{"id":"https://openalex.org/W2108470302","doi":"https://doi.org/10.1093/icb/icq094","title":"A Network Perspective on Metabolism and Aging","display_name":"A Network Perspective on Metabolism and Aging","publication_year":2010,"publication_date":"2010-07-12","ids":{"openalex":"https://openalex.org/W2108470302","doi":"https://doi.org/10.1093/icb/icq094","mag":"2108470302","pmid":"https://pubmed.ncbi.nlm.nih.gov/21031036","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2965189"},"language":"en","primary_location":{"id":"doi:10.1093/icb/icq094","doi":"https://doi.org/10.1093/icb/icq094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/icb/icq094","pdf_url":"https://academic.oup.com/icb/article-pdf/50/5/844/1804150/icq094.pdf","source":{"id":"https://openalex.org/S103356783","display_name":"Integrative and Comparative Biology","issn_l":"1540-7063","issn":["1540-7063","1557-7023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrative and Comparative Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/icb/article-pdf/50/5/844/1804150/icq094.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087949227","display_name":"Quinlyn A. Soltow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Q. A. Soltow","raw_affiliation_strings":["Department of Medicine, Emory University, Atlanta, GA 30322, USA. promislow@uga.edu","**Department of Medicine, Emory University, Atlanta, GA 30322, USA","\u2020Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Emory University, Atlanta, GA 30322, USA. promislow@uga.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"**Department of Medicine, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"\u2020Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035904189","display_name":"Dean P. Jones","orcid":"https://orcid.org/0000-0002-2090-0677","observed_orcids":["https://orcid.org/0000-0002-2090-0677"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. P. Jones","raw_affiliation_strings":["Department of Medicine, Emory University, Atlanta, GA 30322, USA; \u2020 Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA","**Department of Medicine, Emory University, Atlanta, GA 30322, USA","\u2020Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Emory University, Atlanta, GA 30322, USA; \u2020 Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA","institution_ids":["https://openalex.org/I150468666","https://openalex.org/I165733156"]},{"raw_affiliation_string":"**Department of Medicine, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"\u2020Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002183519","display_name":"Daniel Promislow","orcid":"https://orcid.org/0000-0001-7088-4495","observed_orcids":["https://orcid.org/0000-0001-7088-4495"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. E. L. Promislow","raw_affiliation_strings":["\u2020Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA","Seattle , Washington","**Department of Medicine, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Department of Genetics, University of Georgia, Athens, Georgia, 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Seattle , Washington","institution_ids":[]},{"raw_affiliation_string":"**Department of Medicine, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002183519"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I165733156"],"apc_list":{"value":4243,"currency":"USD","value_usd":4243},"apc_paid":null,"fwci":0.6007,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.50312283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"50","issue":"5","first_page":"844","last_page":"854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.7172999978065491,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.241799995303154,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.949999988079071},{"id":"https://openalex.org/keywords/metabolism","display_name":"metabolism","score":0.9909999966621399},{"id":"https://openalex.org/keywords/metabolic-networks","display_name":"metabolic networks","score":0.8130000233650208},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.7149999737739563},{"id":"https://openalex.org/keywords/network-analysis","display_name":"network analysis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/gene-expression-networks","display_name":"gene expression networks","score":0.7570000290870667},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.9660000205039978},{"id":"https://openalex.org/keywords/theories-of-aging","display_name":"theories of aging","score":0.6679999828338623},{"id":"https://openalex.org/keywords/age-related-decline","display_name":"age-related decline","score":0.6029999852180481},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6795065402984619},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6498618721961975},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6151894330978394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5961886644363403},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.5452159643173218},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5358961820602417},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.48651236295700073},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4754069447517395},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4605812728404999},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4591291844844818},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4481012523174286},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3378244936466217},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.322922021150589},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22263512015342712},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21974733471870422},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13887056708335876},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.1290900707244873}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/icb/icq094","doi":"https://doi.org/10.1093/icb/icq094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/icb/icq094","pdf_url":"https://academic.oup.com/icb/article-pdf/50/5/844/1804150/icq094.pdf","source":{"id":"https://openalex.org/S103356783","display_name":"Integrative and Comparative Biology","issn_l":"1540-7063","issn":["1540-7063","1557-7023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrative and Comparative Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2965189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2965189","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integr Comp Biol","raw_type":"Text"},{"id":"pmid:21031036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21031036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrative and comparative biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.714.1876","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.714.1876","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.promislowlab.org/reprints/SoltowICB.