{"id":"https://openalex.org/W2108818873","doi":"https://doi.org/10.1128/mcb.17.4.1881","title":"DNA-Binding Specificity of Mcm1: Operator Mutations That Alter DNA-Bending and Transcriptional Activities by a MADS Box Protein","display_name":"DNA-Binding Specificity of Mcm1: Operator Mutations That Alter DNA-Bending and Transcriptional Activities by a MADS Box Protein","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W2108818873","doi":"https://doi.org/10.1128/mcb.17.4.1881","mag":"2108818873","pmid":"https://pubmed.ncbi.nlm.nih.gov/9121436","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/232035"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.17.4.1881","doi":"https://doi.org/10.1128/mcb.17.4.1881","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mcb.17.4.1881","pdf_url":"https://www.tandfonline.com/doi/abs/10.1128/MCB.17.4.1881","source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/abs/10.1128/MCB.17.4.1881","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028579654","display_name":"Thomas Acton","orcid":"https://orcid.org/0000-0003-0898-4203","observed_orcids":["https://orcid.org/0000-0003-0898-4203"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas B. Acton","raw_affiliation_strings":["Waksman Institute of Microbiology Rutgers University","Waksman Institute of Microbiology Rutgers University, Piscataway, New Jersey 08855-0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute of Microbiology Rutgers University","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute of Microbiology Rutgers University, Piscataway, New Jersey 08855-0759","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015374101","display_name":"Hualin Zhong","orcid":"https://orcid.org/0009-0003-4004-2395","observed_orcids":["https://orcid.org/0009-0003-4004-2395"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hualin Zhong","raw_affiliation_strings":["Waksman Institute of Microbiology Rutgers University","Waksman Institute of Microbiology Rutgers University, Piscataway, New Jersey 08855-0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Waksman Institute of Microbiology Rutgers University","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute of Microbiology Rutgers University, Piscataway, New Jersey 08855-0759","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013003121","display_name":"Andrew K. Vershon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew K. Vershon","raw_affiliation_strings":["Department of Molecular Biology and Biochemistry Rutgers University","Waksman Institute of Microbiology Rutgers University","Department of Molecular Biology and Biochemistry Rutgers University, Piscataway, New Jersey 08855-0759","Waksman Institute of Microbiology Rutgers University, Piscataway, New Jersey 08855-0759"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry Rutgers University","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute of Microbiology Rutgers University","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry Rutgers University, Piscataway, New Jersey 08855-0759","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Waksman Institute of Microbiology Rutgers University, Piscataway, New Jersey 08855-0759","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013003121"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":null,"apc_paid":null,"fwci":2.2519,"has_fulltext":true,"cited_by_count":62,"citation_normalized_percentile":{"value":0.88803556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"17","issue":"4","first_page":"1881","last_page":"1889"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.8755000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.04230000078678131,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13187","display_name":"Diffusion and Search Dynamics","score":0.03849999979138374,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcm1","display_name":"MCM1","score":0.996999979019165},{"id":"https://openalex.org/keywords/mads-box-transcription-factors","display_name":"MADS-box transcription factors","score":0.9070000052452087},{"id":"https://openalex.org/keywords/dna-binding-specificity","display_name":"DNA binding specificity","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dna-bending","display_name":"DNA bending","score":0.9890000224113464},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.953000009059906},{"id":"https://openalex.org/keywords/dna-binding-affinity","display_name":"DNA binding affinity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/serum-response-factor","display_name":"serum response factor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/photo-crosslinking","display_name":"photocrosslinking","score":0.6980000138282776},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8709999918937683},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8907699584960938},{"id":"https://openalex.org/C160956161","wikidata":"https://www.wikidata.org/wiki/Q83164704","display_name":"MADS-box","level":5,"score":0.8127225637435913},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6379570960998535},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5888410806655884},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.5225997567176819},{"id":"https://openalex.org/C5179208","wikidata":"https://www.wikidata.org/wiki/Q3782057","display_name":"HMG-box","level":5,"score":0.4754447937011719},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.45104312896728516},{"id":"https://openalex.org/C17020691","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operator (biology)","level":5,"score":0.44402509927749634},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4410724639892578},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43038254976272583},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.42748868465423584},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.36941683292388916},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36085015535354614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29991859197616577},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.18896010518074036},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16734075546264648},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.085807204246521},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009875","descriptor_name":"Operator Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026341","descriptor_name":"Minichromosome