{"id":"https://openalex.org/W2108645007","doi":"https://doi.org/10.1093/biostatistics/4.4.597","title":"Statistical analysis of microarray data: a Bayesian approach","display_name":"Statistical analysis of microarray data: a Bayesian approach","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2108645007","doi":"https://doi.org/10.1093/biostatistics/4.4.597","mag":"2108645007","pmid":"https://pubmed.ncbi.nlm.nih.gov/14557114"},"language":"en","primary_location":{"id":"doi:10.1093/biostatistics/4.4.597","doi":"https://doi.org/10.1093/biostatistics/4.4.597","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biostatistics/4.4.597","pdf_url":null,"source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005741024","display_name":"Rapha\u00ebl Gottardo","orcid":"https://orcid.org/0000-0002-3867-0232","observed_orcids":["https://orcid.org/0000-0002-3867-0232"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. Gottardo","raw_affiliation_strings":["University of Washington, Department of Statistics, Box 354322, Seattle, WA 98195-4322, USA. raph@stat.washington.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Department of Statistics, Box 354322, Seattle, WA 98195-4322, USA. raph@stat.washington.edu","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005741024"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":3296,"currency":"USD","value_usd":3296},"apc_paid":null,"fwci":1.8856,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.85331092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"4","issue":"4","first_page":"597","last_page":"620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microarray-data","display_name":"microarray data","score":0.8730000257492065},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7170000076293945},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8790000081062317},{"id":"https://openalex.org/keywords/empirical-bayes","display_name":"empirical Bayes","score":0.9110000133514404},{"id":"https://openalex.org/keywords/multiple-testing","display_name":"multiple comparisons","score":0.8259999752044678},{"id":"https://openalex.org/keywords/two-sample-problem","display_name":"two-sample problem","score":0.5559999942779541},{"id":"https://openalex.org/keywords/one-sample-problem","display_name":"one-sample problem","score":0.8489999771118164},{"id":"https://openalex.org/keywords/prior-knowledge","display_name":"prior knowledge","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.8191268444061279},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.6021977663040161},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5955729484558105},{"id":"https://openalex.org/C207201462","wikidata":"https://www.wikidata.org/wiki/Q182505","display_name":"Bayes' theorem","level":3,"score":0.5952917337417603},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.573907196521759},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5193701386451721},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.46600541472435},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.46563616394996643},{"id":"https://openalex.org/C183905921","wikidata":"https://www.wikidata.org/wiki/Q1038757","display_name":"Multiple comparisons problem","level":2,"score":0.43962541222572327},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.41770702600479126},{"id":"https://openalex.org/C169857963","wikidata":"https://www.wikidata.org/wiki/Q1461038","display_name":"Test statistic","level":3,"score":0.41286996006965637},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2984796166419983},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2103191316127777},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11328181624412537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08842208981513977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001408","descriptor_name":"Bacillus anthracis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002245","descriptor_name":"Carbon Dioxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018401","descriptor_name":"Sample Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/biostatistics/4.4.597","doi":"https://doi.org/10.1093/biostatistics/4.4.597","is_oa":false,"landing_page_url":"https://doi.org/10.1093/biostatistics/4.4.597","pdf_url":null,"source":{"id":"https://openalex.org/S190140075","display_name":"Biostatistics","issn_l":"1465-4644","issn":["1465-4644","1468-4357"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics","raw_type":"journal-article"},{"id":"pmid:14557114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14557114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biostatistics (Oxford, England)","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.330.476","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.330.476","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://biostatistics.oxfordjournals.org/content/4/4/597.