{"id":"https://openalex.org/W2108184274","doi":"https://doi.org/10.1161/circresaha.112.266593","title":"Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes","display_name":"Gene Silencing of the Mitochondrial Adaptor p66 Shc Suppresses Vascular Hyperglycemic Memory in Diabetes","publication_year":2012,"publication_date":"2012-06-13","ids":{"openalex":"https://openalex.org/W2108184274","doi":"https://doi.org/10.1161/circresaha.112.266593","mag":"2108184274","pmid":"https://pubmed.ncbi.nlm.nih.gov/22693349"},"language":"en","primary_location":{"id":"doi:10.1161/circresaha.112.266593","doi":"https://doi.org/10.1161/circresaha.112.266593","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.112.266593","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.112.266593?download=true","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.112.266593?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050799541","display_name":"Francesco Paneni","orcid":"https://orcid.org/0000-0001-6483-7844","observed_orcids":["https://orcid.org/0000-0001-6483-7844"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Francesco Paneni","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107599856","display_name":"Pavani Mocharla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Pavani Mocharla","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077886543","display_name":"Alexander T. Akhmedov","orcid":"https://orcid.org/0000-0003-3052-9493","observed_orcids":["https://orcid.org/0000-0003-3052-9493"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Alexander Akhmedov","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035872503","display_name":"Sarah Costantino","orcid":"https://orcid.org/0000-0002-3003-7213","observed_orcids":["https://orcid.org/0000-0002-3003-7213"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Sarah Costantino","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040422518","display_name":"Elena Osto","orcid":"https://orcid.org/0000-0001-8196-5696","observed_orcids":["https://orcid.org/0000-0001-8196-5696"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Elena Osto","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054282642","display_name":"Massimo Volpe","orcid":"https://orcid.org/0000-0002-9642-8380","observed_orcids":["https://orcid.org/0000-0002-9642-8380"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Massimo Volpe","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113435275","display_name":"Thomas Felix L\u00fcscher","orcid":"https://orcid.org/0000-0002-5259-538X","observed_orcids":["https://orcid.org/0000-0002-5259-538X"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Thomas Felix L\u00fcscher","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070855397","display_name":"Francesco Cosentino","orcid":"https://orcid.org/0000-0002-6967-5685","observed_orcids":["https://orcid.org/0000-0002-6967-5685"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I3018288129","display_name":"Istituto Neurologico Mediterraneo","ror":"https://ror.org/00cpb6264","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I3018288129","https://openalex.org/I4210153126"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Francesco Cosentino","raw_affiliation_strings":["From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Cardiovascular Research, Institute of Physiology, University of Z\u00fcrich, Switzerland (F.P., P.M., A.A., S.C., E.O., T.F.L., F.C.); IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.); Cardiology, Cardiovascular Center, University Hospital, Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); Center for Integrative Human Physiology, University of Z\u00fcrich, Switzerland (P.M., A.A., E.O., T.F.L., F.C.); the Department of Experimental Medicine, Section of Pharmacology, Second University of Study of Naples,","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I3018288129","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"Cardiology, Department of Clinical and Molecular Medicine, University of Rome \"Sapienza,\" Italy (M.V., F.C.)","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"IRCCS Neuromed, Pozzilli, Italy (F.P., M.V.)","institution_ids":["https://openalex.org/I3018288129"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.5606,"has_fulltext":true,"cited_by_count":258,"citation_normalized_percentile":{"value":0.99494305,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"111","issue":"3","first_page":"278","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p66shc","display_name":"p66Shc","score":0.9950000047683716},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7239999771118164},{"id":"https://openalex.org/keywords/vascular-dysfunction","display_name":"vascular dysfunction","score":0.8349999785423279},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6679999828338623},{"id":"https://openalex.org/keywords/protein-kinase-c-beta-ii","display_name":"protein kinase