{"id":"https://openalex.org/W2108944651","doi":"https://doi.org/10.1152/advan.00045.2004","title":"Regulation of intracellular pH","display_name":"Regulation of intracellular pH","publication_year":2004,"publication_date":"2004-11-15","ids":{"openalex":"https://openalex.org/W2108944651","doi":"https://doi.org/10.1152/advan.00045.2004","mag":"2108944651","pmid":"https://pubmed.ncbi.nlm.nih.gov/15545345"},"language":"en","primary_location":{"id":"doi:10.1152/advan.00045.2004","doi":"https://doi.org/10.1152/advan.00045.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/advan.00045.2004","pdf_url":null,"source":{"id":"https://openalex.org/S95725323","display_name":"AJP Advances in Physiology Education","issn_l":"1043-4046","issn":["1043-4046","1522-1229"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Physiology Education","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084438654","display_name":"Walter F. Boron","orcid":"https://orcid.org/0000-0003-4741-7287","observed_orcids":["https://orcid.org/0000-0003-4741-7287"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Walter F. Boron","raw_affiliation_strings":["Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520-8026","Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8026, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520-8026","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8026, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084438654"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.4593,"has_fulltext":false,"cited_by_count":366,"citation_normalized_percentile":{"value":0.41250657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"28","issue":"4","first_page":"160","last_page":"179"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intracellular-ph-regulation","display_name":"intracellular pH regulation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acid-base-transport","display_name":"acid-base transport","score":0.734000027179718},{"id":"https://openalex.org/keywords/buffering-capacity","display_name":"buffering capacity","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C134897140","wikidata":"https://www.wikidata.org/wiki/Q6058355","display_name":"Intracellular pH","level":3,"score":0.6524698138237},{"id":"https://openalex.org/C198091228","wikidata":"https://www.wikidata.org/wiki/Q19557","display_name":"Alkali metal","level":2,"score":0.5890322923660278},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5551608800888062},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.5452429056167603},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5445459485054016},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4824541211128235},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4185223877429962},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38270092010498047},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17209964990615845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15191757678985596},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08039894700050354},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000136","descriptor_name":"Acid-Base Equilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010827","descriptor_name":"Physiology","qualifier_ui":"Q000193","qualifier_name":"education","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/advan.00045.2004","doi":"https://doi.org/10.1152/advan.00045.2004","is_oa":false,"landing_page_url":"https://doi.org/10.1152/advan.00045.2004","pdf_url":null,"source":{"id":"https://openalex.org/S95725323","display_name":"AJP Advances in Physiology Education","issn_l":"1043-4046","issn":["1043-4046","1522-1229"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Physiology Education","raw_type":"journal-article"},{"id":"pmid:15545345","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15545345","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in physiology education","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G273780343","display_name":null,"funder_award_id":"DK-30344","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G296572248","display_name":"Cellular and Molecular Studies of Renal Transport","funder_award_id":"P01DK017433","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6572974884","display_name":"Molecular Physiology of Bicarbonate Transport in the Brain","funder_award_id":"R01NS018400","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6667261113","display_name":"Hypoxia in Development; Injury and Adaptation