{"id":"https://openalex.org/W2108744437","doi":null,"title":"The role of peroxiredoxins as mechanosensitive antioxidants in endothelial cells","display_name":"The role of peroxiredoxins as mechanosensitive antioxidants in endothelial cells","publication_year":2008,"publication_date":"2008-05-19","ids":{"openalex":"https://openalex.org/W2108744437","mag":"2108744437"},"language":"en","primary_location":{"id":"pmh:oai:smartech.gatech.edu:1853/24779","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/24779","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060830566","display_name":"Amy L. Mowbray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Amy L. Mowbray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060830566"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"16","first_page":"182","last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peroxiredoxin","display_name":"peroxiredoxin","score":0.9909999966621399},{"id":"https://openalex.org/keywords/prrx1","display_name":"PRRX1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/laminar-shear-stress","display_name":"laminar shear stress","score":0.8320000171661377},{"id":"https://openalex.org/keywords/oscillatory-shear-stress","display_name":"oscillatory shear stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8090000152587891},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.7680000066757202},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.7710000276565552},{"id":"https://openalex.org/keywords/mechanosensing","display_name":"mechanosensing","score":0.5960000157356262},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.6349999904632568},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.892410159111023},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7502819299697876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49726393818855286},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.1519179344177246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1364867389202118},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12895110249519348},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:smartech.gatech.edu:1853/24779","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/24779","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:2108744437","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/theses/ETH/2867","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":144,"referenced_works":["https://openalex.org/W153428855","https://openalex.org/W274441265","https://openalex.org/W1494356335","https://openalex.org/W1936770188","https://openalex.org/W1964752630","https://openalex.org/W1966728645","https://openalex.org/W1966833353","https://openalex.org/W1967487924","https://openalex.org/W1968472971","https://openalex.org/W1968550282","https://openalex.org/W1970871266","https://openalex.org/W1973129732","https://openalex.org/W1974838532","https://openalex.org/W1974966731","https://openalex.org/W1975249997","https://openalex.org/W1975512386","https://openalex.org/W1975529354","https://openalex.org/W1975695039","https://openalex.org/W1976136891","https://openalex.org/W1982217935","https://openalex.org/W1985776151","https://openalex.org/W1986153062","https://openalex.org/W1989746297","https://openalex.org/W1989899139","https://openalex.org/W1991833325","https://openalex.org/W1992935548","https://openalex.org/W2000155150","https://openalex.org/W2001340083","https://openalex.org/W2002018178","https://openalex.org/W2004789344","https://openalex.org/W2007417655","https://openalex.org/W2008961036","https://openalex.org/W2010359252","https://openalex.org/W2017265125","https://openalex.org/W2017642315","https://openalex.org/W2022104672","https://openalex.org/W2022239851","https://openalex.org/W2022573332","https://openalex.org/W2023062971","https://openalex.org/W2023520478","https://openalex.org/W2025725129","https