{"id":"https://openalex.org/W2108514533","doi":"https://doi.org/10.2174/092986707781696555","title":"Serum Cystatin C-A Useful Endogenous Marker of Renal Function in Intensive Care Unit Patients at Risk for or with Acute Renal Failure?","display_name":"Serum Cystatin C-A Useful Endogenous Marker of Renal Function in Intensive Care Unit Patients at Risk for or with Acute Renal Failure?","publication_year":2007,"publication_date":"2007-08-29","ids":{"openalex":"https://openalex.org/W2108514533","doi":"https://doi.org/10.2174/092986707781696555","mag":"2108514533","pmid":"https://pubmed.ncbi.nlm.nih.gov/17896979"},"language":"en","primary_location":{"id":"doi:10.2174/092986707781696555","doi":"https://doi.org/10.2174/092986707781696555","is_oa":false,"landing_page_url":"https://doi.org/10.2174/092986707781696555","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044887807","display_name":"Annick A. N. M. Royakkers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Annick A. Royakkers","raw_affiliation_strings":["Department of Intensive Care, Tergooi Hospitals, location Blaricum, Rijksstraatweg 1, 1261 AN Blaricum, the Netherlands. aroyakkers@gooi-noord.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Tergooi Hospitals, location Blaricum, Rijksstraatweg 1, 1261 AN Blaricum, the Netherlands. aroyakkers@gooi-noord.nl","institution_ids":["https://openalex.org/I4210147058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110285227","display_name":"Jeroen D.E. van Suijlen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeroen van Suijlen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019178370","display_name":"Lieuwe S. Hofstra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lieuwe Hofstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066083330","display_name":"Michael A. Kuiper","orcid":"https://orcid.org/0000-0001-6201-7332","observed_orcids":["https://orcid.org/0000-0001-6201-7332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Kuiper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024748941","display_name":"Catherine S. C. Bouman","orcid":"https://orcid.org/0000-0003-1322-2190","observed_orcids":["https://orcid.org/0000-0003-1322-2190"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Bouman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059033441","display_name":"Peter E. Spronk","orcid":"https://orcid.org/0000-0003-3319-8706","observed_orcids":["https://orcid.org/0000-0003-3319-8706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Spronk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013315693","display_name":"Marcus Josephus Schultz","orcid":"https://orcid.org/0000-0003-3969-7792","observed_orcids":["https://orcid.org/0000-0003-3969-7792","https://orcid.org/0000-0002-4821-9955"]},"institutions":[{"id":"https://openalex.org/I4210147058","display_name":"Tergooi","ror":"https://ror.org/045nawc23","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210147058"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marcus Schultz","raw_affiliation_strings":["Department of Intensive Care, Tergooi Hospitals, location Blaricum, Rijksstraatweg 1, 1261 AN Blaricum, the Netherlands.,Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Tergooi Hospitals, location Blaricum, Rijksstraatweg 1, 1261 AN Blaricum, the Netherlands.,Netherlands","institution_ids":["https://openalex.org/I4210147058"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013315693"],"corresponding_institution_ids":["https://openalex.org/I4210147058"],"apc_list":null,"apc_paid":null,"fwci":2.1475,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.87584083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"14","issue":"21","first_page":"2314","last_page":"2317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.9890000224113464},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9350000023841858},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.9179999828338623},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.9419999718666077},{"id":"https://openalex.org/keywords/continuous-renal-replacement-therapy","display_name":"continuous renal replacement therapy","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glomerular-filtration-rate","display_name":"glomerular filtration rate","score":0.878000020980835},{"id":"https://openalex.org/keywords/early-detection-of-renal-dysfunction","display_name":"early detection of renal dysfunction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/renal-recovery","display_name":"renal function