{"id":"https://openalex.org/W2108902008","doi":"https://doi.org/10.3109/02713683.2011.622853","title":"Effects of Instillation of Eyedrops Containing Disulfiram and Hydroxypropyl-\u03b2-Cyclodextrin Inclusion Complex on Endotoxin-Induced Uveitis in Rats","display_name":"Effects of Instillation of Eyedrops Containing Disulfiram and Hydroxypropyl-\u03b2-Cyclodextrin Inclusion Complex on Endotoxin-Induced Uveitis in Rats","publication_year":2011,"publication_date":"2011-10-26","ids":{"openalex":"https://openalex.org/W2108902008","doi":"https://doi.org/10.3109/02713683.2011.622853","mag":"2108902008","pmid":"https://pubmed.ncbi.nlm.nih.gov/22029776"},"language":"en","primary_location":{"id":"doi:10.3109/02713683.2011.622853","doi":"https://doi.org/10.3109/02713683.2011.622853","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713683.2011.622853","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071359386","display_name":"Kazutaka Kanai","orcid":"https://orcid.org/0000-0003-3690-2332","observed_orcids":["https://orcid.org/0000-0003-3690-2332"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazutaka Kanai","raw_affiliation_strings":["Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan. kanai@vmas.kitasato-u.ac.jp","Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan. kanai@vmas.kitasato-u.ac.jp","institution_ids":["https://openalex.org/I64189623"]},{"raw_affiliation_string":"Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090089333","display_name":"Yoshimasa Ito","orcid":"https://orcid.org/0000-0003-0141-948X","observed_orcids":["https://orcid.org/0000-0003-0141-948X"]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshimasa Ito","raw_affiliation_strings":["Department of Advanced Design for Pharmaceuticals, School of Pharmacy, University of Kinki, Higashi-Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Design for Pharmaceuticals, School of Pharmacy, University of Kinki, Higashi-Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054296045","display_name":"Noriaki Nagai","orcid":"https://orcid.org/0009-0007-1266-038X","observed_orcids":["https://orcid.org/0009-0007-1266-038X"]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriaki Nagai","raw_affiliation_strings":["Department of Advanced Design for Pharmaceuticals, School of Pharmacy, University of Kinki, Higashi-Osaka, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Design for Pharmaceuticals, School of Pharmacy, University of Kinki, Higashi-Osaka, Osaka, Japan","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081073229","display_name":"Naoyuki Itoh","orcid":"https://orcid.org/0000-0001-6424-3886","observed_orcids":["https://orcid.org/0000-0001-6424-3886"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoyuki Itoh","raw_affiliation_strings":["Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102874877","display_name":"Yasutomo Hori","orcid":"https://orcid.org/0000-0001-8333-0600","observed_orcids":["https://orcid.org/0000-0001-8333-0600"]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasutomo Hori","raw_affiliation_strings":["Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004241510","display_name":"Seishirou Chikazawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seishirou Chikazawa","raw_affiliation_strings":["Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086298438","display_name":"Fumio Hoshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fumio Hoshi","raw_affiliation_strings":["Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan","institution_ids":["https://openalex.org/I64189623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110113131","display_name":"Seiichi Higuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64189623","display_name":"Kitasato University","ror":"https://ror.org/00f2txz25","country_code":"JP","type":"education","lineage":["https://openalex.org/I64189623"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiichi Higuchi","raw_affiliation_strings":["Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Small Animal Internal Medicine, School of Veterinary Medicine, University of