{"id":"https://openalex.org/W2108337464","doi":"https://doi.org/10.1096/fj.08-113266","title":"Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine\u2010rich protein 61","display_name":"Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine\u2010rich protein 61","publication_year":2008,"publication_date":"2008-08-07","ids":{"openalex":"https://openalex.org/W2108337464","doi":"https://doi.org/10.1096/fj.08-113266","mag":"2108337464","pmid":"https://pubmed.ncbi.nlm.nih.gov/18687805","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3980657"},"language":"en","primary_location":{"id":"doi:10.1096/fj.08-113266","doi":"https://doi.org/10.1096/fj.08-113266","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.08-113266","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3980657","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109124747","display_name":"Colin T. Walsh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Colin T. Walsh","raw_affiliation_strings":["Department of Pharmacology University of California San Diego La Jolla California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology University of California San Diego La Jolla California USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016819547","display_name":"Julie Radeff\u2010Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie Radeff\u2010Huang","raw_affiliation_strings":["Department of Pharmacology University of California San Diego La Jolla California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology University of California San Diego La Jolla California USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042969376","display_name":"Rosal\u00eda Matteo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosalia Matteo","raw_affiliation_strings":["Department of Pharmacology University of California San Diego La Jolla California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology University of California San Diego La Jolla California USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084967705","display_name":"Albert Hsiao","orcid":"https://orcid.org/0000-0002-9412-1369","observed_orcids":["https://orcid.org/0000-0002-9412-1369"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert Hsiao","raw_affiliation_strings":["Department of Bioengineering University of California San Diego La Jolla California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering University of California San Diego La Jolla California USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063396453","display_name":"Shankar Subramaniam","orcid":"https://orcid.org/0000-0002-8059-4659","observed_orcids":["https://orcid.org/0000-0002-8059-4659"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shankar Subramaniam","raw_affiliation_strings":["Department of Bioengineering University of California San Diego La Jolla California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering University of California San Diego La Jolla California USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057799963","display_name":"Dwayne G. Stupack","orcid":"https://orcid.org/0000-0003-4396-5745","observed_orcids":["https://orcid.org/0000-0003-4396-5745"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dwayne Stupack","raw_affiliation_strings":["Department of Pathology and The John and Rebecca Moores Cancer Center University of California San Diego La Jolla California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and The John and Rebecca Moores Cancer Center University of California San Diego La Jolla California USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045287779","display_name":"Joan Heller Brown","orcid":"https://orcid.org/0000-0002-1555-9363","observed_orcids":["https://orcid.org/0000-0002-1555-9363"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan Heller Brown","raw_affiliation_strings":["Department of Pharmacology University of California San Diego La Jolla California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology University of California San Diego La Jolla California USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.896,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.703971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"11","first_page":"4011","last_page":"4021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.8051999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.1738000065088272,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protease-activated-receptor-1","display_name":"protease-activated receptor 1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/par1","display_name":"PAR1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ccn1","display_name":"CYR61","score":0.9950000047683716},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.8519999980926514},{"id":"https://openalex.org/keywords/integrin-alpha5","display_name":"integrin alpha5","score":0.8529999852180481},{"id":"https://openalex.org/keywords/integrin-alpha6","display_name":"CD49f","score":0.8889999985694885},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8450000286102295},{"id":"https://openalex.org/keywords/astrocytoma-cells","display_name":"astrocytoma cells","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.703000009059906},{"id":"https://openalex.org/keywords/matricellular-proteins","display_name":"matricellular proteins","score":0.8159999847412109},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C2778753947","wikidata":"https://www.wikidata.org/wiki/Q18027691","display_name":"CYR61","level":5,"score":0.7859171628952026},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.7774434089660645},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5790547728538513},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.5664490461349487},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5454576015472412},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4528256058692932},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4391750693321228},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43287280201911926},{"id":"https://openalex.org/C2775893135","wikidata":"https://www.wikidata.org/wiki/Q6787792","display_name":"Matricellular protein","level":3,"score":0.43059250712394714},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.411583811044693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3838736116886139},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.37823209166526794},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3543074131011963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2194150686264038},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.2013668417930603},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.13432437181472778},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.12167680263519287},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09959080815315247},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.077301025390625},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002217","descriptor_name":"Carbachol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002316","descriptor_name":"Cardiotonic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017874","descriptor_name":"Immediate-Early Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020742","descriptor_name":"rhoA