{"id":"https://openalex.org/W2108281237","doi":"https://doi.org/10.1212/wnl.56.3.355","title":"Independent HIV replication in paired CSF and blood viral isolates during antiretroviral therapy","display_name":"Independent HIV replication in paired CSF and blood viral isolates during antiretroviral therapy","publication_year":2001,"publication_date":"2001-02-13","ids":{"openalex":"https://openalex.org/W2108281237","doi":"https://doi.org/10.1212/wnl.56.3.355","mag":"2108281237","pmid":"https://pubmed.ncbi.nlm.nih.gov/11171901"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.56.3.355","doi":"https://doi.org/10.1212/wnl.56.3.355","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.56.3.355","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001998969","display_name":"Karoline Stingele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Stingele","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038633707","display_name":"J\u00fcrgen Haas","orcid":"https://orcid.org/0000-0002-2314-7465","observed_orcids":["https://orcid.org/0000-0002-2314-7465"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Haas","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103197081","display_name":"Thomas Philipp Zimmermann","orcid":"https://orcid.org/0000-0002-2047-9907","observed_orcids":["https://orcid.org/0000-0002-2047-9907"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. Zimmermann","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040592274","display_name":"Robert Stingele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"R. Stingele","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057617923","display_name":"C H\u00fcbsch-M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Hu\u0308bsch\u2013Mu\u0308ller","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030850537","display_name":"M. Freitag","orcid":"https://orcid.org/0000-0002-7572-2011","observed_orcids":["https://orcid.org/0000-0002-7572-2011"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Freitag","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091787485","display_name":"Brigitte Storch-Hagenlocher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Storch\u2013Hagenlocher","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082054480","display_name":"Matthias Hartmann","orcid":"https://orcid.org/0000-0003-1596-0613","observed_orcids":["https://orcid.org/0000-0003-1596-0613"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Hartmann","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011686938","display_name":"Brigitte Wildemann","orcid":"https://orcid.org/0000-0002-5389-3338","observed_orcids":["https://orcid.org/0000-0002-5389-3338"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Wildemann","raw_affiliation_strings":["From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. K. Stingele, Haas, R. Stingele, Storch\u2013Hagenlocher, Wildemann, and M. Freitag) and Dermatology (Drs. Zimmerman, Hu\u0308bsch\u2013Mu\u0308ller, and Hartmann), University of Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":2.2351,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.87643678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"56","issue":"3","first_page":"355","last_page":"361"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.5400000214576721,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9599999785423279},{"id":"https://openalex.org/keywords/blood","display_name":"blood","score":0.4359999895095825},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.722000002861023},{"id":"https://openalex.org/keywords/viral-load","display_name":"viral load","score":0.5960000157356262},{"id":"https://openalex.org/keywords/hiv-1-rna","display_name":"HIV-1 RNA","score":0.3919999897480011},{"id":"https://openalex.org/keywords/viral-compartmentalization","display_name":"viral compartmentalization","score":0.5379999876022339},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.5},{"id":"https://openalex.org/keywords/resistance-mutations","display_name":"resistance mutations","score":0.5799999833106995},{"id":"https://openalex.org/keywords/hiv-genotyping","display_name":"HIV genotyping","score":0.3970000147819519},{"id":"https://openalex.org/keywords/neuroaids","display_name":"neuroAIDS","score":0.31200000643730164}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7135136723518372},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.7082121968269348},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.6940388679504395},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6563404202461243},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6052958369255066},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.5449270009994507},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5422642230987549},{"id":"https://openalex.org/C182707283","wikidata":"https://www.wikidata.org/wiki/Q7315622","display_name":"Resistance mutation","level":5,"score":0.48495128750801086},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4696727693080902},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.4390132427215576},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.43087148666381836},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.37940847873687744},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3766672611236572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22633662819862366},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2178904116153717}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023241","descriptor_name":"Antiretroviral