{"id":"https://openalex.org/W2108683347","doi":"https://doi.org/10.1117/1.jbo.18.3.031107","title":"Two-photon excited fluorescence lifetime imaging and spectroscopy of melanins in vitro and in vivo","display_name":"Two-photon excited fluorescence lifetime imaging and spectroscopy of melanins in vitro and in vivo","publication_year":2012,"publication_date":"2012-12-12","ids":{"openalex":"https://openalex.org/W2108683347","doi":"https://doi.org/10.1117/1.jbo.18.3.031107","mag":"2108683347","pmid":"https://pubmed.ncbi.nlm.nih.gov/23235925","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3595716"},"language":"en","primary_location":{"id":"doi:10.1117/1.jbo.18.3.031107","doi":"https://doi.org/10.1117/1.jbo.18.3.031107","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.18.3.031107","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-18/issue-3/031107/Two-photon-excited-fluorescence-lifetime-imaging-and-spectroscopy-of-melanins/10.1117/1.JBO.18.3.031107.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-18/issue-3/031107/Two-photon-excited-fluorescence-lifetime-imaging-and-spectroscopy-of-melanins/10.1117/1.JBO.18.3.031107.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055387372","display_name":"Tatiana B. Krasieva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana B. Krasieva","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic","University of California, Beckman Laser Institute and Medical Clinic, Irvine, CA 92617-1475, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic","institution_ids":["https://openalex.org/I4210133819"]},{"raw_affiliation_string":"University of California, Beckman Laser Institute and Medical Clinic, Irvine, CA 92617-1475, USA","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060905185","display_name":"Chiara Stringari","orcid":"https://orcid.org/0000-0002-0550-7463","observed_orcids":["https://orcid.org/0000-0002-0550-7463"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chiara Stringari","raw_affiliation_strings":["Univ. of California, Irvine","University of California, Laboratory for Fluorescence Dynamics (LFD), Biomedical Engineering, Irvine, California 92697-2715"],"raw_orcid":"https://orcid.org/0000-0002-0550-7463","affiliations":[{"raw_affiliation_string":"Univ. of California, Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Laboratory for Fluorescence Dynamics (LFD), Biomedical Engineering, Irvine, California 92697-2715","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415350","display_name":"Feng Liu","orcid":"https://orcid.org/0000-0003-3963-0651","observed_orcids":["https://orcid.org/0000-0003-3963-0651"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4390039238","display_name":"UC Irvine Chao Family Comprehensive Cancer Center","ror":"https://ror.org/05gzqy922","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I204250578","https://openalex.org/I4390039238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feng Liu","raw_affiliation_strings":["Univ. of California, Irvine","University of California, Department of Medicine and Chao Family Comprehensive Cancer Center, Irvine, California 92697-2675"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of California, Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Department of Medicine and Chao Family Comprehensive Cancer Center, Irvine, California 92697-2675","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4390039238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102116347","display_name":"Chung\u2010Ho Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chung-Ho Sun","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic","University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92617-1475"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic","institution_ids":["https://openalex.org/I4210133819"]},{"raw_affiliation_string":"University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92617-1475","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yu Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Kong","raw_affiliation_strings":["Xi'an Jiaotong Univ","Xi\u2019an Jiaotong University, School of Life Science and Technology, Xi\u2019an, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Xi'an Jiaotong Univ","institution_ids":["https://openalex.org/I87445476"]},{"raw_affiliation_string":"Xi\u2019an Jiaotong University, School of Life Science and Technology, Xi\u2019an, Shaanxi Province, China","institution_ids":["https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049517030","display_name":"Mihaela Balu","orcid":"https://orcid.org/0000-0002-8018-5134","observed_orcids":["https://orcid.org/0000-0002-8018-5134"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mihaela Balu","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic","University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92617-1475"],"raw_orcid":"https://orcid.org/0000-0002-8018-5134","affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic","institution_ids":["https://openalex.org/I4210133819"]},{"raw_affiliation_string":"University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92617-1475","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210133819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060872059","display_name":"Frank Louis Meyskens","orcid":"https://orcid.org/0000-0002-8827-4334","observed_orcids":["https://orcid.org/0000-0002-8827-4334"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4390039238","display_name":"UC Irvine Chao Family Comprehensive Cancer Center","ror":"https://ror.org/05gzqy922","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I204250578","https://openalex.org/I4390039238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank L. Meyskens","raw_affiliation_strings":["Univ. of California, Irvine","University of California, Department of Medicine and Chao Family Comprehensive Cancer Center, Irvine, California 92697-2675"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of California, Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Department of Medicine and Chao Family Comprehensive Cancer Center, Irvine, California 