{"id":"https://openalex.org/W2108847784","doi":null,"title":"Regulation of anti-oxidant and anti-apoptotic genes by progesterone in cardiomyocytes","display_name":"Regulation of anti-oxidant and anti-apoptotic genes by progesterone in cardiomyocytes","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2108847784","mag":"2108847784"},"language":"en","primary_location":{"id":"pmh:oai:repository.arizona.edu:10150/194129","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/194129","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111663501","display_name":"Stephen J. Morrissy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephen J. Morrissy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5111663501"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9169999957084656},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8479999899864197},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7590000033378601},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9390000104904175},{"id":"https://openalex.org/keywords/mifepristone","display_name":"mifepristone","score":0.7409999966621399},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.8999999761581421},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9340000152587891},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cycloheximide","display_name":"cycloheximide","score":0.625},{"id":"https://openalex.org/keywords/actinomycin","display_name":"actinomycin","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.7191895246505737},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.671292781829834},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.5775625705718994},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5504223704338074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5303581357002258},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.51277095079422},{"id":"https://openalex.org/C2777990912","wikidata":"https://www.wikidata.org/wiki/Q420886","display_name":"Dicoumarol","level":4,"score":0.5027906894683838},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.42541080713272095},{"id":"https://openalex.org/C75520062","wikidata":"https://www.wikidata.org/wiki/Q15321392","display_name":"NAD+ kinase","level":3,"score":0.40440869331359863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32539284229278564},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2780452370643616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2730368375778198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18700578808784485},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16408458352088928},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.07236975431442261},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repository.arizona.edu:10150/194129","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10150/194129","pdf_url":null,"source":{"id":"https://openalex.org/S4306400271","display_name":"UA Campus Repository (The University of Arizona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I138006243","host_organization_name":"University of Arizona","host_organization_lineage":["https://openalex.org/I138006243"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Electronic Dissertation"},{"id":"mag:2108847784","doi":null,"is_oa":false,"landing_page_url":"http://arizona.openrepository.com/arizona/handle/10150/194129","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":340,"referenced_works":["https://openalex.org/W42143944","https://openalex.org/W65495747","https://openalex.org/W65521289","https://openalex.org/W79076124","https://openalex.org/W123585256","https://openalex.org/W162092248","https://openalex.org/W178726855","https://openalex.org/W200411836","https://openalex.org/W203770522","https://openalex.org/W227157476","https://openalex.org/W422161596","https://openalex.org/W1417333514","https://openalex.org/W1483108854","https://openalex.org/W1486980795","https://openalex.org/W1492302205","https://openalex.org/W1503552721","https://openalex.org/W1506642042","https://openalex.org/W1508395055","https://openalex.org/W1515506492","https://openalex.org/W1519370193","https://openalex.org/W1520650580","https://openalex.org/W1523600676","https://openalex.org/W1530888481","https://openalex.org/W1550287245","https://openalex.org/W1556814137","https://openalex.org/W1564511338","https://openalex.org/W1572006943","https://openalex.org/W1585518597","https://openalex.org/W1589415602","https://openalex.org/W1596495551","https://openalex.org/W1598719623","https://openalex.org/W1632979324","https://openalex.org/W1745634660","https://openalex.org/W1758646032","https://openalex.org/W1791262955","https://openalex.org/W1828224642","https://openalex.org/W1845459216","https://openalex.org/W1847379925","https://openalex.org/W1851414862","https://openalex.org/W1858389298","https://openalex.org/W1920198420","https://openalex.org/W1938696607","https://openalex.org/W1944984946","https://openalex.org/W1963928942","https://openalex.org/W1964542869","https://openalex.org/W1965566566","https://openalex.org/W1966012757","https://openalex.org/W1967469446","https://openalex.org/W1967894548","https://openalex.org/W1967912613","https://openalex.org/W1967963412","https://openalex.org/W1967970013","https://openalex.org/W1969262864","https://openalex.org/W1970395849","https://openalex.org/W1970741201","https://openalex.org/W1972216016","https://openalex.org/W1972253696","https://openalex.org/W1974539684","https://openalex.org/W1974779596","https://openalex.org/W1975618936","https://openalex.org/W1976129366","https://openalex.org/W1976680355","https://openalex.org/W1976883744","https://openalex.org/W1978018487","https://openalex.org/W1978933336","https://openalex.org/W1979241878","https://openalex.org/W1979662749","https://openalex.org/W1980010223","https://openalex.org/W1980322984","https://openalex.org/W1980405844","https://openalex.org/W1981155570","https://openalex.org/W1982411138","https://openalex.org/W1982947678","https://openalex.org/W1983261302","https://openalex.org/W1983373981","https://openalex.org/W1984259765","https://openalex.org/W1984745009","https://openalex.org/W1985177933","https://openalex.org/W1985642146","https://openalex.org/W1987144846","https://openalex.org/W1987239083","https://openalex.org/W1987417875","https://openalex.org/W1987457816","https://openalex.org/W1987593270","https://openalex.org/W1987674382","https://openalex.org/W1987927092","https://openalex.org/W1988241811","https://openalex.org/W1988323635","https://openalex.org/W1989061125","https://openalex.org/W1989327230","https://openalex.org/W1990466528","https://openalex.org/W1992390260","https://openalex.org/W1992527837","https://openalex.org/W1995308264","https://openalex.org/W1995388611","https://openalex.org/W1995505431","https://openalex.org/W1996455911","https://openalex.org/W1996957952","https://openalex.org/W1996999531","https://openalex.org/W1997380395","https://openalex.org/W1997465421","https://openalex.org/W1998958700","https://openalex.org/W1999197294","https://openalex.org/W1999370710","https://openalex.org/W1999514033","https://openalex.org/W2000305075","https://openalex.org/W2001880177","https://openalex.org/W2002314190","https://openalex.org/W2003052492","https://openalex.org/W2003384266","https://openalex.org/W2003941028","https://openalex.org/W2004773057","https://openalex.org/W2005408885","https://openalex.org/W2005415709","https://openalex.org/W2005520585","https://openalex.org/W2007048730","https://openalex.org/W2008493497","https://openalex.org/W2009183786","https://openalex.org/W2009396488","https://openalex.org/W2010094123","https://openalex.org/W2010183849","https://openalex.org/W2010219403","https://openalex.org/W2010243701","https://openalex.org/W2011624509","https://openalex.org/W2011692458","https://openalex.org/W2012697879","https://openalex.org/W2013784424","https://openalex.org/W2014107736","https://openalex.org/W2014871892","https://openalex.org/W2016006057","https://openalex.org/W2017348949","https://openalex.org/W2018459962","https://openalex.org/W2018495209","https://openalex.org/W2018874703","https://openalex.org/W2019830720","https://openalex.org/W2020457477","https://openalex.org/W2020940689","https://openalex.org/W2021580979","https://openalex.org/W2021953512","https://openalex.org/W2022247016","https://openalex.org/W2022286593","https://openalex.org/W2023395420","https://openalex.org/W2023458895","https://openalex.org/W2023677185","https://openalex.org/W2024195