{"id":"https://openalex.org/W2109029563","doi":"https://doi.org/10.1073/pnas.1633516100","title":"The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3","display_name":"The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3","publication_year":2003,"publication_date":"2003-07-16","ids":{"openalex":"https://openalex.org/W2109029563","doi":"https://doi.org/10.1073/pnas.1633516100","mag":"2109029563","pmid":"https://pubmed.ncbi.nlm.nih.gov/12867595","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/170920"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1633516100","doi":"https://doi.org/10.1073/pnas.1633516100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1633516100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/170920","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100433187","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-6523-7573","observed_orcids":["https://orcid.org/0000-0002-6523-7573"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jinbo Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Jinbo Yang","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102833431","display_name":"Sanjit Kumer Roy","orcid":"https://orcid.org/0000-0002-0406-7259","observed_orcids":["https://orcid.org/0000-0002-0406-7259"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Sanjit K. Roy","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001183039","display_name":"Silvia Tininini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Silvia Tininini","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113566173","display_name":"Jiadi Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Jiadi Hu","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040275059","display_name":"Jacqueline Bromberg","orcid":"https://orcid.org/0000-0002-7957-9339","observed_orcids":["https://orcid.org/0000-0002-7957-9339"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Jacqueline F. Bromberg","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019791912","display_name":"Valeria Poli","orcid":"https://orcid.org/0000-0002-3739-3966","observed_orcids":["https://orcid.org/0000-0002-3739-3966"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Valeria Poli","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080998429","display_name":"George Robert Stark","orcid":"https://orcid.org/0000-0002-8776-9597","observed_orcids":["https://orcid.org/0000-0002-8776-9597"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"George R. Stark","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031774412","display_name":"Dhananjaya V. Kalvakolanu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Dhananjaya V. Kalvakolanu","raw_affiliation_strings":["Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Greenebaum Cancer Center, Department of\r Microbiology and Immunology, University of Maryland School of Medicine,\r Baltimore, MD 21201;Department of Molecular\r Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH\r 44195; Sloan\u2013Kettering Cancer Center, New\r York, NY 10021; and Department of Genetics,\r Biology, and Biochemistry, University of Turin, 10126 Turin, Italy","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1316902750","https://openalex.org/I1334819555","https://openalex.org/I4405287411","https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3875,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.89222915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"100","issue":"16","first_page":"9342","last_page":"9347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/grim-19","display_name":"GRIM-19","score":1.0},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6620000004768372},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6679999828338623},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.6439999938011169},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.38499999046325684},{"id":"https://openalex.org/keywords/transactivation-domain","display_name":"transactivation domain","score":0.7480000257492065},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/antiapoptotic-genes","display_name":"anti-apoptotic genes","score":0.7829999923706055},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.6430000066757202},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.7243773937225342},{"id":"https://openalex.org/C171958077","wikidata":"https://www.wikidata.org/wiki/Q419333","display_name":"STAT protein","level":4,"score":0.680640459060669},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6582096219062805},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6428411602973938},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5836995840072632},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5789852738380432},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5510650873184204},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5388436317443848},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.5337560772895813},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5099378824234009},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.49729636311531067},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4645848572254181},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.39610469341278076},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38426458835601807},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38228940963745117},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3352445960044861},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3262668251991272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3017774820327759},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21258747577667236},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009247","descriptor_name":"NADH, NADPH