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1093/icb/icq094","doi":"https://doi.org/10.1093/icb/icq094","is_oa":true,"landing_page_url":"https://doi.org/10.1093/icb/icq094","pdf_url":"https://academic.oup.com/icb/article-pdf/50/5/844/1804150/icq094.pdf","source":{"id":"https://openalex.org/S103356783","display_name":"Integrative and Comparative Biology","issn_l":"1540-7063","issn":["1540-7063","1557-7023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Integrative and Comparative Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6352031883","display_name":"Emory Parkinson's Disease Collaborative Environmental Research Center","funder_award_id":"P01ES016731","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000912079","display_name":"Graduate and Postdoctoral Training in Environmental Health Science and Toxicology","funder_award_id":"T32ES012870","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108470302.pdf","grobid_xml":"https://content.openalex.org/works/W2108470302.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W174222763","https://openalex.org/W1497450746","https://openalex.org/W1513767024","https://openalex.org/W1561767438","https://openalex.org/W1573602524","https://openalex.org/W1623155147","https://openalex.org/W1644749979","https://openalex.org/W1914762032","https://openalex.org/W1964622469","https://openalex.org/W1969753425","https://openalex.org/W1969889522","https://openalex.org/W1971421925","https://openalex.org/W1974632191","https://openalex.org/W1974777883","https://openalex.org/W1981913094","https://openalex.org/W1983113601","https://openalex.org/W1983202741","https://openalex.org/W1984101451","https://openalex.org/W1985966076","https://openalex.org/W1986920971","https://openalex.org/W2001054969","https://openalex.org/W2002203210","https://openalex.org/W2006710737","https://openalex.org/W2009291602","https://openalex.org/W2013946586","https://openalex.org/W2014698799","https://openalex.org/W2015607124","https://openalex.org/W2015776405","https://openalex.org/W2015953751","https://openalex.org/W2018045523","https://openalex.org/W2018698085","https://openalex.org/W2021727217","https://openalex.org/W2023446807","https://openalex.org/W2029158589","https://openalex.org/W2032254348","https://openalex.org/W2034873249","https://openalex.org/W2035530476","https://openalex.org/W2052017338","https://openalex.org/W2053089067","https://openalex.org/W2053385401","https://openalex.org/W2056595894","https://openalex.org/W2060915805","https://openalex.org/W2062776142","https://openalex.org/W2065769502","https://openalex.org/W2069049877","https://openalex.org/W2074280444","https://openalex.org/W2076710572","https://openalex.org/W2084703853","https://openalex.org/W2084833542","https://openalex.org/W2091546930","https://openalex.org/W2096554020","https://openalex.org/W2097805330","https://openalex.org/W2099665470","https://openalex.org/W2101501829","https://openalex.org/W2102225814","https://openalex.org/W2102732029","https://openalex.org/W2104828064","https://openalex.org/W2109278577","https://openalex.org/W2110699703","https://openalex.org/W2113654344","https://openalex.org/W2114390083","https://openalex.org/W2114518254","https://openalex.org/W2115935479","https://openalex.org/W2120782532","https://openalex.org/W2121477676","https://openalex.org/W2130319566","https://openalex.org/W2130382164","https://openalex.org/W2130727648","https://openalex.org/W2130790725","https://openalex.org/W2134800568","https://openalex.org/W2138649409","https://openalex.org/W2142075099","https://openalex.org/W2142411278","https://openalex.org/W2144885342","https://openalex.org/W2148606196","https://openalex.org/W2152027317","https://openalex.org/W2156182405","https://openalex.org/W2156499012","https://openalex.org/W2163043810","https://openalex.org/W2163219351","https://openalex.org/W2163480486","https://openalex.org/W2167190345","https://openalex.org/W2171282332","https://openalex.org/W2219872050","https://openalex.org/W2490156446","https://openalex.org/W2952078448","https://openalex.org/W3103071483","https://openalex.org/W4244086115","https://openalex.org/W4256140420"],"related_works":["https://openalex.org/W7097281463","https://openalex.org/W3045189572","https://openalex.org/W2130861466","https://openalex.org/W3145682598","https://openalex.org/W2994725613","https://openalex.org/W3192088386","https://openalex.org/W4386253238","https://openalex.org/W2489856836","https://openalex.org/W4307553471","https://openalex.org/W4309094756"],"abstract_inverted_index":{"Aging":[0],"affects":[1],"a":[2,32],"myriad":[3],"of":[4,18,26,66,79,91,108,117,134,147,164,168],"genetic,":[5],"biochemical,":[6],"and":[7,10,63,69,81,100,110,139,145,167],"metabolic":[8,92],"processes,":[9],"efforts":[11],"to":[12,40,94,130,170],"understand":[13],"the":[14,24,27,42,77,89,96,105,128,148],"underlying":[15],"molecular":[16],"basis":[17],"aging":[19,28,149],"are":[20,159],"often":[21],"thwarted":[22],"by":[23],"complexity":[25],"process.":[29],"By":[30],"taking":[31],"systems":[33],"biology":[34],"approach,":[35],"network":[36,82,124,153],"analysis":[37,49],"is":[38,104],"well-suited":[39],"study":[41],"decline":[43],"in":[44,54,114,156],"function":[45,146,171],"with":[46,122,137,172],"age.":[47,173],"Network":[48],"has":[50,111],"already":[51],"been":[52,112],"utilized":[53],"describing":[55],"other":[56],"complex":[57],"processes":[58],"such":[59],"as":[60],"development,":[61],"evolution,":[62],"robustness.":[64],"Networks":[65],"gene":[67],"expression":[68],"protein-protein":[70],"interaction":[71],"have":[72],"provided":[73],"valuable":[74],"insight":[75],"into":[76],"loss":[78],"connectivity":[80],"structure":[83],"throughout":[84],"lifespan.":[85],"Here,":[86],"we":[87],"advocate":[88],"use":[90],"networks":[93],"expand":[95],"work":[97],"from":[98],"genomics":[99],"proteomics.":[101],"As":[102],"metabolism":[103],"final":[106],"fingerprint":[107],"functionality":[109],"implicated":[113],"multiple":[115],"theories":[116],"aging,":[118],"metabolomic":[119,152],"methods":[120],"combined":[121],"metabolite":[123],"analyses":[125],"should":[126],"pave":[127],"way":[129],"investigate":[131],"how":[132,140],"relationships":[133],"metabolites":[135],"change":[136],"age":[138],"these":[141],"interactions":[142],"affect":[143],"phenotype":[144],"individual.":[150],"The":[151],"approaches":[154],"highlighted":[155],"this":[157],"review":[158],"fundamental":[160],"for":[161],"an":[162],"understanding":[163],"systematic":[165],"declines":[166],"failure":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}