{"id":"https://openalex.org/W2108913064","doi":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","title":"Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown","display_name":"Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: Matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2108913064","doi":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","mag":"2108913064","pmid":"https://pubmed.ncbi.nlm.nih.gov/10996843"},"language":"en","primary_location":{"id":"doi:10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","doi":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2108913064"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34585008","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057660100","display_name":"W. D. Shingleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"W.D. Shingleton","raw_affiliation_strings":["Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041571330","display_name":"A.J. Ellis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.J. Ellis","raw_affiliation_strings":["Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071925382","display_name":"Andrew D. Rowan","orcid":"https://orcid.org/0000-0002-5338-1295","observed_orcids":["https://orcid.org/0000-0002-5338-1295"]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.D. Rowan","raw_affiliation_strings":["Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111986009","display_name":"Tim E. Cawston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T.E. Cawston","raw_affiliation_strings":["Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, The Medical School, Unviersity of Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057660100"],"corresponding_institution_ids":["https://openalex.org/I84884186"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":null,"fwci":0.6669,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.64838931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"79","issue":"4","first_page":"519","last_page":"531"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":1.0},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/nasal-cartilage","display_name":"nasal cartilage","score":0.8169999718666077},{"id":"https://openalex.org/keywords/collagen-degradation","display_name":"collagen degradation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.9049999713897705},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-13","display_name":"matrix metalloproteinase-13","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tissue-inhibitors-of-metalloproteinases","display_name":"tissue inhibitors of metalloproteinases","score":0.968999981880188},{"id":"https://openalex.org/keywords/proteoglycan-release","display_name":"proteoglycan release","score":0.7990000247955322},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.5460000038146973},{"id":"https://openalex.org/keywords/cartilage-resorption","display_name":"cartilage resorption","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bovine-cartilage","display_name":"bovine cartilage","score":0.8510000109672546}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8182464838027954},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.8119733333587646},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7585974335670471},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5661129355430603},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5214811563491821},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47785231471061707},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.46941766142845154},{"id":"https://openalex.org/C2776729418","wikidata":"https://www.wikidata.org/wiki/Q12229608","display_name":"Nasal cartilages","level":4,"score":0.41251444816589355},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38876670598983765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3670792877674103},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34763771295547485},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32317420840263367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24775931239128113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1882653534412384},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.10332170128822327},{"id":"https://openalex.org/C2778311950","wikidata":"https://www.wikidata.org/wiki/Q7363","display_name":"Nose","level":2,"score":0.08456873893737793},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C2776050027","wikidata":"https://www.wikidata.org/wiki/Q840929","display_name":"Rhinoplasty","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017364","descriptor_name":"Collagenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019715","descriptor_name":"Tissue Inhibitor of Metalloproteinase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053509","descriptor_name":"Matrix Metalloproteinase 13","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","doi":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.0.co;2-u","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"doi:10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.3.co;2-l","doi":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.3.co;2-l","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1097-4644(20001215)79:4<519::aid-jcb10>3.3.co;2-l","pdf_url":null,"source":{"id":"https://openalex.org/S53807158","display_name":"Journal of Cellular Biochemistry","issn_l":"0730-2312","issn":["0730-2312","1097-4644"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmid:10996843","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10996843","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular biochemistry","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34585008","doi":"https://doi.org/10.25405/ncl.34585008","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34585008","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34585008.v1","doi":"https://doi.org/10.25405/ncl.34585008.