{"id":"https://openalex.org/W2108826353","doi":"https://doi.org/10.1164/ajrccm.149.6.8004325","title":"Nontuberculous Mycobacteria. An Underappreciated Cause of Geriatric Lung Disease","display_name":"Nontuberculous Mycobacteria. An Underappreciated Cause of Geriatric Lung Disease","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W2108826353","doi":"https://doi.org/10.1164/ajrccm.149.6.8004325","mag":"2108826353","pmid":"https://pubmed.ncbi.nlm.nih.gov/8004325"},"language":"en","primary_location":{"id":"doi:10.1164/ajrccm.149.6.8004325","doi":"https://doi.org/10.1164/ajrccm.149.6.8004325","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.149.6.8004325","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090825625","display_name":"Thomas P. Kennedy","orcid":"https://orcid.org/0000-0002-8862-2765","observed_orcids":["https://orcid.org/0000-0002-8862-2765"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T P Kennedy","raw_affiliation_strings":["Division of Respiratory and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033818354","display_name":"David J. Weber","orcid":"https://orcid.org/0000-0002-8824-1110","observed_orcids":["https://orcid.org/0000-0002-8824-1110"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J Weber","raw_affiliation_strings":["Division of Respiratory and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6001,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.92559443,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"149","issue":"6","first_page":"1654","last_page":"1658"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12317","display_name":"Actinomycetales infections and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nontuberculous-mycobacteria","display_name":"nontuberculous mycobacteria","score":1.0},{"id":"https://openalex.org/keywords/mycobacterium-avium-complex","display_name":"Mycobacterium avium complex","score":0.8149999976158142},{"id":"https://openalex.org/keywords/mycobacterium-abscessus","display_name":"Mycobacterium abscessus","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mycobacterium-kansasii","display_name":"Mycobacterium kansasii","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chronic-lung-infection","display_name":"chronic lung infection","score":0.6299999952316284},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.7549999952316284},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.675000011920929},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hiv-associated-infections","display_name":"HIV-associated infections","score":0.36800000071525574},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9046812057495117},{"id":"https://openalex.org/C2778679867","wikidata":"https://www.wikidata.org/wiki/Q1881705","display_name":"Nontuberculous mycobacteria","level":4,"score":0.8708194494247437},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.7768396139144897},{"id":"https://openalex.org/C2780931024","wikidata":"https://www.wikidata.org/wiki/Q4044720","display_name":"Mycobacterium kansasii","level":4,"score":0.6602852940559387},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5655771493911743},{"id":"https://openalex.org/C2775961462","wikidata":"https://www.wikidata.org/wiki/Q6946984","display_name":"Mycobacterium avium-intracellulare infection","level":4,"score":0.5648238658905029},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.4669768810272217},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.45430004596710205},{"id":"https://openalex.org/C2781455004","wikidata":"https://www.wikidata.org/wiki/Q3311330","display_name":"Mycobacterium avium complex","level":2,"score":0.4492000937461853},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44763123989105225},{"id":"https://openalex.org/C2779196057","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic infection","level":4,"score":0.44699373841285706},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44332316517829895},{"id":"https://openalex.org/C2909201284","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"AIDS-Related Opportunistic Infections","level":5,"score":0.4425725042819977},{"id":"https://openalex.org/C2983914783","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Lung disease","level":3,"score":0.4346832036972046},{"id":"https://openalex.org/C2779379686","wikidata":"https://www.wikidata.org/wiki/Q32778","display_name":"Bronchiectasis","level":3,"score":0.42529261112213135},{"id":"https://openalex.org/C2777607303","wikidata":"https://www.wikidata.org/wiki/Q641307","display_name":"Immunodeficiency","level":3,"score":0.42350831627845764},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.40087899565696716},{"id":"https://openalex.org/C2776452011","wikidata":"https://www.wikidata.org/wiki/Q311463","display_name":"Sida","level":4,"score":0.39761608839035034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3590649366378784},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.29122787714004517},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2785876989364624},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.08757227659225464}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000995","descriptor_name":"Antitubercular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D001999","descriptor_name":"Bronchoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009165","descriptor_name":"Mycobacterium