{"id":"https://openalex.org/W2108301226","doi":"https://doi.org/10.4088/jcp.v58n0306","title":"Risperidone Augmentation of Serotonin Reuptake Inhibitors in Obsessive-Compulsive and Related Disorders","display_name":"Risperidone Augmentation of Serotonin Reuptake Inhibitors in Obsessive-Compulsive and Related Disorders","publication_year":1997,"publication_date":"1997-03-15","ids":{"openalex":"https://openalex.org/W2108301226","doi":"https://doi.org/10.4088/jcp.v58n0306","mag":"2108301226","pmid":"https://pubmed.ncbi.nlm.nih.gov/9108814"},"language":"en","primary_location":{"id":"doi:10.4088/jcp.v58n0306","doi":"https://doi.org/10.4088/jcp.v58n0306","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.v58n0306","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073216705","display_name":"Dan Joseph Stein","orcid":"https://orcid.org/0000-0001-7218-7810","observed_orcids":["https://orcid.org/0000-0001-7218-7810","https://orcid.org/0000-0002-0741-1780","https://orcid.org/0000-0001-7022-1106"]},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Dan J. Stein","raw_affiliation_strings":["Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Stellenbosch, Tygerberg, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056930608","display_name":"Colin Bouwer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin Bouwer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110232569","display_name":"Susan M. Hawkridge","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Hawkridge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103581566","display_name":"Robin A. Emsley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin A. Emsley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":31.5665,"has_fulltext":false,"cited_by_count":168,"citation_normalized_percentile":{"value":0.99950122,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"58","issue":"3","first_page":"119","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11132","display_name":"Psychoanalysis and Psychopathology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":0.9900000095367432},{"id":"https://openalex.org/keywords/augmentation-therapy","display_name":"augmentation therapy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/serotonin-reuptake-inhibitors","display_name":"serotonin reuptake inhibitors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.996999979019165},{"id":"https://openalex.org/keywords/trichotillomania","display_name":"trichotillomania","score":0.984000027179718},{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.9860000014305115},{"id":"https://openalex.org/keywords/treatment-refractory-ocd","display_name":"treatment-refractory OCD","score":0.777999997138977},{"id":"https://openalex.org/keywords/atypical-antipsychotics","display_name":"atypical antipsychotics","score":0.8240000009536743},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.7361026406288147},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5404679775238037},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.5293674468994141},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.5143845677375793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48625385761260986},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4718192517757416},{"id":"https://openalex.org/C2780092697","wikidata":"https://www.wikidata.org/wiki/Q7455053","display_name":"Serotonin reuptake inhibitor","level":4,"score":0.4610516130924225},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.45055344700813293},{"id":"https://openalex.org/C2777026814","wikidata":"https://www.wikidata.org/wiki/Q191779","display_name":"Tourette syndrome","level":2,"score":0.43468815088272095},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4185256361961365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3120894432067871},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.20075193047523499},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.17347273230552673},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.16583874821662903},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006753","descriptor_name":"Hospital Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014256","descriptor_name":"Trichotillomania","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014256","descriptor_name":"Trichotillomania","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018967","descriptor_name":"Risperidone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.4088/jcp.v58n0306","doi":"https://doi.org/10.4088/jcp.v58n0306","is_oa":false,"landing_page_url":"https://doi.org/10.4088/jcp.v58n0306","pdf_url":null,"source":{"id":"https://openalex.org/S17992710","display_name":"The Journal of Clinical Psychiatry","issn_l":"0160-6689","issn":["0160-6689","1534-8628","1555-2101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4322614534","host_organization_name":"Physicians Postgraduate Press, Inc.","host_organization_lineage":["https://openalex.org/P4322614534"],"host_organization_lineage_names":["Physicians Postgraduate Press, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Psychiatry","raw_type":"journal-article"},{"id":"pmid:9108814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9108814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:scholar.sun.ac.za:10019.1/12239","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10019.1/12239","pdf_url":null,"source":{"id":"https://openalex.org/S4306400300","display_name":"SUNScholar (Stellenbosch University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I26092322","host_organization_name":"Stellenbosch University","host_organization_lineage":["https://openalex.org/I26092322"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W126775747","https://openalex.org/W2367662090","https://openalex.org/W183177044","https://openalex.org/W2407703539","https://openalex.org/W2066030263","https://openalex.org/W141608893","https://openalex.org/W2057872708","https://openalex.org/W2345632172","https://openalex.org/W2017631740","https://openalex.org/W2159990726"],"abstract_inverted_index":{"BACKGROUND:":[0],"While":[1],"serotonin":[2,27,60,106,146],"is":[3,15,162],"the":[4,31,56],"neurotransmitter":[5],"most":[6],"commonly":[7],"implicated":[8],"in":[9,41,51,154],"obsessive-compulsive":[10,42],"and":[11,63,71,94,136],"related":[12,137],"disorders,":[13],"there":[14],"also":[16],"evidence":[17],"for":[18],"dopaminergic":[19],"mediation":[20],"of":[21,26,47,58,69,83,116,126,151],"these":[22],"conditions.":[23],"Indeed,":[24],"augmentation":[25,153],"reuptake":[28,61,107,147],"inhibitors":[29,108],"with":[30,55,85,105,134,145],"atypical":[32],"neuroleptic":[33],"risperidone":[34,64,111,152],"has":[35],"been":[36],"suggested":[37],"to":[38,74,103,143,164,170],"be":[39],"useful":[40],"disorder":[43],"(OCD).":[44],"METHOD:":[45],"Charts":[46],"all":[48],"patients":[49,70,84,127,156],"treated":[50],"our":[52],"OCD":[53,86,135],"clinic":[54],"combination":[57],"a":[59,114,124],"inhibitor":[62],"were":[65,78,101],"reviewed.":[66],"Demographic":[67],"details":[68],"clinical":[72],"response":[73],"this":[75,118],"pharmacotherapeutic":[76],"strategy":[77,119],"tabulated.":[79],"RESULTS:":[80],"A":[81],"series":[82],"(N":[87,91,97],"=":[88,92,98],"8),":[89],"trichotillomania":[90],"5),":[93],"Tourette's":[95],"syndrome":[96],"3)":[99],"who":[100],"refractory":[102,142],"treatment":[104,144],"had":[109],"received":[110],"augmentation.":[112],"In":[113,159],"number":[115],"cases,":[117],"proved":[120],"clinically":[121],"effective.":[122],"However,":[123],"minority":[125],"experienced":[128],"significant":[129],"adverse":[130,172],"effects.":[131,173],"CONCLUSION:":[132],"Patients":[133],"disorders":[138],"are":[139],"not":[140],"infrequently":[141],"inhibitors.":[148],"Controlled":[149],"trials":[150],"such":[155],"seem":[157],"warranted.":[158],"particular,":[160],"it":[161],"necessary":[163],"determine":[165],"an":[166],"appropriate":[167],"dose":[168],"range":[169],"minimize":[171]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