Mechanisms","funder_award_id":"P01HD032573","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1510331108","https://openalex.org/W1574095484","https://openalex.org/W1593222340","https://openalex.org/W1627569217","https://openalex.org/W1819543855","https://openalex.org/W1835526604","https://openalex.org/W1969848842","https://openalex.org/W1970675780","https://openalex.org/W1973058160","https://openalex.org/W1974642350","https://openalex.org/W1976217538","https://openalex.org/W1976365446","https://openalex.org/W1982784692","https://openalex.org/W1985832800","https://openalex.org/W1987051971","https://openalex.org/W1992962615","https://openalex.org/W2015971228","https://openalex.org/W2025100148","https://openalex.org/W2027092642","https://openalex.org/W2038899845","https://openalex.org/W2039469985","https://openalex.org/W2042464273","https://openalex.org/W2057989984","https://openalex.org/W2059164023","https://openalex.org/W2065986052","https://openalex.org/W2073411380","https://openalex.org/W2078236572","https://openalex.org/W2088075659","https://openalex.org/W2091025692","https://openalex.org/W2091130738","https://openalex.org/W2092557395","https://openalex.org/W2095758052","https://openalex.org/W2122399252","https://openalex.org/W2122457010","https://openalex.org/W2130415889","https://openalex.org/W2135114065","https://openalex.org/W2149674234","https://openalex.org/W2158699967","https://openalex.org/W2160656615","https://openalex.org/W2163004322","https://openalex.org/W2325523016","https://openalex.org/W2328048220","https://openalex.org/W2406345433","https://openalex.org/W2410446840","https://openalex.org/W2415040429","https://openalex.org/W2417874101","https://openalex.org/W2419257610","https://openalex.org/W2432971542","https://openalex.org/W3011835441","https://openalex.org/W4231337093","https://openalex.org/W4238605098"],"related_works":["https://openalex.org/W7098974172","https://openalex.org/W1973069942","https://openalex.org/W7160612871","https://openalex.org/W2498113912","https://openalex.org/W1562628830","https://openalex.org/W173858090","https://openalex.org/W2279166538","https://openalex.org/W2217309746","https://openalex.org/W2005496979","https://openalex.org/W1015212399"],"abstract_inverted_index":{"The":[0],"approach":[1],"that":[2,250,271],"most":[3],"animal":[4],"cells":[5,166,261],"employ":[6],"to":[7,90,105,123,141,150,168,194,263],"regulate":[8,24],"intracellular":[9],"pH":[10],"(pH(i))":[11],"is":[12],"not":[13,82],"too":[14],"different":[15],"conceptually":[16],"from":[17,247],"the":[18,25,32,51,84,225,228],"way":[19],"a":[20,28,37,56,99,103,108,132,146,195,214,222,242],"sophisticated":[21],"system":[22,244],"might":[23,148,245],"temperature":[26,41],"of":[27,36,55,227],"house.":[29],"Just":[30,144],"as":[31,145,209,241],"heat":[33,49,162,205,256],"capacity":[34],"(C)":[35],"house":[38,100,147],"minimizes":[39,58,75],"sudden":[40,59],"(T)":[42],"shifts":[43,61],"caused":[44,62],"by":[45,63,157,213],"acute":[46,64],"cold":[47,199,254],"and":[48,66,255],"loads,":[50],"buffering":[52],"power":[53],"(beta)":[54],"cell":[57,109,133],"pH(i)":[60,174],"acid":[65,119,231,237],"alkali":[67],"loads.":[68],"However,":[69],"increasing":[70],"C":[71],"(or":[72,77,88,96,153,163,171,178,182,187,200,206,219,230,236],"beta)":[73],"only":[74,191],"T":[76,87,95,156,186,218],"pH(i))":[78,89,188],"changes;":[79],"it":[80],"does":[81],"eliminate":[83],"changes,":[85],"return":[86],"normal,":[91],"or":[92,203,221,233,267],"shift":[93],"steady-state":[94],"pH(i)).":[97],"Whereas":[98,126],"may":[101],"have":[102,264],"furnace":[104,229],"raise":[106,124],"T,":[107,131],"generally":[110,134],"has":[111,135],"more":[112,136],"than":[113,137],"one":[114,138],"acid-extruding":[115],"transporter":[116,140],"(which":[117],"exports":[118],"and/or":[120],"imports":[121],"alkali)":[122,207],"pH(i).":[125,143],"an":[127],"air":[128,234],"conditioner":[129,235],"lowers":[130],"acid-loading":[139],"lower":[142],"respond":[149,167],"graded":[151,159,169,176],"decreases":[152,170],"increases)":[154,172],"in":[155,161,173,180,192,197,216,224],"producing":[158],"increases":[160,177],"cold)":[164],"output,":[165],"with":[175],"decreases)":[179],"acid-extrusion":[181],"acid-loading)":[183],"rate.":[184],"Steady-state":[185],"can":[189],"change":[190,196,215,223],"response":[193],"chronic":[198,204],"acid)":[201],"loading":[202,208],"produced,":[210],"for":[211],"example,":[212],"environmental":[217,248],"pH)":[220],"kinetics":[226],"extrudes)":[232],"loaders).":[238],"Finally,":[239],"just":[240],"temperature-control":[243],"benefit":[246],"sensors":[249,270],"provide":[251],"clues":[252],"about":[253],"loading,":[257],"at":[258],"least":[259],"some":[260],"seem":[262],"extracellular":[265,268],"CO(2)":[266],"HCO(3)(-)":[269],"modulate":[272],"acid-base":[273],"transport.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":28},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
