{"id":"https://openalex.org/W2108352017","doi":"https://doi.org/10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","title":"Patterns of response to acute naloxone infusion in Tourette's syndrome","display_name":"Patterns of response to acute naloxone infusion in Tourette's syndrome","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2108352017","doi":"https://doi.org/10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","mag":"2108352017","pmid":"https://pubmed.ncbi.nlm.nih.gov/11104215"},"language":"en","primary_location":{"id":"doi:10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","doi":"https://doi.org/10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S163027424","display_name":"Movement Disorders","issn_l":"0885-3185","issn":["0885-3185","1531-8257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004194822","display_name":"Pieter Joost van Wattum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pieter Joost van Wattum","raw_affiliation_strings":["Child Study Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Study Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028985869","display_name":"Phillip B. Chappell","orcid":"https://orcid.org/0000-0001-5124-6236","observed_orcids":["https://orcid.org/0000-0001-5124-6236"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phillip B. Chappell","raw_affiliation_strings":["Child Study Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","Pfizer Inc., Central Research Division, Groton, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Study Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Pfizer Inc., Central Research Division, Groton, Connecticut, U.S.A","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031525441","display_name":"Daniel A. Zelterman","orcid":"https://orcid.org/0000-0003-0711-8688","observed_orcids":["https://orcid.org/0000-0003-0711-8688"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Zelterman","raw_affiliation_strings":["Yale School of Epidemiology and Public Health, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yale School of Epidemiology and Public Health, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072643268","display_name":"Lawrence David Scahill","orcid":"https://orcid.org/0000-0001-5073-1707","observed_orcids":["https://orcid.org/0000-0001-5073-1707"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence D. Scahill","raw_affiliation_strings":["Child Study Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Study Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029578725","display_name":"James Frederick Leckman","orcid":"https://orcid.org/0000-0002-3902-4478","observed_orcids":["https://orcid.org/0000-0002-3902-4478"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James F. Leckman","raw_affiliation_strings":["Child Study Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, U.S.A","Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child Study Center, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, U.S.A","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5029578725"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":2.2317,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.88456369,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"15","issue":"6","first_page":"1252","last_page":"1254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/naloxone","display_name":"naloxone","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tics","display_name":"tics","score":0.8539999723434448},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.8569999933242798},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.765999972820282},{"id":"https://openalex.org/keywords/opioid-antagonists","display_name":"opioid antagonists","score":0.5509999990463257},{"id":"https://openalex.org/keywords/replication","display_name":"replication","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2778750930","wikidata":"https://www.wikidata.org/wiki/Q4540629","display_name":"(+)-Naloxone","level":4,"score":0.8763469457626343},{"id":"https://openalex.org/C2777200579","wikidata":"https://www.wikidata.org/wiki/Q738538","display_name":"Tics","level":2,"score":0.7882618308067322},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.7199369668960571},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6625069379806519},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.6032490730285645},{"id":"https://openalex.org/C3019590667","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Narcotic antagonist","level":5,"score":0.5587655305862427},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5223663449287415},{"id":"https://openalex.org/C2775962371","wikidata":"https://www.wikidata.org/wiki/Q908096","display_name":"Opioid antagonist","level":5,"score":0.5199533700942993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4995133876800537},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4731748402118683},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4592042565345764},{"id":"https://openalex.org/C2909837681","wikidata":"https://www.wikidata.org/wiki/Q7836907","display_name":"Tourette's syndrome","level":2,"score":0.4325867295265198},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4054356515407562},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32215020060539246},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17004558444023132},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.11940312385559082}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009270","descriptor_name":"Naloxone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009292","descriptor_name":"Narcotic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011957","descriptor_name":"Receptors, Opioid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013981","descriptor_name":"Tic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","doi":"https://doi.org/10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","is_oa":false,"landing_page_url":"https://doi.org/10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i","pdf_url":null,"source":{"id":"https://openalex.org/S163027424","display_name":"Movement Disorders","issn_l":"0885-3185","issn":["0885-3185","1531-8257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders","raw_type":"journal-article"},{"id":"pmid:11104215","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11104215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement disorders : official journal of the Movement Disorder Society","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G3410390140","display_name":null,"funder_award_id":"MH49351","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4034874065","display_name":"PATHOGENESIS &TREATMENT OF TS, OCD &RELATED DISORDERS","funder_award_id":"P01MH049351","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4111234213","display_name":null,"funder_award_id":"P03-CA16359","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W104985332","https://openalex.org/W1968683631","https://openalex.org/W1974842875","https://openalex.org/W1983337012","https://openalex.org/W1985928268","https://openalex.org/W2003662972","https://openalex.org/W2012119611","https://openalex.org/W2019101336","https://openalex.org/W2019714158","https://openalex.org/W2025591321","https://openalex.org/W2047687410","https://openalex.org/W2074311797","https://openalex.org/W2113162630","https://openalex.org/W2115370667","https://openalex.org/W2121696264","https://openalex.org/W2133672910","https://openalex.org/W2150139344","https://openalex.org/W2196988190","https://openalex.org/W2217608321","https://openalex.org/W2401155317","https://openalex.org/W3028520611"],"related_works":["https://openalex.org/W2401155317","https://openalex.org/W2040716453","https://openalex.org/W2066983997","https://openalex.org/W2031991400","https://openalex.org/W2088107729","https://openalex.org/W2112988364","https://openalex.org/W2022372742","https://openalex.org/W1983337012","https://openalex.org/W2490290529","https://openalex.org/W2109373090"],"abstract_inverted_index":{"The":[0,76],"purpose":[1],"of":[2,21,48,55,105],"this":[3],"study":[4,13],"was":[5],"to":[6,101,112],"replicate":[7],"findings":[8],"from":[9],"an":[10],"earlier":[11],"pilot":[12],"in":[14,29,60,83,93,110,114],"which":[15],"we":[16],"found":[17,65],"a":[18,61,80,90,121],"dose-related":[19],"effect":[20],"the":[22,86,103,108],"opioid":[23,98],"antagonist":[24],"naloxone":[25,49,67,113],"on":[26,71,120],"tic":[27,56],"behavior":[28,57],"patients":[30],"with":[31,37,41],"Tourette's":[32],"syndrome":[33],"(TS).":[34],"Fifteen":[35],"subjects":[36,116],"TS":[38,115],"were":[39,58],"challenged":[40],"randomized":[42],"doses":[43],"(30":[44],"and":[45,107],"300":[46],"microg/kg)":[47],"at":[50,73,97],"3-day":[51],"intervals.":[52],"Videotaped":[53],"recordings":[54],"counted":[59],"\"blind\"":[62],"fashion.":[63],"We":[64],"that":[66],"had":[68],"opposite":[69],"effects":[70],"tics":[72],"different":[74],"dosages.":[75],"low":[77],"dose":[78,88],"caused":[79,89],"significant":[81,91],"decrease":[82],"tics,":[84],"whereas":[85],"high":[87],"increase":[92],"tics.":[94],"Therefore,":[95],"activity":[96],"receptors":[99],"appears":[100],"influence":[102],"expression":[104],"TS,":[106],"difference":[109],"response":[111],"may":[117],"be":[118],"based":[119],"dose-response":[122],"effect.":[123]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}