92697-2675","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4390039238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005039590","display_name":"Enrico Gratton","orcid":"https://orcid.org/0000-0002-6450-7391","observed_orcids":["https://orcid.org/0000-0002-6450-7391"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enrico Gratton","raw_affiliation_strings":["Univ. of California, Irvine","University of California, Laboratory for Fluorescence Dynamics (LFD), Biomedical Engineering, Irvine, California 92697-2715"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of California, Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"University of California, Laboratory for Fluorescence Dynamics (LFD), Biomedical Engineering, Irvine, California 92697-2715","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015656700","display_name":"Bruce J. Tromberg","orcid":"https://orcid.org/0000-0002-7481-7975","observed_orcids":["https://orcid.org/0000-0002-7481-7975"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I4210133819","display_name":"Beckman Laser Institute and Medical Clinic","ror":"https://ror.org/03bfp2076","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210133819"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce J. Tromberg","raw_affiliation_strings":["Beckman Laser Institute and Medical Clinic","University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92617-1475"],"raw_orcid":"https://orcid.org/0000-0002-7481-7975","affiliations":[{"raw_affiliation_string":"Beckman Laser Institute and Medical Clinic","institution_ids":["https://openalex.org/I4210133819"]},{"raw_affiliation_string":"University of California, Beckman Laser Institute and Medical Clinic, Irvine, California 92617-1475","institution_ids":["https://openalex.org/I204250578","https://openalex.org/I4210133819"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1675,"currency":"USD","value_usd":1675},"apc_paid":{"value":1675,"currency":"USD","value_usd":1675},"fwci":1.556,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.80104947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"03","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.15860000252723694,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.0560000017285347,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eumelanin","display_name":"eumelanin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/pheomelanin","display_name":"pheomelanin","score":1.0},{"id":"https://openalex.org/keywords/two-photon-fluorescence","display_name":"two-photon fluorescence","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fluorescence-lifetime-imaging-microscopy","display_name":"fluorescence lifetime imaging","score":0.9359999895095825},{"id":"https://openalex.org/keywords/melanoma-cells","display_name":"melanoma cells","score":0.7459999918937683},{"id":"https://openalex.org/keywords/phasor-analysis","display_name":"phasor analysis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hair","display_name":"hair","score":0.3230000138282776},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7034955620765686},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.6732619404792786},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6449257731437683},{"id":"https://openalex.org/C47785574","wikidata":"https://www.wikidata.org/wiki/Q373859","display_name":"Two-photon excitation microscopy","level":3,"score":0.6245938539505005},{"id":"https://openalex.org/C181500209","wikidata":"https://www.wikidata.org/wiki/Q215328","display_name":"Excited state","level":2,"score":0.5986284613609314},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.5269142985343933},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.5202223658561707},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5177768468856812},{"id":"https://openalex.org/C57477423","wikidata":"https://www.wikidata.org/wiki/Q1434196","display_name":"Fluorescence-lifetime imaging microscopy","level":3,"score":0.5177754163742065},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5102975368499756},{"id":"https://openalex.org/C159317903","wikidata":"https://www.wikidata.org/wiki/Q3198","display_name":"Photon","level":2,"score":0.4762589931488037},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4489143490791321},{"id":"https://openalex.org/C92630104","wikidata":"https://www.wikidata.org/wiki/Q4115103","display_name":"Optical imaging","level":2,"score":0.42799103260040283},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4166656732559204},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.33882707357406616},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.232328861951828},{"id":"https://openalex.org/C184779094","wikidata":"https://www.wikidata.org/wiki/Q26383","display_name":"Atomic physics","level":1,"score":0.2027047872543335},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1421833634376526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11059105396270752},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.07829734683036804},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006197","descriptor_name":"Hair","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009243","descriptor_name":"NAD","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061848","descriptor_name":"Optical Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1117/1.jbo.18.3.031107","doi":"https://doi.org/10.1117/1.jbo.18.3.031107","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.18.3.031107","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-18/issue-3/031107/Two-photon-excited-fluorescence-lifetime-imaging-and-spectroscopy-of-melanins/10.1117/1.JBO.18.3.031107.