{"id":"https://openalex.org/W2108914157","doi":"https://doi.org/10.1155/2013/369172","title":"The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention","display_name":"The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2108914157","doi":"https://doi.org/10.1155/2013/369172","mag":"2108914157","pmid":"https://pubmed.ncbi.nlm.nih.gov/23606868","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3626239"},"language":"en","primary_location":{"id":"doi:10.1155/2013/369172","doi":"https://doi.org/10.1155/2013/369172","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/369172","pdf_url":"https://downloads.hindawi.com/journals/jir/2013/369172.pdf","source":{"id":"https://openalex.org/S201433933","display_name":"Clinical and Developmental Immunology","issn_l":"1740-2522","issn":["1740-2522","1740-2530"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Developmental Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/jir/2013/369172.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039597079","display_name":"Soren M. Gantt","orcid":"https://orcid.org/0000-0001-5743-3606","observed_orcids":["https://orcid.org/0000-0001-5743-3606"]},"institutions":[{"id":"https://openalex.org/I1295499534","display_name":"Seattle Children's Hospital","ror":"https://ror.org/01njes783","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Soren Gantt","raw_affiliation_strings":["Department of Pediatrics, Division of Infectious Diseases, University of Washington and Seattle Children\u2019s Hospital, Seattle, WA 98105, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Infectious Diseases, University of Washington and Seattle Children\u2019s Hospital, Seattle, WA 98105, USA","institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061679177","display_name":"William J. Muller","orcid":"https://orcid.org/0000-0001-7690-0695","observed_orcids":["https://orcid.org/0000-0001-7690-0695"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Muller","raw_affiliation_strings":["Department of Pediatrics, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA"],"raw_orcid":"https://orcid.org/0000-0001-7690-0695","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5039597079"],"corresponding_institution_ids":["https://openalex.org/I1295499534","https://openalex.org/I201448701"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.666,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.57633588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-herpes-simplex-virus-infection","display_name":"neonatal herpes simplex virus infection","score":0.8759999871253967},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":1.0},{"id":"https://openalex.org/keywords/neonatal-immunity","display_name":"neonatal immunity","score":0.7310000061988831},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immunodeficiency","display_name":"immunodeficiency","score":0.6129999756813049},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6832403540611267},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6799485683441162},{"id":"https://openalex.org/C156662089","wikidata":"https://www.wikidata.org/wiki/Q6931223","display_name":"Mucocutaneous zone","level":3,"score":0.6570821404457092},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5956956148147583},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.5948330760002136},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5488000512123108},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5424606800079346},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.471266508102417},{"id":"https://openalex.org/C2781452722","wikidata":"https://www.wikidata.org/wiki/Q9386039","display_name":"Neonatal infection","level":3,"score":0.44992953538894653},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30767685174942017},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.30256515741348267},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28550851345062256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10966584086418152},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006564","descriptor_name":"Herpesviridae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007232","descriptor_name":"Infant, Newborn, Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009092","descriptor_name":"Mucous Membrane","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D056704","descriptor_name":"Adaptive