{"id":"https://openalex.org/W2108265342","doi":"https://doi.org/10.1210/en.2005-0416","title":"Up-Regulation ofc-metProtooncogene Product Expression through Hypoxia-Inducible Factor-1\u03b1 Is Involved in Trophoblast Invasion under Low-Oxygen Tension","display_name":"Up-Regulation ofc-metProtooncogene Product Expression through Hypoxia-Inducible Factor-1\u03b1 Is Involved in Trophoblast Invasion under Low-Oxygen Tension","publication_year":2005,"publication_date":"2005-08-12","ids":{"openalex":"https://openalex.org/W2108265342","doi":"https://doi.org/10.1210/en.2005-0416","mag":"2108265342","pmid":"https://pubmed.ncbi.nlm.nih.gov/16099863"},"language":"en","primary_location":{"id":"doi:10.1210/en.2005-0416","doi":"https://doi.org/10.1210/en.2005-0416","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2005-0416","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060186654","display_name":"Masami Hayashi","orcid":"https://orcid.org/0000-0002-8075-4990","observed_orcids":["https://orcid.org/0000-0002-8075-4990"]},"institutions":[{"id":"https://openalex.org/I4210155576","display_name":"Osaka University Hospital","ror":"https://ror.org/05rnn8t74","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masami Hayashi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Osaka University Faculty of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. masami@gyne.med.osaka-u.ac.jp","Department of Obstetrics and Gynecology, Osaka University, Faculty of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Osaka University Faculty of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. masami@gyne.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Osaka University, Faculty of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019463160","display_name":"Masahiro Sakata","orcid":"https://orcid.org/0000-0001-7406-3117","observed_orcids":["https://orcid.org/0000-0001-7406-3117"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Sakata","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009399227","display_name":"Takashi Takeda","orcid":"https://orcid.org/0000-0003-2428-1946","observed_orcids":["https://orcid.org/0000-0003-2428-1946"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Takeda","raw_affiliation_strings":["Osaka Medical Center for Cancer and Cardiovascular Diseases (T.T.), Higashinari-ku, Osaka 537-8511, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osaka Medical Center for Cancer and Cardiovascular Diseases (T.T.), Higashinari-ku, Osaka 537-8511, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034831994","display_name":"Masahiro Tahara","orcid":"https://orcid.org/0000-0002-3266-6726","observed_orcids":["https://orcid.org/0000-0002-3266-6726"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Tahara","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101888571","display_name":"Toshiya Yamamoto","orcid":"https://orcid.org/0000-0002-2106-8421","observed_orcids":["https://orcid.org/0000-0002-2106-8421"]},"institutions":[{"id":"https://openalex.org/I4210104391","display_name":"Sakai City Medical Center","ror":"https://ror.org/014nm9q97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104391","https://openalex.org/I4405286217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiya Yamamoto","raw_affiliation_strings":["Sakai Municipal Hospital (T.Y.), Sakai, Osaka 590-0064, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sakai Municipal Hospital (T.Y.), Sakai, Osaka 590-0064, Japan","institution_ids":["https://openalex.org/I4210104391"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101828479","display_name":"Yoko Okamoto","orcid":"https://orcid.org/0000-0002-9222-0662","observed_orcids":["https://orcid.org/0000-0002-9222-0662"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Okamoto","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080253062","display_name":"Ryoko Minekawa","orcid":"https://orcid.org/0000-0001-7429-3203","observed_orcids":["https://orcid.org/0000-0001-7429-3203"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoko Minekawa","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110199877","display_name":"Aki Isobe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aki Isobe","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114250506","display_name":"Masahide Ohmichi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahide Ohmichi","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040789531","display_name":"Keiichi Tasaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Tasaka","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110769838","display_name":"Yuji Murata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Murata","raw_affiliation_strings":["Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology (M.H., M.S., M.T., Y.O., R.M., A.I., M.O., K.T., Y.M.), Osaka University Faculty of Medicine, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5060186654"],"corresponding_institution_ids":["https://openalex.org/I4210155576","https://openalex.org/I98285908"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":6.4133,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.96404455,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"146","issue":"11","first_page":"4682","last_page":"4689"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.07270000129938126,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12587","display_name":"Gestational Trophoblastic Disease Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/trophoblast-invasion","display_name":"trophoblast invasion","score":0.9700000286102295},{"id":"https://openalex.org/keywords/low-oxygen-tension","display_name":"low oxygen tension","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/placentation","display_name":"placentation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/decidua","display_name":"decidua","score":0.7070000171661377},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.5830000042915344},{"id":"https://openalex.org/keywords/bewo-cells","display_name":"BeWo cells","score":0.746999979019165},{"id":"https://openalex.org/keywords/jeg-3-cells","display_name":"JEG-3 cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/early-pregnancy","display_name":"early pregnancy","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C2777495146","wikidata":"https://www.wikidata.org/wiki/Q1889778","display_name":"Trophoblast","level":5,"score":0.7550356388092041},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.7506662607192993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6869503259658813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6844415664672852},{"id":"https://openalex.org/C2993207723","wikidata":"https://www.wikidata.org/wiki/Q4927803","display_name":"Oxygen