{"id":"https://openalex.org/W2108672999","doi":null,"title":"Activity of endothelial nitric oxide synthase: substrates, modulators and products","display_name":"Activity of endothelial nitric oxide synthase: substrates, modulators and products","publication_year":2006,"publication_date":"2006-11-14","ids":{"openalex":"https://openalex.org/W2108672999","mag":"2108672999"},"language":"en","primary_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/13834","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/13834","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://dspace.library.uu.nl/handle/1874/13834","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051501412","display_name":"Lonneke M. Bevers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lonneke M. Bevers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5051501412"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8389999866485596},{"id":"https://openalex.org/keywords/enos-uncoupling","display_name":"eNOS uncoupling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.7919999957084656},{"id":"https://openalex.org/keywords/l-arginine","display_name":"L-arginine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bend-3-cells","display_name":"bEnd.3 cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.7820000052452087},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.8980000019073486},{"id":"https://openalex.org/keywords/hypoalbuminemia","display_name":"hypoalbuminemia","score":0.972000002861023},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/anoxia","display_name":"anoxia","score":0.8629999756813049},{"id":"https://openalex.org/keywords/nitric-oxide-synthase-inhibitors","display_name":"nitric oxide synthase inhibitors","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.9754912853240967},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.683891773223877},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.5792758464813232},{"id":"https://openalex.org/C2908688039","wikidata":"https://www.wikidata.org/wiki/Q408853","display_name":"Nitric Oxide Synthase Type III","level":5,"score":0.5462989807128906},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5380155444145203},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.4710530936717987},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4619830548763275},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.43160736560821533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4181564152240753},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4111575186252594},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3613869845867157},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35105836391448975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29354965686798096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22634410858154297},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16961181163787842}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:dspace.library.uu.nl:1874/13834","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/13834","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},{"id":"pmh:uu:oai:dspace.library.uu.nl:1874/13834","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/13834","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralthesis"},{"id":"mag:2108672999","doi":null,"is_oa":false,"landing_page_url":"https://dspace.library.uu.nl/bitstream/1874/13834/1/title.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dspace.library.uu.nl:1874/13834","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/13834","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Dissertation"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":387,"referenced_works":["https://openalex.org/W30399182","https://openalex.org/W63530261","https://openalex.org/W96661271","https://openalex.org/W111313680","https://openalex.org/W119779276","https://openalex.org/W133994298","https://openalex.org/W143870286","https://openalex.org/W150673205","https://openalex.org/W176199101","https://openalex.org/W205975924","https://openalex.org/W600254821","https://openalex.org/W1146279305","https://openalex.org/W1493971026","https://openalex.org/W1499490708","https://openalex.org/W1507800048","https://openalex.org/W1511795950","https://openalex.org/W1536518696","https://openalex.org/W1536773986","https://openalex.org/W1537398036","https://openalex.org/W1538844921","https://openalex.org/W1545481155","https://openalex.org/W1566111314","