033","https://openalex.org/W2024581871","https://openalex.org/W2025128734","https://openalex.org/W2025267983","https://openalex.org/W2025995094","https://openalex.org/W2026211921","https://openalex.org/W2026577542","https://openalex.org/W2027665091","https://openalex.org/W2027735831","https://openalex.org/W2028551239","https://openalex.org/W2028761750","https://openalex.org/W2029475329","https://openalex.org/W2029497427","https://openalex.org/W2031512686","https://openalex.org/W2033847504","https://openalex.org/W2034445775","https://openalex.org/W2034548788","https://openalex.org/W2036376206","https://openalex.org/W2036557777","https://openalex.org/W2036718044","https://openalex.org/W2040013083","https://openalex.org/W2040923416","https://openalex.org/W2041505585","https://openalex.org/W2041781038","https://openalex.org/W2041888873","https://openalex.org/W2042975710","https://openalex.org/W2044117808","https://openalex.org/W2045008512","https://openalex.org/W2045629927","https://openalex.org/W2045848177","https://openalex.org/W2046544773","https://openalex.org/W2047538251","https://openalex.org/W2047966108","https://openalex.org/W2048180919","https://openalex.org/W2048655147","https://openalex.org/W2049727461","https://openalex.org/W2049755195","https://openalex.org/W2049850903","https://openalex.org/W2051916700","https://openalex.org/W2052124418","https://openalex.org/W2052613188","https://openalex.org/W2052631997","https://openalex.org/W2053536319","https://openalex.org/W2055545648","https://openalex.org/W2056235868","https://openalex.org/W2056650214","https://openalex.org/W2057919737","https://openalex.org/W2058452689","https://openalex.org/W2059028056","https://openalex.org/W2060067383","https://openalex.org/W2060077704","https://openalex.org/W2060641538","https://openalex.org/W2060697601","https://openalex.org/W2061497413","https://openalex.org/W2061614070","https://openalex.org/W2061629609","https://openalex.org/W2061675994","https://openalex.org/W2062014088","https://openalex.org/W2063069698","https://openalex.org/W2063176993","https://openalex.org/W2063685767","https://openalex.org/W2064177299","https://openalex.org/W2065750553","https://openalex.org/W2065907781","https://openalex.org/W2068158002","https://openalex.org/W2068697888","https://openalex.org/W2069584266","https://openalex.org/W2070218696","https://openalex.org/W2070759302","https://openalex.org/W2074575631","https://openalex.org/W2078741714","https://openalex.org/W2078971279","https://openalex.org/W2079028801","https://openalex.org/W2079307020","https://openalex.org/W2080742616","https://openalex.org/W2082531877","https://openalex.org/W2082559087","https://openalex.org/W2085106881","https://openalex.org/W2086319830","https://openalex.org/W2087840325","https://openalex.org/W2088749722","https://openalex.org/W2090881549","https://openalex.org/W2091271679","https://openalex.org/W2092198518","https://openalex.org/W2092512238","https://openalex.org/W2092575722","https://openalex.org/W2093044000","https://openalex.org/W2093258620","https://openalex.org/W2093857799","https://openalex.org/W2094423407","https://openalex.org/W2094897853","https://openalex.org/W2094985040","https://openalex.org/W2095241287","https://openalex.org/W2096791929","https://openalex.org/W2097066872","https://openalex.org/W2097744068","https://openalex.org/W2098963564","https://openalex.org/W2099530293","https://openalex.org/W2100110742","https://openalex.org/W2100730635","https://openalex.org/W2101082219","https://openalex.org/W2101851222","https://openalex.org/W2101987325","https://openalex.org/W2103143130","https://openalex.org/W2103310685","https://openalex.org/W2103453132","https://openalex.org/W2103981611","https://openalex.org/W2105025016","https://openalex.org/W2106697922","https://openalex.org/W2108582141","https://openalex.org/W2108592009","https://openalex.org/W2111426313","https://openalex.org/W2111951034","https://openalex.org/W2112220414","https://openalex.org/W2113007696","https://openalex.org/W2113509381","https://openalex.org/W2117444223","https://openalex.org/W2120353772","https://openalex.org/W2122368744","https://openalex.org/W2122931119","https://openalex.org/W2124485728","https://openalex.org/W2125088647","https://