{"id":"https://openalex.org/W2108985372","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1841","title":"Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03","display_name":"Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03","publication_year":2012,"publication_date":"2012-08-24","ids":{"openalex":"https://openalex.org/W2108985372","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1841","mag":"2108985372","pmid":"https://pubmed.ncbi.nlm.nih.gov/22923449","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3947570"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-12-1841","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1841","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-1841","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3947570","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035087247","display_name":"Eudocia Q. Lee","orcid":"https://orcid.org/0000-0003-3355-5179","observed_orcids":["https://orcid.org/0000-0003-3355-5179"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eudocia Q. Lee","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037535298","display_name":"Vinay K. Puduvalli","orcid":"https://orcid.org/0000-0001-8396-9500","observed_orcids":["https://orcid.org/0000-0001-8396-9500"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinay K. Puduvalli","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027416118","display_name":"Joel M. Reid","orcid":"https://orcid.org/0000-0003-2872-3123","observed_orcids":["https://orcid.org/0000-0003-2872-3123"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel M. Reid","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075492015","display_name":"John G. Kuhn","orcid":"https://orcid.org/0000-0002-7359-8643","observed_orcids":["https://orcid.org/0000-0002-7359-8643"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John G. Kuhn","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061018141","display_name":"Kathleen R. Lamborn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen R. Lamborn","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063511816","display_name":"Timothy Francis Cloughesy","orcid":"https://orcid.org/0000-0002-8656-7483","observed_orcids":["https://orcid.org/0000-0002-8656-7483"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy F. Cloughesy","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111908438","display_name":"Susan Marina Chang","orcid":"https://orcid.org/0000-0003-3521-364X","observed_orcids":["https://orcid.org/0000-0003-3521-364X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M. Chang","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091053515","display_name":"Jan Drappatz","orcid":"https://orcid.org/0000-0001-8187-7119","observed_orcids":["https://orcid.org/0000-0001-8187-7119"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Drappatz","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113691310","display_name":"W. K. Alfred Yung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. K. Alfred Yung","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark R. Gilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Gilbert","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057427180","display_name":"H. Ian Robins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Ian Robins","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014264452","display_name":"Frank Scott Lieberman","orcid":"https://orcid.org/0000-0003-2577-3336","observed_orcids":["https://orcid.org/0000-0003-2577-3336"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank S. Lieberman","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057541817","display_name":"Andrew B. Lassman","orcid":"https://orcid.org/0000-0001-7386-9928","observed_orcids":["https://orcid.org/0000-0001-7386-9928"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew B. Lassman","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110580704","display_name":"Renee M. McGovern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renee M. McGovern","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101188061","display_name":"Jihong Xu","orcid":"https://orcid.org/0009-0007-5776-6057","observed_orcids":["https://orcid.org/0009-0007-5776-6057"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihong Xu","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091849918","display_name":"Serena Desideri","orcid":"https://orcid.org/0009-0007-0682-6080","observed_orcids":["https://orcid.org/0009-0007-0682-6080"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serena Desideri","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017772220","display_name":"Xiabu Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiabu Ye","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066722006","display_name":"Matthew M. Ames","orcid":"https://orcid.org/0000-0003-3652-209X","observed_orcids":["https://orcid.org/0000-0003-3652-209X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew M. Ames","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014445762","display_name":"Igor Espinoza\u2010Delgado","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Espinoza-Delgado","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046264008","display_name":"Michael D. Prados","orcid":"https://orcid.org/0000-0002-9630-2075","observed_orcids":["https://orcid.org/0000-0002-9630-2075"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael D. Prados","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021656597","display_name":"Patrick Yung Wen","orcid":"https://orcid.org/0000-0002-0774-7700","observed_orcids":["https://orcid.org/0000-0002-0774-7700","https://orcid.org/0000-0003-3224-3042","https://orcid.org/0000-0002-2452-0540"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210161994","display_name":"Dana-Farber Brigham Cancer Center","ror":"https://ror.org/05rgrbr06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I4210117453","https://openalex.org/I4210161994","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick Y. Wen","raw_affiliation_strings":["Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Center for Neuro-Oncology, Dana Farber/Brigham and Women's Cancer Center, Boston, Massachusetts; 2Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 3Mayo Clinic Comprehensive Cancer Center, Rochester, Minnesota; 4University of Texas Health Science Center, San Antonio, Texas; 5Department of Neurosurgery, University of California, San Francisco, San Francisco; 6University of California, Los Angeles California; 7Universty of Pittsburgh Medical Center Cancer Center, Pittsburgh, Pennsylvania; 8University of Wisconsin, Madison, Wisconsin; 9Department of Neurology, Memorial Sloan Kettering Cancer Center, New York; 10Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore; and 11Cancer Therapy Evaluation Program, National Cancer