https://openalex.org/W1571324662","https://openalex.org/W1572120598","https://openalex.org/W1574625282","https://openalex.org/W1584876031","https://openalex.org/W1585709511","https://openalex.org/W1586512411","https://openalex.org/W1589586351","https://openalex.org/W1590567489","https://openalex.org/W1593282904","https://openalex.org/W1596452944","https://openalex.org/W1603091372","https://openalex.org/W1607892649","https://openalex.org/W1671715243","https://openalex.org/W1678800844","https://openalex.org/W1750690213","https://openalex.org/W1752614770","https://openalex.org/W1770314811","https://openalex.org/W1775374114","https://openalex.org/W1799692929","https://openalex.org/W1809056726","https://openalex.org/W1861095564","https://openalex.org/W1871942206","https://openalex.org/W1879669251","https://openalex.org/W1916986742","https://openalex.org/W1919315131","https://openalex.org/W1923492067","https://openalex.org/W1928175618","https://openalex.org/W1929009802","https://openalex.org/W1932489422","https://openalex.org/W1948870077","https://openalex.org/W1963606923","https://openalex.org/W1963805558","https://openalex.org/W1965148671","https://openalex.org/W1965983458","https://openalex.org/W1966805153","https://openalex.org/W1967345257","https://openalex.org/W1967880167","https://openalex.org/W1970164806","https://openalex.org/W1970924996","https://openalex.org/W1971022956","https://openalex.org/W1971860517","https://openalex.org/W1972724464","https://openalex.org/W1972771748","https://openalex.org/W1973638531","https://openalex.org/W1974248143","https://openalex.org/W1976367987","https://openalex.org/W1980284010","https://openalex.org/W1981361599","https://openalex.org/W1981905227","https://openalex.org/W1982687474","https://openalex.org/W1982811953","https://openalex.org/W1985251254","https://openalex.org/W1985292239","https://openalex.org/W1985977889","https://openalex.org/W1986948325","https://openalex.org/W1987325894","https://openalex.org/W1989137854","https://openalex.org/W1990390910","https://openalex.org/W1990527302","https://openalex.org/W1990931414","https://openalex.org/W1990999359","https://openalex.org/W1991583073","https://openalex.org/W1991825108","https://openalex.org/W1992830364","https://openalex.org/W1993950854","https://openalex.org/W1994768696","https://openalex.org/W1995572986","https://openalex.org/W1996728375","https://openalex.org/W1997439028","https://openalex.org/W1997469875","https://openalex.org/W1997731166","https://openalex.org/W1997766296","https://openalex.org/W1998155352","https://openalex.org/W1998426676","https://openalex.org/W1999431127","https://openalex.org/W2001251332","https://openalex.org/W2001505200","https://openalex.org/W2001783405","https://openalex.org/W2001984777","https://openalex.org/W2002111141","https://openalex.org/W2002338268","https://openalex.org/W2003294380","https://openalex.org/W2003801493","https://openalex.org/W2004661390","https://openalex.org/W2005232152","https://openalex.org/W2005466083","https://openalex.org/W2005585532","https://openalex.org/W2006705030","https://openalex.org/W2006847107","https://openalex.org/W2007671598","https://openalex.org/W2008354631","https://openalex.org/W2009451441","https://openalex.org/W2009681967","https://openalex.org/W2010020462","https://openalex.org/W2010055809","https://openalex.org/W2012337490","https://openalex.org/W2012457700","https://openalex.org/W2012457821","https://openalex.org/W2013000509","https://openalex.org/W2013103361","https://openalex.org/W2013475025","https://openalex.org/W2014226775","https://openalex.org/W2014730766","https://openalex.org/W2015628428","https://openalex.org/W2016161630","https://openalex.org/W2016675420","https://openalex.org/W2017023848","https://openalex.org/W2017296879","https://openalex.org/W2018997231","https://openalex.org/W2020319663","https://openalex.org/W2020584414","https://openalex.org/W2020990593","https://openalex.org/W2021334430","https://openalex.org/W2021951475","https://openalex.org/W2022068789","https://openalex.org/W2022568707","https://openalex.org/W2023506304","https://openalex.org/W2023690476","https://openalex.org/W2023775650","https://openalex.org/W2024984581","https://openalex.org/W2025064480","https://openalex.org/W2025284114","https://openalex.org/W2026425756","https://openalex.org/W2027873788","https://openalex.org/W2028010937","https://openalex.org/W2028514452","https://openalex.org/W2028880044","https://openalex.org/W2029634948","https://openalex.org/W2031583642","https://openalex.org/W2032932944","https://openalex.org/W2033357754","https://openalex.org/W2033974115","https://openalex.org/W2034659340","https://openalex.org/W2034694403","https://openalex.org/W2034825883","https://openalex.org/W2035508242","https://openalex.org/W2035617135","https://openalex.org/W2036062936","https://openalex.org/W2037000455","https://openalex.org/W2037268745","https://openalex.org/W2040802598","https://openalex.org/W2041385810","https://openalex.org/W2042038416","https://openalex.org/W2042277367","https://openalex.org/W2042448092","https://openalex.org/W2042674230","https://openalex.org/W2042695353","https://openalex.org/W2042703282","https://openalex.org/W2043852940","https://openalex.org/W2044051878","https://openalex.org/W2044568120","https://openalex.org/W2044941841","https://openalex.org/W2045429393","https://openalex.org/W2045639174","https://openalex.org/W2047273078","https://openalex.org/W2048460480","https://openalex.org/W2048565622","https://openalex.org/W2048574237","https://openalex.org/W2048707852","https://openalex.org/W2049563995","https://openalex.org/W2049803654","https://openalex.org/W2052327619","https://openalex.org/W2052971617","https://openalex.org/W2054030668","https://openalex.org/W2054150424","https://openalex.org/W2055444768","https://openalex.org/W2056318837","https://openalex.org/W2058242086","https://openalex.org/W2058675280","https://openalex.org/W2059379142","https://openalex.org/W2059694609","https://openalex.org/W2063024150","https://openalex.org/W2063074529","https://openalex.org/W2063596708","https://openalex.org/W2064358616","https://openalex.org/W2064745690","https://openalex.org/W2065335664","https://openalex.org/W2065501573","https://openalex.org/W2065789432","https://openalex.org/W2065853122","https://openalex.org/W2066290187","https://openalex.org/W2066777233","https://openalex.org/W2067868943","https://openalex.org/W2067958032","https://openalex.org/W2068642993","https://openalex.org/W2068820862","https://openalex.org/W2069083293","https://openalex.org/W2069514751","https://openalex.org/W2070471641","https://openalex.org/W2070513297","https://openalex.org/W2070543199","https://openalex.org/W2070999822","https://openalex.org/W2071067860","https://openalex.org/W2071919212","https://openalex.org/W2072204309","https://openalex.org/W2072793621","https://openalex.org/W2077011385","https://openalex.org/W2077244492","https://openalex.org/W2077951117","https://openalex.org/W2078370178","https://openalex.org/W2078779904","https://openalex.org/W2078862165","https://openalex.org/W2079331192","https://openalex.org/W2081188915","https://openalex.org/W2082323486","https://openalex.org/W2083358105","https://openalex.org/W2083681928","https://openalex.org/W2083714336","https://openalex.org/W2084830265","https://openalex.org/W2085742386","https://openalex.org/W2086558138","https://openalex.org/W2086785365","https://openalex.org/W2087018994","https://openalex.org/W2087375899","https://openalex.org/W2087666795","https://openalex.org/W2089467843","https://openalex.org/W2089549133","https://openalex.org/W2090147611","https://openalex.org/W2091380103","https://openalex.org/W2091454170","https://openalex.org/W2091626578","https://openalex.org/W2092145002","https://openalex.org/W2092175186","https://openalex.org/W2092564592","https://openalex.org/W2093021792","https://openalex.org/W2093869152","https://openalex.org/W2094308520","https://openalex.org/W2094663006","https://openalex.org/W2094949453","https://openalex.org/W2095400859","https://openalex.org/W2096940328","https://openalex.org/W2097143249","https://openalex.org/W2097799015","https://openalex.org/W2097980836","https://openalex.org/W2098453482","https://openalex.org/W2098534438","https://openalex.org/W2098576019","https://openalex.org/W2098816300","https://openalex.org/W2099094190","https://openalex.org/W2101290420","https://openalex.org/W2103394904","https://openalex.org/W2103636227","https://openalex.org/W2103790130","https://openalex.org/W2104645520","https://openalex.org/W2105493228","https://openalex.org/W2105744925","https://openalex.org/W2107946046","https://openalex.org/W2108116605","https://openalex.org/W2108654428","https://openalex.org/W2109168147","https://openalex.org/W2109544293","https://openalex.org/W2112577081","https://openalex.org/W2113269981","https://openalex.org/W2113355631","https://openalex.org/W2114365046","https://openalex.org