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34585008.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34585008","doi":"https://doi.org/10.25405/ncl.34585008","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34585008","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W105052296","https://openalex.org/W1516340717","https://openalex.org/W1516383449","https://openalex.org/W1524239466","https://openalex.org/W1593295279","https://openalex.org/W1668309971","https://openalex.org/W1768920928","https://openalex.org/W1964480364","https://openalex.org/W1964753544","https://openalex.org/W1964857234","https://openalex.org/W1965147385","https://openalex.org/W1965609918","https://openalex.org/W1968356908","https://openalex.org/W1969179229","https://openalex.org/W1971481363","https://openalex.org/W1972861978","https://openalex.org/W1975523013","https://openalex.org/W1979972616","https://openalex.org/W1981072821","https://openalex.org/W1988965815","https://openalex.org/W1989949914","https://openalex.org/W1990455581","https://openalex.org/W1995304518","https://openalex.org/W2002807336","https://openalex.org/W2007056555","https://openalex.org/W2010706639","https://openalex.org/W2011234068","https://openalex.org/W2011557116","https://openalex.org/W2017720269","https://openalex.org/W2019207339","https://openalex.org/W2019210742","https://openalex.org/W2025573775","https://openalex.org/W2032255522","https://openalex.org/W2032337876","https://openalex.org/W2032541805","https://openalex.org/W2043068076","https://openalex.org/W2046331668","https://openalex.org/W2047175057","https://openalex.org/W2051819610","https://openalex.org/W2053865268","https://openalex.org/W2055002540","https://openalex.org/W2060955746","https://openalex.org/W2065014069","https://openalex.org/W2067782706","https://openalex.org/W2069118847","https://openalex.org/W2069448431","https://openalex.org/W2072774880","https://openalex.org/W2074016505","https://openalex.org/W2076861638","https://openalex.org/W2084168776","https://openalex.org/W2086224102","https://openalex.org/W2088930264","https://openalex.org/W2094990443","https://openalex.org/W2095165075","https://openalex.org/W2103691455","https://openalex.org/W2109658199","https://openalex.org/W2116013040","https://openalex.org/W2129791991","https://openalex.org/W2138960046","https://openalex.org/W2141041168","https://openalex.org/W2152964348","https://openalex.org/W2167973356","https://openalex.org/W2209205153","https://openalex.org/W2409477757","https://openalex.org/W4255870175"],"related_works":["https://openalex.org/W2088930264","https://openalex.org/W2072774880","https://openalex.org/W2143390187","https://openalex.org/W1971481363","https://openalex.org/W2010974424","https://openalex.org/W2076861638","https://openalex.org/W2063210598","https://openalex.org/W2162379603","https://openalex.org/W2023560282","https://openalex.org/W2163555453"],"abstract_inverted_index":{"Retinoic":[0],"acid":[1],"(RetA)":[2],"and":[3,55,135,162,166],"interleukin-1alpha":[4],"(IL-1)":[5],"together":[6],"can":[7],"induce":[8],"a":[9,117],"reproducible":[10],"release":[11,22,60,129],"of":[12,23,38,66,83,106,115,130,148,155],"proteoglycan":[13],"fragments":[14,25],"from":[15,44,98,132],"bovine":[16,45,176],"nasal":[17,46],"cartilage":[18,47,107,177],"in":[19,48,69,96,151,171,196],"culture.":[20],"However,":[21,179],"collagen":[24,41,75,108,157],"with":[26],"either":[27],"agent":[28],"alone":[29],"is":[30,192],"often":[31],"variable.":[32],"In":[33],"this":[34,197],"study":[35],"over":[36],"70%":[37],"the":[39,64,70,78,113,127,133,145,152,181,193],"total":[40],"was":[42,61,87],"released":[43],"culture":[49,71,156],"by":[50,63,112],"day":[51,90,102],"14":[52],"when":[53,142],"RetA":[54,125,174],"IL-1":[56,137,172],"were":[57,164],"combined.":[58],"This":[59],"accompanied":[62],"appearance":[65],"collagenolytic":[67],"activity":[68,86],"medium":[72],"that":[73,124,136,190],"cleaved":[74],"specifically":[76],"at":[77,89,101],"(1/4)/(3/4)":[79],"position.":[80],"Tissue":[81],"inhibitor":[82],"metalloproteinases":[84],"(TIMP)":[85],"present":[88,186],"7":[91],"but":[92],"low":[93],"or":[94],"absent":[95],"media":[97],"resorbing":[99],"tissue":[100,134],"14.":[103],"The":[104],"breakdown":[105],"could":[109],"be":[110,169],"prevented":[111],"addition":[114],"BB-94,":[116],"specific":[118],"metalloproteinase":[119],"inhibitor.":[120],"These":[121],"results":[122],"suggest":[123,189],"promotes":[126],"early":[128],"TIMP":[131],"stimulates":[138],"pro-collagenase":[139],"secretion":[140],"which,":[141],"activated,":[143],"exceeds":[144],"local":[146],"concentration":[147],"TIMP.":[149],"Thus":[150],"later":[153],"stages":[154],"destruction":[158],"occurs.":[159],"Both":[160],"MMP-1":[161],"MMP-13":[163,191],"detected":[165],"appear":[167],"to":[168,188],"involved":[170],"+":[173],"induced":[175],"destruction.":[178],"for":[180],"first":[182],"time,":[183],"we":[184],"also":[185],"evidence":[187],"predominant":[194],"collagenase":[195],"system.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}