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2842936","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3595716","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3595716","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3595716","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biomed Opt","raw_type":"Text"},{"id":"pmid:23235925","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23235925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomedical optics","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt37r8g7xj","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/37r8g7xj","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of biomedical optics, vol 18, iss 3","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1117/1.jbo.18.3.031107","doi":"https://doi.org/10.1117/1.jbo.18.3.031107","is_oa":true,"landing_page_url":"https://doi.org/10.1117/1.jbo.18.3.031107","pdf_url":"https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-18/issue-3/031107/Two-photon-excited-fluorescence-lifetime-imaging-and-spectroscopy-of-melanins/10.1117/1.JBO.18.3.031107.pdf","source":{"id":"https://openalex.org/S117354312","display_name":"Journal of Biomedical Optics","issn_l":"1083-3668","issn":["1083-3668","1560-2281"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomedical Optics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3272595726","display_name":"Laboratory for Fluorescence Dynamics","funder_award_id":"P41GM103540","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4607486877","display_name":"A Laser Microbeam Biotechnology Resource","funder_award_id":"P41RR001192","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G479823528","display_name":"Systems Biology of Morphogeneisis and Spatial Information Flow","funder_award_id":"P50GM076516","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G687051928","display_name":"Laboratory for Fluorescence Dynamics","funder_award_id":"P41RR003155","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7861206232","display_name":null,"funder_award_id":"P41EB015890","funder_id":"https://openalex.org/F4320306253","funder_display_name":"Arnold and Mabel Beckman Foundation"},{"id":"https://openalex.org/G7965973299","display_name":"A Laser Microbeam Biotechnology Resource","funder_award_id":"P41EB015890","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000352407","display_name":null,"funder_award_id":"GM076516","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000877839","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA062203","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306253","display_name":"Arnold and Mabel Beckman Foundation","ror":"https://ror.org/05avmtm72"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108683347.pdf","grobid_xml":"https://content.openalex.org/works/W2108683347.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W161968958","https://openalex.org/W1524775751","https://openalex.org/W1970177777","https://openalex.org/W1973947033","https://openalex.org/W1976753632","https://openalex.org/W1987173133","https://openalex.org/W2005893031","https://openalex.org/W2009518472","https://openalex.org/W2012846873","https://openalex.org/W2023215494","https://openalex.org/W2035429965","https://openalex.org/W2037094500","https://openalex.org/W2047404221","https://openalex.org/W2049197678","https://openalex.org/W2052809877","https://openalex.org/W2071505837","https://openalex.org/W2073130092","https://openalex.org/W2074457543","https://openalex.org/W2080125733","https://openalex.org/W2080446659","https://openalex.org/W2085916906","https://openalex.org/W2087723473","https://openalex.org/W2089519100","https://openalex.org/W2111061735","https://openalex.org/W2113531954","https://openalex.org/W2121706068","https://openalex.org/W2163307673","https://openalex.org/W2168528571","https://openalex.org/W2411893017","https://openalex.org/W4231559568","https://openalex.org/W4250566810","https://openalex.org/W4255137887","https://openalex.org/W6643917826"],"related_works":["https://openalex.org/W2082487756","https://openalex.org/W2752373057","https://openalex.org/W1573460780","https://openalex.org/W2004068658","https://openalex.org/W2068689596","https://openalex.org/W2994001322","https://openalex.org/W4280530385","https://openalex.org/W2073361681","https://openalex.org/W2021950025","https://openalex.org/W4214511476"],"abstract_inverted_index":{"Changes":[0],"in":[1,43,51,141,167,212,215],"the":[2,59,92,106,116],"amounts":[3],"of":[4,16,31,41,94,166,173],"cellular":[5],"eumelanin":[6,70],"and":[7,50,69,99,122,132,176,200,214],"pheomelanin":[8,60,127,177],"have":[9],"been":[10],"associated":[11],"with":[12,144],"carcinogenesis.":[13],"The":[14,102,137,170],"goal":[15],"this":[17],"work":[18],"is":[19,111],"to":[20,66,77,151],"develop":[21],"methods":[22],"based":[23,197],"on":[24,81,198],"two-photon-excited-fluorescence":[25],"(TPEF)":[26],"for":[27,105,185,206],"measuring":[28],"relative":[29,171],"concentrations":[30,172],"these":[32,82],"compounds.":[33],"We":[34,56],"acquire":[35],"TPEF":[36,195],"emission":[37,61],"spectra":[38,199],"(\u03bb(ex)=1000":[39],"nm)":[40],"melanin":[42,88,146,154,208],"vitro":[44,168,213],"from":[45,53,156],"melanoma":[46,108],"cells,":[47],"hair":[48],"specimens,":[49],"vivo":[52],"healthy":[54],"volunteers.":[55],"find":[57],"that":[58,192],"peaks":[62],"at":[63,75,97],"approximately":[64],"615":[65,100],"625":[67],"nm":[68],"exhibits":[71],"a":[72,182,193],"broad":[73],"maximum":[74],"640":[76],"680":[78],"nm.":[79,101],"Based":[80],"data":[83],"we":[84,160],"define":[85],"an":[86],"optical":[87],"index":[89,196],"(OMI)":[90],"as":[91],"ratio":[93,209],"fluorescence":[95,155,162],"intensities":[96],"645":[98],"measured":[103,138],"OMI":[104],"MNT-1":[107],"cell":[109],"line":[110],"1.6":[112],"\u00b1":[113,130,134],"0.22":[114],"while":[115],"Mc1R":[117],"gene":[118],"knockdown":[119],"lines":[120],"MNT-46":[121],"MNT-62":[123],"show":[124],"substantially":[125],"greater":[126],"production":[128],"(OMI=0.5":[129],"0.05":[131],"0.17":[133],"0.03,":[135],"respectively).":[136],"values":[139],"are":[140,179],"good":[142],"agreement":[143],"chemistry-based":[145],"extraction":[147],"methods.":[148],"In":[149],"order":[150],"better":[152],"separate":[153],"other":[157],"intrinsic":[158],"fluorophores,":[159],"perform":[161],"lifetime":[163,187,201],"imaging":[164],"microscopy":[165],"specimens.":[169],"keratin,":[174],"eumelanin,":[175],"components":[178],"resolved":[180],"using":[181],"phasor":[183],"approach":[184],"analyzing":[186],"data.":[188],"Our":[189],"results":[190],"suggest":[191],"noninvasive":[194],"could":[202],"potentially":[203],"be":[204],"used":[205],"rapid":[207],"characterization":[210],"both":[211],"vivo.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