://openalex.org/W2026234852","https://openalex.org/W2026425756","https://openalex.org/W2028553942","https://openalex.org/W2030720809","https://openalex.org/W2032536106","https://openalex.org/W2032575260","https://openalex.org/W2032610571","https://openalex.org/W2036852690","https://openalex.org/W2037854429","https://openalex.org/W2040536713","https://openalex.org/W2043038263","https://openalex.org/W2043513358","https://openalex.org/W2048569323","https://openalex.org/W2050420714","https://openalex.org/W2050445860","https://openalex.org/W2051690606","https://openalex.org/W2052364512","https://openalex.org/W2054312358","https://openalex.org/W2054891396","https://openalex.org/W2056184839","https://openalex.org/W2058461613","https://openalex.org/W2059129711","https://openalex.org/W2059571803","https://openalex.org/W2059635174","https://openalex.org/W2059672779","https://openalex.org/W2059694609","https://openalex.org/W2059804383","https://openalex.org/W2061782567","https://openalex.org/W2063665585","https://openalex.org/W2065591461","https://openalex.org/W2065661936","https://openalex.org/W2067396516","https://openalex.org/W2068664248","https://openalex.org/W2069408960","https://openalex.org/W2072881410","https://openalex.org/W2074499846","https://openalex.org/W2075584603","https://openalex.org/W2076864486","https://openalex.org/W2076935230","https://openalex.org/W2079557671","https://openalex.org/W2084893631","https://openalex.org/W2087736884","https://openalex.org/W2088129599","https://openalex.org/W2088204476","https://openalex.org/W2088411222","https://openalex.org/W2097097751","https://openalex.org/W2097155911","https://openalex.org/W2097325779","https://openalex.org/W2097631901","https://openalex.org/W2100124039","https://openalex.org/W2101032933","https://openalex.org/W2101214961","https://openalex.org/W2101537600","https://openalex.org/W2104251051","https://openalex.org/W2107919301","https://openalex.org/W2109091720","https://openalex.org/W2109698138","https://openalex.org/W2110223248","https://openalex.org/W2111076607","https://openalex.org/W2111172134","https://openalex.org/W2115128893","https://openalex.org/W2116398482","https://openalex.org/W2118814154","https://openalex.org/W2125764762","https://openalex.org/W2128016314","https://openalex.org/W2128651724","https://openalex.org/W2129793754","https://openalex.org/W2130640877","https://openalex.org/W2134634647","https://openalex.org/W2135633069","https://openalex.org/W2137570167","https://openalex.org/W2137622163","https://openalex.org/W2141443485","https://openalex.org/W2144471412","https://openalex.org/W2147228426","https://openalex.org/W2147367812","https://openalex.org/W2148637873","https://openalex.org/W2151625863","https://openalex.org/W2153157231","https://openalex.org/W2153479733","https://openalex.org/W2155056314","https://openalex.org/W2155144802","https://openalex.org/W2155753475","https://openalex.org/W2157122108","https://openalex.org/W2158496331","https://openalex.org/W2159087408","https://openalex.org/W2159869559","https://openalex.org/W2160099189","https://openalex.org/W2165346935","https://openalex.org/W2166302161","https://openalex.org/W2166581295","https://openalex.org/W2166672988","https://openalex.org/W2168163927","https://openalex.org/W2168783124","https://openalex.org/W2169878907","https://openalex.org/W2170551438","https://openalex.org/W2172249877","https://openalex.org/W2185085212","https://openalex.org/W2316918019","https://openalex.org/W2324841714","https://openalex.org/W2397022935","https://openalex.org/W3215573568","https://openalex.org/W4253434130"],"related_works":["https://openalex.org/W2023520478","https://openalex.org/W67592441","https://openalex.org/W2253846539","https://openalex.org/W4242570104","https://openalex.org/W1575276508","https://openalex.org/W2022573332","https://openalex.org/W2118814154","https://openalex.org