Kitasato, Towada, Aomori, Japan","institution_ids":["https://openalex.org/I64189623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071359386"],"corresponding_institution_ids":["https://openalex.org/I64189623"],"apc_list":null,"apc_paid":null,"fwci":1.4497,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.81452779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37","issue":"2","first_page":"124","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfiram","display_name":"disulfiram","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hydroxypropyl-beta-cyclodextrin","display_name":"hydroxypropyl-\u03b2-cyclodextrin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/inclusion-complexes","display_name":"inclusion complexes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.6940000057220459},{"id":"https://openalex.org/keywords/endotoxin-induced-uveitis","display_name":"endotoxin-induced uveitis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ocular-inflammation","display_name":"ocular inflammation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6660000085830688},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.824999988079071},{"id":"https://openalex.org/keywords/iris-ciliary-body","display_name":"iris-ciliary body","score":0.7940000295639038},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9359999895095825},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8889999985694885},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.7720000147819519},{"id":"https://openalex.org/keywords/eye-drops","display_name":"eye drops","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C2776390293","wikidata":"https://www.wikidata.org/wiki/Q2035485","display_name":"Subcutaneous injection","level":2,"score":0.6533915400505066},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6403086185455322},{"id":"https://openalex.org/C2778523461","wikidata":"https://www.wikidata.org/wiki/Q409665","display_name":"Disulfiram","level":2,"score":0.6156361103057861},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5854108929634094},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5768097043037415},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.5339948534965515},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.521135151386261},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5034345984458923},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.4974375069141388},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4901052415370941},{"id":"https://openalex.org/C2776194053","wikidata":"https://www.wikidata.org/wiki/Q280027","display_name":"Uveitis","level":2,"score":0.48951804637908936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4432685673236847},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4405618906021118},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4205082654953003},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2861217260360718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23816823959350586},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1653830111026764}],"mesh":[{"descriptor_ui":"D000073738","descriptor_name":"2-Hydroxypropyl-beta-cyclodextrin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001082","descriptor_name":"Aqueous Humor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004221","descriptor_name":"Disulfiram","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009883","descriptor_name":"Ophthalmic Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014605","descriptor_name":"Uveitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047392","descriptor_name":"beta-Cyclodextrins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/02713683.2011.622853","doi":"https://doi.org/10.3109/02713683.2011.622853","is_oa":false,"landing_page_url":"https://doi.org/10.3109/02713683.2011.622853","pdf_url":null,"source":{"id":"https://openalex.org/S74941265","display_name":"Current Eye Research","issn_l":"0271-3683","issn":["0271-3683","1460-2202"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Eye Research","raw_type":"journal-article"},{"id":"pmid:22029776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22029776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current eye