{"id":"https://openalex.org/W2108587285","doi":"https://doi.org/10.2174/1381612033391928","title":"Multicenter Randomized Controlled Trial for the Treatment of Ulcerative Colitis with a Leukocytapheresis Column","display_name":"Multicenter Randomized Controlled Trial for the Treatment of Ulcerative Colitis with a Leukocytapheresis Column","publication_year":2003,"publication_date":"2003-02-01","ids":{"openalex":"https://openalex.org/W2108587285","doi":"https://doi.org/10.2174/1381612033391928","mag":"2108587285","pmid":"https://pubmed.ncbi.nlm.nih.gov/12570823"},"language":"en","primary_location":{"id":"doi:10.2174/1381612033391928","doi":"https://doi.org/10.2174/1381612033391928","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612033391928","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042956748","display_name":"Koji Sawada","orcid":"https://orcid.org/0000-0002-9708-4786","observed_orcids":["https://orcid.org/0000-0002-9708-4786"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Sawada","raw_affiliation_strings":["Dept of Gastroenterology, Hyogo College of Medicine, Nishinomiya, Tokyo, Japan. sawadako@hyo-med.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Gastroenterology, Hyogo College of Medicine, Nishinomiya, Tokyo, Japan. sawadako@hyo-med.ac.jp","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066926591","display_name":"Tetsuichiro Muto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsuichiro Muto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109498875","display_name":"Takashi Shimoyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi Shimoyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060419971","display_name":"Masamichi Satomi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masamichi Satomi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112642590","display_name":"Toshio Sawada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshio Sawada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059967481","display_name":"Hirokazu Nagawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirokazu Nagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034905709","display_name":"Nobuo Hiwatashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuo Hiwatashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109508065","display_name":"Hitoshi Asakura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hitoshi Asakura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5026205612","display_name":"Toshifumi Hibi\u2225","orcid":"https://orcid.org/0000-0002-6256-1204","observed_orcids":["https://orcid.org/0000-0002-6256-1204"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshifumi Hibi","raw_affiliation_strings":["Dept. of Gastroenterology, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo, 663-8501 Japan,Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Gastroenterology, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo, 663-8501 Japan,Japan","institution_ids":["https://openalex.org/I137459256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026205612"],"corresponding_institution_ids":["https://openalex.org/I137459256"],"apc_list":null,"apc_paid":null,"fwci":12.6772,"has_fulltext":false,"cited_by_count":173,"citation_normalized_percentile":{"value":0.98871574,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"9","issue":"4","first_page":"307","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11865","display_name":"Anorectal Disease Treatments and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":1.0},{"id":"https://openalex.org/keywords/leukapheresis","display_name":"leukapheresis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/high-dose-prednisolone","display_name":"high-dose prednisolone","score":0.9269999861717224},{"id":"https://openalex.org/keywords/steroid-sparing-therapy","display_name":"steroid-sparing therapy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.5049999952316284},{"id":"https://openalex.org/keywords/endoscopic-disease-activity","display_name":"endoscopic activity","score":0.593999981880188},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.6990000009536743},{"id":"https://openalex.org/keywords/intensive-therapy","display_name":"intensive treatment","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7925704121589661},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7391698360443115},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.717228353023529},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6116282343864441},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.560212254524231},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.5420412421226501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5212507843971252},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4702174663543701},{"id":"https://openalex.org/C2775965419","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter trial","level":4,"score":0.453098326921463},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4451962113380432},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.43008026480674744},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4156917631626129},{"id":"https://openalex.org/C2992435398","wikidata":"https://www.wikidata.org/wiki/Q6934595","display_name":"Multicenter study","level":3,"score":0.23454052209854126},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1269402801990509},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003093","descriptor_name":"Colitis, Ulcerative","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007937","descriptor_name":"Leukapheresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007937","descriptor_name":"Leukapheresis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011239","descriptor_name":"Prednisolone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/1381612033391928","doi":"https://doi.org/10.2174/1381612033391928","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1381612033391928","pdf_url":null,"source":{"id":"https://openalex.org/S55674637","display_name":"Current Pharmaceutical Design","issn_l":"1381-6128","issn":["1381-6128","1873-4286"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Design","raw_type":"journal-article"},{"id":"pmid:12570823","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12570823","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical design","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322832","display_name":"University of Tokyo","ror":"https://ror.org/057zh3y96"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2147574498","https://openalex.org/W2055974053","https://openalex.org/W2032928925","https://openalex.org/W2319865298","https://openalex.org/W2994722268","https://openalex.org/W2076558547","https://openalex.org/W2288532955","https://openalex.org/W2031221397","https://openalex.org/W2006281660","https://openalex.org/W2040929713"],"abstract_inverted_index":{"The":[0,52,157,179,217],"administration":[1,241],"of":[2,11,57,71,172,219],"steroids":[3,102],"is":[4,35,233],"not":[5,106],"always":[6],"effective":[7,235],"for":[8,87,141,149,187,242],"the":[9,45,80,97,124,185,192,196,206,213,220],"treatment":[10,34],"ulcerative":[12],"colitis":[13],"(UC).":[14],"Their":[15],"long-term":[16],"use":[17],"often":[18],"causes":[19],"adverse":[20,55,173],"effects":[21,56,174],"which":[22],"sometimes":[23],"result":[24],"in":[25,37,63,76,191,228],"their":[26],"stoppage":[27],"and":[28,43,54,108,144,152,169,202,232,236,245],"acute":[29],"exacerbation.":[30],"Therefore,":[31],"an":[32,91],"alternative":[33],"necessary":[36],"order":[38],"to":[39,96,114,183],"decrease":[40],"steroid":[41],"dosage":[42,231],"avoid":[44],"clinical":[46],"problems":[47],"associated":[48],"with":[49,68],"steroids.":[50],"Methods":[51],"effectiveness":[53,164],"a":[58,64,120,161,188,226],"leukocytapheresis":[59],"(LCAP)":[60],"were":[61,103,181],"investigated":[62],"controlled":[65],"multicenter":[66],"trial":[67,186,221],"randomized":[69],"assignment":[70],"76":[72],"active-stage":[73],"UC":[74],"patients":[75,151,180],"two":[77],"groups.":[78],"In":[79,123],"LCAP":[81,85,110,158,193,207,224,246],"group":[82,129,159,194,198,208],"(39":[83],"patients),":[84,131],"weekly":[86],"5":[88],"weeks":[89,118],"as":[90,119],"intensive":[92,243],"therapy":[93],"was":[94,111,133],"added":[95,134],"on-going":[98],"drug":[99],"therapy,":[100,244],"while":[101],"maintained":[104],"but":[105],"increased,":[107],"then":[109,153],"gradually":[112,154],"reduced":[113],"once":[115],"every":[116],"4":[117],"maintenance":[121],"therapy.":[122],"high":[125],"dose":[126],"prednisolone":[127],"(h-PSL)":[128],"(37":[130],"PSL":[132,230,240],"or":[135],"increased":[136],"30":[137],"approximately":[138,146],"40":[139],"mg/day":[140,148],"moderately":[142],"severe":[143,150],"60":[145],"80":[147],"tapered.":[155],"Findings":[156],"showed":[160,205],"significantly":[162],"higher":[163],"(74%":[165],"vs.":[166,176],"38%;":[167],"p=0.005)":[168],"lower":[170],"incidence":[171],"(24%":[175],"68%;":[177],"p<0.001).":[178],"able":[182],"continue":[184],"longer":[189,250],"period":[190],"than":[195,212,238,251],"h-PSL":[197,214],"(p=0.012).":[199],"Clinical":[200],"activity":[201],"endoscopic":[203],"indexes":[204],"had":[209],"better":[210],"improvements":[211],"group.":[215],"Interpretation":[216],"results":[218],"show":[222],"that":[223],"permits":[225],"reduction":[227],"total":[229],"more":[234],"safer":[237],"high-dose":[239],"may":[247],"maintain":[248],"remission":[249],"PSL.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}