{"id":"https://openalex.org/W2108621079","doi":"https://doi.org/10.1073/pnas.95.7.4035","title":"Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single G \u03b2\u03b3 subunit","display_name":"Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single G \u03b2\u03b3 subunit","publication_year":1998,"publication_date":"1998-03-31","ids":{"openalex":"https://openalex.org/W2108621079","doi":"https://doi.org/10.1073/pnas.95.7.4035","mag":"2108621079","pmid":"https://pubmed.ncbi.nlm.nih.gov/9520488","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/19958"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.95.7.4035","doi":"https://doi.org/10.1073/pnas.95.7.4035","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.7.4035","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC19958","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064090722","display_name":"Gerald Werner Zamponi","orcid":"https://orcid.org/0000-0002-0644-9066","observed_orcids":["https://orcid.org/0000-0002-0644-9066"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gerald W. Zamponi","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada T2N 4N1; and Biotechnology Laboratory, Room 237, 6174 University Boulevard, University of British Columbia, Vancouver, Canada V6T 1Z3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada T2N 4N1; and Biotechnology Laboratory, Room 237, 6174 University Boulevard, University of British Columbia, Vancouver, Canada V6T 1Z3","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I168635309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113633350","display_name":"Terry P. Snutch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Terry P. Snutch","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada T2N 4N1; and Biotechnology Laboratory, Room 237, 6174 University Boulevard, University of British Columbia, Vancouver, Canada V6T 1Z3"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada T2N 4N1; and Biotechnology Laboratory, Room 237, 6174 University Boulevard, University of British Columbia, Vancouver, Canada V6T 1Z3","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7787,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.94598252,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"95","issue":"7","first_page":"4035","last_page":"4039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-type-calcium-channels","display_name":"N-type calcium channels","score":0.9440000057220459},{"id":"https://openalex.org/keywords/g-protein-beta-gamma-subunits","display_name":"G protein beta gamma subunits","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prepulse-facilitation","display_name":"prepulse facilitation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/recovery-time-constant","display_name":"recovery time constant","score":0.656000018119812},{"id":"https://openalex.org/keywords/barium-currents","display_name":"barium currents","score":0.8100000023841858},{"id":"https://openalex.org/keywords/alpha1b-subunit","display_name":"alpha1B subunit","score":0.8080000281333923},{"id":"https://openalex.org/keywords/alpha2-delta-subunit","display_name":"alpha2delta subunit","score":0.8190000057220459},{"id":"https://openalex.org/keywords/rat-brain","display_name":"rat brain","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6855774521827698},{"id":"https://openalex.org/C1337776","wikidata":"https://www.wikidata.org/wiki/Q1941955","display_name":"Facilitation","level":2,"score":0.6814786195755005},{"id":"https://openalex.org/C141421786","wikidata":"https://www.wikidata.org/wiki/Q1128897","display_name":"Prepulse inhibition","level":3,"score":0.6785189509391785},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6148570775985718},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5661380290985107},{"id":"https://openalex.org/C117499352","wikidata":"https://www.wikidata.org/wiki/Q2600696","display_name":"L-type calcium channel","level":4,"score":0.5498951077461243},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5065852403640747},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4419260621070862},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.4084573984146118},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3349071741104126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22476038336753845},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2091260850429535},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.14481842517852783},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.10950911045074463},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.95.7.4035","doi":"https://doi.org/10.1073/pnas.95.7.4035","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.95.7.4035","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:189356","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC19958","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:19958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/19958","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9520488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9520488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:189356","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC19958","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1578096869","https://openalex.org/W1582905488","https://openalex.org/W1844939284","https://openalex.org/W1964036468","https://openalex.org/W1965543460","https://openalex.org/W1965772541","https://openalex.org/W1968094290","https://openalex.org/W1968124094","https://openalex.org/W1972211504","https://openalex.org/W1974015977","https://openalex.org/W1975140133","https://openalex.org/W1983458197","https://openalex.org/W1983635763","https://openalex.org/W2001201602","https://openalex.org/W2003218087","https://openalex.org/W2017810117","https://openalex.org/W2020911593","https://openalex.org/W2026655497","https://openalex.org/W2035460326","https://openalex.org/W2036684355","https://openalex.org/W2040009964","https://openalex.org/W2040778655","https://openalex.org/W2045827767","https://openalex.org/W2052344768","https://openalex.org/W2055012870","https://openalex.org/W2058735462","https://openalex.org/W2062189135","https://openalex.org/W2062933575","https://openalex.org/W2064748241","https://openalex.org/W2068617048","https://openalex.org/W2074730021","https://openalex.org/W2075338922","https://openalex.org/W2075654108","https://openalex.org/W2078316320","https://openalex.org/W2083352797","https://openalex.org/W2090157435","https://openalex.org/W2118309627","https://openalex.org/W2121352744","https://openalex.org/W2129726073","https://openalex.org/W2130950257","https://openalex.org/W2136065229","https://openalex.org/W2163615816","https://openalex.org/W2170587185","https://openalex.org/W2170912183","https://openalex.org/W2171405755","https://openalex.org/W2401952485","https://openalex.org/W2913636289","https://openalex.org/W4301356103"],"related_works":["https://openalex.org/W1991025687","https://openalex.org/W1974107807","https://openalex.org/W1973487122","https://openalex.org/W2084814544","https://openalex.org/W2130430445","https://openalex.org/W7208654693","https://openalex.org/W1496951250","https://openalex.org/W1972211504","https://openalex.org/W2088184760","https://openalex.org/W2118719900"],"abstract_inverted_index":{"We":[0],"have":[1],"examined":[2],"the":[3,31,56,78,86,89,93,97,112,123,130,134,148,151,159,162],"modulation":[4],"of":[5,33,45,52,69,77,80,99,125,156],"cloned":[6],"and":[7,92,153],"stably":[8],"expressed":[9],"rat":[10],"brain":[11],"N":[12,38,61],"type":[13,39,62],"calcium":[14],"channels":[15,40],"(alpha1B":[16],"+":[17,19],"beta1b":[18],"alpha2delta":[20],"subunits)":[21],"by":[22,43,73],"exogenously":[23],"applied":[24],"purified":[25,53],"G":[26],"protein":[27],"betagamma":[28],"subunits.":[29],"In":[30,49],"absence":[32],"Gbetagamma,":[34,120],"barium":[35],"currents":[36,63],"through":[37],"are":[41,136],"unaffected":[42],"application":[44,68],"strong":[46],"depolarizing":[47],"prepulses.":[48],"contrast,":[50],"inclusion":[51],"Gbetagamma":[54,131,144,157],"in":[55,60,103],"patch":[57],"pipette":[58],"results":[59],"that":[64,84,122,154],"initially":[65],"facilitated":[66],"upon":[67],"positive":[70],"prepulses":[71],"followed":[72],"rapid":[74],"reinhibition.":[75],"Examination":[76],"kinetics":[79],"Gbetagamma-dependent":[81],"reinhibition":[82],"showed":[83],"as":[85,165],"duration":[87],"between":[88],"test":[90],"pulse":[91],"prepulse":[94,163],"was":[95,101,116],"increased,":[96],"degree":[98],"facilitation":[100,115],"attenuated":[102],"a":[104,139,142,166],"monoexponential":[105],"fashion.":[106],"The":[107],"time":[108],"constant":[109],"tau":[110,126],"for":[111],"recovery":[113],"from":[114,147],"sensitive":[117],"to":[118],"exogenous":[119],"so":[121],"inverse":[124],"linearly":[127],"depended":[128],"on":[129],"concentration.":[132],"Overall,":[133],"data":[135],"consistent":[137],"with":[138,158],"model":[140],"whereby":[141],"single":[143],"molecule":[145],"dissociates":[146],"channel":[149,160],"during":[150],"prepulse,":[152],"reassociation":[155],"after":[161],"occurs":[164],"bimolecular":[167],"reaction.":[168]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
