{"id":"https://openalex.org/W2108892010","doi":"https://doi.org/10.1161/circresaha.110.223917","title":"Neuregulin/ErbB Signaling Regulates Cardiac Subtype Specification in Differentiating Human Embryonic Stem Cells","display_name":"Neuregulin/ErbB Signaling Regulates Cardiac Subtype Specification in Differentiating Human Embryonic Stem Cells","publication_year":2010,"publication_date":"2010-07-30","ids":{"openalex":"https://openalex.org/W2108892010","doi":"https://doi.org/10.1161/circresaha.110.223917","mag":"2108892010","pmid":"https://pubmed.ncbi.nlm.nih.gov/20671236","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2941561"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.110.223917","doi":"https://doi.org/10.1161/circresaha.110.223917","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.110.223917","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.223917","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.223917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103054820","display_name":"Weizhong Zhu","orcid":"https://orcid.org/0000-0002-8740-3210","observed_orcids":["https://orcid.org/0000-0002-8740-3210"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Zhong Zhu","raw_affiliation_strings":["From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","Geron Corporation (J.D.G.), Menlo Park, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210114060"]},{"raw_affiliation_string":"Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042396121","display_name":"Yiheng Xie","orcid":"https://orcid.org/0000-0002-2689-3471","observed_orcids":["https://orcid.org/0000-0002-2689-3471"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiheng Xie","raw_affiliation_strings":["From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","Geron Corporation (J.D.G.), Menlo Park, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210114060"]},{"raw_affiliation_string":"Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017139671","display_name":"Kara White Moyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara White Moyes","raw_affiliation_strings":["From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","Geron Corporation (J.D.G.), Menlo Park, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210114060"]},{"raw_affiliation_string":"Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Joseph D. Gold","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph D. Gold","raw_affiliation_strings":["From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","Geron Corporation (J.D.G.), Menlo Park, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210114060"]},{"raw_affiliation_string":"Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017080599","display_name":"Bardia Askari","orcid":"https://orcid.org/0000-0002-7970-5817","observed_orcids":["https://orcid.org/0000-0002-7970-5817"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bardia Askari","raw_affiliation_strings":["From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","Geron Corporation (J.D.G.), Menlo Park, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210114060"]},{"raw_affiliation_string":"Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I4210114060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076256367","display_name":"Michael A. Laflamme","orcid":"https://orcid.org/0000-0001-5908-880X","observed_orcids":["https://orcid.org/0000-0001-5908-880X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210114060","display_name":"Geron (United States)","ror":"https://ror.org/026vpvt76","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114060"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Laflamme","raw_affiliation_strings":["From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","Geron Corporation (J.D.G.), Menlo Park, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Center for Cardiovascular Biology, Department of Pathology (W.-Z.Z., Y.X., K.W.M., B.A., M.A.L.) and Institute for Stem Cell and Regenerative Medicine (W.-Z.Z., Y.X., K.W.M., M.A.L.), University of Washington, Seattle; and Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210114060"]},{"raw_affiliation_string":"Geron Corporation (J.D.G.), Menlo Park, Calif","institution_ids":["https://openalex.org/I4210114060"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.7521,"has_fulltext":true,"cited_by_count":229,"citation_normalized_percentile":{"value":0.9858059,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"107","issue":"6","first_page":"776","last_page":"786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuregulin-1beta","display_name":"neuregulin-1\u03b2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/erbb-signaling-pathway","display_name":"ErbB signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/human-embryonic-stem-cell-derived-cardiomyocytes","display_name":"human embryonic stem cell-derived