{"id":"https://openalex.org/W2108900749","doi":"https://doi.org/10.1002/stem.5530130109","title":"Effects of continuous stem cell factor administration on normal and erythropoietin\u2010stimulated murine hemopoiesis: Experimental results and model analysis","display_name":"Effects of continuous stem cell factor administration on normal and erythropoietin\u2010stimulated murine hemopoiesis: Experimental results and model analysis","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W2108900749","doi":"https://doi.org/10.1002/stem.5530130109","mag":"2108900749","pmid":"https://pubmed.ncbi.nlm.nih.gov/7536513"},"language":"en","primary_location":{"id":"doi:10.1002/stem.5530130109","doi":"https://doi.org/10.1002/stem.5530130109","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.5530130109","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025350377","display_name":"Gerald de Haan","orcid":"https://orcid.org/0000-0001-9706-0138","observed_orcids":["https://orcid.org/0000-0001-9706-0138"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerald De Haan","raw_affiliation_strings":["Groningen Institute for Drug Studies, Department of Hematology, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groningen Institute for Drug Studies, Department of Hematology, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110046622","display_name":"Bert Dontje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bert Dontje","raw_affiliation_strings":["Groningen Institute for Drug Studies, Department of Hematology, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groningen Institute for Drug Studies, Department of Hematology, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001561654","display_name":"WILLEM NIJHOF","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Willem Nijhof","raw_affiliation_strings":["Groningen Institute for Drug Studies, Department of Hematology, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Groningen Institute for Drug Studies, Department of Hematology, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025964385","display_name":"Markus Loeffler","orcid":"https://orcid.org/0000-0002-0424-9933","observed_orcids":["https://orcid.org/0000-0002-0424-9933"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Loeffler","raw_affiliation_strings":["Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.4833,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.82273148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"13","issue":"1","first_page":"65","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5273000001907349,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.5273000001907349,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.4650999903678894,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"stem cell factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.906000018119812},{"id":"https://openalex.org/keywords/cfu-e","display_name":"CFU-E","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cfu-s","display_name":"CFU-S","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cfu-gm","display_name":"CFU-GM","score":0.7870000004768372},{"id":"https://openalex.org/keywords/bfu-e","display_name":"BFU-E","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hematocrit","display_name":"hematocrit","score":0.6830000281333923},{"id":"https://openalex.org/keywords/cytokine-synergy","display_name":"cytokine synergy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/erythroid-progenitors","display_name":"erythroid progenitor cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.905218780040741},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7782422304153442},{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.7243568301200867},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6759517788887024},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.5203278064727783},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46344971656799316},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36960524320602417},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21284207701683044}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003114","descriptor_name":"Colony-Forming Units Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016298","descriptor_name":"Hematopoietic Cell Growth Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019089","descriptor_name":"Stem Cell Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/stem.5530130109","doi":"https://doi.org/10.1002/stem.5530130109","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.5530130109","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},{"id":"pmid:7536513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7536513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W11315424","https://openalex.org/W133944846","https://openalex.org/W322263802","https://openalex.org/W1222115765","https://openalex.org/W1593116832","https://openalex.org/W1608480048","https://openalex.org/W1610096280","https://openalex.org/W1902451473","https://openalex.org/W1976321898","https://openalex.org/W1991388591","https://openalex.org/W2037695813","https://openalex.org/W2049316691","https://openalex.org/W2055610467","https://openalex.org/W2058655873","https://openalex.org/W2059228557","https://openalex.org/W2067272716","https://openalex.org/W2076287231","https://openalex.org/W2095285798","https://openalex.org/W2103546044","https://openalex.org/W2140922568","https://openalex.org/W2149295197","https://openalex.org/W2151900782","https://openalex.org/W2168146165","https://openalex.org/W2170097602","https://openalex.org/W2253467765","https://openalex.org/W2287425674","https://openalex.org/W2302020344","https://openalex.org/W2340524664","https://openalex.org/W2412522564","https://openalex.org/W2419728729","https://openalex.org/W4252030004","https://openalex.org/W4256110821"],"related_works":["https://openalex.org/W7000130613","https://openalex.org/W1825811600","https://openalex.org/W2089391077","https://openalex.org/W7096683676","https://openalex.org/W184800828","https://openalex.org/W2084246600","https://openalex.org/W1989344540","https://openalex.org/W1977264012","https://openalex.org/W199105648","https://openalex.org/W2124113701"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,22,39,52,55,62,143,149,161,169],"this":[3,204],"study":[4],"was":[5,153,205],"to":[6,43,58,99,109,121,186],"determine":[7],"how":[8,60],"stem":[9],"cell":[10,15,112,118],"factor":[11],"(SCF)":[12],"modifies":[13],"hemopoietic":[14,79,217],"production.":[16],"First":[17],"we":[18,48],"determined":[19],"the":[20,32,45,50,78,97,141,158,213],"effects":[21,51,61,188],"a":[23,35,74,144],"prolonged":[24],"SCF":[25,68,156,181,211],"administration":[26,69,184],"on":[27,174,189],"murine":[28],"hemopoiesis":[29,40],"and":[30,64,90,164,171,182,192],"analyzed":[31],"results":[33],"by":[34,103],"mathematical":[36,147],"simulation":[37],"model":[38,148],"in":[41,124],"order":[42],"explain":[44],"data.":[46],"Subsequently":[47],"investigated":[49],"simultaneous":[53],"coadministration":[54],"SCF+erythropoietin":[56],"(Epo),":[57],"see":[59],"early":[63],"late":[65,220],"cytokines":[66,222],"superimpose.":[67],"during":[70],"14":[71,125],"days":[72],"induced":[73],"proliferative":[75],"wave":[76,135],"through":[77],"system;":[80],"colony":[81,91,127],"forming":[82,87,92,128],"units-granulocyte":[83],"macrophage":[84],"(CFU-GM),":[85],"burst":[86],"units-erythroid":[88],"(BFU-E)":[89],"units":[93],"erythroid":[94,170],"(CFU-E)":[95],"were":[96,177],"first":[98],"be":[100,138],"augmented,":[101],"followed":[102],"their":[104],"respective":[105],"progeny,":[106],"ultimately":[107],"leading":[108],"increased":[110],"blood":[111],"numbers.":[113],"Despite":[114],"continued":[115],"treatment":[116],"most":[117],"numbers":[119,191],"returned":[120],"normal":[122],"values":[123,194],"days,":[126],"units-spleen":[129],"(CFU-S),":[130],"however,":[131,203],"remained":[132],"elevated.":[133],"This":[134],"pattern":[136],"could":[137],"explained":[139],"within":[140],"framework":[142],"previously":[145],"established":[146],"hemopoiesis,":[150],"if":[151,165],"it":[152],"assumed":[154],"that":[155,210],"affected":[157],"cycling":[159],"status":[160],"primitive":[162],"cells":[163,176],"regulatory":[166],"feedback":[167],"loops":[168],"myeloid":[172],"progenitors":[173],"these":[175],"also":[178],"allowed.":[179],"Simultaneous":[180],"Epo":[183,197,201],"led":[185],"synergistic":[187],"CFU-E":[190],"hematocrit":[193],"at":[195],"moderate":[196],"doses.":[198],"At":[199],"high":[200],"doses,":[202],"less":[206],"pronounced.":[207],"We":[208],"conclude":[209],"increases":[212],"input":[214],"into":[215],"committed":[216],"lineages,":[218],"where":[219],"acting":[221],"can":[223],"induce":[224],"further":[225],"amplification.":[226]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}