{"id":"https://openalex.org/W2108318591","doi":null,"title":"Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization.","display_name":"Numerical chromosome 1, 7, 9, and 11 aberrations in bladder cancer detected by in situ hybridization.","publication_year":1991,"publication_date":"1991-01-15","ids":{"openalex":"https://openalex.org/W2108318591","mag":"2108318591","pmid":"https://pubmed.ncbi.nlm.nih.gov/1985781"},"language":"en","primary_location":{"id":"pmid:1985781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1985781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083290106","display_name":"Anton H. N. Hopman","orcid":"https://orcid.org/0000-0002-5136-2955","observed_orcids":["https://orcid.org/0000-0002-5136-2955"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A H Hopman","raw_affiliation_strings":["Department of Pathology, University Hospital Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Hospital Nijmegen, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049856525","display_name":"Olof Moesker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Moesker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011811002","display_name":"A. W. G. B. SMEETS","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A W Smeets","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062650498","display_name":"Ruud P. E. Pauwels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Pauwels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112194255","display_name":"G. Peter Vooijs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G P Vooijs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109930271","display_name":"Frans C. S. Ramaekers","orcid":"https://orcid.org/0009-0002-1324-5843","observed_orcids":["https://orcid.org/0009-0002-1324-5843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F C Ramaekers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":50.7386,"has_fulltext":false,"cited_by_count":227,"citation_normalized_percentile":{"value":0.9996702,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"51","issue":"2","first_page":"644","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.9477999806404114,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chromosome-7-trisomy","display_name":"chromosome 7 trisomy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tetraploidization","display_name":"tetraploidization","score":0.890999972820282},{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.8059999942779541},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5580000281333923},{"id":"https://openalex.org/keywords/interphase-cytogenetics","display_name":"interphase cytogenetics","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C2779142324","wikidata":"https://www.wikidata.org/wiki/Q3321288","display_name":"Monosomy","level":5,"score":0.8371952772140503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6524609327316284},{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.6308199763298035},{"id":"https://openalex.org/C109748351","wikidata":"https://www.wikidata.org/wiki/Q657319","display_name":"Chromosome 7 (human)","level":4,"score":0.6089672446250916},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5840742588043213},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.5651991367340088},{"id":"https://openalex.org/C2776229224","wikidata":"https://www.wikidata.org/wiki/Q844903","display_name":"Trisomy","level":2,"score":0.5232628583908081},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.4892730414867401},{"id":"https://openalex.org/C2780238508","wikidata":"https://www.wikidata.org/wiki/Q840604","display_name":"Chromosome 9","level":4,"score":0.4880146086215973},{"id":"https://openalex.org/C47924181","wikidata":"https://www.wikidata.org/wiki/Q668633","display_name":"Chromosome 3","level":4,"score":0.47354787588119507},{"id":"https://openalex.org/C2777542201","wikidata":"https://www.wikidata.org/wiki/Q1336182","display_name":"Fluorescence in situ hybridization","level":4,"score":0.43837660551071167},{"id":"https://openalex.org/C137555145","wikidata":"https://www.wikidata.org/wiki/Q753218","display_name":"Chromosome 21","level":4,"score":0.4293849766254425},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4192982017993927},{"id":"https://openalex.org/C167752854","wikidata":"https://www.wikidata.org/wiki/Q220677","display_name":"Chromosome 17 (human)","level":4,"score":0.41479814052581787},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40094977617263794},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06725993752479553}],"mesh":[{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002878","descriptor_name":"Chromosomes, Human, Pair 