Immunity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056747","descriptor_name":"Immunomodulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1155/2013/369172","doi":"https://doi.org/10.1155/2013/369172","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/369172","pdf_url":"https://downloads.hindawi.com/journals/jir/2013/369172.pdf","source":{"id":"https://openalex.org/S201433933","display_name":"Clinical and Developmental Immunology","issn_l":"1740-2522","issn":["1740-2522","1740-2530"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Developmental Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2626266","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3626239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3626239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3626239","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Dev Immunol","raw_type":"Text"},{"id":"pmid:23606868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23606868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical & developmental immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b91a0b63e9b14ccba3671eee0be65003","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b91a0b63e9b14ccba3671eee0be65003","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical and Developmental Immunology, Vol 2013 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2013/369172","doi":"https://doi.org/10.1155/2013/369172","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/369172","pdf_url":"https://downloads.hindawi.com/journals/jir/2013/369172.pdf","source":{"id":"https://openalex.org/S201433933","display_name":"Clinical and Developmental Immunology","issn_l":"1740-2522","issn":["1740-2522","1740-2530"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Developmental Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5739274444","display_name":"Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)","funder_award_id":"UL1TR000150","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6278966093","display_name":"Herpes Simplex Virus Entry Receptors in Immune Memory and Newborn Infection","funder_award_id":"K08AI089942","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108914157.pdf","grobid_xml":"https://content.openalex.org/works/W2108914157.grobid-xml"},"referenced_works_count":246,"referenced_works":["https://openalex.org/W15032478","https://openalex.org/W47538583","https://openalex.org/W118312391","https://openalex.org/W152869668","https://openalex.org/W202635507","https://openalex.org/W1504209748","https://openalex.org/W1512558791","https://openalex.org/W1515503939","https://openalex.org/W1517021800","https://openalex.org/W1536955134","https://openalex.org/W1546723842","https://openalex.org/W1560468264","https://openalex.org/W1578914995","https://openalex.org/W1580237032","https://openalex.org/W1590965838","https://openalex.org/W1597573846","https://openalex.org/W1599185640","https://openalex.org/W1741544496","https://openalex.org/W1756855871","https://openalex.org/W1876666037","https://openalex.org/W1925841472","https://openalex.org/W1948920444","https://openalex.org/W1963816826","https://openalex.org/W1967123364","https://openalex.org/W1968290008","https://openalex.org/W1968918888","https://openalex.org/W1969013760","https://openalex.org/W1972249806","https://openalex.org/W1973406626","https://openalex.org/W1973682675","https://openalex.org/W1974368123","https://openalex.org/W1975773750","https://openalex.org/W1978618775","https://openalex.org/W1981459273","https://openalex.org/W1981744729","https://openalex.org/W1983217686","https://openalex.org/W1983598990","https://openalex.org/W1984624532","https://openalex.org/W1985339853","https://openalex.org/W1986536654","https://openalex.org/W1987177740","https://openalex.org/W1987374240","https://openalex.org/W1989234621","https://openalex.org/W1989782337","https://openalex.org/W1991378857","https://openalex.org/W1991513141","https://openalex.org/W1991692801","https://openalex.org/W1994864933","https://openalex.org/W1995981398","https://openalex.org/W1996408717","https://openalex.org/W1998420309","https://openalex.org/W1998844140","https://openalex.org/W1999705860","https://openalex.org/W2000728415","https://openalex.org/W2001752982","https://openalex.org/W2001904356","https://openalex.org/W2006760510","https://openalex.org/W2007048801","https://openalex.org/W2008221423","https://openalex.org/W2008535980","https://openalex.org/W2009136927","https://openalex.org/W2010180443","https://openalex.org/W2012053514