{"id":"https://openalex.org/W2108227401","doi":"https://doi.org/10.1158/0008-5472.can-06-4312","title":"BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia","display_name":"BCR-Tyrosine 177 Plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in Chronic Myelogenous Leukemia","publication_year":2007,"publication_date":"2007-07-15","ids":{"openalex":"https://openalex.org/W2108227401","doi":"https://doi.org/10.1158/0008-5472.can-06-4312","mag":"2108227401","pmid":"https://pubmed.ncbi.nlm.nih.gov/17638918"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-06-4312","doi":"https://doi.org/10.1158/0008-5472.can-06-4312","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-4312","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104091789","display_name":"Su Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su Chu","raw_affiliation_strings":["Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California","Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]},{"raw_affiliation_string":"Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420615","display_name":"Liang Li","orcid":"https://orcid.org/0000-0001-5453-3839","observed_orcids":["https://orcid.org/0000-0001-5453-3839"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liang Li","raw_affiliation_strings":["Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101762428","display_name":"Harjeet Singh","orcid":"https://orcid.org/0000-0001-6314-5790","observed_orcids":["https://orcid.org/0000-0001-6314-5790"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harjeet Singh","raw_affiliation_strings":["Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010061250","display_name":"Ravi Bhatia","orcid":"https://orcid.org/0000-0001-5740-2316","observed_orcids":["https://orcid.org/0000-0001-5740-2316"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravi Bhatia","raw_affiliation_strings":["Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Stem Cell and Leukemia Research, Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California","institution_ids":["https://openalex.org/I1301076528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1301076528"],"apc_list":null,"apc_paid":null,"fwci":2.2434,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.88408054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"67","issue":"14","first_page":"7045","last_page":"7053"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ras-activation","display_name":"Ras activation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/akt-activation","display_name":"Akt activation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cd34-cells","display_name":"CD34+ cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/imatinib-mesylate","display_name":"imatinib mesylate","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.8541522026062012},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7618755102157593},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6792834401130676},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.5775874853134155},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5701518058776855},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5359913110733032},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5303911566734314},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.527652382850647},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.45390215516090393},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.40221694111824036},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.39741963148117065},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.3670223355293274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3058505654335022},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3002035617828369},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25742894411087036},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10682308673858643},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.09806814789772034},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08683207631111145}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012190","descriptor_name":"Retroviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018952","descriptor_name":"Antigens, CD34","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051562","descriptor_name":"Proto-Oncogene Proteins c-bcr","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-06-4312","doi":"https://doi.org/10.1158/0008-5472.can-06-4312","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-06-4312","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:17638918","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17638918","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1622372912","display_name":"Resistance of CML Stem Cells to Imatinib (Gleevec)","funder_award_id":"R01CA095684","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4727590170","display_name":"Human Hematopoietic Cell Transformation by BCR/ABL","funder_award_id":"R01HL077847","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5900184332","display_name":"General Clinical Research Center","funder_award_id":"M01RR000043","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W12631990","https://openalex.org/W165143749","https://openalex.org/W1520290955","https://openalex.org/W1964445294","https://openalex.org/W1968655578","https://openalex.org/W1971727526","https://openalex.org/W1979775936","https://openalex.org/W1983075214","https://openalex.org/W1990065094","https://openalex.org/W1994572080","https://openalex.org/W1994721658","https://openalex.org/W1999614615","https://openalex.org/W2006917576","https://openalex.org/W2008198386","https://openalex.org/W2009181525","https://openalex.org/W2012828386","https://openalex.org/W2016086822","https://openalex.org/W2018279800","https://openalex.org/W2018988691","https://openalex.org/W2025722101","https://openalex.org/W2028959752","https://openalex.org/W2035258932","https://openalex.org/W2040396943","https://openalex.org/W2041397417","https://openalex.org/W2054838977","https://openalex.org/W2059059532","https://openalex.org/W2062980512","https://openalex.org/W2066878282","https://openalex.org/W2067493438","https://openalex.org/W2076153728","https://openalex.org/W2079517811","https://openalex.org/W2095169768","https://openalex.org/W2101744311","https://openalex.org/W2104830066","https://openalex.org/W2105248205","https://openalex.org/W2133124453","https://openalex.org/W2138807703","https://openalex.org/W2142969636","https://openalex.org/W2144323242","https://openalex.org/W2144631066","https://openalex.org/W2159371111","https://openalex.org/W2166830325","https://openalex.org/W2301107877","https://openalex.org/W2327926837","https://openalex.org/W2405323978","https://openalex.org/W2415055188","https://openalex.org/W2417389344","https://openalex.org/W3198337823"],"related_works":["https://openalex.org/W2579612211","https://openalex.org/W2979965759","https://openalex.org/W2142618806","https://openalex.org/W2105248205","https://openalex.org/W2020453068","https://openalex.org/W2036158456","https://openalex.org/W1965264462","https://openalex.org/W2979546445","https://openalex.org/W2557135000","https://openalex.org/W2050992307"],"abstract_inverted_index":{"Chronic":[0],"myelogenous":[1],"leukemia":[2],"(CML)":[3],"results":[4,131],"from":[5],"the":[6,14,29,44,75,83,96],"transformation":[7,45,72,93,184],"of":[8,32,46,66,70,77,85,98,100,159],"a":[9,119],"primitive":[10,47],"hematopoietic":[11,49,146,182],"cell":[12,23],"by":[13,94,151,162],"BCR/ABL":[15,17,33,86,129],"gene.":[16],"signaling":[18,156],"has":[19],"been":[20],"studied":[21],"in":[22,90,122,132,144,174,180,185],"lines":[24],"and":[25,40,63,127,135,176,179],"murine":[26],"models,":[27],"but":[28,138],"transforming":[30],"effects":[31,97],"are":[34],"highly":[35],"dependent":[36],"on":[37,110],"cellular":[38],"context,":[39],"mechanisms":[41,69],"responsible":[42],"for":[43],"human":[48,145,181],"cells":[50],"remain":[51],"poorly":[52],"understood.":[53],"Current":[54],"targeted":[55],"therapies":[56],"fail":[57],"to":[58],"eliminate":[59],"malignant":[60],"CML":[61,91,123,160],"progenitors,":[62],"improved":[64,78],"understanding":[65],"crucial":[67],"molecular":[68],"progenitor":[71,92,124,183],"may":[73],"facilitate":[74],"development":[76],"therapeutic":[79],"approaches.":[80],"We":[81,114],"investigated":[82],"role":[84,121,173],"tyrosine":[87],"177":[88],"(BCR/ABL-Y177)":[89],"comparing":[95],"expression":[99,130],"Y177-mutated":[101],"BCR/ABL,":[102,104],"wild-type":[103],"or":[105],"green":[106],"fluorescent":[107],"protein":[108,141],"alone":[109],"normal":[111],"CD34(+)":[112],"cells.":[113],"show":[115],"that":[116,168],"BCR/ABL-Y177":[117,152,169],"plays":[118,170],"critical":[120],"expansion,":[125],"proliferation,":[126],"survival.":[128],"enhanced":[133],"Ras":[134,175],"Akt":[136,177],"activity":[137,143],"reduced":[139],"mitogen-activated":[140],"kinase":[142],"cells,":[147],"which":[148],"is":[149],"reversed":[150],"mutation.":[153],"Blocking":[154],"BCR/ABL-Y177-mediated":[155],"enhances":[157],"targeting":[158],"progenitors":[161],"imatinib":[163],"mesylate.":[164],"Our":[165],"studies":[166],"indicate":[167],"an":[171],"essential":[172],"activation":[178],"CML.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}