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:biosts:4/4/597","doi":null,"is_oa":false,"landing_page_url":"http://biostatistics.oxfordjournals.org/cgi/content/short/4/4/597","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320337547","display_name":"Laboratory Directed Research and Development","ror":"https://ror.org/01e41cf67"},{"id":"https://openalex.org/F4320338304","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W140512737","https://openalex.org/W1906629914","https://openalex.org/W1974917488","https://openalex.org/W2038437697","https://openalex.org/W2071650644","https://openalex.org/W2091841926","https://openalex.org/W2093784289","https://openalex.org/W2101635534","https://openalex.org/W2105381419","https://openalex.org/W2105793531","https://openalex.org/W2110065044","https://openalex.org/W2121044470","https://openalex.org/W2125905177","https://openalex.org/W2141407136","https://openalex.org/W2144227498","https://openalex.org/W2156246479","https://openalex.org/W2158521027","https://openalex.org/W2277729655","https://openalex.org/W2796856748","https://openalex.org/W2797285548"],"related_works":["https://openalex.org/W7096115559","https://openalex.org/W2144227498","https://openalex.org/W2105793531","https://openalex.org/W1518702183","https://openalex.org/W252705097","https://openalex.org/W2153718589","https://openalex.org/W3104024536","https://openalex.org/W1915362844","https://openalex.org/W7096771757","https://openalex.org/W2078064210"],"abstract_inverted_index":{"The":[0,67,105,190],"potential":[1],"of":[2,14,16,74,112,141,179,206],"microarray":[3,23,65],"data":[4,196],"is":[5,24,70,76,108,114,122,143],"enormous.":[6],"It":[7],"allows":[8],"us":[9],"to":[10,25,47,82,171,212],"monitor":[11],"the":[12,72,95,110,139,175,180,204],"expression":[13,182],"thousands":[15],"genes":[17,28,113],"simultaneously.":[18],"A":[19],"common":[20],"task":[21,51],"with":[22,64,124,197],"determine":[26],"which":[27],"are":[29,54,92,102,134,192],"differentially":[30],"expressed":[31],"between":[32],"two":[33,37],"samples":[34,56],"obtained":[35],"under":[36,57],"different":[38,161],"conditions.":[39],"Recently,":[40],"several":[41],"statistical":[42],"methods":[43,191,211],"have":[44],"been":[45],"proposed":[46],"perform":[48],"such":[49],"a":[50,87,207],"when":[52,138],"there":[53],"replicate":[55],"each":[58],"condition.":[59],"Two":[60],"major":[61],"problems":[62,157],"arise":[63],"data.":[66],"first":[68],"one":[69,121],"that":[71,91,109,154,167],"number":[73,111,140],"replicates":[75,142],"very":[77,116,158],"small":[78],"(usually":[79],"2-10),":[80],"leading":[81],"noisy":[83],"point":[84],"estimates.":[85],"As":[86],"consequence,":[88],"traditional":[89],"statistics":[90,166,214],"based":[93],"on":[94],"means":[96,176],"and":[97,120,187,215],"standard":[98],"deviations,":[99],"e.g.":[100],"t-statistic,":[101],"not":[103],"suitable.":[104],"second":[106],"problem":[107],"usually":[115],"large":[117],"(approximately":[118],"10,000),":[119],"faced":[123],"an":[125,150],"extreme":[126],"multiple":[127,131,216],"testing":[128,132,217],"problem.":[129],"Most":[130],"adjustments":[133],"relatively":[135],"conservative,":[136],"especially":[137],"small.":[144],"In":[145,200],"this":[146],"paper":[147],"we":[148,163,202],"present":[149,203],"empirical":[151],"Bayes":[152],"analysis":[153],"handles":[155],"both":[156,185],"well.":[159],"Using":[160],"parametrizations,":[162],"develop":[164],"four":[165],"can":[168],"be":[169],"used":[170],"test":[172],"hypotheses":[173],"about":[174],"and/or":[177],"variances":[178],"gene":[181],"levels":[183],"in":[184],"one-":[186],"two-sample":[188],"problems.":[189],"illustrated":[193],"using":[194],"experimental":[195],"prior":[198],"knowledge.":[199],"addition,":[201],"result":[205],"simulation":[208],"comparing":[209],"our":[210],"well-known":[213],"adjustments.":[218]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