/W2145413661","https://openalex.org/W2069439360","https://openalex.org/W2170551438"],"abstract_inverted_index":{"Endothelial":[0],"cells":[1,88],"(EC)":[2],"exposed":[3],"to":[4,44,49,57,104,111,123,145,178,211,216,253,265,302],"oscillatory":[5],"shear":[6,20,50,98,146,156],"stress":[7,11,21,99],"(OS)":[8],"experience":[9],"oxidative":[10],"as":[12,329],"a":[13,249,276,330,343],"signature":[14],"of":[15,62,70,153,165,185,267,284,327],"atherosclerosis.":[16],"Conversely,":[17],"unidirectional":[18],"laminar":[19],"(LS)":[22],"reduces":[23],"reactive":[24],"oxygen":[25],"species":[26],"(ROS)":[27],"levels":[28,116,181,194,219],"and":[29,106,198,341],"inflammatory":[30],"responses.":[31],"Peroxiredoxins":[32],"(PRX)":[33],"are":[34,95],"antioxidant":[35,332],"enzymes":[36],"that":[37,54,93,208,243,308],"reduce":[38],"hydrogen":[39,169],"peroxide,":[40],"but":[41,125,137],"have":[42],"yet":[43],"be":[45],"investigated":[46],"in":[47,65,72,84,100,135,143,155,167,182,190,221,248,260,317],"response":[48,144],"stress.":[51,147],"We":[52,241],"hypothesized":[53],"LS,":[55,196],"compared":[56,103,252],"OS,":[58,197],"promotes":[59],"increased":[60],"expression":[61,215,239,261],"PRX,":[63],"which":[64,228],"turn":[66],"influences":[67],"the":[68,150,163,225,285,314,320],"balance":[69],"ROS":[71,180,193,218],"EC.":[73,101,222],"In":[74,128,270],"this":[75,258,325],"study,":[76],"we":[77,91,160,235],"identified":[78],"all":[79],"six":[80],"PRX":[81,94,130],"family":[82],"members":[83],"bovine":[85],"aortic":[86],"endothelial":[87,338],"(BAEC).":[89],"Furthermore,":[90],"revealed":[92,275],"regulated":[96],"by":[97,227,312],"When":[102],"OS":[105,254],"static":[107],"culture":[108],"(ST),":[109],"exposure":[110,210,301],"chronic":[112,209],"LS":[113,118,212,230,244,309],"upregulated":[114,120],"PRX1":[115,154,166,186,214,232,291,311,328],"intracellularly.":[117],"also":[119,236],"PRX5":[121,201],"relative":[122],"ST,":[124,199],"not":[126,141,263],"OS.":[127],"addition,":[129,271],"exhibited":[131],"broad":[132],"subcellular":[133],"localization":[134],"BAEC,":[136],"these":[138],"patterns":[139],"did":[140,203],"change":[142],"To":[148,223],"establish":[149],"functional":[151],"importance":[152],"stress-dependent":[157],"redox":[158],"balance,":[159],"next":[161],"examined":[162],"role":[164],"LS-mediated":[168],"peroxide":[170],"regulation.":[171],"Here,":[172],"Amplex":[173],"Red":[174],"assay":[175],"was":[176,262],"used":[177],"measure":[179],"BAEC.":[183],"Depletion":[184],"using":[187],"siRNA":[188],"resulted":[189],"significantly":[191],"higher":[192],"following":[195,300],"while":[200,294],"depletion":[202,296],"not.":[204],"These":[205],"findings":[206],"indicated":[207],"upregulates":[213,245],"keep":[217],"low":[220],"identify":[224],"pathway":[226],"atheroprotective":[229],"stimulates":[231],"protein":[233,292],"production,":[234,293],"undertook":[237],"gene":[238,247],"studies.":[240],"discovered":[242],"Prdx1":[246,268,272,298,315],"time-dependent":[250],"manner":[251],"or":[255],"ST.":[256],"However,":[257],"increase":[259],"due":[264],"stabilization":[266],"mRNA.":[269],"promoter":[273],"analysis":[274],"Nrf2":[277,287,295],"transcription":[278,321],"factor":[279,322],"binding":[280],"site":[281],"160bp":[282],"upstream":[283],"gene.":[286],"overexpression":[288],"promoted":[289],"basal":[290],"reduced":[297],"mRNA":[299],"LS.":[303],"Collectively,":[304],"our":[305],"work":[306],"illustrated":[307],"affects":[310],"inducing":[313],"gene,":[316],"part":[318],"via":[319],"Nrf2.":[323],"Moreover,":[324],"discovery":[326],"mechanosensitive":[331],"may":[333],"contribute":[334],"important":[335],"insights":[336],"into":[337],"cell":[339],"biology":[340],"provide":[342],"novel":[344],"therapeutic":[345],"target":[346],"for":[347],"vascular":[348],"diseases.":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}