openalex.org/W2125367143","https://openalex.org/W2125876685","https://openalex.org/W2126636055","https://openalex.org/W2128500157","https://openalex.org/W2128840922","https://openalex.org/W2128963271","https://openalex.org/W2130288926","https://openalex.org/W2131616732","https://openalex.org/W2132177748","https://openalex.org/W2132298206","https://openalex.org/W2132330430","https://openalex.org/W2132411546","https://openalex.org/W2132570898","https://openalex.org/W2135564507","https://openalex.org/W2136346802","https://openalex.org/W2138804143","https://openalex.org/W2139763494","https://openalex.org/W2140564585","https://openalex.org/W2141605818","https://openalex.org/W2141663828","https://openalex.org/W2143609528","https://openalex.org/W2144701362","https://openalex.org/W2146433699","https://openalex.org/W2147207030","https://openalex.org/W2147760686","https://openalex.org/W2148931927","https://openalex.org/W2150562016","https://openalex.org/W2150691073","https://openalex.org/W2153785177","https://openalex.org/W2157042020","https://openalex.org/W2157652393","https://openalex.org/W2157944478","https://openalex.org/W2158398694","https://openalex.org/W2159876289","https://openalex.org/W2159982822","https://openalex.org/W2160969949","https://openalex.org/W2161750337","https://openalex.org/W2161936823","https://openalex.org/W2162092150","https://openalex.org/W2162689981","https://openalex.org/W2163149796","https://openalex.org/W2163879269","https://openalex.org/W2165189118","https://openalex.org/W2166188229","https://openalex.org/W2166928107","https://openalex.org/W2167223040","https://openalex.org/W2167318964","https://openalex.org/W2169311207","https://openalex.org/W2220991277","https://openalex.org/W2233044276","https://openalex.org/W2233638732","https://openalex.org/W2234867271","https://openalex.org/W2235129190","https://openalex.org/W2239883543","https://openalex.org/W2243607044","https://openalex.org/W2265195161","https://openalex.org/W2289550921","https://openalex.org/W2325144754","https://openalex.org/W2329711941","https://openalex.org/W2334903440","https://openalex.org/W2335300675","https://openalex.org/W2340424447","https://openalex.org/W2341478304","https://openalex.org/W2400265273","https://openalex.org/W2410120002","https://openalex.org/W2410142412","https://openalex.org/W2415745566","https://openalex.org/W2429220761","https://openalex.org/W2468656408","https://openalex.org/W2473122656","https://openalex.org/W2489124119","https://openalex.org/W3111067077","https://openalex.org/W3142499091","https://openalex.org/W4312861576"],"related_works":["https://openalex.org/W2017159199","https://openalex.org/W2103981611","https://openalex.org/W1541170305","https://openalex.org/W4367319122","https://openalex.org/W2047397577","https://openalex.org/W325444978","https://openalex.org/W3092801289","https://openalex.org/W4362733449","https://openalex.org/W1994519849","https://openalex.org/W1965759641"],"abstract_inverted_index":{"The":[0,45,68,103,173,344,450,469,517],"anthracycline":[1],"quinone,":[2],"doxorubicin":[3,56,65,89],"(Adriamycin)":[4],"is":[5,27,34,50,141,148,243,280,335,574],"an":[6,204,259,499,513],"antineoplastic":[7],"agent":[8,26],"that":[9,88,127,151,232,256,278,292,330,362,432],"has":[10],"substantial":[11],"therapeutic":[12],"activity":[13,180,345,416,441,497,511],"against":[14,170],"a":[15,74,111,118,149,154,160,167,186,210,281,300,331,347,418,532,541,552],"broad":[16],"variety":[17],"of":[18,24,47,106,134,157,175,200,206,217,227,235,248,261,267,275,297,311,314,340,346,367,376,386,417,423,427,442,446,452,498,512,519,531,544,563,572],"human":[19],"cancers.":[20],"Unfortunately,":[21],"the":[22,132,138,224,245,265,272,295,308,338,368,374,384,415,424,428,440,443,447,453,496,510,520,548,570],"use":[23],"this":[25,48,242],"limited":[28],"by":[29,100,110,197,202,219,251,316,320,326,342,353,357,382,457,467,525,529,576,579],"its":[30],"cardiac":[31,79],"toxicity,":[32],"which":[33],"associated":[35],"with":[36,191,307],"free":[37],"radical":[38],"formation":[39],"leading":[40],"to":[41,51,60,63,159,388,587],"apoptotic":[42],"cell":[43],"death.":[44],"goal":[46],"work":[49],"improve":[52],"our":[53],"understanding":[54],"about":[55],"induced":[57,66,90,240,250,258