{"id":"https://openalex.org/W2108417784","doi":null,"title":"Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells.","display_name":"Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells.","publication_year":2003,"publication_date":"2003-11-01","ids":{"openalex":"https://openalex.org/W2108417784","mag":"2108417784","pmid":"https://pubmed.ncbi.nlm.nih.gov/14612511"},"language":"en","primary_location":{"id":"pmid:14612511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14612511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073264275","display_name":"Michael Allen Sheard","orcid":"https://orcid.org/0000-0002-4960-7650","observed_orcids":["https://orcid.org/0000-0002-4960-7650"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michael A Sheard","raw_affiliation_strings":["Laboratory of Apoptosis Research, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic. msheard@chla.usc.edu","Laboratory of Apoptosis Research, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Apoptosis Research, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic. msheard@chla.usc.edu","institution_ids":["https://openalex.org/I4210115043"]},{"raw_affiliation_string":"Laboratory of Apoptosis Research, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059927382","display_name":"Stjepan Uldrijan","orcid":"https://orcid.org/0000-0001-8316-2539","observed_orcids":["https://orcid.org/0000-0001-8316-2539"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Stjepan Uldrijan","raw_affiliation_strings":["Laboratory of Apoptosis Research [M. A. S.] and Laboratory of Tumor Biology [S. U., B. V.], Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Apoptosis Research [M. A. S.] and Laboratory of Tumor Biology [S. U., B. V.], Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017937179","display_name":"Bo\u0159ivoj Vojt\u011b\u0161ek","orcid":"https://orcid.org/0000-0001-6194-3705","observed_orcids":["https://orcid.org/0000-0001-6194-3705"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Borivoj Vojtesek","raw_affiliation_strings":["Laboratory of Apoptosis Research [M. A. S.] and Laboratory of Tumor Biology [S. U., B. V.], Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Apoptosis Research [M. A. S.] and Laboratory of Tumor Biology [S. U., B. V.], Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115043"],"apc_list":null,"apc_paid":null,"fwci":1.9999,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.85818157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"21","first_page":"7176","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.11739999800920486,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9610000252723694},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fas-apo-1","display_name":"Fas/APO-1","score":0.8330000042915344},{"id":"https://openalex.org/keywords/death-receptors","display_name":"death receptors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.8510000109672546},{"id":"https://openalex.org/keywords/p53-tumor-suppressor","display_name":"p53 tumor suppressor","score":0.7329999804496765},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7979999780654907},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/p53-knockout","display_name":"p53 knockout","score":0.6980000138282776},{"id":"https://openalex.org/keywords/p53-inhibitors","display_name":"p53 inhibitors","score":0.7149999737739563},{"id":"https://openalex.org/keywords/cell-type-specificity","display_name":"cell type specificity","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.7644838690757751},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5658659934997559},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5398669838905334},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5105410814285278},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5056784152984619},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4117482602596283},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3716282248497009},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3595264256000519},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0703045129776001}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:14612511","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14612511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2108417784","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