{"id":"https://openalex.org/W2108720133","doi":"https://doi.org/10.1089/neu.2015.4058","title":"A Soluble Activin Receptor IIB Fails to Prevent Muscle Atrophy in a Mouse Model of Spinal Cord Injury","display_name":"A Soluble Activin Receptor IIB Fails to Prevent Muscle Atrophy in a Mouse Model of Spinal Cord Injury","publication_year":2015,"publication_date":"2015-11-03","ids":{"openalex":"https://openalex.org/W2108720133","doi":"https://doi.org/10.1089/neu.2015.4058","mag":"2108720133","pmid":"https://pubmed.ncbi.nlm.nih.gov/26529111"},"language":"en","primary_location":{"id":"doi:10.1089/neu.2015.4058","doi":"https://doi.org/10.1089/neu.2015.4058","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2015.4058","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075051906","display_name":"Zachary Graham","orcid":"https://orcid.org/0000-0002-6506-7025","observed_orcids":["https://orcid.org/0000-0002-6506-7025"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary A. Graham","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020727600","display_name":"Lauren Collier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Collier","raw_affiliation_strings":["National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102771219","display_name":"Yuanzhen Peng","orcid":"https://orcid.org/0000-0001-8827-3377","observed_orcids":["https://orcid.org/0000-0001-8827-3377"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanzhen Peng","raw_affiliation_strings":["National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009773603","display_name":"Juan Carlos S\u00e1ez","orcid":"https://orcid.org/0000-0003-3811-0347","observed_orcids":["https://orcid.org/0000-0003-3811-0347"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Juan C. Sa\u00e9z","raw_affiliation_strings":["Centro Interdisciplinario de Neurociencias de Valparaiso, Valparaiso, Chile","Department of Physiology, Pontificia Universidad Cat\u00f3lica, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro Interdisciplinario de Neurociencias de Valparaiso, Valparaiso, Chile","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, Pontificia Universidad Cat\u00f3lica, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022709890","display_name":"William A. Bauman","orcid":"https://orcid.org/0000-0002-6724-7150","observed_orcids":["https://orcid.org/0000-0002-6724-7150"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A. Bauman","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","Medical Service, James J. Peters VA Medical Center, Bronx, New York","National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Medical Service, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]},{"raw_affiliation_string":"National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074748701","display_name":"Weiping Qin","orcid":"https://orcid.org/0000-0002-5763-5846","observed_orcids":["https://orcid.org/0000-0002-5763-5846"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiping Qin","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080343219","display_name":"Christopher P. Cardozo","orcid":"https://orcid.org/0000-0003-4013-2537","observed_orcids":["https://orcid.org/0000-0003-4013-2537"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher P. Cardozo","raw_affiliation_strings":["Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","Medical Service, James J. Peters VA Medical Center, Bronx, New York","National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York","Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Department of Rehabilitation Medicine, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Medical Service, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]},{"raw_affiliation_string":"National Center of Excellence for the Medical Consequences of Spinal Cord Injury, James J. Peters VA Medical Center, Bronx, New York","institution_ids":["https://openalex.org/I4210116369"]},{"raw_affiliation_string":"Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080343219"],"corresponding_institution_ids":["https://openalex.org/I4210116369","https://openalex.org/I98704320"],"apc_list":null,"apc_paid":null,"fwci":1.3012,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.79283192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"33","issue":"12","first_page":"1128","last_page":"1135"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myostatin-inhibition","display_name":"myostatin inhibition","score":0.8080000281333923},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9480000138282776},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/lean-body-mass","display_name":"lean body mass","score":0.6589999794960022},{"id":"https://openalex.org/keywords/muscle-mass","display_name":"muscle mass","score":0.5019999742507935},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.7170000076293945},{"id":"https://openalex.org/keywords/muscle-inflammation","display_name":"muscle inflammation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7829999923706055},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.5870000123977661},{"id":"https://openalex.org/keywords/gastrocnemius-muscle","display_name":"gastrocnemius","score":0.6690000295639038},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7720000147819519},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.8199489712715149},{"id":"https://openalex.org/C2777488582","wikidata":"https://www.wikidata.org/wiki/Q29630","display_name":"Myostatin","level":3,"score":0.7732176780700684},{"id":"https://openalex.org/C2781425419","wikidata":"https://www.wikidata.org/wiki/Q201363","display_name":"Biceps","level":2,"score":0.6527549624443054},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6434233784675598},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6033627390861511},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5987629294395447},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5877617001533508},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.56963711977005},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.4945802390575409},{"id":"https://openalex.org/C2778649528","wikidata":"https://www.wikidata.org/wiki/Q4677603","display_name":"Activin