{"id":"https://openalex.org/W2108218869","doi":null,"title":"Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib.","display_name":"Pathogenetic pathways leading to glioblastoma multiforme: association between gene expressions and resistance to erlotinib.","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W2108218869","mag":"2108218869","pmid":"https://pubmed.ncbi.nlm.nih.gov/19189657"},"language":"en","primary_location":{"id":"pmid:19189657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073203881","display_name":"Sarah Hong Hui Low","orcid":"https://orcid.org/0000-0001-7587-6435","observed_orcids":["https://orcid.org/0000-0001-7587-6435"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah L\u00f6w","raw_affiliation_strings":["Department of Neurosurgery, Ruprecht Karls University, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Ruprecht Karls University, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018424453","display_name":"Vassilios I. Vougioukas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vassilios I Vougioukas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087348033","display_name":"Thomas Hielscher","orcid":"https://orcid.org/0000-0003-1277-310X","observed_orcids":["https://orcid.org/0000-0003-1277-310X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Hielscher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111753413","display_name":"Ursula I. Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ursula Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014073957","display_name":"Andreas Wilhelm Unterberg","orcid":"https://orcid.org/0000-0003-3742-3288","observed_orcids":["https://orcid.org/0000-0003-3742-3288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Unterberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016488328","display_name":"Marc\u2010Eric Halatsch","orcid":"https://orcid.org/0000-0002-6981-2280","observed_orcids":["https://orcid.org/0000-0002-6981-2280"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc E Halatsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9199,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.75692896,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"28","issue":"6A","first_page":"3729","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/erlotinib-resistance","display_name":"erlotinib resistance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9319999814033508},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7609999775886536},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.7279999852180481},{"id":"https://openalex.org/keywords/pik3c2b","display_name":"PIK3C2B","score":1.0},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.9617328643798828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6583490371704102},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.610166072845459},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5976982116699219},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5494319200515747},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.48132479190826416},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.48116740584373474},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44664013385772705},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4311680197715759},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4189267158508301},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33780190348625183},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21293872594833374},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1740286946296692}],"mesh":[{"descriptor_ui":"D000069347","descriptor_name":"Erlotinib Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058541","descriptor_name":"Class II Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19189657","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2108218869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19189657","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1988835053","https://openalex.org/W2054692239","https://openalex.org/W2063445389","https://openalex.org/W2092264059","https://openalex.org/W2123452735","https://openalex.org/W2147960762","https://openalex.org/W2160933524","https://openalex.org/W2166476411","https://openalex.org/W2166708153"],"related_works":["https://openalex.org/W2403197302","https://openalex.org/W2090577904","https://openalex.org/W200638445","https://openalex.org/W2051766943","https://openalex.org/W6889842887","https://openalex.org/W2899600861","https://openalex.org/W2745554064","https://openalex.org/W2490103503","https://openalex.org/W2104743043","https://openalex.org/W2055476710"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"antiproliferative":[2],"effects":[3],"of":[4,32,48,65,82,117,129,139,156,181],"erlotinib,":[5,167],"an":[6],"epidermal":[7],"growth":[8],"factor":[9],"receptor":[10],"(EGFR)":[11],"tyrosine":[12],"kinase":[13],"inhibitor,":[14],"on":[15],"human":[16,83],"glioblastoma":[17],"multiforme":[18],"(GBM)":[19],"cell":[20,93],"lines":[21,94],"in":[22,25,77],"vitro":[23],"and":[24,30,71,102,126],"vivo":[26],"are":[27],"widely":[28],"variable":[29],"independent":[31],"EGFR":[33],"baseline":[34],"expression":[35,138],"levels,":[36],"indicating":[37],"that":[38,169],"more":[39],"complex":[40],"genetic":[41,63],"signatures":[42],"may":[43,74,162,174],"form":[44],"the":[45,69,79,98,124,137,150,178],"molecular":[46],"basis":[47],"GBM":[49,66,84,130,157,164],"response":[50,81],"to":[51,56,96,108,123],"erlotinib.":[52,86,147],"This":[53],"study":[54],"sought":[55],"determine":[57],"which":[58,140],"genes":[59,121,134,151,161],"within":[60],"two":[61,133,153,159],"common":[62,154],"pathways":[64,128,155],"pathogenesis,":[67,158],"i.e.,":[68],"primary":[70,125],"secondary":[72,127],"pathways,":[73],"be":[75,175],"involved":[76],"mediating":[78],"cellular":[80,144],"towards":[85,146,166,171],"MATERIALS":[87],"AND":[88],"METHODS:":[89],"Complementary":[90],"(c)RNAs":[91],"from":[92],"selected":[95,119],"represent":[97],"sensitive,":[99],"intermediately":[100],"responsive":[101],"resistant":[103],"phenotypes,":[104],"respectively,":[105],"were":[106],"hybridized":[107],"CodeLink":[109],"Human":[110],"Whole":[111],"Genome":[112],"Bioarrays.":[113],"RESULTS:":[114],"Expression":[115],"analysis":[116],"prospectively":[118],"104":[120],"pertaining":[122],"pathogenesis":[131],"identified":[132],"(IGF1,":[135],"PIK3C2B)":[136],"significantly":[141],"correlated":[142],"with":[143],"resistance":[145,165,170],"CONCLUSION:":[148],"Among":[149],"constituting":[152],"candidate":[160],"confer":[163],"suggesting":[168],"this":[172],"compound":[173],"acquired":[176],"during":[177],"natural":[179],"evolution":[180],"GBM.":[182]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