cardiomyocytes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/ag1478","display_name":"AG1478","score":0.8330000042915344},{"id":"https://openalex.org/keywords/biological-pacemaker","display_name":"biological pacemaker","score":0.8320000171661377},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.8417072892189026},{"id":"https://openalex.org/C185323287","wikidata":"https://www.wikidata.org/wiki/Q59252204","display_name":"Neuregulin","level":3,"score":0.8153315782546997},{"id":"https://openalex.org/C2778560701","wikidata":"https://www.wikidata.org/wiki/Q14914188","display_name":"Neuregulin 1","level":3,"score":0.764380693435669},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.7242699861526489},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6125677227973938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5499628186225891},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5103084444999695},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4485642611980438},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3401854634284973},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1863805055618286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1690264642238617}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D012849","descriptor_name":"Sinoatrial Node","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020890","descriptor_name":"Neuregulin-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1161/circresaha.110.223917","doi":"https://doi.org/10.1161/circresaha.110.223917","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.110.223917","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.223917","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:20671236","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20671236","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Comparative Study"},{"id":"pmh:oai:europepmc.org:2178702","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2941561","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2941561","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2941561","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Res","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1031.905","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1031.905","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/circresaha/107/6/776.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/circresaha.110.223917","doi":"https://doi.org/10.1161/circresaha.110.223917","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.110.223917","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.223917","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1423956633","display_name":null,"funder_award_id":"R01-HL064387","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3853863098","display_name":"Myocardium and Conduction System from ESCs","funder_award_id":"K08HL080431","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6481784457","display_name":"STEM CELLS AND CARDIOVASCULAR REPAIR","funder_award_id":"P01HL094374","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8733628426","display_name":"Engineered Cardiac Morphogenesis-Stem Cells and Scaffolds","funder_award_id":"5r01hl064387-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108892010.pdf","grobid_xml":"https://content.openalex.org/works/W2108892010.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W1530324520","https://openalex.org/W1537135332","https://openalex.org/W1596115288","https://openalex.org/W1903925553","https://openalex.org/W1932853204","https://openalex.org/W1963518748","https://openalex.org/W1964392860","https://openalex.org/W1967639969","https://openalex.org/W1973472018","https://openalex.org/W1979187233","https://openalex.org/W1980141913","https://openalex.org/W1980646691","https://openalex.org/W1980831122","https://openalex.org/W1982210988","https://openalex.org/W1982548006","https://openalex.org/W1988459667","https://openalex.org/W1988498011","https://openalex.org/W1992657103","https://openalex.org/W1999804043","https://openalex.org/W2003352173","https://openalex.org/W2004454319","https://openalex.org/W2010417854","https://openalex.org/W2016010426","https://openalex.org/W2018110387","https://openalex.org/W2019242831","https://openalex.org/W2026641491","https://openalex.org/W2026905879","https://openalex.org/W2034238319","https://openalex.org/W2040796799","https://openalex.org/W2042324758","https://openalex.org/W2043345702","https://openalex.org/W2046025408","https://openalex.org/W2048902535","https://openalex.org/W2054012275","https://openalex.org/W2054375986","https://openalex.org/W2054850711","https://openalex.org/W2064124462","https://openalex.org/W2065171831","https://openalex.org/W2065939635","https://openalex.org/W2066048575","https://openalex.org/W2068480440","https://openalex.org/W2069940803","https://openalex.org/W2071402191","https://openalex.org/W2080399383","https://openalex.org/W2081409458","https://openalex.org/W2083077654","https://openalex.org/W2084217457","https://openalex.org/W2084874490","https://openalex.org/W2