,286,294,352,378,404,414,439,495,509],"cardiomyopathy":[58],"and":[59,84,178,188,194,302,355,394,400,434,485],"identify":[61],"compounds":[62],"limit":[64],"cardiomyopathy.":[67],"knowledge":[69],"gained":[70],"here":[71],"will":[72],"have":[73,483],"generalized":[75],"impact":[76],"on":[77],"all":[78,560],"diseases":[80],"involving":[81],"oxidative":[82,171],"stress":[83],"apoptosis.":[85],"We":[86,371],"show":[87],"apoptosis":[91,405],"in":[92,181,185,209,212,284,299,406,546,590],"primary":[93,246],"neonatal":[94],"rat":[95],"cardiomyocytes":[96,130,182],"can":[97,152,237],"be":[98,588],"attenuated":[99],"progesterone":[101,112,119],"(PG).":[102],"anti-apoptotic":[104,273],"action":[105],"PG":[107,128,192,257,285,293,317,354,363,377,387,413,438,494,508],"was":[108,183,195,318,323,351,459,465,527],"blocked":[109,196,319,325,356,528],"receptor":[113,120,461,565],"antagonist,":[114],"Mifepristone":[115],"(MF),":[116],"indicating":[117,329,540],"dependent":[121,304],"pathyway.":[122],"Affymetrix":[123],"gene":[124,380],"analyses":[125,254,290],"found":[126],"treated":[129],"increased":[131],"expression":[133,266,296,381,530],"180":[135],"genes.":[136],"Among":[137],"genes":[139],"upregulated":[140],"NAD(P)H:":[142],"Quinone":[143],"Oxidoreductase-1":[144],"(NQO1)":[145],"gene.":[146],"NQO1":[147,176,179,201,218,236],"flavo-enzyme":[150],"catalyze":[153],"two-electron":[155],"reduction":[156],"Dox":[158,239,403],"more":[161],"stable":[162],"hydroquinone,":[163],"thereby":[164],"acting":[165],"as":[166,537],"defense":[168],"mechanism":[169,247,334,375],"stress.":[172],"induction":[174,234,339,451,518],"mRNA":[177],"observed":[184],"dose":[187,301],"time-dependent":[189],"manner":[190,305],"treatment":[193],"MF.":[198,358,468],"Induction":[199,313],"b-naphoflavone,":[203],"inducer":[205],"NQO1,":[207],"resulted":[208],"decrease":[211,238],"caspase-3":[213],"activity.":[214],"However,":[215],"inhibition":[216],"dicoumarol":[220],"did":[221],"not":[222,244,324,410,437,473,491,505],"attenuate":[223,402],"cytoprotective":[225],"effect":[226,274,310,385,543,571],"PG.":[228,252,312,343],"This":[229],"data":[230,360],"indicates":[231],"although":[233,559],"apoptosis,":[241],"cytoprotection":[249],"Microarray":[253],"revealed":[255],"increase":[260],"Bcl-XL":[262,268,279,298,315,341,379,429,448,470,522,549],"mRNA.":[263,370],"Inhibiting":[264],"using":[269],"siRNA":[270],"reduced":[271],"PG,":[276],"suggesting":[277],"key":[282],"player":[283],"cytoprotection.":[287],"Western":[288],"blot":[289],"indicated":[291,431],"time":[303],"consistent":[306],"protective":[309],"cyclohexamide,":[321],"but":[322,409,436,481,490,504],"Actinomycin":[327],"D":[328],"transcriptionally":[332],"independent":[333],"responsible":[336],"for":[337],"bcl-x":[348],"3'UTR":[349],"reporter":[350,420,455,501,515,523],"These":[359],"suggest":[361],"may":[364],"induce":[365,567],"stabilization":[366],"Bcl-X":[369],"further":[372],"explored":[373],"comparing":[383],"two":[389],"other":[390],"steroids:":[391],"corticosterone":[392],"(CT)":[393],"retinoic":[395],"acid":[396],"(RA).":[397],"Both":[398],"CT":[399,458,506,526,545,573],"RA":[401,411,433,492,591],"cardiomyocytes.":[407],"CT,":[408,435,489],"or":[412,477,493,507],"GRE":[419],"plasmid.":[421,502,516],"Analysis":[422],"5'":[425],"region":[426,445],"promoter":[430,471,550],"0.9kb":[444,454,521],"promoter.":[449],"plasmid":[456,524],"glucocorticoid":[460,476],"dependent,":[462],"since":[463],"it":[464],"inhibited":[466],"does":[472,482],"contain":[474],"any":[475],"retinoid":[478],"response":[479,487],"elements,":[480],"AP-1":[484,500,556,580],"NFkB":[486,514],"elements.":[488],"RA,":[503],"dominant":[533],"negative":[534],"c-jun,":[535],"TAM67":[536],"well":[538],"SB202190":[539],"nongenomic":[542],"activating":[547],"through":[551],"p38":[553],"MAPK":[554],"mediated":[555,575],"mechanism.":[557],"Therefore":[558],"three":[561],"types":[562],"nuclear":[564],"ligands":[566],"bcl-xL":[568,593],"expression,":[569],"transcriptional":[577],"activation":[578],"signaling":[581],"while":[582],"NF-kB":[583],"transcription":[584],"factor":[585],"appears":[586],"involved":[589],"indced":[592],"transcription.":[594]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}