recovery","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.925225555896759},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.8347834348678589},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.8152204155921936},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8035329580307007},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.7503193020820618},{"id":"https://openalex.org/C2780412452","wikidata":"https://www.wikidata.org/wiki/Q4505907","display_name":"Cystatin","level":4,"score":0.6119387745857239},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.60003662109375},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.5486940145492554},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.47098657488822937},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.4385543465614319},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.4367668032646179},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.4364836513996124},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.42560523748397827},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42412269115448}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015891","descriptor_name":"Cystatins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015891","descriptor_name":"Cystatins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055316","descriptor_name":"Cystatin C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/092986707781696555","doi":"https://doi.org/10.2174/092986707781696555","is_oa":false,"landing_page_url":"https://doi.org/10.2174/092986707781696555","pdf_url":null,"source":{"id":"https://openalex.org/S33159018","display_name":"Current Medicinal Chemistry","issn_l":"0929-8673","issn":["0929-8673","1875-533X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:17896979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17896979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/4a154ae8-c9f6-4664-90b1-970a5cc21880","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/serum-cystatin-ca-useful-endogenous-marker-of-renal-function-in-intensive-care-unit-patients-at-risk-for-or-with-acute-renal-failure(4a154ae8-c9f6-4664-90b1-970a5cc21880).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current medicinal chemistry, 14(21), 2314 - 2317. Bentham Science Publishers B.V.","raw_type":"info:eu-repo/semantics/other"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/2b1ab568-07e0-4394-bfa0-925fbe84eb51","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/2b1ab568-07e0-4394-bfa0-925fbe84eb51","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Royakkers, A A N M, van Suijlen, J D E, Hofstra, L S, Kuiper, M A, Bouman, C S C, Spronk, P E & Schultz, M J 2007, 'Serum cystatin C-A useful endogenous marker of renal function in intensive care unit patients at risk for or with acute renal failure?', Current medicinal chemistry, vol. 14, no. 21, pp. 2314-2317. https://doi.org/10.2174/092986707781696555","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970951370","https://openalex.org/W1600729955","https://openalex.org/W1518004885","https://openalex.org/W1984305980","https://openalex.org/W2090137005","https://openalex.org/W2489132413","https://openalex.org/W3166927573","https://openalex.org/W1508934959","https://openalex.org/W2183150468","https://openalex.org/W2393100140"],"abstract_inverted_index":{"Critically":[0],"ill":[1,163,215],"patients":[2],"are":[3,97,109,219],"at":[4],"high":[5],"risk":[6],"for":[7,136,156],"developing":[8],"acute":[9],"renal":[10,44,57,65,102,121,134,157,175,202,207],"failure":[11],"(ARF).":[12],"The":[13,59],"prevention":[14],"of":[15,18,37,52,61,64,118,120,133,151,222],"ARF":[16],"is":[17,35,67,182],"outmost":[19],"importance":[20],"in":[21,84,189,212,220],"order":[22],"to":[23,54,172,174,185,199,205],"improve":[24],"the":[25,85,90,112,146,149,161,213],"increased":[26],"morbidity":[27],"and":[28,74,94,177,204],"mortality":[29],"associated":[30],"with":[31],"ARF.":[32],"Unfortunately,":[33],"there":[34],"lack":[36],"adequate":[38],"endogenous":[39,93,131],"markers":[40,63,96,108],"that":[41,179],"can":[42,76],"identify":[43,206],"dysfunction":[45,203],"early":[46,116,201],"-":[47],"this":[48,142],"hampers":[49],"timely":[50],"application":[51],"measures":[53],"prevent":[55],"further":[56],"damage.":[58],"use":[60],"exogenous":[62,95],"function":[66,135],"not":[68,77,98],"only":[69],"time-consuming":[70],"but":[71],"also":[72],"expensive,":[73],"therefore":[75],"be":[78,194],"used":[79,92],"on":[80,148,160,210],"a":[81],"regular":[82],"basis":[83],"intensive":[86],"care":[87],"unit.":[88],"Both":[89],"presently":[91],"reliable":[99],"during":[100],"continuous":[101],"replacement":[103],"therapy":[104,113],"(CRRT)":[105],"because":[106],"these":[107],"removed":[110],"by":[111],"itself":[114],"impeding":[115],"detection":[117],"recovering":[119],"function.":[122],"Cystatin":[123,191],"C":[124,153,167,181,192],"has":[125],"been":[126,170],"proposed":[127],"as":[128,154],"an":[129,195],"alternative":[130],"marker":[132,155],"more":[137,183,223],"than":[138],"15":[139],"years.":[140],"In":[141],"manuscript":[143],"we":[144,218],"review":[145],"literature":[147],"role":[150],"cystatin":[152,166,180],"function,":[158],"focusing":[159],"critically":[162,214],"patient.":[164],"Serum":[165],"concentrations":[168],"have":[169],"found":[171],"relate":[173],"impairment":[176],"suggest":[178],"sensitive":[184],"detect":[186],"mild":[187],"decreases":[188],"GFR.":[190],"could":[193],"important":[196],"tool":[197],"both":[198],"recognize":[200],"recovery":[208],"while":[209],"CRRT":[211],"patient,":[216],"however,":[217],"need":[221],"studies.":[224]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}