receptor","level":3,"score":0.46931004524230957},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.44853031635284424},{"id":"https://openalex.org/C2775872116","wikidata":"https://www.wikidata.org/wiki/Q943203","display_name":"Gastrocnemius muscle","level":3,"score":0.4136383533477783},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.3979729413986206},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39063337445259094},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.356400728225708},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015519","descriptor_name":"Bone Density","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D030301","descriptor_name":"Activin Receptors, Type II","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D030301","descriptor_name":"Activin Receptors, Type II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055435","descriptor_name":"Myostatin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/neu.2015.4058","doi":"https://doi.org/10.1089/neu.2015.4058","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2015.4058","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},{"id":"pmid:26529111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26529111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurotrauma","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1636375233","https://openalex.org/W1932610186","https://openalex.org/W1955609192","https://openalex.org/W1968353004","https://openalex.org/W1976200139","https://openalex.org/W1976957743","https://openalex.org/W1979057337","https://openalex.org/W1983443021","https://openalex.org/W2001759531","https://openalex.org/W2004609839","https://openalex.org/W2010313933","https://openalex.org/W2012669537","https://openalex.org/W2013562548","https://openalex.org/W2020643735","https://openalex.org/W2023911754","https://openalex.org/W2027112527","https://openalex.org/W2027579570","https://openalex.org/W2029591368","https://openalex.org/W2034975399","https://openalex.org/W2036985965","https://openalex.org/W2039714528","https://openalex.org/W2047388153","https://openalex.org/W2049080962","https://openalex.org/W2052009804","https://openalex.org/W2056289230","https://openalex.org/W2062739455","https://openalex.org/W2065056367","https://openalex.org/W2067475521","https://openalex.org/W2070521842","https://openalex.org/W2078192607","https://openalex.org/W2082476418","https://openalex.org/W2087423776","https://openalex.org/W2088935745","https://openalex.org/W2096582848","https://openalex.org/W2107277218","https://openalex.org/W2113036381","https://openalex.org/W2115106640","https://openalex.org/W2116991990","https://openalex.org/W2134713720","https://openalex.org/W2143232127","https://openalex.org/W2146084470","https://openalex.org/W2147478863","https://openalex.org/W2149075623","https://openalex.org/W2160273104","https://openalex.org/W2162256138","https://openalex.org/W2171489161","https://openalex.org/W3023700677"],"related_works":["https://openalex.org/W2461531763","https://openalex.org/W3209892019","https://openalex.org/W2791032448","https://openalex.org/W3129319879","https://openalex.org/W4281486697","https://openalex.org/W3197468344","https://openalex.org/W3175169887","https://openalex.org/W3173157709","https://openalex.org/W3166240374","https://openalex.org/W1984832913"],"abstract_inverted_index":{"Myostatin":[0],"(MST)":[1],"is":[2,28],"a":[3,47],"potent":[4],"regulator":[5],"of":[6,19,24,44,196],"muscle":[7,20,37,56,113,134,222,229],"growth":[8],"and":[9,70,118,122,139,157,200,207,210],"size.":[10],"Spinal":[11],"cord":[12],"injury":[13],"(SCI)":[14],"results":[15],"in":[16,132,163,180,236],"marked":[17],"atrophy":[18,38],"below":[21],"the":[22,63,137,143,164,168,181,197,234],"level":[23,81],"injury.":[25],"Currently,":[26],"there":[27],"no":[29,130],"effective":[30],"pharmaceutical":[31],"treatment":[32],"available":[33],"to":[34,62,107,167,185],"prevent":[35,227],"sublesional":[36,54,228],"post-SCI.":[39,99],"To":[40],"determine":[41],"whether":[42],"inhibition":[43,219],"MST":[45,218],"with":[46],"soluble":[48],"activin":[49],"IIB":[50],"receptor":[51],"(RAP-031)":[52],"prevents":[53],"SCI-induced":[55],"atrophy,":[57],"mice":[58],"were":[59,84,129,203,211],"randomly":[60],"assigned":[61],"following":[64],"groups:":[65],"Sham-SCI;":[66],"SCI+Vehicle":[67],"group":[68],"(SCI-VEH);":[69],"SCI+RAP-031":[71],"(SCI-RAP-031).":[72],"SCI":[73],"was":[74,149,177],"induced":[75],"by":[76,116,214],"complete":[77],"transection":[78],"at":[79,86],"thoracic":[80],"10.":[82],"Animals":[83],"euthanized":[85],"56":[87],"days":[88],"post-surgery.":[89],"RAP-031":[90,100,110,138,182,187],"reduced,":[91],"but":[92,224],"did":[93,188,225],"not":[94,189,212,226],"prevent,":[95],"body":[96],"weight":[97],"loss":[98],"increased":[101,111,220],"total":[102],"lean":[103],"tissue":[104],"mass":[105,114],"compared":[106,166,184],"SCI-VEH":[108,140],"(14.8%).":[109],"forelimb":[112],"post-SCI":[115,205],"38%":[117],"19%":[119],"for":[120,151],"biceps":[121],"triceps,":[123],"respectively":[124],"(p":[125],"<":[126],"0.001).":[127],"There":[128],"differences":[131],"hindlimb":[133],"weights":[135],"between":[136],"groups.":[141],"In":[142,216],"gastrocnemius,":[144],"messenger":[145],"RNA":[146],"(mRNA)":[147],"expression":[148],"elevated":[150],"interleukin":[152],"(IL)-6":[153],"(8-fold),":[154],"IL-1\u03b2":[155],"(3-fold),":[156],"tumor":[158],"necrosis":[159],"factor":[160],"alpha":[161],"(8-fold)":[162],"SCI-VEH,":[165],"Sham":[169],"group.":[170],"Muscle":[171],"RING":[172],"finger":[173],"protein":[174],"1":[175],"mRNA":[176],"2-fold":[178],"greater":[179],"group,":[183],"Sham-SCI.":[186],"influence":[190],"cytokine":[191],"expression.":[192],"Bone":[193],"mineral":[194],"density":[195],"distal":[198],"femur":[199],"proximal":[201],"tibia":[202],"decreased":[204],"(-26%":[206],"-28%,":[208],"respectively)":[209],"altered":[213],"RAP-031.":[215],"conclusion,":[217],"supralesional":[221],"mass,":[223],"or":[230,233],"bone":[231],"loss,":[232],"inflammation":[235],"paralyzed":[237],"muscle.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}