{"id":"https://openalex.org/W2108225457","doi":null,"title":"Preoperative chemotherapy with S-1 and cisplatin for highly advanced gastric cancer.","display_name":"Preoperative chemotherapy with S-1 and cisplatin for highly advanced gastric cancer.","publication_year":2009,"publication_date":"2009-11-01","ids":{"openalex":"https://openalex.org/W2108225457","mag":"2108225457","pmid":"https://pubmed.ncbi.nlm.nih.gov/20032421"},"language":"en","primary_location":{"id":"pmid:20032421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20032421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111842673","display_name":"Atsushi Nashimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092137","display_name":"Niigata Cancer Center Hospital","ror":"https://ror.org/00e18hs98","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210092137"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Nashimoto","raw_affiliation_strings":["Department of Surgery, Niigata Cancer Center Hospital, Chuo-ku, Niigata 951-8566, Japan. nasimoto@niigata-cc.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Niigata Cancer Center Hospital, Chuo-ku, Niigata 951-8566, Japan. nasimoto@niigata-cc.jp","institution_ids":["https://openalex.org/I4210092137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022874036","display_name":"Hiroshi Yabusaki","orcid":"https://orcid.org/0000-0002-0288-4968","observed_orcids":["https://orcid.org/0000-0002-0288-4968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Yabusaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067160675","display_name":"Satoru Nakagawa","orcid":"https://orcid.org/0000-0002-7826-4335","observed_orcids":["https://orcid.org/0000-0002-7826-4335","https://orcid.org/0000-0001-7234-5807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoru Nakagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054353327","display_name":"Yasugiro Takii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasugiro Takii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108755553","display_name":"Yoshiaki Tsuchiya","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoshiaki Tsuchiya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110401976","display_name":"Otsuo Tanaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanaka Otsuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2174,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.79242645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"29","issue":"11","first_page":"4689","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-gastric-cancer","display_name":"advanced gastric cancer","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/s-1","display_name":"S-1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tegafur-uracil","display_name":"tegafur-uracil","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/r2-resection","display_name":"R2 resection","score":0.8930000066757202},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.8450000286102295},{"id":"https://openalex.org/keywords/survival-factors","display_name":"survival factors","score":0.5559999942779541},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5910000205039978},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8628127574920654},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8523740768432617},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.7124215364456177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6194984912872314},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5699795484542847},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5318707227706909},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.5262766480445862},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49469444155693054},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.4776134192943573},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4599875509738922},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4129635691642761},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3896730840206146},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14488065242767334}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010094","descriptor_name":"Oxonic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20032421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20032421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2108225457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20032421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W356565621","https://openalex.org/W2004703251","https://openalex.org/W2008575122","https://openalex.org/W2013930113","https://openalex.org/W2018619890","https://openalex.org/W2024865752","https://openalex.org/W2026986976","https://openalex.org/W2041407427","https://openalex.org/W2059845681","https://openalex.org/W2060731557","https://openalex.org/W2093519706","https://openalex.org/W2104965946","https://openalex.org/W2115072149","https://openalex.org/W2116893774","https://openalex.org/W2137991416","https://openalex.org/W2145390243","https://openalex.org/W2161990928","https://openalex.org/W2171075804","https://openalex.org/W2528428498"],"related_works":["https://openalex.org/W7095802693","https://openalex.org/W2083572997","https://openalex.org/W2414440415","https://openalex.org/W2078751305","https://openalex.org/W2086804583","https://openalex.org/W2404905956","https://openalex.org/W2414382557","https://openalex.org/W2044630780","https://openalex.org/W2094100986","https://openalex.org/W3140341033"],"abstract_inverted_index":{"UNLABELLED:":[0],"Feasibility":[1],"and":[2,6,13,44,58,96,115,134],"efficacy":[3],"of":[4,98,130],"S-1":[5,37,114],"cisplatin":[7,45,116],"followed":[8],"by":[9,106],"surgery":[10],"was":[11,55,78,87,117],"evaluated,":[12],"factors":[14,105],"contributing":[15],"to":[16],"survival":[17,76],"benefit":[18],"were":[19,34,70,100],"analyzed.":[20],"PATIENTS":[21],"AND":[22],"METHODS:":[23],"In":[24],"total,":[25],"120":[26],"consecutive":[27,42],"patients":[28,83,131],"with":[29,36,62,113,132],"highly":[30],"advanced":[31],"gastric":[32],"cancer":[33],"treated":[35],"(80":[38],"mg/m(2)":[39,47],"for":[40,60,124],"21":[41],"days)":[43],"(50":[46],"on":[48],"day":[49],"8).":[50],"RESULTS:":[51],"The":[52,74,119],"response":[53,99],"rate":[54],"62.5%":[56],"overall,":[57],"75.7%":[59],"these":[61,135],"metastatic":[63],"lymph":[64],"nodes.":[65],"Grade":[66],"3/4":[67],"adverse":[68],"events":[69],"less":[71],"than":[72],"10%.":[73],"median":[75],"time":[77],"41.9":[79],"months":[80],"among":[81],"93":[82],"whose":[84],"primary":[85],"lesion":[86],"resected.":[88],"Liver":[89],"metastasis,":[90],"R2":[91],"resection,":[92],"poor":[93],"performance":[94],"status":[95],"lack":[97],"identified":[101],"as":[102],"independent":[103],"risk":[104],"a":[107],"multivariate":[108],"analysis.":[109],"CONCLUSION:":[110],"Preoperative":[111],"chemotherapy":[112],"effective.":[118],"results":[120],"show":[121],"the":[122,128],"need":[123],"different":[125],"approaches":[126],"in":[127],"treatment":[129],"metastases":[133],"without.":[136]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
