{"id":"https://openalex.org/W2108889261","doi":null,"title":"CYTOKINE AND EFFECTOR MOLECULE DYSREGULATION IN PLASMODIUM FALCIPARUM MALARIA","display_name":"CYTOKINE AND EFFECTOR MOLECULE DYSREGULATION IN PLASMODIUM FALCIPARUM MALARIA","publication_year":2005,"publication_date":"2005-09-12","ids":{"openalex":"https://openalex.org/W2108889261","mag":"2108889261"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9301","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107835416","display_name":"CHRISTOPHER C. KELLER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christopher Keller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5107835416"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3687,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.72171249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9259999990463257},{"id":"https://openalex.org/keywords/pediatric-malaria","display_name":"pediatric malaria","score":0.75},{"id":"https://openalex.org/keywords/malarial-anemia","display_name":"malarial anemia","score":0.8510000109672546},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.7620000243186951},{"id":"https://openalex.org/keywords/hemozoin","display_name":"hemozoin","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cytokine-dysregulation","display_name":"cytokine imbalance","score":0.8920000195503235},{"id":"https://openalex.org/keywords/il-12p70","display_name":"IL-12p70","score":0.9070000052452087},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8650000095367432},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-2","display_name":"nitric oxide synthase 2","score":0.8830000162124634},{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.7699999809265137},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.5730000138282776},{"id":"https://openalex.org/keywords/malaria-vaccine","display_name":"malaria vaccine","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2776028358","wikidata":"https://www.wikidata.org/wiki/Q3144960","display_name":"Hemozoin","level":4,"score":0.8635804057121277},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7125223875045776},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6165147423744202},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.6142977476119995},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5814123749732971},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.572160005569458},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.5397073030471802},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.5349885821342468},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.4640030264854431},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.45804092288017273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4235605001449585},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3812679648399353},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9301","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:2108889261","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9301","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","pdf_url":"http://d-scholarship.pitt.edu/9301/1/Keller2005.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108889261.pdf","grobid_xml":"https://content.openalex.org/works/W2108889261.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W68814448","https://openalex.org/W88566818","https://openalex.org/W149126180","https://openalex.org/W184726500","https://openalex.org/W1498725227","https://openalex.org/W1532157284","https://openalex.org/W1540583882","https://openalex.org/W1547082701","https://openalex.org/W1562185454","https://openalex.org/W1604614381","https://openalex.org/W1652987014","https://openalex.org/W1709780155","https://openalex.org/W1757255427","https://openalex.org/W1782561717","https://openalex.org/W1812003545","https://openalex.org/W1837576575","https://openalex.org/W1860105952","https://openalex.org/W1899361801","https://openalex.org/W1900999978","https://openalex.org/W1926521347","https://openalex.org/W1975528993","https://openalex.org/W1990022750","https://openalex.org/W1991443246","https://openalex.org/W1992276344","https://openalex.org/W1994318619","https://openalex.org/W1996802488","https://openalex.org/W1998232267","https://openalex.org/W1998386114","https://openalex.org/W1999405791","https://openalex.org/W2004759032","https://openalex.org/W2005898614","https://openalex.org/W2009905488","https://openalex.org/W2014210122","https://openalex.org/W2021166646","https://openalex.org/W2021581026","https://openalex.org/W2022647835","https://openalex.org/W2023439178","https://openalex.org/W2034018631","https://openalex.org/W2035451205","https://openalex.org/W2037796326","https://openalex.org/W2039358393","https://openalex.org/W2039802164","https://openalex.org/W2039976430","https://openalex.org/W2058074298","https://openalex.org/W2060199389","https://openalex.org/W2061411892","https://openalex.org/W2062359227","https://openalex.org/W2063310657","https://openalex.org/W2063548456","https://openalex.org/W2064938586","https://openalex.org/W2065733983","https://openalex.org/W2066243724","https://openalex.org/W2069741079","https://openalex.org/W2083547256","https://openalex.org/W2085419002","https://openalex.org/W2086153672","https://openalex.org/W2091396227","https://openalex.org/W2096468951","https://openalex.org/W2100008151","https://openalex.org/W2102457341","https://openalex.org/W2104439753","https://openalex.org/W2107919511","https://openalex.org/W2111905638","https://openalex.org/W2112262032","https://openalex.org/W2114804