Therapy, Highly Active","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.56.3.355","doi":"https://doi.org/10.1212/wnl.56.3.355","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.56.3.355","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:11171901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11171901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W51905203","https://openalex.org/W1735143085","https://openalex.org/W1778677241","https://openalex.org/W1964508839","https://openalex.org/W1983996649","https://openalex.org/W1989041073","https://openalex.org/W1991006424","https://openalex.org/W1997844736","https://openalex.org/W2002254372","https://openalex.org/W2007025117","https://openalex.org/W2007763270","https://openalex.org/W2009151310","https://openalex.org/W2011630381","https://openalex.org/W2012139740","https://openalex.org/W2012143024","https://openalex.org/W2022098233","https://openalex.org/W2026455599","https://openalex.org/W2028143521","https://openalex.org/W2029097526","https://openalex.org/W2029220999","https://openalex.org/W2046134251","https://openalex.org/W2055705838","https://openalex.org/W2061999212","https://openalex.org/W2064502505","https://openalex.org/W2064945443","https://openalex.org/W2065740427","https://openalex.org/W2070060564","https://openalex.org/W2074495023","https://openalex.org/W2090126383","https://openalex.org/W2097291433","https://openalex.org/W2114994968","https://openalex.org/W2120400009","https://openalex.org/W2128371289","https://openalex.org/W2130635171","https://openalex.org/W2133315239","https://openalex.org/W2166256774","https://openalex.org/W2169753949","https://openalex.org/W2314791685","https://openalex.org/W2316364653","https://openalex.org/W2318289184"],"related_works":["https://openalex.org/W2010128338","https://openalex.org/W2106142539","https://openalex.org/W2294204347","https://openalex.org/W2148784233","https://openalex.org/W2120100732","https://openalex.org/W2103216867","https://openalex.org/W4280620613","https://openalex.org/W1987415729","https://openalex.org/W2045696382","https://openalex.org/W2097059709"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,61,157,211,222],"goal":[2],"of":[3,40,42,50,68,81,88,108,120,173,177,216,224],"highly":[4],"active":[5],"antiretroviral":[6,103],"therapy":[7,242],"in":[8,53,72,125,139,160,185,194,218,227,234,248],"HIV-infected":[9,83],"patients":[10,126],"is":[11,47,57,199],"to":[12,102,243],"reduce":[13],"plasma":[14,128,155],"viral":[15,73,161,202],"load":[16],"(VL)":[17],"below":[18,132],"quantifiable":[19],"levels.":[20],"Mutations":[21],"associated":[22,180],"with":[23,127,143,181],"drug":[24,182],"resistance":[25,71,101,183,245],"within":[26],"the":[27,66,174,228],"HIV-1":[28,89,217],"genome":[29],"can":[30],"limit":[31],"therapeutic":[32],"success.":[33],"Low":[34],"VL":[35,64,113,131,135],"implicates":[36],"a":[37,115],"low":[38],"risk":[39],"emergence":[41],"resistant":[43,225],"mutants.":[44],"Whether":[45],"there":[46],"divergent":[48,214],"development":[49],"HIV":[51,121,205],"strains":[52],"different":[54,219],"biologic":[55,220],"compartments":[56],"not":[58,169],"understood.":[59],"METHODS:":[60],"authors":[62],"studied":[63],"and":[65,78,96,112,154,166],"occurrence":[67],"mutations":[69,111,179],"conferring":[70],"genomes":[74],"isolated":[75],"from":[76,164],"blood":[77,144,165,186],"CSF":[79,130,140,153,167,195,229],"samples":[80],"23":[82],"patients.":[84],"They":[85,99],"determined":[86],"sequences":[87],"RNA":[90,206],"by":[91,106,114],"reverse":[92],"transcriptase":[93],"PCR":[94],"amplification":[95],"direct":[97],"sequencing.":[98],"measured":[100],"drugs":[104],"genotypically":[105],"detection":[107,133],"drug-related":[109],"point":[110],"branched-DNA":[116],"assay.":[117],"RESULTS:":[118],"Amplification":[119],"was":[122,136,149,168],"successful":[123],"even":[124],"or":[129],"limit.":[134],"considerably":[137],"lower":[138],"as":[141],"compared":[142],"(p":[145],"<":[146],"0.0001).":[147],"There":[148,198],"no":[150],"correlation":[151],"between":[152],"VL.":[156],"mutational":[158],"pattern":[159],"copies":[162],"derived":[163],"identical.":[170],"Ten":[171],"(9%)":[172],"total":[175],"number":[176],"118":[178],"occurred":[184],"isolates":[187],"only;":[188],"14":[189],"(11%)":[190],"were":[191],"detected":[192,247],"exclusively":[193],"strains.":[196],"CONCLUSION:":[197],"evidence":[200],"for":[201],"replication":[203],"at":[204],"levels":[207],"less":[208],"than":[209],"50/mL.":[210],"results":[212],"suggest":[213],"evolution":[215],"compartments.":[221],"presence":[223],"mutants":[226],"may":[230,238],"escape":[231],"regular":[232],"diagnostic":[233],"blood.":[235],"Therapeutic":[236],"success":[237],"fail":[239],"after":[240],"adapting":[241],"genotypic":[244],"patterns":[246],"one":[249],"compartment":[250],"only.":[251]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