Infections, Nontuberculous","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009165","descriptor_name":"Mycobacterium Infections, Nontuberculous","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D009165","descriptor_name":"Mycobacterium Infections, Nontuberculous","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009165","descriptor_name":"Mycobacterium Infections, Nontuberculous","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010044","descriptor_name":"Outpatient Clinics, Hospital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011013","descriptor_name":"Pneumonectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014397","descriptor_name":"Tuberculosis, Pulmonary","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017714","descriptor_name":"Community-Acquired Infections","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1164/ajrccm.149.6.8004325","doi":"https://doi.org/10.1164/ajrccm.149.6.8004325","is_oa":false,"landing_page_url":"https://doi.org/10.1164/ajrccm.149.6.8004325","pdf_url":null,"source":{"id":"https://openalex.org/S93356601","display_name":"American Journal of Respiratory and Critical Care Medicine","issn_l":"1073-449X","issn":["1073-449X","1535-4970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316311","host_organization_name":"American Thoracic Society","host_organization_lineage":["https://openalex.org/P4310316311"],"host_organization_lineage_names":["American Thoracic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"journal-article"},{"id":"pmid:8004325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8004325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of respiratory and critical care medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W191320516","https://openalex.org/W1992786632","https://openalex.org/W2019023077","https://openalex.org/W2075830613","https://openalex.org/W2081729245","https://openalex.org/W2087010421","https://openalex.org/W2157395107","https://openalex.org/W2167216218"],"related_works":["https://openalex.org/W3095384213","https://openalex.org/W4404096313","https://openalex.org/W4417304000","https://openalex.org/W3031381913","https://openalex.org/W4386779474","https://openalex.org/W3097890348","https://openalex.org/W2136105589","https://openalex.org/W4413011605","https://openalex.org/W4394892992","https://openalex.org/W2186400061"],"abstract_inverted_index":{"Nontuberculous":[0],"mycobacteria":[1,164],"(NTM)":[2],"infection":[3,8,19,34,109,202,213],"is":[4],"a":[5,51,56,182,206],"frequent":[6],"opportunistic":[7],"in":[9,23,35,152,168,191,218],"patients":[10,48,60,217],"infected":[11,89],"with":[12,62,84,90,105,143,197,203],"the":[13,30,36,41,68,111,115,153,192,219],"human":[14],"immunodeficiency":[15,117],"virus.":[16],"However,":[17],"NTM":[18,204],"may":[20],"also":[21],"occur":[22],"nonimmunocompromised":[24],"hosts.":[25],"In":[26],"order":[27],"to":[28,50],"determine":[29],"spectrum":[31],"of":[32,46,162,175,179,188,210],"mycobacterial":[33,64,189],"nonacademic":[37],"setting,":[38],"we":[39],"analyzed":[40],"demographic":[42],"and":[43,97,127,146],"clinical":[44],"characteristics":[45],"all":[47],"presenting":[49],"suburban":[52,184],"multispecialty":[53],"clinic":[54],"during":[55,67],"24-mo":[57],"period.":[58,70],"Twenty-one":[59],"presented":[61,142],"active":[63],"lung":[65,82,212],"infections":[66,83,190],"study":[69],"Of":[71],"these,":[72],"only":[73],"one":[74],"had":[75,81,94,99],"Mycobacterium":[76],"tuberculosis.":[77],"The":[78,119,160],"remaining":[79,120],"20":[80],"NTM.":[85,198],"One":[86,103],"patient":[87,104],"was":[88,171],"M.":[91,95,100,107,166],"kansasii,":[92],"three":[93],"abscessus,":[96],"16":[98],"avium":[101,108],"complex.":[102],"disseminated":[106],"met":[110],"diagnostic":[112],"criteria":[113],"for":[114],"acquired":[116],"syndrome.":[118],"19":[121],"were":[122,128,196],"largely":[123],"normal":[124],"at":[125],"presentation":[126],"predominantly":[129],"elderly":[130,215],"(mean":[131],"age,":[132],"71":[133],"+/-":[134],"11":[135],"yr),":[136],"female":[137],"(79%),":[138],"nonsmokers":[139],"(89%)":[140],"who":[141],"cough":[144],"(94%)":[145],"localized":[147],"radiographic":[148],"infiltrates":[149],"(84%),":[150],"often":[151],"right":[154],"middle":[155],"lobe":[156],"and/or":[157],"lingula":[158],"(73%).":[159],"predominance":[161],"nontuberculous":[163],"over":[165],"tuberculosis":[167],"our":[169],"practice":[170],"mirrored":[172],"by":[173],"results":[174],"an":[176],"11-yr":[177],"review":[178],"experience":[180],"from":[181],"nearby":[183],"hospital,":[185],"where":[186],"65%":[187],"previous":[193],"5":[194],"yr":[195],"We":[199],"conclude":[200],"that":[201],"represents":[205],"previously":[207],"underappreciated":[208],"cause":[209],"chronic":[211],"among":[214],"middle-class":[216],"community":[220],"setting.":[221]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}