","https://openalex.org/W2012232904","https://openalex.org/W2012895860","https://openalex.org/W2013150268","https://openalex.org/W2014516093","https://openalex.org/W2015360618","https://openalex.org/W2018020394","https://openalex.org/W2018106813","https://openalex.org/W2018143371","https://openalex.org/W2018706148","https://openalex.org/W2018856385","https://openalex.org/W2019576909","https://openalex.org/W2019663253","https://openalex.org/W2019840235","https://openalex.org/W2020130616","https://openalex.org/W2021750859","https://openalex.org/W2023088041","https://openalex.org/W2024223500","https://openalex.org/W2024391357","https://openalex.org/W2024909307","https://openalex.org/W2025382930","https://openalex.org/W2025580438","https://openalex.org/W2025974782","https://openalex.org/W2028536701","https://openalex.org/W2028590527","https://openalex.org/W2028645756","https://openalex.org/W2029142822","https://openalex.org/W2030436099","https://openalex.org/W2031352878","https://openalex.org/W2031783599","https://openalex.org/W2032502668","https://openalex.org/W2032634316","https://openalex.org/W2033193447","https://openalex.org/W2033538415","https://openalex.org/W2033638986","https://openalex.org/W2034339817","https://openalex.org/W2034455104","https://openalex.org/W2035000359","https://openalex.org/W2035830531","https://openalex.org/W2036729671","https://openalex.org/W2037351497","https://openalex.org/W2038111443","https://openalex.org/W2042361781","https://openalex.org/W2047905725","https://openalex.org/W2049279407","https://openalex.org/W2050211620","https://openalex.org/W2051838336","https://openalex.org/W2053174568","https://openalex.org/W2054462963","https://openalex.org/W2055214021","https://openalex.org/W2056107229","https://openalex.org/W2057064398","https://openalex.org/W2057204592","https://openalex.org/W2057379935","https://openalex.org/W2058075271","https://openalex.org/W2058758230","https://openalex.org/W2060672294","https://openalex.org/W2060843008","https://openalex.org/W2062415238","https://openalex.org/W2063231944","https://openalex.org/W2063874265","https://openalex.org/W2064048288","https://openalex.org/W2065669337","https://openalex.org/W2066951766","https://openalex.org/W2067853799","https://openalex.org/W2069091455","https://openalex.org/W2069322489","https://openalex.org/W2070416023","https://openalex.org/W2072066004","https://openalex.org/W2072409135","https://openalex.org/W2072509185","https://openalex.org/W2072743252","https://openalex.org/W2073406292","https://openalex.org/W2073606915","https://openalex.org/W2074748680","https://openalex.org/W2076119890","https://openalex.org/W2076379914","https://openalex.org/W2076714085","https://openalex.org/W2077051235","https://openalex.org/W2077055924","https://openalex.org/W2077809737","https://openalex.org/W2079289169","https://openalex.org/W2080006730","https://openalex.org/W2080932940","https://openalex.org/W2081598158","https://openalex.org/W2082199453","https://openalex.org/W2084603524","https://openalex.org/W2085497211","https://openalex.org/W2089336237","https://openalex.org/W2089965577","https://openalex.org/W2090320337","https://openalex.org/W2090672759","https://openalex.org/W2090851364","https://openalex.org/W2091155469","https://openalex.org/W2091985331","https://openalex.org/W2093083083","https://openalex.org/W2094036101","https://openalex.org/W2096049841","https://openalex.org/W2096623637","https://openalex.org/W2097550991","https://openalex.org/W2099703022","https://openalex.org/W2102179509","https://openalex.org/W2102727891","https://openalex.org/W2104472095","https://openalex.org/W2106380751","https://openalex.org/W2106539372","https://openalex.org/W2106541614","https://openalex.org/W2108045530","https://openalex.org/W2111418333","https://openalex.org/W2112265428","https://openalex.org/W2112449417","https://openalex.org/W2112601576","https://openalex.org/W2115374657","https://openalex.org/W2115911672","https://openalex.org/W2116603221","https://openalex.org/W2116924131","https://openalex.org/W2120342549","https://openalex.org/W2120968381","https://openalex.org/W2121570963","https://openalex.org/W2122597475","https://openalex.org/W2123586959","https://openalex.org/W2125399875","https://openalex.org/W2127472356","https://openalex.org/W2127534669","https://openalex.org/W2130184435","https://openalex.org/W2130909829","https://openalex.org/W2131498198","https://openalex.org/W2131987313","https://openalex.org