C beta II","score":0.8270000219345093},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9670000076293945},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.734000027179718},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cpg-hypomethylation","display_name":"CpG hypomethylation","score":0.8510000109672546},{"id":"https://openalex.org/keywords/histone-h3-acetylation","display_name":"histone H3 acetylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.6489999890327454},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.7879999876022339},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/diabetic-vascular-complications","display_name":"diabetic vascular complications","score":0.9039999842643738}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5561164021492004},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.45405083894729614},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.4481830894947052},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.43051978945732117},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4232664406299591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4225688576698303},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39553382992744446},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38059818744659424},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3581112325191498},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3503124415874481},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3102331757545471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21849557757377625},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18601375818252563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07196405529975891}],"mesh":[{"descriptor_ui":"D000071425","descriptor_name":"Src Homology 2 Domain-Containing, Transforming Protein 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055765","descriptor_name":"Shc Signaling Adaptor Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D055765","descriptor_name":"Shc Signaling Adaptor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055765","descriptor_name":"Shc Signaling Adaptor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057507","descriptor_name":"Mice, 129 Strain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1161/circresaha.112.266593","doi":"https://doi.org/10.1161/circresaha.112.266593","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.112.266593","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.112.266593?download=true","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:22693349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22693349","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.889.7607","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.889.7607","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/111/3/278.full.pdf%2Bhtml?frame%3Dsidebarr111/3/278","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.897.2510","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.897.2510","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circres.ahajournals.org/content/111/3/278.full.pdf","raw_type":"text"},{"id":"pmh:oai:iris.uniroma1.it:11573/450918","doi":null,"is_oa":false,"landing_page_url":"http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000306994700007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396a","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1161/circresaha.112.266593","doi":"https://doi.org/10.1161/circresaha.112.266593","is_oa":true,"landing_page_url":"https://doi.org/10.1161/circresaha.112.266593","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.112.266593?download=true","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318516","display_name":"Societ\u00e0 Italiana dell'Ipertensione Arteriosa","ror":"https://ror.org/05wma2347"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322584","display_name":"Schweizerische Herzstiftung","ror":"https://ror.org/01k789405"},{"id":"https://openalex.org/F4320329188","display_name":"Fondazione Roma","ror":"https://ror.org/00gtjrz72"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108184274.pdf","grobid_xml":"https://content.openalex.org/works/W2108184274.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W172609984","https://openalex.org/W1526927233","https://openalex.org/W1529417727","https://openalex.org/W1529592271","https://openalex.org/W1558553647","https://openalex.org/W1752045965","https://openalex.org/W1966627775","https://openalex.org/W1974332277","https://openalex.org/W1974850809","https://openalex.org/W1977312306","https://openalex.org/W1980100638","https://openalex.org/W1981280554","https://openalex.org/W1982235892","https://openalex.org/W1984388650","https://openalex.org/W1995731966","https://openalex.org/W2002285022","https://openalex.org/W2011344898","https://openalex.org/W2015174450","https://openalex.org/W2021294790","https://openalex.org/W2022101330","https://openalex.org/W2029188025","https://openalex.org/W2036066426","https://openalex.org/W2039940772","https://openalex.org/W2044928798","https://openalex.org/W2055168506","https://openalex.org/W2059169851","https://openalex.org/W2062566852","https://openalex.org/W2081202575","https://openalex.org/W2090688283","https://openalex.org/W2101209889","https://openalex.org/W2105731956","https://openalex.org/W2106375653","https://openalex.org/W2114833253","https://openalex.org/W2115274672","https://openalex.org/W2115653936","https://openalex.org/W2121808478","https://openalex.org/W2123212032","https://openalex.org/W2126589938","https://openalex.org/W2135297555","https://openalex.org/W2137927701","https://openalex.org/W2140180120","https://openalex.org/W2141932446","https://openalex.org/W2144151719","https://openalex.org/W2148034645","https://openalex.org/W2157042020","https://openalex.org/W2158103340","https://openalex.org/W2158106881","https://openalex.org/W2158666727","https://openalex.org/W2165209574","https://openalex.org/W2165256339","https://openalex.org/W2166665238","https://openalex.org/W2171233986","https://openalex.org/W2171294019","https://openalex.org/W2171349277","https://openalex.org/W2331274940","https://openalex.org/W2345903479","https://openalex.org/W3001949083","https://openalex.org/W4234393699"],"related_works":["https://openalex.org/W7096656317","https://openalex.org/W2316637828","https://openalex.org/W2148034645","https://openalex.org/W2327358462","https://openalex.org/W2885767674","https://openalex.org/W2130856395","https://openalex.org/W2103924705","https://openalex.org/W2121808478","https://openalex.org/W7098842854","https://openalex.org/W2146837920"],"abstract_inverted_index":{"RATIONALE:":[0],"Hyperglycemic":[1],"memory":[2,219],"may":[3,238],"explain":[4],"why":[5],"intensive":[6],"glucose":[7,26,65,185],"control":[8,121,236],"has":[9],"failed":[10],"to":[11,36,63,83,146,240],"improve":[12],"cardiovascular":[13],"outcomes":[14],"in":[15,50,174,220],"patients":[16],"with":[17,93],"diabetes.":[18,221],"Indeed,":[19],"hyperglycemia":[20],"promotes":[21],"vascular":[22,217,232],"dysfunction":[23],"even":[24],"after":[25,81],"normalization.":[27],"However,":[28],"the":[29,44,160,164,182,213,228],"molecular":[30,225],"mechanisms":[31],"of":[32,46,68,72,138,153,163,178,184,206,230],"this":[33,51],"phenomenon":[34],"remain":[35],"be":[37],"elucidated.":[38],"OBJECTIVE:":[39],"The":[40],"present":[41],"study":[42,223],"investigated":[43],"role":[45],"mitochondrial":[47,89],"adaptor":[48],"p66(Shc)":[49,73,86,109,156,211],"setting.":[52],"METHODS":[53],"AND":[54],"RESULTS:":[55],"In":[56,171],"human":[57],"aortic":[58],"endothelial":[59,139],"cells":[60],"(HAECs)":[61],"exposed":[62],"high":[64],"and":[66,88,104,119,134,173,193,204,237],"aortas":[67],"diabetic":[69,231],"mice,":[70],"activation":[71,157],"by":[74,115,196],"protein":[75],"kinase":[76],"C":[77],"\u03b2II":[78],"(PKC\u03b2II)":[79],"persisted":[80],"returning":[82],"normoglycemia.":[84,154],"Persistent":[85],"upregulation":[87,133],"translocation":[90],"were":[91],"associated":[92],"continued":[94],"reactive":[95],"oxygen":[96],"species":[97],"(ROS)":[98],"production,":[99,189],"reduced":[100],"nitric":[101,140],"oxide":[102,141],"bioavailability,":[103],"apoptosis.":[105],"We":[106],"show":[107],"that":[108],"gene":[110,176],"overexpression":[111],"was":[112],"epigenetically":[113],"regulated":[114],"promoter":[116],"CpG":[117],"hypomethylation":[118],"general":[120],"nonderepressible":[122],"5-induced":[123],"histone":[124],"3":[125,202],"acetylation.":[126],"Furthermore,":[127],"p66(Shc)-derived":[128],"ROS":[129,188],"production":[130],"maintained":[131],"PKC\u03b2II":[132],"PKC\u03b2II-dependent":[135],"inhibitory":[136],"phosphorylation":[137],"synthase":[142],"at":[143,181],"Thr-495,":[144],"leading":[145],"a":[147],"detrimental":[148],"vicious":[149],"cycle":[150],"despite":[151,234],"restoration":[152],"Moreover,":[155],"accounted":[158],"for":[159,227],"persistent":[161],"elevation":[162],"advanced":[165],"glycated":[166],"end":[167],"product":[168],"precursor":[169],"methylglyoxal.":[170],"vitro":[172],"vivo":[175],"silencing":[177],"p66(Shc),":[179],"performed":[180],"time":[183],"normalization,":[186],"blunted":[187],"restored":[190],"endothelium-dependent":[191],"vasorelaxation,":[192],"attenuated":[194],"apoptosis":[195],"limiting":[197],"cytochrome":[198],"c":[199],"release,":[200],"caspase":[201],"activity,":[203],"cleavage":[205],"poly":[207],"(ADP-ribose)":[208],"polymerase.":[209],"CONCLUSIONS:":[210],"is":[212],"key":[214],"effector":[215],"driving":[216],"hyperglycemic":[218],"Our":[222],"provides":[224],"insights":[226],"progression":[229],"complications":[233],"glycemic":[235],"help":[239],"define":[241],"novel":[242],"therapeutic":[243],"targets.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":21},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}