{"id":"https://openalex.org/W2108937883","doi":"https://doi.org/10.1111/dom.12573","title":"Comparison of insulin degludec with insulin detemir in type 1 diabetes: a 1\u2010year treat\u2010to\u2010target trial","display_name":"Comparison of insulin degludec with insulin detemir in type 1 diabetes: a 1\u2010year treat\u2010to\u2010target trial","publication_year":2015,"publication_date":"2015-09-07","ids":{"openalex":"https://openalex.org/W2108937883","doi":"https://doi.org/10.1111/dom.12573","mag":"2108937883","pmid":"https://pubmed.ncbi.nlm.nih.gov/26435472"},"language":"en","primary_location":{"id":"doi:10.1111/dom.12573","doi":"https://doi.org/10.1111/dom.12573","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12573","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084593004","display_name":"Melanie Jane Davies","orcid":"https://orcid.org/0000-0002-9987-9371","observed_orcids":["https://orcid.org/0000-0002-9987-9371"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2800440371","display_name":"Leicester General Hospital","ror":"https://ror.org/02zg49d29","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800440371","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M. Davies","raw_affiliation_strings":["Diabetes Research Centre, Leicester General Hospital University of Leicester Leicester UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes Research Centre, Leicester General Hospital University of Leicester Leicester UK","institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2800440371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021357642","display_name":"Takashi Sasaki","orcid":"https://orcid.org/0000-0002-1413-6983","observed_orcids":["https://orcid.org/0000-0002-1413-6983"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Sasaki","raw_affiliation_strings":["Internal Medicine, Sasaki Hospital Internal Medicine Hokkaido Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Sasaki Hospital Internal Medicine Hokkaido Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102728954","display_name":"Jorge Luiz Gross","orcid":"https://orcid.org/0000-0003-4721-4623","observed_orcids":["https://orcid.org/0000-0003-4721-4623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. L. Gross","raw_affiliation_strings":["Centro de Pesquisas em Diabetes Porto Alegre Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Pesquisas em Diabetes Porto Alegre Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113719640","display_name":"Ganapati Bantwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145302","display_name":"St.John's Medical College Hospital","ror":"https://ror.org/04z7fc725","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210129261","https://openalex.org/I4210145302"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G. Bantwal","raw_affiliation_strings":["Department of Endocrinology, St. Johns Medical College Bangalore, Bangalore, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, St. Johns Medical College Bangalore, Bangalore, India","institution_ids":["https://openalex.org/I4210145302"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Y. Ono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Ono","raw_affiliation_strings":["Internal Medicine, Yuri Ono Clinic Hokkaido Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Yuri Ono Clinic Hokkaido Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060585389","display_name":"Tomoyuki Nishida","orcid":"https://orcid.org/0009-0004-5812-7167","observed_orcids":["https://orcid.org/0009-0004-5812-7167"]},"institutions":[{"id":"https://openalex.org/I4405265707","display_name":"Novo Nordisk Pharma Ltd. (Japan)","ror":"https://ror.org/05gzvb546","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265707"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"T. Nishida","raw_affiliation_strings":["Novo Nordisk Pharma Ltd Tokyo Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk Pharma Ltd Tokyo Japan","institution_ids":["https://openalex.org/I4405265707"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016233126","display_name":"Damon Tojjar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189090001","display_name":"Novo Nordisk (Denmark)","ror":"https://ror.org/0435rc536","country_code":"DK","type":"company","lineage":["https://openalex.org/I189090001","https://openalex.org/I2801134892","https://openalex.org/I4210159963"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"D. Tojjar","raw_affiliation_strings":["Novo Nordisk A/S  S\u00f8borg Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novo Nordisk A/S  S\u00f8borg Denmark","institution_ids":["https://openalex.org/I189090001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006188126","display_name":"Hiroaki Seino","orcid":"https://orcid.org/0000-0003-4690-9722","observed_orcids":["https://orcid.org/0000-0003-4690-9722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Seino","raw_affiliation_strings":["Internal Medicine, Seino Internal Medicine Clinic Fukushima Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Seino Internal Medicine Clinic Fukushima Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5084593004"],"corresponding_institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2800440371"],"apc_list":{"value":5380,"currency":"USD","value_usd":5380},"apc_paid":null,"fwci":1.7604,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.83159004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"96","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-degludec","display_name":"insulin degludec","score":1.0},{"id":"https://openalex.org/keywords/insulin-detemir","display_name":"insulin detemir","score":1.0},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.902999997138977},{"id":"https://openalex.org/keywords/basal-insulin","display_name":"basal