/W2114446978","https://openalex.org/W2114634451","https://openalex.org/W2115784975","https://openalex.org/W2116832778","https://openalex.org/W2116948662","https://openalex.org/W2117392010","https://openalex.org/W2119841264","https://openalex.org/W2121174059","https://openalex.org/W2121585177","https://openalex.org/W2121621281","https://openalex.org/W2122941568","https://openalex.org/W2123931357","https://openalex.org/W2125076307","https://openalex.org/W2125647807","https://openalex.org/W2127479364","https://openalex.org/W2128022125","https://openalex.org/W2128556711","https://openalex.org/W2129050578","https://openalex.org/W2132440861","https://openalex.org/W2132704929","https://openalex.org/W2132826785","https://openalex.org/W2135297555","https://openalex.org/W2136257776","https://openalex.org/W2137098613","https://openalex.org/W2137258759","https://openalex.org/W2138220081","https://openalex.org/W2138220407","https://openalex.org/W2138936938","https://openalex.org/W2138962306","https://openalex.org/W2141144622","https://openalex.org/W2141998216","https://openalex.org/W2143256430","https://openalex.org/W2145055214","https://openalex.org/W2145526552","https://openalex.org/W2145561716","https://openalex.org/W2145750731","https://openalex.org/W2146242381","https://openalex.org/W2146304788","https://openalex.org/W2146736971","https://openalex.org/W2147176626","https://openalex.org/W2147332678","https://openalex.org/W2147741927","https://openalex.org/W2147812298","https://openalex.org/W2148227152","https://openalex.org/W2149914661","https://openalex.org/W2150017087","https://openalex.org/W2151425074","https://openalex.org/W2152259320","https://openalex.org/W2152467696","https://openalex.org/W2153802091","https://openalex.org/W2154346498","https://openalex.org/W2155603952","https://openalex.org/W2155853522","https://openalex.org/W2156588431","https://openalex.org/W2157167939","https://openalex.org/W2157520113","https://openalex.org/W2158745632","https://openalex.org/W2159930565","https://openalex.org/W2160042367","https://openalex.org/W2160930691","https://openalex.org/W2161131990","https://openalex.org/W2162431165","https://openalex.org/W2162582363","https://openalex.org/W2162779892","https://openalex.org/W2163000500","https://openalex.org/W2163287575","https://openalex.org/W2163532796","https://openalex.org/W2163889067","https://openalex.org/W2164124107","https://openalex.org/W2164680983","https://openalex.org/W2164765386","https://openalex.org/W2166005447","https://openalex.org/W2166236611","https://openalex.org/W2166445799","https://openalex.org/W2166865140","https://openalex.org/W2168038844","https://openalex.org/W2169182236","https://openalex.org/W2170551438","https://openalex.org/W2172004618","https://openalex.org/W2184702858","https://openalex.org/W2201221710","https://openalex.org/W2208022181","https://openalex.org/W2208872067","https://openalex.org/W2216783194","https://openalex.org/W2222422800","https://openalex.org/W2266482114","https://openalex.org/W2267534767","https://openalex.org/W2272427918","https://openalex.org/W2299966384","https://openalex.org/W2304869088","https://openalex.org/W2313177109","https://openalex.org/W2318533894","https://openalex.org/W2325815717","https://openalex.org/W2327263422","https://openalex.org/W2341153079","https://openalex.org/W2341876151","https://openalex.org/W2342414629","https://openalex.org/W2394660565","https://openalex.org/W2395675726","https://openalex.org/W2398286824","https://openalex.org/W2404801948","https://openalex.org/W2407386961","https://openalex.org/W2409761204","https://openalex.org/W2412045520","https://openalex.org/W2413524415","https://openalex.org/W2416654412","https://openalex.org/W2417110066","https://openalex.org/W2419535196","https://openalex.org/W2439052683","https://openalex.org/W2471605942"],"related_works":["https://openalex.org/W2071067860","https://openalex.org/W1968651360","https://openalex.org/W2146190354","https://openalex.org/W2165029049","https://openalex.org/W93186474","https://openalex.org/W1531133799","https://openalex.org/W2161433683","https://openalex.org/W4323537084","https://openalex.org/W2369634539","https://openalex.org/W2165073849"],"abstract_inverted_index":{"In":[0,66,92,139,166,187,214,241,341,413],"this":[1],"thesis,":[2],"the":[3,12,47,53,104,122,132,155,219,242,272,357,416,420,439],"activity":[4,252,292,400],"of":[5,14,46,55,84,100,106,115,125,157,174,199,209,221,224,244,247,271,285,361,369,374,387