812","https://openalex.org/W2118011548","https://openalex.org/W2119672443","https://openalex.org/W2121356018","https://openalex.org/W2122612937","https://openalex.org/W2125930156","https://openalex.org/W2127952767","https://openalex.org/W2128378359","https://openalex.org/W2128882718","https://openalex.org/W2129250847","https://openalex.org/W2132575805","https://openalex.org/W2133972984","https://openalex.org/W2134812217","https://openalex.org/W2135694413","https://openalex.org/W2147996070","https://openalex.org/W2149753875","https://openalex.org/W2150075376","https://openalex.org/W2150195134","https://openalex.org/W2156411751","https://openalex.org/W2157458289","https://openalex.org/W2157890819","https://openalex.org/W2159652780","https://openalex.org/W2160039183","https://openalex.org/W2160714033","https://openalex.org/W2164903088","https://openalex.org/W2166495198","https://openalex.org/W2166946397","https://openalex.org/W2171449573","https://openalex.org/W2187810646","https://openalex.org/W2293977658","https://openalex.org/W2323870293","https://openalex.org/W2398572679","https://openalex.org/W2400357540","https://openalex.org/W2408310638","https://openalex.org/W2412486808","https://openalex.org/W2418509754","https://openalex.org/W2418840241","https://openalex.org/W2800526221","https://openalex.org/W3021778177"],"related_works":["https://openalex.org/W2109172245","https://openalex.org/W2106893498","https://openalex.org/W2146615611","https://openalex.org/W2318162843","https://openalex.org/W4402310966","https://openalex.org/W6920421983","https://openalex.org/W2130553006","https://openalex.org/W7096965845","https://openalex.org/W2096468951","https://openalex.org/W2113419783"],"abstract_inverted_index":{"Childhood":[0],"malarial":[1,55],"anemia":[2],"(MA)":[3],"remains":[4],"a":[5,38,300],"global":[6],"health":[7,322],"burden":[8],"with":[9,91,114,170,175,264,271,312],"the":[10,30,118,150,327],"vast":[11],"morbidity":[12],"and":[13,22,68,73,81,100,102,109,152,156,165,181,186,210,232,235,331,343],"mortality":[14],"occurring":[15],"mostly":[16],"in":[17,59,166,189,229,251,262,286,310,324],"sub-Saharan":[18],"Africa.":[19],"Although":[20],"design":[21,342],"testing":[23],"of":[24,32,97,106,124,130,145,154,184,202,207,215,217,237,242,247,253,257,291,295,303,319,329],"malaria":[25,164,273,337],"vaccines":[26],"is":[27,51,57,127],"currently":[28],"underway,":[29],"pattern":[31,123,302],"inflammatory":[33,146,304],"mediator":[34,147,305],"production":[35,126,226,306,334],"that":[36,89,196,308,325],"predicts":[37],"protective":[39],"immune":[40,125],"response":[41],"against":[42],"severe":[43,92,265,272,313,336],"malaria,":[44,116],"which":[45,212,244,282],"would":[46],"dramatically":[47],"enhance":[48],"vaccine":[49,341],"testing,":[50],"largely":[52],"unknown.":[53,128],"Protective":[54],"immunity":[56],"regulated":[58],"part":[60,287],"by":[61,136,297],"cytokines,":[62],"such":[63,76,133],"as":[64,77,134],"interleukin":[65],"(IL)-12,":[66],"IL-10,":[67,107,203,249],"tumor":[69],"necrosis":[70],"factor":[71],"(TNF)-\u03b1,":[72],"effector":[74,157,332],"molecules,":[75],"prostaglandin":[78],"E2":[79],"(PGE2)":[80],"nitric":[82,276],"oxide":[83,277],"(NO).":[84],"Previous":[85],"studies":[86],"have":[87,94],"illustrated":[88],"children":[90,113,263,270,311],"MA":[93],"lower":[95],"levels":[96,105,183],"circulating":[98],"IL-12p70":[99,180,199],"PGE2,":[101,243],"increased":[103,182],"plasma":[104,258],"TNF-\u03b1,":[108],"NO":[110],"relative":[111],"to":[112,307],"mild":[115],"however,":[117],"mechanism(s)":[119],"responsible":[120],"for":[121],"this":[122],"Phagocytosis":[129],"parasitic":[131],"products,":[132],"hemozoin,":[135],"cultured":[137,167,190],"peripheral":[138],"blood":[139],"mononuclear":[140],"cell":[141],"(PBMC)":[142],"elicits":[143,299],"dysregulation":[144],"production,":[148],"therefore,":[149],"regulation":[151,328],"interactions":[153],"cytokines":[155],"molecules":[158],"was":[159,213,245,260],"investigated":[160],"during":[161,335],"acute":[162],"childhood":[163],"PBMC":[168,191,268,289,298],"stimulated":[169],"Plasmodium":[171],"falciparum-derived":[172],"hemozoin.":[173,292],"Children":[174],"high-density":[176],"parasitemia":[177],"had":[178,274],"decreased":[179,261],"IL-10":[185],"TNF-\u03b1.":[187,254],"Experiments":[188],"from":[192,269],"malaria-na\u00efve":[193],"donors":[194],"revealed":[195],"hemozoin":[197,296],"suppressed":[198],"through":[200,227,288],"induction":[201],"but":[204],"not":[205],"over-expression":[206],"TNF-\u03b1":[208],"transcripts":[209],"protein,":[211],"independent":[214,246],"suppressor":[216],"cytokine":[218,330],"signaling":[219],"(SOCS)-3":[220],"induction.":[221],"Hemozoinsuppressed":[222],"cyclooxygenase":[223],"(COX)-2-dependent":[224],"PGE2":[225],"reductions":[228],"COX-2":[230,238],"transcript":[231],"protein":[233],"formation,":[234],"inhibition":[236],"enzymatic":[239],"activity.":[240],"Suppression":[241],"hemozoin-induced":[248],"resulted":[250],"over-production":[252],"The":[255],"ratio":[256],"PGE2/TNF-\u03b1":[259],"disease.":[266],"Cultured":[267],"elevated":[275],"synthase":[278],"(NOS)2":[279],"enzyme":[280],"activity,":[281],"occurred":[283],"at":[284],"least":[285],"ingestion":[290,294],"Thus,":[293],"similar":[301],"observed":[309],"MA.":[314],"Results":[315],"presented":[316],"here":[317],"are":[318],"significant":[320],"public":[321],"relevance":[323],"understanding":[326],"molecule":[333],"will":[338],"vastly":[339],"improve":[340],"testing.":[344]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