Maintenance 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/mcb.17.4.1881","doi":"https://doi.org/10.1128/mcb.17.4.1881","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mcb.17.4.1881","pdf_url":"https://www.tandfonline.com/doi/abs/10.1128/MCB.17.4.1881","source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:232035","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/232035","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:9121436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9121436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/mcb.17.4.1881","doi":"https://doi.org/10.1128/mcb.17.4.1881","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mcb.17.4.1881","pdf_url":"https://www.tandfonline.com/doi/abs/10.1128/MCB.17.4.1881","source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2360253100","display_name":null,"funder_award_id":"GM-49265","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3717155376","display_name":"Combinatorial Control of Transcription in Yeast","funder_award_id":"R01GM049265","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108818873.pdf","grobid_xml":"https://content.openalex.org/works/W2108818873.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W98631111","https://openalex.org/W99595223","https://openalex.org/W102941930","https://openalex.org/W120691053","https://openalex.org/W187501465","https://openalex.org/W315803869","https://openalex.org/W1495819388","https://openalex.org/W1573365260","https://openalex.org/W1603788311","https://openalex.org/W1816187765","https://openalex.org/W1969589388","https://openalex.org/W1973763076","https://openalex.org/W1975839628","https://openalex.org/W1978230172","https://openalex.org/W1979551779","https://openalex.org/W1982910659","https://openalex.org/W1983780653","https://openalex.org/W1987851611","https://openalex.org/W1992010506","https://openalex.org/W2005150284","https://openalex.org/W2012018496","https://openalex.org/W2012463306","https://openalex.org/W2012959255","https://openalex.org/W2013061140","https://openalex.org/W2020257254","https://openalex.org/W2020672093","https://openalex.org/W2030830758","https://openalex.org/W2033825826","https://openalex.org/W2034442843","https://openalex.org/W2034648179","https://openalex.org/W2037161789","https://openalex.org/W2038813658","https://openalex.org/W2038874225","https://openalex.org/W2040328923","https://openalex.org/W2043839008","https://openalex.org/W2046278558","https://openalex.org/W2046689965","https://openalex.org/W2047810769","https://openalex.org/W2048500913","https://openalex.org/W2049434768","https://openalex.org/W2075018296","https://openalex.org/W2080184511","https://openalex.org/W2086995781","https://openalex.org/W2098352536","https://openalex.org/W2109170723","https://openalex.org/W2109824650","https://openalex.org/W2116289234","https://openalex.org/W2129523337","https://openalex.org/W2133335149","https://openalex.org/W2133623948","https://openalex.org/W2145354091","https://openalex.org/W2166131670","https://openalex.org/W2220745507","https://openalex.org/W2253910735","https://openalex.org/W2279351340","https://openalex.org/W4237493484","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2142202514","https://openalex.org/W1992678801","https://openalex.org/W2152698146","https://openalex.org/W2093766978","https://openalex.org/W2109170723","https://openalex.org/W2099901107","https://openalex.org/W2046689965","https://openalex.org/W2047810769","https://openalex.org/W2079070002","https://openalex.org/W2147863635"],"abstract_inverted_index":{"The":[0],"yeast":[1],"Mcm1":[2,38,56,74,122,190,203],"protein":[3,103,144],"is":[4,115,123,154,191,244],"a":[5,16,76,98,158,211,224],"member":[6],"of":[7,12,18,37,50,137,161,232,241],"the":[8,34,80,88,92,106,131,135,138,142,162,186,196,229,233,239],"MADS":[9,101],"box":[10,102],"family":[11],"transcriptional":[13,65,218,247],"regulatory":[14],"factors,":[15],"class":[17],"DNA-binding":[19,68,230],"proteins":[20],"found":[21],"in":[22,39,42,104,124,130],"such":[23],"diverse":[24],"organisms":[25],"as":[26],"yeast,":[27],"plants,":[28],"flies,":[29],"and":[30,41,59,67,194,204,217],"humans.":[31],"To":[32],"explore":[33],"protein-DNA":[35],"interactions":[36],"vivo":[40],"vitro,":[43],"we":[44],"have":[45,174,210,223],"introduced":[46],"an":[47,55],"extensive":[48],"series":[49],"base":[51],"pair":[52],"substitutions":[53,173,209],"into":[54],"operator":[57],"site":[58,140,165],"examined":[60],"their":[61],"effects":[62],"on":[63,177,214,228],"Mcm1-mediated":[64],"regulation":[66],"affinity.":[69],"Our":[70],"results":[71],"show":[72],"that":[73,82,116,121,155,185,195,238],"uses":[75],"mechanism":[77],"to":[78,127],"contact":[79],"DNA":[81,169,178,187,215,242],"has":[83,109],"some":[84],"significant":[85,152],"differences":[86],"from":[87],"one":[89],"used":[90],"by":[91,180,189,220,249],"human":[93],"serum":[94],"response":[95],"factor":[96],"(SRF),":[97],"closely":[99],"related":[100],"which":[105],"three-dimensional":[107],"structure":[108],"been":[110],"determined.":[111],"One":[112],"major":[113,132],"difference":[114,153],"5-bromouracil-mediated":[117],"photo-cross-linking":[118],"experiments":[119],"indicate":[120],"close":[125],"proximity":[126],"functional":[128],"groups":[129],"groove":[133],"at":[134,157],"center":[136],"recognition":[139],"whereas":[141],"SRF":[143],"did":[145],"not":[146],"exhibit":[147],"this":[148],"characteristic.":[149],"A":[150],"more":[151],"mutations":[156],"position":[159],"outside":[160],"conserved":[163],"CC(A/T)6GG":[164],"significantly":[166],"reduce":[167],"Mcm1-dependent":[168],"bending,":[170],"while":[171],"these":[172,208],"no":[175],"effect":[176,213,227],"bending":[179,188,200,216,243],"SRF.":[181,205],"This":[182,235],"result":[183,236],"shows":[184],"sequence":[192],"dependent":[193],"base-specific":[197],"requirements":[198],"for":[199,246],"differ":[201],"between":[202],"Interestingly,":[206],"although":[207],"large":[212],"activation":[219,248],"Mcm1,":[221],"they":[222],"relatively":[225],"small":[226],"affinity":[231],"protein.":[234],"suggests":[237],"degree":[240],"important":[245],"Mcm1.":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
