{"id":"https://openalex.org/W2108995155","doi":"https://doi.org/10.1158/1940-6207.capr-08-0157","title":"Effects of Vitamin D and Calcium Supplementation on Markers of Apoptosis in Normal Colon Mucosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","display_name":"Effects of Vitamin D and Calcium Supplementation on Markers of Apoptosis in Normal Colon Mucosa: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2108995155","doi":"https://doi.org/10.1158/1940-6207.capr-08-0157","mag":"2108995155","pmid":"https://pubmed.ncbi.nlm.nih.gov/19258546","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2712935"},"language":"en","primary_location":{"id":"doi:10.1158/1940-6207.capr-08-0157","doi":"https://doi.org/10.1158/1940-6207.capr-08-0157","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-08-0157","pdf_url":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/2/3/213/2336113/213.pdf","source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/2/3/213/2336113/213.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038151302","display_name":"Veronika Fedirko","orcid":"https://orcid.org/0000-0002-7805-9913","observed_orcids":["https://orcid.org/0000-0002-7805-9913"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronika Fedirko","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056577980","display_name":"Roberd M. Bostick","orcid":"https://orcid.org/0000-0001-8626-4186","observed_orcids":["https://orcid.org/0000-0001-8626-4186"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roberd M. Bostick","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088838308","display_name":"W. Dana Flanders","orcid":"https://orcid.org/0000-0003-4069-3262","observed_orcids":["https://orcid.org/0000-0003-4069-3262"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Dana Flanders","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002149616","display_name":"Qi Long","orcid":"https://orcid.org/0000-0003-0660-5230","observed_orcids":["https://orcid.org/0000-0003-0660-5230"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Long","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000135593","display_name":"Aasma Shaukat","orcid":"https://orcid.org/0000-0003-2446-8858","observed_orcids":["https://orcid.org/0000-0003-2446-8858"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aasma Shaukat","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113765451","display_name":"Robin E. Rutherford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robin E. Rutherford","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076793624","display_name":"Carrie R. Daniel","orcid":"https://orcid.org/0000-0002-6455-9482","observed_orcids":["https://orcid.org/0000-0002-6455-9482"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie R. Daniel","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010708905","display_name":"Vaunita Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaunita Cohen","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023642264","display_name":"Chiranjeev Dash","orcid":"https://orcid.org/0000-0002-3314-8461","observed_orcids":["https://orcid.org/0000-0002-3314-8461"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I4390039307","display_name":"Winship Cancer Institute","ror":"https://ror.org/02gars961","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I132943300","https://openalex.org/I150468666","https://openalex.org/I4390039307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiranjeev Dash","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Epidemiology and 2Biostatistics and Bioinformatics, Rollins School of Public Health, 3Winship Cancer Institute, and 4Nutrition and Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University; 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and 6Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"]},{"raw_affiliation_string":"Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia and Department of Medicine, GI Division University of Minnesota, Minneapolis, Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056577980"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I150468666","https://openalex.org/I4390039307"],"apc_list":null,"apc_paid":null,"fwci":10.6943,"has_fulltext":true,"cited_by_count":141,"citation_normalized_percentile":{"value":0.98734869,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"2","issue":"3","first_page":"213","last_page":"223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.7490000128746033},{"id":"https://openalex.org/keywords/calcium-supplementation","display_name":"calcium supplementation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/colorectal-cancer-chemoprevention","display_name":"colorectal cancer chemoprevention","score":0.8999999761581421},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7739999890327454},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.8209999799728394},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/colorectal-mucosa","display_name":"colorectal mucosa","score":0.8579999804496765},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.7551146745681763},{"id":"https://openalex.org/C2776861080","wikidata":"https://www.wikidata.org/wiki/Q2825480","display_name":"Colorectal adenoma","level":4,"score":0.7167186141014099},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6943459510803223},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6672666668891907},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.666475772857666},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6153461337089539},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6081191301345825},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5698386430740356},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5591438412666321},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5399510860443115},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.5084875822067261},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4081735610961914},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33083003759384155},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.262337327003479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2198050618171692},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05478113889694214},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010919","descriptor_name":"Placebos","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/1940-6207.capr-08-0157","doi":"https://doi.org/10.1158/1940-6207.capr-08-0157","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-08-0157","pdf_url":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/2/3/213/2336113/213.pdf","source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},{"id":"pmid:19258546","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19258546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer prevention research (Philadelphia, Pa.