14612511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W70287103","https://openalex.org/W1501273614","https://openalex.org/W1523845694","https://openalex.org/W1527393478","https://openalex.org/W1557111800","https://openalex.org/W1559658698","https://openalex.org/W1650797637","https://openalex.org/W1750740856","https://openalex.org/W1944130357","https://openalex.org/W1964165239","https://openalex.org/W1976153333","https://openalex.org/W1984696190","https://openalex.org/W1986932341","https://openalex.org/W1988756673","https://openalex.org/W1988769807","https://openalex.org/W1989864703","https://openalex.org/W1993331127","https://openalex.org/W2040881358","https://openalex.org/W2044524618","https://openalex.org/W2057658557","https://openalex.org/W2063669247","https://openalex.org/W2080125477","https://openalex.org/W2087768095","https://openalex.org/W2097810231","https://openalex.org/W2098458060","https://openalex.org/W2101456601","https://openalex.org/W2105571100","https://openalex.org/W2105789996","https://openalex.org/W2111714805","https://openalex.org/W2115310513","https://openalex.org/W2118480292","https://openalex.org/W2124052729","https://openalex.org/W2124380422","https://openalex.org/W2130521757","https://openalex.org/W2138179384","https://openalex.org/W2148200419","https://openalex.org/W2149287328","https://openalex.org/W2150183586","https://openalex.org/W2154063020","https://openalex.org/W2158938816","https://openalex.org/W2166899308","https://openalex.org/W2170523250","https://openalex.org/W2171458163","https://openalex.org/W2314477394","https://openalex.org/W2322112788","https://openalex.org/W2750896950"],"related_works":["https://openalex.org/W2148200419","https://openalex.org/W2090928782","https://openalex.org/W1966240117","https://openalex.org/W2022039464","https://openalex.org/W2038619560","https://openalex.org/W1979250727","https://openalex.org/W2118480292","https://openalex.org/W2162746990","https://openalex.org/W2105789996","https://openalex.org/W1989864703"],"abstract_inverted_index":{"The":[0],"p53":[1,86,103,138,181],"tumor":[2],"suppressor":[3],"protein":[4],"is":[5,40,50],"known":[6],"to":[7,46,73,126,158],"regulate":[8],"the":[9,12,109,123,155,199],"expression":[10,39,64,111,152,186],"of":[11,21,37,102,112,142,150,189,202,206],"CD95":[13,38,62,114,144,151,159,190,207],"(Fas/APO-1)":[14],"death":[15,49],"receptor":[16],"in":[17,28,67,118,162,167,183,191],"a":[18,99,176],"small":[19],"subset":[20],"normal":[22],"cell":[23,31,48,107,132,210],"types":[24],"as":[25,27,121],"well":[26],"many":[29],"cancer":[30],"types.":[32],"However,":[33],"whether":[34],"p53-dependent":[35],"regulation":[36],"consistently":[41],"associated":[42],"with":[43,84,95,136],"increased":[44],"susceptibility":[45],"CD95-mediated":[47],"poorly":[51],"understood.":[52],"To":[53],"address":[54],"this":[55],"issue,":[56],"we":[57],"examined":[58],"constitutive":[59,110,185],"and":[60,65,89,187],"induced":[61],"surface":[63,113,143],"function":[66,188],"wild-type":[68,137,180],"p53-expressing":[69],"carcinoma":[70,82,93,192],"cells":[71,83,94,97,135,164],"relative":[72],"their":[74,85],"isogenic":[75],"p53-inactivated":[76,119],"counterparts.":[77],"We":[78],"compared":[79],"HCT116":[80,168],"colorectal":[81],"biallelic":[87],"knock-outs":[88],"control-transfected":[90],"MCF-7":[91,96,163],"breast":[92],"expressing":[98],"miniprotein":[100],"inhibitor":[101],"(p53DD).":[104],"In":[105,130],"both":[106,131],"lines,":[108,133],"was":[115,122],"significantly":[116],"reduced":[117],"cells,":[120],"apoptotic":[124,156],"response":[125,157],"agonistic":[127],"anti-CD95":[128],"antibody.":[129],"only":[134,161],"activity":[139,182],"exhibited":[140],"up-regulation":[141,205],"after":[145],"ionizing":[146],"irradiation.":[147],"Interestingly,":[148],"induction":[149],"substantially":[153],"enhanced":[154],"ligation":[160],"but":[165],"not":[166],"cells.":[169],"These":[170],"findings":[171],"provide":[172],"direct":[173],"evidence":[174],"for":[175,179],"major":[177],"role":[178],"regulating":[184],"cells;":[193],"however,":[194],"they":[195],"also":[196],"demonstrate":[197],"that":[198],"functional":[200],"effect":[201],"DNA":[203],"damage-induced":[204],"may":[208],"be":[209],"type":[211],"specific.":[212]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