,401,431],"endothelial":[6,73,338,442],"nitric":[7,24],"oxide":[8,25],"synthase":[9],"(eNOS)":[10],"and":[11,18,34,162,217,228,236,255,274,293,394,433,444],"effects":[13,220],"its":[15,434],"substrates,":[16],"modulators":[17],"products":[19],"are":[20,36,239,423,447],"described.":[21],"eNOS":[22,42,64,85,175,185,206,212,232,251,276,291,402,432],"produces":[23],"(NO),":[26],"which":[27,102,279],"is":[28,77,136,149,170,253,259,280,364,376,382,403],"involved":[29],"in":[30,109,194,205,268,289,296,303,317,349,409,419,425,438],"vascular":[31,321,411],"biology.":[32],"L-arginine":[33,200],"BH4":[35,210,265],"both":[37],"essential":[38,183],"factors":[39],"for":[40,184,405],"adequate":[41],"function.":[43],"Reduced":[44],"levels":[45,83,223],"substrate":[48],"or":[49,89,119],"cofactor":[50,273],"lead":[51],"to":[52,62,153,181,189,202,332,367,384],"formation":[54,363],"superoxide":[56],"by":[57,128,160,378,390],"eNOS,":[58],"a":[59,71,113,137,269,346,426],"process":[60],"referred":[61],"as":[63,112,329],"uncoupling.":[65,207,213,277],"all":[67],"studies":[68],"described":[69],"here,":[70],"microvascular":[72],"cell":[74],"line":[75],"(bEnd.3)":[76],"used.":[78],"These":[79],"cells":[80,95],"express":[81],"high":[82,123,245],"but":[86,311],"lack":[87],"neuronal":[88],"inducible":[90],"NOS.":[91],"addition,":[93],"bEnd.3":[94,129,164],"produce":[96],"relatively":[97],"large":[98],"amounts":[99],"NO,":[101],"facilitates":[103],"detection":[105],"subtle":[107],"differences":[108],"NO":[110,126,134,158,234,294,322,339,350,362,375,407],"production":[111,235,258,295,351],"consequence":[114],"treatment":[116],"with":[117,282],"agonists":[118],"antagonists.":[120],"Despite":[121],"concentrations":[124,246],"produced":[127,159],"cells,":[130],"determining":[131],"exact":[133],"concentration":[135],"chalenge.":[138],"chapter":[140,167,195,215,342,414],"3,":[141],"we":[142,192,344],"describe":[143],"that":[144,172,197,316,326,397],"electron":[145],"paramagnetic":[146],"resonance":[147],"(EPR)":[148],"an":[150,203],"excellent":[151],"tool":[152],"quantify":[154],"amount":[156],"stimulated":[161],"unstimulated":[163],"cells.":[165],"4":[168],"it":[169],"shown":[171],"localisation":[173],"at":[176],"cell-cell":[177],"contact":[178],"site":[179],"proofs":[180],"be":[182],"activity.":[186],"contrast":[188],"earlier":[190],"reports,":[191],"show":[193,325,345],"5":[196],"addition":[198],"leads":[201],"increase":[204,348],"Addition":[208],"prevents":[211],"6":[216],"7":[218],"elevated":[222],"free":[225,248],"fatty":[226,249],"acids":[227],"hypoalbuminaemia,":[229],"respectively,":[230],"on":[231],"activity,":[233],"down-stream":[237],"effectors":[238],"discussed.":[240,448],"presence":[243],"acids,":[250],"decreased":[254],"mitochondrial":[256],"ROS":[257,262],"increased.":[260,313],"Mitochondrial-derived":[261],"can":[263],"induce":[264],"oxidation,":[266],"resulting":[267],"shortage":[270],"subsequent":[275],"Hypoalbuminemia,":[278],"associated":[281],"increased":[283,290],"risk":[284],"cardiovascular":[286,445],"disease,":[287],"results":[288,417],"vitro.":[297],"Endothelium-independent":[298],"relaxation":[299],"was":[300,309],"markedly":[301],"blunted":[302],"analbuminemic":[304],"rats,":[305],"while":[306],"endothelium-dependent":[307],"dilatation":[308],"slightly,":[310],"significantly,":[312],"This":[314,380],"implies":[315],"vivo":[318],"hypoalbuminemia":[319],"reduces":[320],"sensitivity.":[323],"We":[324],"low":[327],"albumin":[328],"such":[330],"seems":[331],"enhance,":[333],"rather":[334],"than":[335],"diminish,":[336],"eNOS-mediated":[337],"production.":[340],"8,":[343],"marked":[347],"under":[352],"anoxic":[353,372,385],"conditions,":[354],"even":[355],"though":[356],"normal":[358],"arginine":[359],"pathway":[360],"blocked":[365],"due":[366],"absence":[368],"oxygen.":[370],"The":[371,429],"release":[373],"mediated":[377],"eNOS.":[379,391],"phenomenon":[381],"attributed":[383],"reduction":[386],"intracellular":[388],"nitrite":[389,398],"Its":[392],"magnitude":[393],"duration":[395],"suggests":[396],"reductase":[399],"relevant":[404],"fast":[406],"delivery":[408],"hypoxic":[410],"tissues.":[412],"9,":[415],"presented":[418],"previous":[421],"chapters":[422],"discussed":[424],"broader":[427],"context.":[428],"importance":[430],"possible":[435],"therapeutic":[436],"benefits":[437],"struggle":[440],"against":[441],"dysfunction":[443],"disease":[446]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}