{"id":"https://openalex.org/W2109042013","doi":"https://doi.org/10.3109/13693786.2010.535031","title":"Disruption of sphingolipid biosynthetic geneIPT1reducesCandida albicansadhesion and prevents activation of human gingival epithelial cell innate immune defense","display_name":"Disruption of sphingolipid biosynthetic geneIPT1reducesCandida albicansadhesion and prevents activation of human gingival epithelial cell innate immune defense","publication_year":2010,"publication_date":"2010-11-22","ids":{"openalex":"https://openalex.org/W2109042013","doi":"https://doi.org/10.3109/13693786.2010.535031","mag":"2109042013","pmid":"https://pubmed.ncbi.nlm.nih.gov/21091155"},"language":"en","primary_location":{"id":"doi:10.3109/13693786.2010.535031","doi":"https://doi.org/10.3109/13693786.2010.535031","is_oa":false,"landing_page_url":"https://doi.org/10.3109/13693786.2010.535031","pdf_url":null,"source":{"id":"https://openalex.org/S93288122","display_name":"Medical Mycology","issn_l":"0268-1218","issn":["0268-1218","1365-280X","1369-3786","1460-2709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Mycology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017099324","display_name":"Mahmoud Rouabhia","orcid":"https://orcid.org/0000-0003-2205-8281","observed_orcids":["https://orcid.org/0000-0003-2205-8281"]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mahmoud Rouabhia","raw_affiliation_strings":["Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada. mahmoud.rouabhia@fmd.ulaval.ca","Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire , Universit\u00e9 Laval , Quebec City, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire, Universit\u00e9 Laval, Qu\u00e9bec City, Qu\u00e9bec, Canada. mahmoud.rouabhia@fmd.ulaval.ca","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire , Universit\u00e9 Laval , Quebec City, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049239234","display_name":"Pranab K. Mukherjee","orcid":"https://orcid.org/0000-0003-0244-6068","observed_orcids":["https://orcid.org/0000-0003-0244-6068"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranab K. Mukherjee","raw_affiliation_strings":["\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075408488","display_name":"Ali Abdul Lattif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ali Abdul Lattif","raw_affiliation_strings":["\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080861792","display_name":"S\u00e8verine Curt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S\u00e8verine Curt","raw_affiliation_strings":["Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire , Universit\u00e9 Laval , Quebec City, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groupe de Recherche en \u00c9cologie Buccale, Facult\u00e9 de M\u00e9decine Dentaire , Universit\u00e9 Laval , Quebec City, Quebec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112335636","display_name":"Jyotsna Chandra","orcid":"https://orcid.org/0000-0003-0689-8918","observed_orcids":["https://orcid.org/0000-0003-0689-8918"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jyotsna Chandra","raw_affiliation_strings":["\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089635085","display_name":"Mahmoud Afif Ghannoum","orcid":"https://orcid.org/0000-0002-8833-7323","observed_orcids":["https://orcid.org/0000-0002-8833-7323"]},"institutions":[{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahmoud A. Ghannoum","raw_affiliation_strings":["\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Center for Medical Mycology, Department of Dermatology, School of Medicine, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I4210108791","https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4889,"currency":"USD","value_usd":4889},"apc_paid":null,"fwci":1.2516,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.7788408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"49","issue":"5","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.95169997215271,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.015799999237060547,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9430000185966492},{"id":"https://openalex.org/keywords/sphingolipid-biosynthesis","display_name":"sphingolipid biosynthesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/fungal-adhesion","display_name":"fungal adhesion","score":0.7630000114440918},{"id":"https://openalex.org/keywords/gingival-epithelial-cells","display_name":"gingival epithelial cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/innate-immune-defense","display_name":"innate immune defense","score":0.7519999742507935},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.7720000147819519},{"id":"https://openalex.org/keywords/beta-defensins","display_name":"beta-defensins","score":0.8479999899864197},{"id":"https://openalex.org/keywords/human-beta-defensin-2","display_name":"human beta-defensin 2","score":0.75},{"id":"https://openalex.org/keywords/human-beta-defensin-3","display_name":"human beta-defensin 3","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oral-candidiasis","display_name":"oral