tension","level":3,"score":0.6787254810333252},{"id":"https://openalex.org/C160450060","wikidata":"https://www.wikidata.org/wiki/Q104598479","display_name":"Hypoxia-inducible factors","level":3,"score":0.5595843195915222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5053516030311584},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3558962345123291},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35492223501205444},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33448752760887146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29260578751564026},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1884225606918335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18521758913993835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17878291010856628},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.1570570468902588},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.156294047832489},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.14434322714805603},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014327","descriptor_name":"Trophoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1210/en.2005-0416","doi":"https://doi.org/10.1210/en.2005-0416","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2005-0416","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:16099863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16099863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W86858381","https://openalex.org/W171819190","https://openalex.org/W181093158","https://openalex.org/W248225102","https://openalex.org/W1545448340","https://openalex.org/W1580471935","https://openalex.org/W1749022239","https://openalex.org/W1775749144","https://openalex.org/W1964037605","https://openalex.org/W1971885221","https://openalex.org/W1973092951","https://openalex.org/W1973248233","https://openalex.org/W1982285178","https://openalex.org/W1987912870","https://openalex.org/W1990940102","https://openalex.org/W1994276744","https://openalex.org/W2002926055","https://openalex.org/W2003194137","https://openalex.org/W2003425522","https://openalex.org/W2005638713","https://openalex.org/W2005782838","https://openalex.org/W2022527563","https://openalex.org/W2032665278","https://openalex.org/W2038290092","https://openalex.org/W2052612011","https://openalex.org/W2054042846","https://openalex.org/W2054633892","https://openalex.org/W2071678579","https://openalex.org/W2072713210","https://openalex.org/W2075054245","https://openalex.org/W2077838938","https://openalex.org/W2082183799","https://openalex.org/W2085609942","https://openalex.org/W2092602709","https://openalex.org/W2102277066","https://openalex.org/W2106782975","https://openalex.org/W2110000957","https://openalex.org/W2120477615","https://openalex.org/W2126592654","https://openalex.org/W2128945729","https://openalex.org/W2135836641","https://openalex.org/W2137123465","https://openalex.org/W2137262465","https://openalex.org/W2143474398","https://openalex.org/W2143936341","https://openalex.org/W2144050843","https://openalex.org/W2145782275","https://openalex.org/W2147150467","https://openalex.org/W2153412547","https://openalex.org/W2155925117","https://openalex.org/W2166997615","https://openalex.org/W2408190811","https://openalex.org/W2582709257","https://openalex.org/W2600875608"],"related_works":["https://openalex.org/W2742415502","https://openalex.org/W2174396521","https://openalex.org/W2596707374","https://openalex.org/W2102277066","https://openalex.org/W1996638945","https://openalex.org/W2325960562","https://openalex.org/W2143936341","https://openalex.org/W4283805940","https://openalex.org/W3022552961","https://openalex.org/W2368144658"],"abstract_inverted_index":{"During":[0],"early":[1,247],"pregnancy,":[2],"the":[3,9,12,17,55,69,78,106,119,147,175,185,189,222,230,244,251,257,260],"invasion":[4,56,252],"of":[5,11,16,57,60,71,80,108,129,143,149,157,166,188,214,232,246,253,259],"trophoblast":[6,26,81,254],"cells":[7,27,82,91,120,131,196,255],"into":[8,256],"decidua":[10,258],"uterus":[13],"is":[14,41],"one":[15],"essential":[18],"steps":[19],"in":[20,53,118,243],"appropriate":[21],"placentation.":[22],"In":[23],"this":[24,164],"period,":[25],"are":[28],"exposed":[29],"to":[30,67,139,184],"a":[31,42,133,158,202],"relatively":[32],"low-oxygen":[33,72,101,193,236],"environment.":[34],"The":[35,62],"c-met":[36],"protooncogene":[37],"product":[38],"(Met),":[39],"which":[40,179],"high-affinity":[43],"receptor":[44],"for":[45],"hepatocyte":[46],"growth":[47,115],"factor,":[48],"plays":[49],"an":[50,240],"important":[51,241],"role":[52,242],"controlling":[54],"many":[58],"types":[59],"cells.":[61,94],"present":[63],"study":[64],"was":[65,121,168],"designed":[66],"investigate":[68],"effect":[70],"tension":[73,102,237],"on":[74],"Met":[75,109,150,167,190,215,233],"expression":[76,107,137,142,216,234],"and":[77,88,92,96,111,152],"invasiveness":[79],"isolated":[83],"from":[84],"early-stage":[85],"human":[86],"placenta":[87],"trophoblast-derived":[89],"BeWo":[90,130],"JEG-3":[93,195],"RT-PCR":[95],"immunoblot":[97],"analyses":[98],"demonstrated":[99],"that":[100,181,229],"(1%":[103],"O2)":[104],"stimulated":[105],"mRNA":[110,151],"protein,":[112,153],"respectively.":[113],"Hepatocyte":[114],"factor":[116,135],"production":[117],"not":[122],"affected":[123],"by":[124,171,217,235,249],"oxygen":[125],"tension.":[126,194],"Transient":[127],"transfection":[128,156],"with":[132,155],"hypoxia-inducible":[134],"(HIF)-1alpha":[136],"vector":[138],"induce":[140],"exogenous":[141],"HIF-1alpha":[144,182],"significantly":[145],"increased":[146],"level":[148],"compared":[154],"control":[159],"vector.":[160],"To":[161],"examine":[162],"whether":[163],"up-regulation":[165],"directly":[169],"induced":[170],"HIF-1alpha,":[172],"we":[173],"performed":[174],"chromatin":[176],"immunoprecipitation":[177],"assay,":[178],"revealed":[180],"binds":[183],"promoter":[186],"region":[187],"gene":[191],"under":[192,198,209],"cultured":[197,208],"1%":[199],"O2":[200],"showed":[201],"more":[203],"invasive":[204],"character":[205],"than":[206],"those":[207],"20%":[210],"O2,":[211],"whereas":[212],"inhibition":[213],"small":[218],"interfering":[219],"RNAs":[220],"prevented":[221],"low-oxygen,":[223],"tension-induced":[224],"invasiveness.":[225],"These":[226],"results":[227],"suggest":[228],"induction":[231],"may":[238],"play":[239],"physiology":[245],"pregnancy":[248],"promoting":[250],"uterus.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