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2712935","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2712935","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Prev Res (Phila)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1940-6207.capr-08-0157","doi":"https://doi.org/10.1158/1940-6207.capr-08-0157","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1940-6207.capr-08-0157","pdf_url":"https://aacrjournals.org/cancerpreventionresearch/article-pdf/2/3/213/2336113/213.pdf","source":{"id":"https://openalex.org/S68240649","display_name":"Cancer Prevention Research","issn_l":"1940-6207","issn":["1940-6207","1940-6215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Prevention Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G6378573763","display_name":"Calcium, Vitamin D, and Colon Cancer Risk Biomarkers","funder_award_id":"R01CA104637","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306352","display_name":"Georgia Cancer Coalition","ror":"https://ror.org/0009gvn90"},{"id":"https://openalex.org/F4320309381","display_name":"Emory University","ror":"https://ror.org/03czfpz43"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108995155.pdf","grobid_xml":"https://content.openalex.org/works/W2108995155.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W53976003","https://openalex.org/W633735835","https://openalex.org/W1501337617","https://openalex.org/W1524633813","https://openalex.org/W1848438463","https://openalex.org/W1874198797","https://openalex.org/W1911229066","https://openalex.org/W1925555331","https://openalex.org/W1943978442","https://openalex.org/W1975299982","https://openalex.org/W1981459672","https://openalex.org/W1985008364","https://openalex.org/W1985681748","https://openalex.org/W2002749521","https://openalex.org/W2013461192","https://openalex.org/W2027217217","https://openalex.org/W2032466214","https://openalex.org/W2043103956","https://openalex.org/W2045187623","https://openalex.org/W2059031176","https://openalex.org/W2061758378","https://openalex.org/W2065195395","https://openalex.org/W2075328076","https://openalex.org/W2086702544","https://openalex.org/W2088095827","https://openalex.org/W2108581685","https://openalex.org/W2118656744","https://openalex.org/W2122047019","https://openalex.org/W2130359015","https://openalex.org/W2131239997","https://openalex.org/W2138302361","https://openalex.org/W2138328097","https://openalex.org/W2145093848","https://openalex.org/W2147878702","https://openalex.org/W2148652353","https://openalex.org/W2152879728","https://openalex.org/W2153523313","https://openalex.org/W2156394393","https://openalex.org/W2160754318","https://openalex.org/W2162288503","https://openalex.org/W2163083747","https://openalex.org/W2163626466","https://openalex.org/W2164290357","https://openalex.org/W2168909107","https://openalex.org/W2170521004","https://openalex.org/W2172080383","https://openalex.org/W2182950295","https://openalex.org/W2315087128","https://openalex.org/W2319963574","https://openalex.org/W4242253298","https://openalex.org/W6629768831","https://openalex.org/W6646593427","https://openalex.org/W6657332898","https://openalex.org/W6685048942","https://openalex.org/W6808623432"],"related_works":["https://openalex.org/W2903787460","https://openalex.org/W2111083260","https://openalex.org/W2097199943","https://openalex.org/W2112110686","https://openalex.org/W2114228220","https://openalex.org/W2313926754","https://openalex.org/W4302402048","https://openalex.org/W2460565247","https://openalex.org/W2045187623","https://openalex.org/W2051251986"],"abstract_inverted_index":{"To":[0],"further":[1],"clarify":[2],"and/or":[3],"develop":[4,30],"calcium":[5,56,89,164,169,219],"and":[6,29,57,61,75,106,115,131,159,168,220,235,245],"vitamin":[7,58,93,156,171,183,221,242],"D":[8,157,172,184,243],"as":[9],"chemopreventive":[10],"agents":[11,23],"against":[12],"colorectal":[13,36,71,82,107,233,252],"cancer":[14],"in":[15,62,68,97,120,154,161,190,229,246],"humans,":[16],"understand":[17],"the":[18,27,53,69,144,155,163,179,191,230,236,247,251],"mechanisms":[19],"by":[20,128,133],"which":[21],"these":[22,214],"reduce":[24],"risk":[25,34],"for":[26,35],"disease,":[28],"\"treatable\"":[31],"biomarkers":[32],"of":[33,55,66,110,122,139,147,197,250],"cancer,":[37],"we":[38],"conducted":[39],"a":[40],"pilot,":[41],"randomized,":[42],"double-blind,":[43],"placebo-controlled,":[44],"2":[45,47],"x":[46],"factorial":[48],"clinical":[49],"trial":[50],"to":[51,178],"test":[52],"effects":[54,209,239],"D3,":[59,94],"alone":[60,95],"combination":[63],"on":[64,210],"markers":[65],"apoptosis,":[67],"normal":[70,231],"mucosa.":[72],"Ninety-two":[73],"men":[74],"women":[76],"with":[77,86],"at":[78],"least":[79],"one":[80],"pathology-confirmed":[81],"adenoma":[83],"were":[84,126,204],"treated":[85],"2.0":[87],"g/d":[88],"or":[90,96,194,224],"800":[91],"IU/d":[92],"combination,":[98],"versus":[99],"placebo":[100,180],"over":[101],"6":[102,137],"months.":[103],"Overall":[104],"expression":[105,142],"crypt":[108],"distributions":[109],"Bcl-2":[111,211],"(an":[112,117],"apoptosis":[113,118,228],"inhibitor)":[114],"Bax":[116,141],"promoter)":[119],"biopsies":[121],"normal-appearing":[123],"rectal":[124],"mucosa":[125],"detected":[127],"automated":[129],"immunohistochemistry":[130],"quantified":[132],"image":[134],"analysis.":[135],"After":[136],"months":[138],"treatment,":[140],"along":[143],"full":[145],"lengths":[146],"crypts":[148,198],"increased":[149],"56%":[150],"(P":[151,165,173],"=":[152,166,174,201],"0.02)":[153],"group":[158],"33%":[160],"both":[162],"0.31)":[167],"plus":[170],"0.36)":[175],"groups":[176],"relative":[177],"group.":[181],"The":[182],"treatment":[185,208,238],"effect":[186],"was":[187],"more":[188],"pronounced":[189],"upper":[192,248],"40%,":[193],"differentiation":[195],"zone,":[196],"(80%;":[199],"P":[200],"0.01).":[202],"There":[203],"no":[205],"statistically":[206],"significant":[207],"expression.":[212],"Overall,":[213],"preliminary":[215],"results":[216],"suggest":[217],"that":[218],"D,":[222],"individually":[223],"together,":[225],"may":[226,240],"enhance":[227],"human":[232],"epithelium,":[234],"strongest":[237],"be":[241],"related":[244],"sections":[249],"crypts.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