research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W46936998","https://openalex.org/W71051318","https://openalex.org/W132053806","https://openalex.org/W155677955","https://openalex.org/W1197553475","https://openalex.org/W1520584569","https://openalex.org/W1524070237","https://openalex.org/W1564174228","https://openalex.org/W1581555608","https://openalex.org/W1589139136","https://openalex.org/W1911235202","https://openalex.org/W1978227204","https://openalex.org/W1985312132","https://openalex.org/W1991083995","https://openalex.org/W1996596327","https://openalex.org/W1997094027","https://openalex.org/W1997364548","https://openalex.org/W2004826079","https://openalex.org/W2016844340","https://openalex.org/W2026684097","https://openalex.org/W2027127607","https://openalex.org/W2031099314","https://openalex.org/W2031563447","https://openalex.org/W2043459450","https://openalex.org/W2044864184","https://openalex.org/W2049000648","https://openalex.org/W2054542926","https://openalex.org/W2055091943","https://openalex.org/W2074667498","https://openalex.org/W2083748640","https://openalex.org/W2089747387","https://openalex.org/W2094114218","https://openalex.org/W2105956434","https://openalex.org/W2129612484","https://openalex.org/W2131483303","https://openalex.org/W2141683590","https://openalex.org/W2147921405","https://openalex.org/W2159567970","https://openalex.org/W2395715386","https://openalex.org/W2410091278","https://openalex.org/W2582398023"],"related_works":["https://openalex.org/W2105956434","https://openalex.org/W2021837435","https://openalex.org/W1621802391","https://openalex.org/W2074084355","https://openalex.org/W3207218541","https://openalex.org/W1984896501","https://openalex.org/W2931898219","https://openalex.org/W2119751695","https://openalex.org/W1564174228","https://openalex.org/W2126256701"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,7,95,121,131,158,163,167,175,179,183,206,220,233,240,250],"anti-inflammatory":[4,187],"effects":[5],"of":[6,9,45,67,81,97,104,120,133,160,169,182,189,198,236,252],"instillation":[8,235],"disulfirum":[10],"(DSF)":[11],"eyedrops":[12,238],"that":[13,197,232],"enhance":[14],"solubility":[15],"using":[16],"2-hydroxypropyl-\u03b2-cyclodextrin":[17],"(HP\u03b2CD)":[18],"and":[19,28,53,74,76,94,102,112,144,166,172,177,214,216],"hydroxypropylmethylcellulose":[20],"(HPMC)":[21],"on":[22],"endotoxin-induced":[23],"uveitis":[24],"(EIU)":[25],"in":[26,38,154,174,219,242],"rats":[27,41,68],"mechanisms":[29],"related":[30],"to":[31,64,129],"ocular":[32,184,253],"inflammation.":[33,254],"METHODS:":[34],"EIU":[35],"was":[36,61,87,127,193],"induced":[37],"male":[39],"Lewis":[40],"by":[42],"subcutaneous":[43],"injection":[44,80],"200":[46],"\u03bcg":[47],"lipopolysaccharide":[48],"(LPS).":[49],"DSF":[50,152,191,202,237],"(0.125%,":[51],"0.25%":[52],"0.5%)":[54],"or":[55],"commercially":[56],"available":[57],"0.05%":[58,199],"dexamethasone":[59],"(Dexa)":[60],"topically":[62],"applied":[63],"both":[65],"eyes":[66],"1":[69,75],"hour":[70],"before,":[71],"immediately":[72],"after,":[73],"2":[77],"hours":[78,90,210,223],"after":[79,91,211,224],"LPS.":[82],"The":[83,148,186,228],"aqueous":[84],"humor":[85],"(AqH)":[86],"collected":[88],"24":[89,222],"LPS":[92,212,225],"injection,":[93,213],"number":[96,159],"infiltrating":[98],"cells,":[99,162],"protein":[100,164],"concentration,":[101,165],"levels":[103,168],"tumor":[105],"necrosis":[106],"factor-\u03b1":[107],"(TNF-\u03b1),":[108],"nitric":[109,140],"oxide":[110,141],"(NO)":[111],"prostaglandin":[113],"E2":[114],"(PGE2)":[115],"were":[116],"determined.":[117],"Immunohistochemical":[118],"analysis":[119],"iris":[122],"ciliary":[123],"body":[124],"(ICB)":[125],"cells":[126],"performed":[128],"determine":[130],"expression":[132,218],"activated":[134,207],"nuclear":[135],"factor":[136],"\u03baB":[137],"(NF-\u03baB),":[138],"inducible":[139],"synthase":[142],"(iNOS)":[143],"cyclooxygenase-2":[145],"(COX-2).":[146],"RESULTS:":[147],"topical":[149,234],"administration":[150],"with":[151],"suppressed,":[153],"a":[155,245],"dose-dependent":[156],"manner,":[157],"inflammatory":[161],"NO,":[170],"TNF-\u03b1":[171],"PGE2":[173],"AqH":[176],"improved":[178],"histologic":[180],"status":[181],"tissue.":[185],"potency":[188],"0.5%":[190],"treatment":[192,203,251],"as":[194,196],"strong":[195],"Dexa.":[200],"Topical":[201],"also":[204],"suppressed":[205],"NF-\u03baB":[208],"3":[209],"iNOS":[215],"COX-2":[217],"ICB":[221],"injection.":[226],"CONCLUSIONS:":[227],"present":[229],"results":[230],"demonstrate":[231],"suppresses":[239],"inflammation":[241],"EIU,":[243],"suggesting":[244],"possible":[246],"novel":[247],"approach":[248],"for":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}