/W2133265454","https://openalex.org/W2134263335","https://openalex.org/W2134956255","https://openalex.org/W2135424108","https://openalex.org/W2138583109","https://openalex.org/W2139150306","https://openalex.org/W2139212892","https://openalex.org/W2139731518","https://openalex.org/W2140767223","https://openalex.org/W2140811217","https://openalex.org/W2142127956","https://openalex.org/W2142773983","https://openalex.org/W2144991347","https://openalex.org/W2147328386","https://openalex.org/W2147478587","https://openalex.org/W2148201120","https://openalex.org/W2148223630","https://openalex.org/W2148235146","https://openalex.org/W2151279983","https://openalex.org/W2151412015","https://openalex.org/W2151758954","https://openalex.org/W2153531025","https://openalex.org/W2156244991","https://openalex.org/W2156555210","https://openalex.org/W2156638064","https://openalex.org/W2157269800","https://openalex.org/W2158636026","https://openalex.org/W2159465232","https://openalex.org/W2161155840","https://openalex.org/W2161291046","https://openalex.org/W2163255830","https://openalex.org/W2165668749","https://openalex.org/W2165869380","https://openalex.org/W2166411505","https://openalex.org/W2167213720","https://openalex.org/W2169344740","https://openalex.org/W2169917467","https://openalex.org/W2170445972","https://openalex.org/W2189240570","https://openalex.org/W2310632873","https://openalex.org/W2314670345","https://openalex.org/W2316206988","https://openalex.org/W2319146475","https://openalex.org/W2320783858","https://openalex.org/W2321354409","https://openalex.org/W2331025994","https://openalex.org/W2332559639","https://openalex.org/W2346878152","https://openalex.org/W2401825435","https://openalex.org/W2491531917","https://openalex.org/W4211123708","https://openalex.org/W4234329713","https://openalex.org/W4247684381","https://openalex.org/W4250187127","https://openalex.org/W4252017411","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7098458923","https://openalex.org/W2415896803","https://openalex.org/W2789381522","https://openalex.org/W2106539372","https://openalex.org/W4406560078","https://openalex.org/W2060843008","https://openalex.org/W2115061965","https://openalex.org/W3029961564","https://openalex.org/W4385968854","https://openalex.org/W1986853600"],"abstract_inverted_index":{"Herpes":[0],"simplex":[1],"viruses":[2],"types":[3],"1":[4],"and":[5,8,21,37,53,80,85,92,114,129,147,168],"2":[6],"(HSV-1":[7],"HSV-2)":[9],"infect":[10],"a":[11,54],"large":[12,55],"proportion":[13,56],"of":[14,57,78,82,105,122,145,164,171],"the":[15,45,75,94,123,136,162,169],"world's":[16],"population.":[17],"Infection":[18],"is":[19,50],"life-long":[20],"can":[22],"cause":[23],"periodic":[24],"mucocutaneous":[25],"symptoms,":[26],"but":[27],"it":[28],"only":[29],"rarely":[30],"causes":[31],"life-threatening":[32],"disease":[33],"among":[34],"immunocompetent":[35],"children":[36,84],"adults.":[38],"However,":[39],"when":[40],"HSV":[41,127,151,166,179],"infection":[42,128],"occurs":[43],"during":[44,135],"neonatal":[46,137,165,175],"period,":[47],"viral":[48],"replication":[49],"poorly":[51],"controlled":[52],"infants":[58],"die":[59],"or":[60,111],"develop":[61],"disability":[62],"even":[63],"with":[64,109],"optimal":[65],"antiviral":[66],"therapy.":[67],"Increasingly,":[68],"specific":[69],"differences":[70,154],"are":[71],"being":[72],"elucidated":[73],"between":[74],"immune":[76,176],"system":[77],"newborns":[79],"those":[81],"older":[83],"adults,":[86],"which":[87],"predispose":[88],"to":[89,98,119,150,173],"severe":[90],"infections":[91],"reflect":[93],"transition":[95],"from":[96],"fetal":[97],"postnatal":[99],"life.":[100],"Studies":[101],"in":[102,155],"healthy":[103],"individuals":[104,108],"different":[106],"ages,":[107],"primary":[110],"acquired":[112],"immunodeficiencies,":[113],"animal":[115],"models":[116],"have":[117],"contributed":[118],"our":[120,142],"understanding":[121,144],"mechanisms":[124],"that":[125,158],"control":[126],"how":[130],"these":[131],"may":[132,159],"be":[133],"impaired":[134],"period.":[138],"This":[139],"paper":[140],"outlines":[141],"current":[143],"innate":[146],"adaptive":[148],"immunity":[149],"infection,":[152,167],"immunologic":[153],"early":[156],"infancy":[157],"account":[160],"for":[161],"manifestations":[163],"potential":[170],"interventions":[172],"augment":[174],"protection":[177],"against":[178],"disease.":[180]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}