method":[486],"API":[489],"5000":[490],"(AB":[491],"SCIEX)":[492],"spectrometer":[494],"operating":[495],"electrospray":[498],"ionization":[499],"mode.":[500],"Three":[501],"ion":[502],"transitions":[503],"each":[504],"monitored":[506],"native":[509],"its":[512],"corresponding":[513,632],"standard.":[515],"Results":[516],"4":[527],"negative":[530],"(Table":[533],"1).":[534],"3,":[537],"likely":[538],"HAB-positive":[539],"below":[545],"LOQ":[547],"(<0.5":[548],"but":[552,600],"measured":[553,747],"as":[554,556,576],"high":[555],"604":[557],"\u03bcg/L":[558],"Access.":[561],"3":[564],"clinical":[567],"presentation":[568],"concordant":[570],"absence":[573],"disease,":[575],"predicted":[577],"results.":[582],"2":[584],"these":[586,611,636],"cases,":[587,612],"traditional":[589],"only":[593],"ascertained":[594],"failed":[602],"reliable":[606],"quantitative":[607],"result.":[609],"reagent":[617],"apparent":[622],"concentration":[625],"value":[628],"comparable":[629],"measurement,":[634,731],"also":[638],"showed":[639],"Immulite":[645],"platform,":[646],"albeit":[647],"lower":[648],"than":[649],"assay.":[653],"\u00d72":[654,669],"\u00d74:":[656,671],"1:2":[657,672],"(v/v)":[658,661,673,676],"1:4":[660,675],"from":[663,678],"neat,":[664,679],"NA,":[666,681],"assessed.":[668,683],"conclude":[685],"determination":[688],"obviates":[694],"need":[696],"extensive":[698],"classical":[702],"methods,":[703],"while":[704],"providing":[705],"substantial":[714],"interferences.":[716],"propose":[718],"adopting":[719],"approach":[721,736],"hypothesize":[733],"could":[737],"extended":[739],"analytical":[742],"targets":[743],"LC-MS.":[749],"antibodies.":[763]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}