Institute, Bethesda, Maryland","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5021656597"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I1343551460","https://openalex.org/I161318765","https://openalex.org/I165951966","https://openalex.org/I180670191","https://openalex.org/I4210140884","https://openalex.org/I4210161994"],"apc_list":null,"apc_paid":null,"fwci":3.1977,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.92079975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"21","first_page":"6032","last_page":"6039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":1.0},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":1.0},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.996999979019165},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.7300000190734863},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.968999981880188},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.9829999804496765},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9610000252723694},{"id":"https://openalex.org/keywords/histone-hyperacetylation","display_name":"histone hyperacetylation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pharmacokinetic-interactions","display_name":"pharmacokinetic interactions","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.9358800649642944},{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.8227298259735107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6188373565673828},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5192970633506775},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.51322340965271},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.5013308525085449},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47250163555145264},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.4607819616794586},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.22060304880142212},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1784677803516388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09939694404602051},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.07523533701896667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/1078-0432.ccr-12-1841","doi":"https://doi.org/10.1158/1078-0432.ccr-12-1841","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-12-1841","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:22923449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22923449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:europepmc.org:2930820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3947570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3947570","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3947570","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt0ff8f62v","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/0ff8f62v","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Cancer Research, vol 18, iss 21","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2930820","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3947570","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G1223840067","display_name":"NABTC Central Operation Grant (UCSF Project Leader)","funder_award_id":"U01CA062399","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3276713972","display_name":"UCLA Clinical and Translational Science Institute","funder_award_id":"UL1TR000124","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5664278136","display_name":"University of Pittsburgh Clinical and Translational Science Institute","funder_award_id":"UL1TR000005","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7928967744","display_name":"Patient Oriented Research Program in Neuro-oncology","funder_award_id":"K24CA160777","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000870050","display_name":"UW Comprehensive Cancer Center Support","funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320310145","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1575812451","https://openalex.org/W1974911471","https://openalex.org/W2021577923","https://openalex.org/W2034446797","https://openalex.org/W2050969887","https://openalex.org/W2053504914","https://openalex.org/W2096287682","https://openalex.org/W2102428449","https://openalex.org/W2102650381","https://openalex.org/W2116851173","https://openalex.org/W2150194984","https://openalex.org/W2158681922","https://openalex.org/W2171141282","https://openalex.org/W2609068367","https://openalex.org/W6634546976"],"related_works":["https://openalex.org/W2590790266","https://openalex.org/W2609068367","https://openalex.org/W2268389957","https://openalex.org/W2783692774","https://openalex.org/W2580232946","https://openalex.org/W2602283374","https://openalex.org/W2126085546","https://openalex.org/W2600771186","https://openalex.org/W2017695919","https://openalex.org/W2781261700"],"abstract_inverted_index":{"PURPOSE:":[0],"A":[1,239],"phase":[2,34,240],"I,":[3,35],"dose-finding":[4],"study":[5,38,49,69],"of":[6,50,70,81,91,102,114,143,152,163,217,243],"vorinostat":[7,51,71,103,153,179,209,244],"in":[8,25,41,52,72,118,140,215,222,228,235,250],"combination":[9,53,73,119,229],"with":[10,27,54,74,120,168,230,237,245],"temozolomide":[11,231],"(TMZ)":[12],"was":[13,39,46,66,122,170],"conducted":[14,40],"to":[15,108,112,157,161,187],"determine":[16],"the":[17,82,92,100,141,150],"maximum":[18],"tolerated":[19,234],"dose":[20],"(MTD),":[21],"safety,":[22],"and":[23,85,110,136,159,199,210,220,247],"pharmacokinetics":[24],"patients":[26,236],"high-grade":[28],"glioma":[29],"(HGG).":[30],"EXPERIMENTAL":[31],"DESIGN:":[32],"This":[33],"dose-finding,":[36],"investigational":[37],"two":[42],"parts.":[43],"Part":[44,64],"1":[45,107,156],"a":[47,67],"dose-escalation":[48,68],"TMZ":[55,75,249],"150":[56,76],"mg/m(2)/day":[57,77,87],"for":[58,78,88],"5":[59,79,89,138],"days":[60,80,90,106,155],"every":[61,115,164],"28":[62],"days.":[63],"2":[65],"first":[83],"cycle":[84],"200":[86],"subsequent":[93],"28-day":[94,116,165],"cycles.":[95],"RESULTS:":[96],"In":[97,147],"part":[98,148],"1,":[99],"MTD":[101,151],"administered":[104],"on":[105,154],"7":[109,158],"15":[111,160],"21":[113,162],"cycle,":[117,166],"TMZ,":[121,169],"500":[123],"mg":[124,172],"daily.":[125,173],"Dose-limiting":[126],"toxicities":[127],"(DLT)":[128],"included":[129],"grade":[130,133,137,144],"3":[131,134],"anorexia,":[132],"ALT,":[135],"hemorrhage":[139],"setting":[142],"4":[145],"thrombocytopenia.":[146,188],"2,":[149],"combined":[167],"400":[171],"No":[174],"DLTs":[175],"were":[176,195,203],"encountered,":[177],"but":[178],"dosing":[180],"could":[181],"not":[182],"be":[183],"escalated":[184],"further":[185],"due":[186],"The":[189],"most":[190],"common":[191],"serious":[192],"adverse":[193],"events":[194],"fatigue,":[196],"lymphopenia,":[197],"thrombocytopenia,":[198],"thromboembolic":[200],"events.":[201],"There":[202],"no":[204],"apparent":[205],"pharmacokinetic":[206],"interactions":[207],"between":[208],"TMZ.":[211],"Vorinostat":[212,227],"treatment":[213],"resulted":[214],"hyperacetylation":[216],"histones":[218],"H3":[219],"H4":[221],"peripheral":[223],"mononuclear":[224],"cells.":[225],"CONCLUSION:":[226],"is":[232,254],"well":[233],"HGG.":[238],"I/II":[241],"trial":[242],"radiotherapy":[246],"concomitant":[248],"newly":[251],"diagnosed":[252],"glioblastoma":[253],"underway.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
