{"id":"https://openalex.org/W2108616342","doi":null,"title":"Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7.","display_name":"Modulator inhibits nuclear translocation of the glucocorticoid receptor and inhibits glucocorticoid-induced apoptosis in the human leukemic cell line CEM C-7.","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2108616342","mag":"2108616342","pmid":"https://pubmed.ncbi.nlm.nih.gov/7834624"},"language":"en","primary_location":{"id":"pmid:7834624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108204715","display_name":"Noreen M. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N M Robertson","raw_affiliation_strings":["Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021968564","display_name":"Peter V.N. Bodine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P V Bodine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114191301","display_name":"T. C. Hs\u00fc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T C Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077708146","display_name":"Emad S. Alnemri","orcid":"https://orcid.org/0000-0002-7295-3383","observed_orcids":["https://orcid.org/0000-0002-7295-3383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E S Alnemri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814155","display_name":"Gerald Litwack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Litwack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4551,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.82535113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"55","issue":"3","first_page":"548","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/modulators","display_name":"modulators","score":0.9610000252723694},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/nuclear-translocation","display_name":"nuclear translocation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/glucocorticoid-induced-apoptosis","display_name":"glucocorticoid-induced apoptosis","score":0.9459999799728394},{"id":"https://openalex.org/keywords/leukemia-cells","display_name":"leukemia cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.75},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.5849999785423279},{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.8397270441055298},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.7922385931015015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5503926277160645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5502554774284363},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5311901569366455},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.48160168528556824},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.47537270188331604},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4388807713985443},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34339743852615356},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.31044304370880127},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26545125246047974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17141160368919373},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14273619651794434}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002482","descriptor_name":"Cellulose","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011965","descriptor_name":"Receptors, Glucocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014222","descriptor_name":"Triamcinolone Acetonide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014222","descriptor_name":"Triamcinolone Acetonide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7834624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2108616342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7834624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G537852018","display_name":"MINERALOCORTICOID RECEPTOR","funder_award_id":"5r01dk044441-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6615040380","display_name":"MODULATOR AND THE GLUCOCORTICOID RECEPTOR","funder_award_id":"5r01dk042353-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":63,"referenced_works":["https://openalex.org/W272039099","https://openalex.org/W1501075384","https://openalex.org/W1505264709","https://openalex.org/W1514235376","https://openalex.org/W1516283219","https://openalex.org/W1527910889","https://openalex.org/W1528393588","https://openalex.org/W1530952467","https://openalex.org/W1538236582","https://openalex.org/W1539661677","https://openalex.org/W1559184092","https://openalex.org/W1563644794","https://openalex.org/W1572717394","https://openalex.org/W1582630245","https://openalex.org/W1586414377","https://openalex.org/W1589415602","https://openalex.org/W1589570574","https://openalex.org/W1606548047","https://openalex.org/W1614756392","https://openalex.org/W1639558802","https://openalex.org/W1677984464","https://openalex.org/W1858972768","https://openalex.org/W1909751364","https://openalex.org/W1960503626","https://openalex.org/W1970782117","https://openalex.org/W1974391793","https://openalex.org/W1983162387","https://openalex.org/W1986094270","https://openalex.org/W1993423492","https://openalex.org/W1993809880","https://openalex.org/W1996835243","https://openalex.org/W2004977301","https://openalex.org/W2006369884","https://openalex.org/W2007093129","https://openalex.org/W2011272696","https://openalex.org/W2015005447","https://openalex.org/W2015646187","https://openalex.org/W2030560188","https://openalex.org/W2031564739","https://openalex.org/W2032657465","https://openalex.org/W2033501768","https://openalex.org/W2052853635","https://openalex.org/W2073911512","https://openalex.org/W2081310660","https://openalex.org/W2082067901","https://openalex.org/W2082339677","https://openalex.org/W2084609653","https://openalex.org/W2085124463","https://openalex.org/W2085213714","https://openalex.org/W2087904214","https://openalex.org/W2109133792","https://openalex.org/W2110410009","https://openalex.org/W2129872577","https://openalex.org/W2134399858","https://openalex.org/W2134812217","https://openalex.org/W2137644304","https://openalex.org/W2143417663","https://openalex.org/W2146604249","https://openalex.org/W2161073441","https://openalex.org/W2208707498","https://openalex.org/W2233071446","https://openalex.org/W2342073136","https://openalex.org/W2411550314"],"related_works":["https://openalex.org/W7099575366","https://openalex.org/W1517353469","https://openalex.org/W2169756957","https://openalex.org/W2001040568","https://openalex.org/W50064993","https://openalex.org/W1563644794","https://openalex.org/W2090137967","https://openalex.org/W2417782248","https://openalex.org/W2001744408","https://openalex.org/W2012147548"],"abstract_inverted_index":{"Modulator":[0,108],"is":[1,29],"an":[2],"endogenous":[3],"low-molecular-weight":[4],"regulator":[5],"of":[6,20,61,88,142,155],"both":[7],"glucocorticoid":[8,44,115],"and":[9,85,100,114],"mineralocorticoid":[10],"receptors":[11],"as":[12,14,49,71,132,134,157,159],"well":[13,133,158],"protein":[15],"kinase":[16],"C.":[17],"Structural":[18],"analysis":[19],"modulator":[21,40,56,123,148,156],"purified":[22],"to":[23,125],"apparent":[24],"homogeneity":[25],"suggests":[26],"that":[27,39,79,122],"it":[28],"a":[30],"novel":[31],"ether":[32],"aminophosphoglyceride.":[33],"In":[34,54,138],"this":[35],"report,":[36],"we":[37,77],"show":[38],"inhibits":[41,90,109],"cytosolic":[42,136],"human":[43,66],"receptor":[45,116],"(GR)":[46],"complex":[47],"activation":[48,84],"measured":[50],"by":[51,73,81,94,147,163],"DNA-cellulose":[52],"binding.":[53],"addition,":[55,139],"blocks":[57],"glucocorticoid-induced":[58,110,143],"nuclear":[59],"translocation":[60,87],"the":[62,83,127,140,152,161],"GR":[63,128],"in":[64,103,129,135,167],"intact":[65,130],"leukemic":[67],"(CEM":[68],"C-7)":[69],"cells,":[70],"illustrated":[72],"immunocytochemical":[74],"localization.":[75],"Furthermore,":[76],"demonstrate":[78],"modulator,":[80],"blocking":[82],"subsequent":[86],"GR,":[89],"glucocorticoid-mediated":[91],"apoptosis,":[92],"characterized":[93],"chromatin":[95],"condensation,":[96],"internucleosomal":[97],"DNA":[98],"fragmentation,":[99],"cell":[101,145],"death":[102,146],"glucocorticoid-sensitive":[104],"CEM":[105,168],"C-7":[106,169],"cells.":[107,170],"c-myc":[111],"gene":[112,117],"repression":[113],"up-regulation.":[118],"These":[119],"data":[120],"suggest":[121],"functions":[124],"regulate":[126],"cells":[131],"preparations.":[137],"inhibition":[141],"programmed":[144],"sheds":[149],"light":[150],"on":[151,160],"cellular":[153],"function":[154],"mechanism":[162],"which":[164],"apoptosis":[165],"occurs":[166]},"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