candidiasis","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8130075931549072},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.725320041179657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7205122709274292},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6858670711517334},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6454036831855774},{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.513522207736969},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.5020754337310791},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4796065092086792},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4762133061885834},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.420888751745224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38081517815589905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37213122844696045},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3279578983783722},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.28985947370529175},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22938665747642517},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.08152708411216736},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07261967658996582}],"mesh":[{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009061","descriptor_name":"Mouth Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037521","descriptor_name":"Virulence Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/13693786.2010.535031","doi":"https://doi.org/10.3109/13693786.2010.535031","is_oa":false,"landing_page_url":"https://doi.org/10.3109/13693786.2010.535031","pdf_url":null,"source":{"id":"https://openalex.org/S93288122","display_name":"Medical Mycology","issn_l":"0268-1218","issn":["0268-1218","1365-280X","1369-3786","1460-2709"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Mycology","raw_type":"journal-article"},{"id":"pmid:21091155","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21091155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical mycology","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:mmy:49/5/458","doi":null,"is_oa":false,"landing_page_url":"http://mmy.oxfordjournals.org/cgi/content/short/49/5/458","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1068163607","display_name":"Identification of early phase C. albicans biofilm proteins","funder_award_id":"R01DE017486","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G2294279415","display_name":null,"funder_award_id":"R21-AI74077-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3923289258","display_name":"Role of extracellular matrix proteins in Candida biofilm formation","funder_award_id":"R21AI074077","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1533201513","https://openalex.org/W1541663010","https://openalex.org/W1963556653","https://openalex.org/W1983768017","https://openalex.org/W1992579069","https://openalex.org/W1992718750","https://openalex.org/W1995886924","https://openalex.org/W2004465286","https://openalex.org/W2005537124","https://openalex.org/W2010453472","https://openalex.org/W2017403003","https://openalex.org/W2019497539","https://openalex.org/W2021405971","https://openalex.org/W2023605893","https://openalex.org/W2028325150","https://openalex.org/W2037368492","https://openalex.org/W2049260737","https://openalex.org/W2051691075","https://openalex.org/W2054952543","https://openalex.org/W2063411604","https://openalex.org/W2074680101","https://openalex.org/W2076519123","https://openalex.org/W2081052471","https://openalex.org/W2089559505","https://openalex.org/W2100126957","https://openalex.org/W2100585044","https://openalex.org/W2101059527","https://openalex.org/W2107585300","https://openalex.org/W2110575428","https://openalex.org/W2118902193","https://openalex.org/W2123473536","https://openalex.org/W2125293812","https://openalex.org/W2137115238","https://openalex.org/W2151601011","https://openalex.org/W2157935239","https://openalex.org/W2157978054","https://openalex.org/W2166666225"],"related_works":["https://openalex.org/W1983768017","https://openalex.org/W2131392300","https://openalex.org/W2054461995","https://openalex.org/W2100126957","https://openalex.org/W2071482962","https://openalex.org/W2089225463","https://openalex.org/W7029359727","https://openalex.org/W2946798860","https://openalex.org/W2039605305","https://openalex.org/W1980882000"],"abstract_inverted_index":{"We":[0],"demonstrated":[1],"the":[2,13,32,45,93,97,123,128,139,147,153,162,171],"effect":[3,104,151],"of":[4,149,170],"a":[5,135,168],"Candida":[6,19,37,64,100,132],"albicans":[7],"sphingolipid":[8],"biosynthetic":[9],"gene,":[10],"IPT1,":[11],"on":[12,105,155],"interaction":[14],"between":[15],"gingival":[16,40],"epithelial":[17,41,54,94,156],"and":[18,24,47,73,80,88,120,130,134,181],"cells":[20,55],"using":[21],"monolayer":[22],"cultures":[23],"engineered":[25],"human":[26],"oral":[27],"mucosa":[28],"tissue":[29,125],"(EHOM).":[30],"Disrupting":[31],"IPT1":[33,172],"gene":[34,90,173],"greatly":[35],"reduced":[36],"adhesion":[38,52],"to":[39,44,53,165],"cells,":[42,95],"compared":[43],"wild-type":[46,79,129],"revertant":[48,81,131],"strains.":[49],"The":[50,78],"yeasts":[51],"may":[56],"activate":[57],"toll-like":[58],"receptors":[59],"(TLRs).":[60],"Cell":[61],"response":[62],"against":[63],"infection":[65],"was":[66,110],"thus":[67,177],"investigated":[68],"by":[69,112,152],"evaluating":[70],"TLR":[71,179],"expression":[72,91,116,137],"antimicrobial":[74],"peptide":[75],"(AMP)":[76],"production.":[77],"strains":[82],"both":[83],"activated":[84],"TLR2,":[85],"TLR4,":[86],"TLR6,":[87],"TLR9":[89],"in":[92,122,138],"whereas":[96],"\u0394ipt1":[98,140,154],"mutant":[99],"strain":[101],"had":[102],"no":[103],"this":[106],"expression.":[107,183],"This":[108,160],"finding":[109],"supported":[111],"an":[113],"increased":[114],"AMP":[115],"(human":[117],"\u03b2-defensin":[118,182],"HBD-2":[119],"HBD-3)":[121],"EHOM":[124],"infected":[126],"with":[127],"strains,":[133],"decreased":[136],"mutant-infected":[141],"model.":[142],"HBD":[143],"protein":[144],"secretion":[145],"confirmed":[146],"absence":[148],"any":[150],"cell":[157],"innate":[158],"defense.":[159],"is":[161],"first":[163],"study":[164],"demonstrate":[166],"that":[167],"disruption":[169],"affects":[174],"Candida-host":[175],"interaction,":[176],"preventing":[178],"activation":[180]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}