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002897","descriptor_name":"Chromosomes, Human, Pair 7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002899","descriptor_name":"Chromosomes, Human, Pair 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015342","descriptor_name":"DNA Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1985781","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1985781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2108318591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1985781","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1685865647","https://openalex.org/W1801347750","https://openalex.org/W1863668426","https://openalex.org/W1952335870","https://openalex.org/W1971096058","https://openalex.org/W1973173192","https://openalex.org/W1991008526","https://openalex.org/W1991665028","https://openalex.org/W1993558252","https://openalex.org/W1998562271","https://openalex.org/W2001502532","https://openalex.org/W2008354532","https://openalex.org/W2026176404","https://openalex.org/W2028577664","https://openalex.org/W2030638925","https://openalex.org/W2030885294","https://openalex.org/W2038151125","https://openalex.org/W2043522420","https://openalex.org/W2046240617","https://openalex.org/W2048585324","https://openalex.org/W2049399310","https://openalex.org/W2068550037","https://openalex.org/W2083801462","https://openalex.org/W2087080974","https://openalex.org/W2090607490","https://openalex.org/W2109682892","https://openalex.org/W2112449242","https://openalex.org/W2113674897","https://openalex.org/W2124156899","https://openalex.org/W2158773962"],"related_works":["https://openalex.org/W2101370847","https://openalex.org/W2021838809","https://openalex.org/W1994911484","https://openalex.org/W2031368909","https://openalex.org/W2138584372","https://openalex.org/W2025653242","https://openalex.org/W2188904999","https://openalex.org/W2019196328","https://openalex.org/W2109682892","https://openalex.org/W2147215303"],"abstract_inverted_index":{"Forty":[0],"transitional":[1],"cell":[2],"carcinomas":[3],"of":[4,15,33,52,57,71,122,146,170,176,191,221,225,231,270],"the":[5,111,163,205,212,232,268],"human":[6],"urinary":[7],"bladder":[8],"(TCCs)":[9],"were":[10,39],"examined":[11],"for":[12,48,64,77,97,107,129],"numerical":[13,46,114,141],"aberrations":[14],"chromosomes":[16,54,78,130,165,182],"1,":[17,79,183],"7,":[18,80,184],"9,":[19],"and":[20,81,88,132,154,185,201,211],"11":[21,82,186],"by":[22,41,102,218],"in":[23,55,69,85,103,116,134,179,194,202,236,253],"situ":[24,104,254],"hybridization":[25,255],"using":[26],"chromosome-specific":[27],"probes.":[28],"Our":[29,249],"interphase":[30],"cytogenetic":[31,263],"study":[32,261],"24":[34,72],"low-grade,":[35],"noninvasive":[36,156],"TCCs,":[37,200],"which":[38,265],"near-diploid":[40],"flow":[42,136],"cytometry,":[43],"showed":[44,126],"a":[45,62,95,159,219,271],"aberration":[47],"at":[49],"least":[50],"1":[51,89,93,99,131],"these":[53,58,171],"14":[56],"cases.":[59,120],"Most":[60],"strikingly,":[61],"monosomy":[63,96],"chromosome":[65,98,108,142,147,177,192,210,226],"9":[66,70,109,148,178,193,227],"was":[67,83,100,110,149,166,187],"found":[68],"low-grade":[73,118],"TCCs.":[74],"A":[75],"trisomy":[76],"detected":[84,101,113],"5,":[86],"2,":[87],"case(s),":[90],"respectively.":[91],"In":[92,151,168],"case":[94],"hybridization.":[105],"Monosomy":[106],"only":[112],"change":[115],"5":[117,152,169],"TCC":[119,237],"Examination":[121],"16":[123],"invasive":[124,153],"TCCs":[125,158],"extra":[127],"copies":[128],"7":[133,135],"cytometrically":[137],"diploid":[138],"cases":[139,172,204],"with":[140,239],"aberrations;":[143],"also,":[144],"loss":[145,224],"detected.":[150,188],"2":[155],"aneuploid/tetraploid":[157],"profound":[160],"imbalance":[161],"between":[162,208],"different":[164],"found.":[167],"an":[173],"evident":[174],"underrepresentation":[175,190],"comparison":[180],"to":[181,246,260],"This":[189],"diploid,":[195],"as":[196,198,243],"well":[197],"aneuploid,":[199],"some":[203],"constant":[206],"ratio":[207],"this":[209],"other":[213],"chromosomes,":[214],"may":[215,228],"be":[216,229,257],"explained":[217],"process":[220],"tetraploidization.":[222],"Therefore,":[223],"one":[230],"primary":[233],"genetic":[234],"events":[235],"oncogenesis,":[238],"secondary":[240],"events,":[241],"such":[242],"tetraploidization,":[244],"correlated":[245],"tumor":[247],"progression.":[248],"results":[250],"show":[251],"that":[252],"can":[256],"routinely":[258],"used":[259],"important":[262],"changes":[264],"occur":[266],"during":[267],"development":[269],"malignant":[272],"disease.":[273]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}