GTP-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044463","descriptor_name":"Receptor, PAR-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044463","descriptor_name":"Receptor, PAR-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055515","descriptor_name":"Cysteine-Rich Protein 61","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1096/fj.08-113266","doi":"https://doi.org/10.1096/fj.08-113266","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.08-113266","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2970506","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3980657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3980657","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3980657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB J","raw_type":"Text"},{"id":"pmid:18687805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18687805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2970506","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3980657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1588345431","display_name":"RhoA and GPCR mediated transcriptional activation regulates glioblastoma","funder_award_id":"R01CA218859","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7011837341","display_name":"Rho- and GPCR-mediated signaling through novel cellular effectors","funder_award_id":"R01GM036927","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":78,"referenced_works":["https://openalex.org/W262455939","https://openalex.org/W1484722676","https://openalex.org/W1497165801","https://openalex.org/W1557467023","https://openalex.org/W1562863690","https://openalex.org/W1566538275","https://openalex.org/W1586838517","https://openalex.org/W1593018830","https://openalex.org/W1663829637","https://openalex.org/W1671218943","https://openalex.org/W1793987231","https://openalex.org/W1855597671","https://openalex.org/W1910650341","https://openalex.org/W1925481732","https://openalex.org/W1982573088","https://openalex.org/W1991095318","https://openalex.org/W1994108205","https://openalex.org/W1995093204","https://openalex.org/W1997182423","https://openalex.org/W1999353913","https://openalex.org/W2006473647","https://openalex.org/W2010957690","https://openalex.org/W2013445972","https://openalex.org/W2018812790","https://openalex.org/W2020550595","https://openalex.org/W2020647366","https://openalex.org/W2023397648","https://openalex.org/W2024729393","https://openalex.org/W2032093848","https://openalex.org/W2035497705","https://openalex.org/W2036899152","https://openalex.org/W2038809664","https://openalex.org/W2040448047","https://openalex.org/W2042082129","https://openalex.org/W2047277690","https://openalex.org/W2047655212","https://openalex.org/W2047743989","https://openalex.org/W2049976919","https://openalex.org/W2053257956","https://openalex.org/W2057170598","https://openalex.org/W2058252463","https://openalex.org/W2068773189","https://openalex.org/W2077656002","https://openalex.org/W2080144763","https://openalex.org/W2087823284","https://openalex.org/W2087920840","https://openalex.org/W2091636804","https://openalex.org/W2092758437","https://openalex.org/W2093334711","https://openalex.org/W2093424029","https://openalex.org/W2093629504","https://openalex.org/W2096791952","https://openalex.org/W2100079513","https://openalex.org/W2100847793","https://openalex.org/W2109500399","https://openalex.org/W2111478744","https://openalex.org/W2112417973","https://openalex.org/W2112509049","https://openalex.org/W2115235864","https://openalex.org/W2130172628","https://openalex.org/W2132681046","https://openalex.org/W2139668007","https://openalex.org/W2139833082","https://openalex.org/W2142799375","https://openalex.org/W2143975749","https://openalex.org/W2146133427","https://openalex.org/W2154930694","https://openalex.org/W2162049443","https://openalex.org/W2166988895","https://openalex.org/W2168091755","https://openalex.org/W2168294989","https://openalex.org/W2169906167","https://openalex.org/W2171595654","https://openalex.org/W2181743527","https://openalex.org/W2318959008","https://openalex.org/W2328379124","https://openalex.org/W2483371726","https://openalex.org/W4297119621"],"related_works":["https://openalex.org/W106951663","https://openalex.org/W2093629504","https://openalex.org/W3167651573","https://openalex.org/W2077835424","https://openalex.org/W3168219603","https://openalex.org/W1529429366","https://openalex.org/W3174551596","https://openalex.org/W2057170598","https://openalex.org/W2040448047","https://openalex.org/W1528041100"],"abstract_inverted_index":{"A":[0,23],"subset":[1],"of":[2,71,153],"G-protein":[3],"coupled":[4],"receptors":[5],"(GPCRs),":[6],"including":[7],"the":[8,37,58,118,123],"thrombin":[9],"receptor":[10],"(PAR1),":[11],"elicits":[12],"mitogenic":[13],"responses.":[14],"Thrombin":[15],"also":[16,161],"activates":[17],"Ras":[18],"homolog":[19],"gene":[20,30,50],"family":[21],"member":[22],"(RhoA)":[24],"and":[25,55,121,132,138,144,178],"activating":[26],"protein":[27,60],"(AP-1)":[28],"-mediated":[29],"expression":[31,85,112],"in":[32,117],"1321N1":[33],"astrocytoma":[34],"cells,":[35,137],"whereas":[36],"nonmitogenic":[38],"agonist":[39],"carbachol":[40],"does":[41],"not.":[42],"Transcriptomic":[43],"analysis":[44],"was":[45],"used":[46],"to":[47,74,80,186],"explore":[48],"differential":[49],"induction":[51],"by":[52,67,88],"these":[53,136],"agonists":[54,73],"revealed":[56],"that":[57,184],"matricellular":[59],"cysteine-rich":[61],"61":[62],"(Cyr61/CCN1)":[63],"is":[64,86,93,107,113,168],"selectively":[65],"induced":[66],"thrombin.":[68],"The":[69],"ability":[70,79],"GPCR":[72,177],"induce":[75],"Cyr61":[76,84,92,111,127,154,167],"parallels":[77],"their":[78],"activate":[81],"RhoA;":[82],"agonist-stimulated":[83],"inhibited":[87],"C3":[89],"toxin.":[90],"When":[91,110],"down-regulated":[94],"using":[95],"short":[96],"interfering":[97],"RNA":[98,102],"(siRNA)":[99],"or":[100,158],"short-hairpin":[101],"(shRNA),":[103],"thrombin-induced":[104,148,163],"DNA":[105,149,164],"synthesis":[106],"significantly":[108],"attenuated.":[109],"induced,":[114],"it":[115],"appears":[116],"extracellular":[119,173],"compartment":[120],"on":[122,135],"cell":[124],"surface.":[125],"Extracellular":[126],"interacts":[128],"with":[129,155],"alpha(5),":[130],"alpha(6),":[131],"beta(1)":[133,145],"integrins":[134,146,183],"monoclonal":[139],"antibodies":[140,160],"directed":[141],"against":[142],"alpha(5)":[143],"inhibit":[147],"synthesis.":[150,165],"Functional":[151],"blockade":[152],"soluble":[156],"heparin":[157],"anti-Cyr61":[159],"inhibits":[162],"Thus":[166],"a":[169],"highly":[170],"inducible,":[171],"secreted":[172],"factor":[174],"through":[175],"which":[176],"RhoA":[179],"signaling":[180],"pathways":[181],"engage":[182],"contribute":[185],"GPCR-mediated":[187],"proliferation.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}