{"id":"https://openalex.org/W2108230956","doi":"https://doi.org/10.1080/00365510601175976","title":"Imprecision of cardiac marker analyses among laboratories on the basis of external quality assurance results: Finnish experience","display_name":"Imprecision of cardiac marker analyses among laboratories on the basis of external quality assurance results: Finnish experience","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2108230956","doi":"https://doi.org/10.1080/00365510601175976","mag":"2108230956","pmid":"https://pubmed.ncbi.nlm.nih.gov/17763187"},"language":"en","primary_location":{"id":"doi:10.1080/00365510601175976","doi":"https://doi.org/10.1080/00365510601175976","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365510601175976","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112641997","display_name":"Ilkka Penttil\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"I. M. Penttil\u00e4","raw_affiliation_strings":["Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland. ilkka.penttila@pp.inet.fi","Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland","Kuopio Research Institute of Exercise Medicine, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland. ilkka.penttila@pp.inet.fi","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]},{"raw_affiliation_string":"Kuopio Research Institute of Exercise Medicine, Kuopio, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110390931","display_name":"Aino Laatikainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A. Laatikainen","raw_affiliation_strings":["Department of Microbiology, University of Kuopio, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Kuopio, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Penttil\u00e4","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K. Penttil\u00e4","raw_affiliation_strings":["Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073998688","display_name":"Kari R.A. Punnonen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K. Punnonen","raw_affiliation_strings":["Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":null,"display_name":"T. Rantanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"T. Rantanen","raw_affiliation_strings":["Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Savolainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"K. Savolainen","raw_affiliation_strings":["Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I4210092991"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085338670","display_name":"Ulla Tiikkainen","orcid":"https://orcid.org/0000-0002-1697-6783","observed_orcids":["https://orcid.org/0000-0002-1697-6783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Tiikkainen","raw_affiliation_strings":["Labquality Ltd., Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Labquality Ltd., Helsinki, Finland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8481,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.8276043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"67","issue":"5","first_page":"507","last_page":"518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11890","display_name":"Scientific Measurement and Uncertainty Evaluation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3105","display_name":"Instrumentation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-biomarkers","display_name":"cardiac biomarkers","score":0.8149999976158142},{"id":"https://openalex.org/keywords/assay-imprecision","display_name":"assay imprecision","score":0.8610000014305115},{"id":"https://openalex.org/keywords/external-quality-assessment","display_name":"external quality assessment","score":0.7620000243186951},{"id":"https://openalex.org/keywords/interlaboratory-reproducibility","display_name":"interlaboratory reproducibility","score":0.8199999928474426},{"id":"https://openalex.org/keywords/troponin-i","display_name":"troponin I","score":0.7829999923706055},{"id":"https://openalex.org/keywords/troponin-t","display_name":"troponin T","score":0.8980000019073486},{"id":"https://openalex.org/keywords/creatine-kinase-mb-mass","display_name":"creatine kinase-MB mass","score":0.8830000162124634},{"id":"https://openalex.org/keywords/immunoassay-standardization","display_name":"immunoassay standardization","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C2778618615","wikidata":"https://www.wikidata.org/wiki/Q4008393","display_name":"External quality assessment","level":2,"score":0.9078347682952881},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.655379056930542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6548565626144409},{"id":"https://openalex.org/C2778532138","wikidata":"https://www.wikidata.org/wiki/Q4999340","display_name":"Cardiac marker","level":4,"score":0.5655269622802734},{"id":"https://openalex.org/C106436119","wikidata":"https://www.wikidata.org/wiki/Q836575","display_name":"Quality assurance","level":3,"score":0.5547795295715332},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5129373073577881},{"id":"https://openalex.org/C89838059","wikidata":"https://www.wikidata.org/wiki/Q623738","display_name":"Coefficient of variation","level":2,"score":0.4897763729095459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4381251633167267},{"id":"https://openalex.org/C36036425","wikidata":"https://www.wikidata.org/wiki/Q7846262","display_name":"Troponin","level":3,"score":0.43458572030067444},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3778612017631531},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2192406952381134},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1830381155014038},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12317639589309692},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.09654968976974487}],"mesh":[{"descriptor_ui":"D003402","descriptor_name":"Creatine