085270120","https://openalex.org/W2085826645","https://openalex.org/W2086338483","https://openalex.org/W2088204183","https://openalex.org/W2090130541","https://openalex.org/W2090353883","https://openalex.org/W2095059099","https://openalex.org/W2097246504","https://openalex.org/W2099259128","https://openalex.org/W2102254218","https://openalex.org/W2102650234","https://openalex.org/W2104092642","https://openalex.org/W2111031333","https://openalex.org/W2112259501","https://openalex.org/W2121003871","https://openalex.org/W2122104102","https://openalex.org/W2122652084","https://openalex.org/W2123206362","https://openalex.org/W2124396531","https://openalex.org/W2124668407","https://openalex.org/W2126924780","https://openalex.org/W2128085444","https://openalex.org/W2128923693","https://openalex.org/W2129118672","https://openalex.org/W2130207795","https://openalex.org/W2130306265","https://openalex.org/W2130668754","https://openalex.org/W2133338187","https://openalex.org/W2136122531","https://openalex.org/W2148102243","https://openalex.org/W2148557777","https://openalex.org/W2149455838","https://openalex.org/W2150210372","https://openalex.org/W2153099809","https://openalex.org/W2155600377","https://openalex.org/W2155828174","https://openalex.org/W2157578689","https://openalex.org/W2157979094","https://openalex.org/W2169859308","https://openalex.org/W2185842802","https://openalex.org/W2416501904","https://openalex.org/W4246928383"],"related_works":["https://openalex.org/W2335727582","https://openalex.org/W91115684","https://openalex.org/W2018110387","https://openalex.org/W2090271716","https://openalex.org/W1979187233","https://openalex.org/W2055041567","https://openalex.org/W2090353883","https://openalex.org/W2139493689","https://openalex.org/W2168247876","https://openalex.org/W2625510700"],"abstract_inverted_index":{"RATIONALE:":[0],"Human":[1],"embryonic":[2],"stem":[3],"cell-derived":[4],"cardiomyocytes":[5],"(hESC-CMs)":[6],"exhibit":[7],"either":[8],"a":[9,13,89,101,242],"\"working\"":[10],"chamber":[11],"or":[12,128],"nodal-like":[14],"phenotype.":[15,188],"To":[16,41,80],"generate":[17,225],"optimal":[18],"hESC-CM":[19,62,70,111,202],"preparations":[20,112,226],"for":[21,231,238],"eventual":[22],"clinical":[23],"application":[24],"in":[25,47,61,118,145,200,241],"cell-based":[26],"therapies,":[27],"we":[28,96,172],"will":[29,221],"need":[30],"to":[31,115,138,197,224],"control":[32,110],"their":[33],"differentiation":[34,78],"into":[35],"these":[36],"specialized":[37],"cardiac":[38,58,94,143],"subtypes.":[39],"OBJECTIVE:":[40],"demonstrate":[42],"intact":[43],"neuregulin":[44],"(NRG)-1\u03b2/ErbB":[45],"signaling":[46,55,178,191],"hESC-CMs":[48],"and":[49,87,99,161,204],"test":[50],"the":[51,119,129,140,146,157,181,186,193],"hypothesis":[52],"that":[53,105,174],"this":[54],"pathway":[56],"regulates":[57,192],"subtype":[59],"abundance":[60],"cultures.":[63],"METHODS":[64],"AND":[65],"RESULTS:":[66],"All":[67],"experiments":[68],"used":[69,134],"cultures":[71,203],"generated":[72],"using":[73],"our":[74],"recently":[75],"reported":[76],"directed":[77],"protocol.":[79],"support":[81],"subsequent":[82],"action":[83,150],"potential":[84,151,239],"phenotyping":[85,152],"approaches":[86,137],"provide":[88],"higher-throughput":[90],"method":[91],"of":[92,121,142,156,176,183,195,227],"determining":[93],"subtype,":[95],"first":[97],"developed":[98],"validated":[100],"novel":[102],"genetic":[103,159],"label":[104],"identifies":[106],"nodal-type":[107],"hESC-CMs.":[108],"Next,":[109],"were":[113],"compared":[114],"those":[116],"differentiated":[117],"presence":[120],"exogenous":[122],"NRG-1\u03b2,":[123],"an":[124],"anti-NRG-1\u03b2":[125],"neutralizing":[126],"antibody,":[127],"ErbB":[130],"antagonist":[131],"AG1478.":[132],"We":[133,213],"3":[135,169],"independent":[136],"determine":[139],"ratio":[141,194],"subtypes":[144],"resultant":[147],"populations:":[148],"direct":[149],"under":[153],"current-clamp,":[154],"activation":[155],"aforementioned":[158],"label,":[160],"subtype-specific":[162],"marker":[163],"expression":[164],"by":[165,216],"RT-PCR.":[166],"Using":[167],"all":[168],"end":[170],"points,":[171],"found":[173],"inhibition":[175],"NRG-1\u03b2/ErbB":[177,190,218],"greatly":[179],"enhanced":[180],"proportion":[182],"cells":[184,199,237],"showing":[185],"nodal":[187,236],"CONCLUSIONS:":[189],"nodal-":[196],"working-type":[198,229],"differentiating":[201],"presumably":[205],"functions":[206],"similarly":[207],"during":[208],"early":[209],"human":[210],"heart":[211],"development.":[212],"speculate":[214],"that,":[215],"manipulating":[217],"signaling,":[219],"it":[220],"be":[222],"possible":[223],"enriched":[228],"myocytes":[230],"infarct":[232],"repair,":[233],"or,":[234],"conversely,":[235],"use":[240],"biological":[243],"pacemaker.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":20},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":29}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