insulin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/insulin-aspart","display_name":"insulin aspart","score":0.6320000290870667},{"id":"https://openalex.org/keywords/nocturnal-hypoglycemia","display_name":"nocturnal hypoglycemia","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.9660000205039978},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.9890000224113464},{"id":"https://openalex.org/keywords/long-term-safety-and-tolerability","display_name":"long-term safety and tolerability","score":0.8510000109672546},{"id":"https://openalex.org/keywords/treat-to-target","display_name":"treat-to-target","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.872148871421814},{"id":"https://openalex.org/C2775927303","wikidata":"https://www.wikidata.org/wiki/Q16252338","display_name":"Insulin degludec","level":5,"score":0.8127247095108032},{"id":"https://openalex.org/C2780677441","wikidata":"https://www.wikidata.org/wiki/Q410965","display_name":"Insulin detemir","level":5,"score":0.7740510702133179},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6385583877563477},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6162689328193665},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4811857342720032},{"id":"https://openalex.org/C2779920387","wikidata":"https://www.wikidata.org/wiki/Q417317","display_name":"Insulin glargine","level":4,"score":0.4292592704296112},{"id":"https://openalex.org/C2779908123","wikidata":"https://www.wikidata.org/wiki/Q2754775","display_name":"Insulin aspart","level":4,"score":0.41463980078697205},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.36902058124542236},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.3678327202796936},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.362387478351593},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.27601027488708496},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.2172168493270874}],"mesh":[{"descriptor_ui":"D000069057","descriptor_name":"Insulin Detemir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007003","descriptor_name":"Hypoglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013995","descriptor_name":"Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049528","descriptor_name":"Insulin, Long-Acting","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061267","descriptor_name":"Insulin Aspart","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D062407","descriptor_name":"Meals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/dom.12573","doi":"https://doi.org/10.1111/dom.12573","is_oa":false,"landing_page_url":"https://doi.org/10.1111/dom.12573","pdf_url":null,"source":{"id":"https://openalex.org/S148394532","display_name":"Diabetes Obesity and Metabolism","issn_l":"1462-8902","issn":["1462-8902","1463-1326"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, Obesity and Metabolism","raw_type":"journal-article"},{"id":"pmid:26435472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26435472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes, obesity & metabolism","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320333876","display_name":"Novo Nordisk Pharma","ror":"https://ror.org/05gzvb546"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1565099151","https://openalex.org/W1657095721","https://openalex.org/W1986874694","https://openalex.org/W2054412998","https://openalex.org/W2076822764","https://openalex.org/W2092860355","https://openalex.org/W2760351771"],"related_works":["https://openalex.org/W2092860355","https://openalex.org/W1997883888","https://openalex.org/W2103017735","https://openalex.org/W2050540448","https://openalex.org/W4307727383","https://openalex.org/W2109533147","https://openalex.org/W2150451787","https://openalex.org/W2023283873","https://openalex.org/W2124515853","https://openalex.org/W2281952828"],"abstract_inverted_index":{"The":[0,150],"long-term":[1,155],"safety":[2,156],"and":[3,157],"tolerability":[4,158],"of":[5,13,87,116,160,171],"insulin":[6,14,52,58],"degludec":[7],"(IDeg)":[8],"was":[9,61,67],"compared":[10,90,133],"with":[11,22,42,55,91,134,164],"that":[12],"detemir":[15],"(IDet),":[16],"as":[17,50],"basal":[18,51],"treatment":[19,53],"in":[20,129,162],"participants":[21],"type":[23],"1":[24,79,114],"diabetes":[25],"mellitus":[26],"(T1DM).":[27],"In":[28],"the":[29,154],"present":[30,151],"multinational,":[31],"26-week":[32,35],"core":[33],"+":[34],"extension,":[36],"controlled,":[37],"open-label,":[38],"parallel-group":[39],"trial,":[40],"adults":[41],"T1DM":[43],"were":[44],"randomized":[45],"to":[46,119],"IDeg":[47,60,81,109,122,161,166],"or":[48,70],"IDet":[49,66],"combined":[54],"meal-time":[56],"bolus":[57],"aspart.":[59],"administered":[62,68],"once":[63,69],"daily,":[64],"whilst":[65],"twice":[71],"daily":[72],"depending":[73],"on":[74],"patients'":[75],"glycaemic":[76],"control.":[77],"After":[78],"year,":[80],"provided":[82,124,167],"a":[83,125,168],"33%":[84],"lower":[85,169],"rate":[86,94],"nocturnal":[88,172],"hypoglycaemia":[89,174],"IDet:":[92,135],"estimated":[93,136],"ratio":[95],"(IDeg":[96,138],":":[97],"IDet)":[98,140],"0.67":[99],"[95%":[100],"confidence":[101],"interval":[102],"(CI)":[103],"0.51;":[104],"0.88];":[105],"p":[106,147],"<":[107,148],"0.05.":[108,149],"improved":[110],"glycated":[111],"haemoglobin":[112],"after":[113],"year":[115],"treatment,":[117],"similarly":[118],"IDet,":[120],"but":[121],"also":[123],"significantly":[126],"greater":[127],"reduction":[128],"fasting":[130],"plasma":[131],"glucose":[132],"difference":[137],"-":[139],"-1.11":[141],"(95%":[142],"CI":[143],"-1.83;":[144],"-0.40)":[145],"mmol/l;":[146],"study":[152],"confirmed":[153,173],"profile":[159],"patients":[163],"T1DM.":[165],"risk":[170],"than":[175],"IDet.":[176]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