Kinase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009211","descriptor_name":"Myoglobin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011785","descriptor_name":"Quality Assurance, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D019210","descriptor_name":"Troponin I","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020107","descriptor_name":"Troponin T","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/00365510601175976","doi":"https://doi.org/10.1080/00365510601175976","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00365510601175976","pdf_url":null,"source":{"id":"https://openalex.org/S5501027","display_name":"Scandinavian Journal of Clinical and Laboratory Investigation","issn_l":"0036-5513","issn":["0036-5513","1502-7686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian Journal of Clinical and Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:17763187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17763187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scandinavian journal of clinical and laboratory investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320344","display_name":"European Society of Cardiology","ror":"https://ror.org/02ahe3232"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1967933874","https://openalex.org/W1968799532","https://openalex.org/W1968849994","https://openalex.org/W1974687687","https://openalex.org/W1974718993","https://openalex.org/W1985084751","https://openalex.org/W1991151094","https://openalex.org/W2009855619","https://openalex.org/W2010018970","https://openalex.org/W2013129385","https://openalex.org/W2018151414","https://openalex.org/W2019294839","https://openalex.org/W2026709941","https://openalex.org/W2030136948","https://openalex.org/W2031498851","https://openalex.org/W2035488156","https://openalex.org/W2059915904","https://openalex.org/W2085063325","https://openalex.org/W2112245414","https://openalex.org/W2122563040","https://openalex.org/W2140808477","https://openalex.org/W2141780194","https://openalex.org/W2145963026","https://openalex.org/W2148344623","https://openalex.org/W2159336591","https://openalex.org/W2171532421","https://openalex.org/W2307102029","https://openalex.org/W2620550732","https://openalex.org/W3022105909"],"related_works":["https://openalex.org/W2122563040","https://openalex.org/W4200626261","https://openalex.org/W7098632150","https://openalex.org/W2752238056","https://openalex.org/W2140530360","https://openalex.org/W4410018252","https://openalex.org/W2171068691","https://openalex.org/W2474824194","https://openalex.org/W4391775448","https://openalex.org/W2810015551"],"abstract_inverted_index":{"The":[0,120],"purpose":[1],"of":[2,12,24,32,35,42,69,201,214,233],"this":[3],"report":[4],"was":[5,89,94,136],"to":[6,17,51,109,228],"evaluate":[7],"the":[8,19,30,33,36,48,66,87,104,127,131,173,177,190,199,202],"reproducibility":[9,93],"and":[10,16,76,116,149,156,162,217,238],"harmonization":[11],"cardiac":[13,27,84,142,151,184,236],"marker":[14,62,185],"tests":[15],"describe":[18],"current":[20],"situation":[21],"concerning":[22],"quality":[23,38],"assays":[25,191],"for":[26,57,74,83,113,134,141,150,181,235],"markers":[28,237],"on":[29,231],"basis":[31],"results":[34,240],"external":[37],"control":[39],"schemes":[40],"(EQAS)":[41],"Labquality":[43],"Ltd.,":[44],"Helsinki,":[45],"Finland":[46],"in":[47,96,103,130],"period":[49],"2002":[50],"2005.":[52],"Finnish":[53],"EQAS":[54],"surveys":[55],"obtained":[56,125,241],"proficiency":[58],"samples":[59,108,133],"at":[60,175,198],"low":[61],"concentration":[63,174],"indicated":[64],"that":[65,170,196],"overall":[67],"coefficient":[68],"variation":[70],"(CV)":[71],"between":[72],"laboratories":[73,171],"CK-MBmass":[75,115,135],"troponin":[77,85,118,143,152],"I":[78,153],"exceeded":[79],"10":[80,121,178],"%,":[81],"while":[82],"T":[86,144],"CV":[88],"8.6":[90],"%.":[91],"Intra-laboratory":[92],"investigated":[95],"a":[97,182],"single":[98],"laboratory":[99],"using":[100],"concomitant":[101,128],"testing":[102,129],"same":[105,132],"EDTA":[106],"plasma":[107],"establish":[110],"cut-off":[111],"limits":[112],"one":[114],"three":[117],"assays.":[119],"%":[122,179],"imprecision":[123,180,197],"limit":[124],"from":[126],"(by":[137,145,154],"Elecsys)":[138,146],"8.5":[139],"microg/L,":[140],"0.023":[147],"microg/L":[148,161],"AxSYM)":[155],"by":[157],"Immulite":[158],"2000)":[159],"0.85":[160],"0.63":[163],"microg/L.":[164],"At":[165],"present,":[166],"it":[167],"is":[168,187,227],"recommended":[169],"determine":[172],"which":[176],"specific":[183],"assay":[186],"reached,":[188],"because":[189],"generally":[192],"do":[193],"not":[194],"reach":[195],"level":[200],"99th":[203],"percentile":[204],"value,":[205],"usually":[206],"taken":[207],"as":[208],"decisional":[209],"level.":[210],"However,":[211],"common":[212],"efforts":[213],"scientific":[215],"societies":[216],"professional":[218],"diagnostic":[219],"industry":[220],"associations":[221],"internationally":[222],"are":[223],"needed":[224],"if":[225],"consensus":[226],"be":[229],"reached":[230],"standardization":[232],"immunoassays":[234],"uniform":[239],"among":[242],"laboratories.":[243]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}