Oxidoreductases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016376","descriptor_name":"Oligonucleotides, Antisense","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020798","descriptor_name":"Two-Hybrid System Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1633516100","doi":"https://doi.org/10.1073/pnas.1633516100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1633516100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:170920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/170920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:12867595","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12867595","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/41697","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/41697","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:170920","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/170920","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3301377686","display_name":"Modulation of IFN action via novel regulatory factors","funder_award_id":"R01CA078282","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5188953928","display_name":"TUMOR GROWTH INHIBITION BY INTERFERON B AND RETINOIDS","funder_award_id":"R01CA071401","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W98667219","https://openalex.org/W318497777","https://openalex.org/W1409332955","https://openalex.org/W1560408723","https://openalex.org/W1665377041","https://openalex.org/W1682348115","https://openalex.org/W1821858011","https://openalex.org/W1974778979","https://openalex.org/W1981799488","https://openalex.org/W1981964452","https://openalex.org/W1984486504","https://openalex.org/W1987311887","https://openalex.org/W1988827270","https://openalex.org/W1993520606","https://openalex.org/W1998010996","https://openalex.org/W1999059713","https://openalex.org/W2008228521","https://openalex.org/W2017699858","https://openalex.org/W2026318599","https://openalex.org/W2028202780","https://openalex.org/W2032674547","https://openalex.org/W2036263889","https://openalex.org/W2054194135","https://openalex.org/W2055952888","https://openalex.org/W2062005942","https://openalex.org/W2065404736","https://openalex.org/W2067244501","https://openalex.org/W2068530962","https://openalex.org/W2074356752","https://openalex.org/W2079715612","https://openalex.org/W2086565810","https://openalex.org/W2091232397","https://openalex.org/W2094797375","https://openalex.org/W2108125679","https://openalex.org/W2116988305","https://openalex.org/W2118069570","https://openalex.org/W2121428233","https://openalex.org/W2122506044","https://openalex.org/W2126408170","https://openalex.org/W2137695731","https://openalex.org/W2142656958","https://openalex.org/W2144634347","https://openalex.org/W2159730182","https://openalex.org/W2163046152","https://openalex.org/W2164088683","https://openalex.org/W2174654204","https://openalex.org/W2230705365","https://openalex.org/W2394503112","https://openalex.org/W2412565307","https://openalex.org/W2992868376","https://openalex.org/W4251966084","https://openalex.org/W4323053376","https://openalex.org/W6600908467"],"related_works":["https://openalex.org/W2158666748","https://openalex.org/W1999059713","https://openalex.org/W2372263306","https://openalex.org/W3029871579","https://openalex.org/W2101849490","https://openalex.org/W2001570908","https://openalex.org/W2006780239","https://openalex.org/W3182704329","https://openalex.org/W3030904694","https://openalex.org/W1988827270"],"abstract_inverted_index":{"GRIM-19":[0,47,100,142,145,175],"(gene":[1],"associated":[2],"with":[3],"retinoid-IFN-induced":[4],"mortality":[5],"19),":[6],"isolated":[7],"as":[8],"a":[9,14,31,39,61,79,156],"cell":[10,27,42,51,73],"death":[11,52,74],"activator":[12,93],"in":[13,22,38],"genetic":[15],"screen":[16,82],"used":[17,78],"to":[18,50,64,98,123,125,150,168],"define":[19],"mechanisms":[20],"involved":[21],"IFN-beta-":[23],"and":[24,59,83,92],"retinoic":[25,57],"acid-induced":[26],"death,":[28],"codes":[29],"for":[30,71,141],"approximately":[32],"16-kDa":[33],"protein":[34],"that":[35,85,130],"induces":[36],"apoptosis":[37],"number":[40],"of":[41,46,94,106,117,134,159],"lines.":[43],"Antisense":[44],"ablation":[45],"caused":[48],"resistance":[49],"induced":[53],"by":[54,104,174,182],"IFN":[55],"plus":[56],"acid":[58],"conferred":[60],"growth":[62],"advantage":[63],"cells.":[65],"To":[66],"understand":[67],"the":[68,86,114,131],"molecular":[69],"bases":[70],"its":[72,121,172],"regulatory":[75],"activity,":[76],"we":[77],"yeast":[80],"two-hybrid":[81],"identified":[84],"transcription":[87,95,102],"factor":[88],"STAT3":[89,118,164],"(signal":[90],"transducer":[91],"3)":[96],"binds":[97],"GRIM-19.":[99],"inhibits":[101,113],"driven":[103],"activation":[105,116],"STAT3,":[107,135],"but":[108],"not":[109,147],"STAT1.":[110],"It":[111],"neither":[112],"ligand-induced":[115],"nor":[119],"blocks":[120],"ability":[122],"bind":[124,148],"DNA.":[126],"Mutational":[127],"analysis":[128],"indicates":[129],"transactivation":[132],"domain":[133],"especially":[136],"residue":[137],"S727,":[138],"is":[139],"required":[140],"binding.":[143],"Because":[144,161],"does":[146],"significantly":[149],"other":[151],"STATs,":[152],"our":[153],"studies":[154],"identify":[155],"specific":[157],"inhibitor":[158],"STAT3.":[160],"constitutively":[162],"active":[163],"up-regulates":[165],"antiapoptotic":[166],"genes":[167],"promote":[169],"tumor":[170],"survival,":[171],"inhibition":[173],"also":[176],"demonstrates":[177],"an":[178],"antioncogenic":[179],"effect":[180],"exerted":[181],"biological":[183],"therapeutics.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
