{"id":"https://openalex.org/W2108178787","doi":"https://doi.org/10.1086/653607","title":"Association of Toll\u2010Like Receptor 4 Asp299Gly and Thr399Ile Polymorphisms with Increased Infection Risk in Patients with Advanced HIV\u20101 Infection","display_name":"Association of Toll\u2010Like Receptor 4 Asp299Gly and Thr399Ile Polymorphisms with Increased Infection Risk in Patients with Advanced HIV\u20101 Infection","publication_year":2010,"publication_date":"2010-06-03","ids":{"openalex":"https://openalex.org/W2108178787","doi":"https://doi.org/10.1086/653607","mag":"2108178787","pmid":"https://pubmed.ncbi.nlm.nih.gov/20521908"},"language":"en","primary_location":{"id":"doi:10.1086/653607","doi":"https://doi.org/10.1086/653607","is_oa":true,"landing_page_url":"https://doi.org/10.1086/653607","pdf_url":"https://academic.oup.com/cid/article-pdf/51/2/242/862055/51-2-242.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cid/article-pdf/51/2/242/862055/51-2-242.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071545285","display_name":"Antonios Papadopoulos","orcid":"https://orcid.org/0000-0003-4735-2620","observed_orcids":["https://orcid.org/0000-0003-4735-2620"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Antonios\u00a0I. Papadopoulos","raw_affiliation_strings":["4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece. antpapa1@otenet.gr","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens Medical School, Athens, Greece. antpapa1@otenet.gr","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033288137","display_name":"Bart Ferwerda","orcid":"https://orcid.org/0000-0002-7050-5931","observed_orcids":["https://orcid.org/0000-0002-7050-5931"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bart Ferwerda","raw_affiliation_strings":["Department of Internal Medicine and Center for Infectious Diseases, University St Radboud, Nijmegen Medical Center, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Center for Infectious Diseases, University St Radboud, Nijmegen Medical Center, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064861218","display_name":"Anastasia Antoniadou","orcid":"https://orcid.org/0000-0003-0991-9198","observed_orcids":["https://orcid.org/0000-0003-0991-9198"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasia Antoniadou","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049287378","display_name":"Vissaria Sakka","orcid":"https://orcid.org/0000-0003-4748-1350","observed_orcids":["https://orcid.org/0000-0003-4748-1350"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Vissaria Sakka","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112418441","display_name":"Lambrini Galani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Lambrini Galani","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082119566","display_name":"Dimitra Kavatha","orcid":"https://orcid.org/0000-0002-1805-8695","observed_orcids":["https://orcid.org/0000-0002-1805-8695"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitra Kavatha","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001026149","display_name":"Periklis Panagopoulos","orcid":"https://orcid.org/0000-0003-0643-1090","observed_orcids":["https://orcid.org/0000-0003-0643-1090"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Periklis Panagopoulos","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110556147","display_name":"Garyphalia Poulakou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Garyphalia Poulakou","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038744443","display_name":"Kyriaki Kanellakopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Kyriaki Kanellakopoulou","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008373339","display_name":"Jos W. M. van der Meer","orcid":"https://orcid.org/0000-0001-5120-3690","observed_orcids":["https://orcid.org/0000-0001-5120-3690"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos\u00a0W.\u00a0M. van der Meer","raw_affiliation_strings":["Department of Internal Medicine and Center for Infectious Diseases, University St Radboud, Nijmegen Medical Center, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Center for Infectious Diseases, University St Radboud, Nijmegen Medical Center, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011316933","display_name":"Evangelos J. Giamarellos\u2010Bourboulis","orcid":"https://orcid.org/0000-0003-4713-3911","observed_orcids":["https://orcid.org/0000-0003-4713-3911"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Evangelos\u00a0J. Giamarellos\u2010Bourboulis","raw_affiliation_strings":["th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"th Department of Internal Medicine, University of Athens Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece","institution_ids":["https://openalex.org/I200777214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027955775","display_name":"Mihai Gheorghe Netea","orcid":"https://orcid.org/0000-0003-2421-6052","observed_orcids":["https://orcid.org/0000-0003-2421-6052","https://orcid.org/0000-0002-8907-9143"]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mihai\u00a0G. Netea","raw_affiliation_strings":["Department of Internal Medicine and Center for Infectious Diseases, University St Radboud, Nijmegen Medical Center, Nijmegen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Center for Infectious Diseases, University St Radboud, Nijmegen Medical Center, Nijmegen, Netherlands","institution_ids":["https://openalex.org/I145872427","https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071545285"],"corresponding_institution_ids":["https://openalex.org/I200777214"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":1.1407,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.73704532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"51","issue":"2","first_page":"242","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.6625999808311462,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.31790000200271606,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tlr4-asp299gly-polymorphism","display_name":"TLR4 Asp299Gly polymorphism","score":0.9760000109672546},{"id":"https://openalex.org/keywords/tlr4-thr399ile-polymorphism","display_name":"TLR4 Thr399Ile polymorphism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hiv-1-infection","display_name":"HIV-1 infection","score":0.9819999933242798},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.7850000262260437},{"id":"https://openalex.org/keywords/infection-risk","display_name":"infection risk","score":0.6710000038146973},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8169999718666077},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7236036658287048},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.713870108127594},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.6905280947685242},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.596803605556488},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5784414410591125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5762807130813599},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5142040252685547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39905762672424316},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32143670320510864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2975704073905945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17364352941513062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1444479525089264}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017088","descriptor_name":"AIDS-Related Opportunistic Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1086/653607","doi":"https://doi.org/10.1086/653607","is_oa":true,"landing_page_url":"https://doi.org/10.1086/653607","pdf_url":"https://academic.oup.com/cid/article-pdf/51/2/242/862055/51-2-242.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:20521908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20521908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/9a8c3e1b-2640-4133-88dd-b23990855c7a","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/9a8c3e1b-2640-4133-88dd-b23990855c7a","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Papadopoulos, A I, Ferwerda, B, Antoniadou, A, Sakka, V, Galani, L, Kavatha, D, Panagopoulos, P, Poulakou, G, Kanellakopoulou, K, Van Der Meer, J W M, Giamarellos-Bourboulis, E J & Netea, M G 2010, 'Association of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms with increased infection risk in patients with advanced HIV-1 infection', Clinical infectious diseases, vol. 51, no. 2, pp. 242-247. https://doi.org/10.1086/653607","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.935.8409","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.935.8409","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cid.oxfordjournals.org/content/51/2/242.full.pdf","raw_type":"text"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/860ca305-20e6-4763-a58e-6b40f536bb90","doi":null,"is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/association-of-tolllike-receptor-4-asp299gly-and-thr399ile-polymorphisms-with-increased-infection-risk-in-patients-with-advanced-hiv1-infection(860ca305-20e6-4763-a58e-6b40f536bb90).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical infectious diseases, 51(2), 242 - 247. Oxford University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/88374","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/88374","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/88374","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/88374","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Clinical Infectious Diseases, 51, 242 - 7","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1086/653607","doi":"https://doi.org/10.1086/653607","is_oa":true,"landing_page_url":"https://doi.org/10.1086/653607","pdf_url":"https://academic.oup.com/cid/article-pdf/51/2/242/862055/51-2-242.pdf","source":{"id":"https://openalex.org/S72350973","display_name":"Clinical Infectious Diseases","issn_l":"1058-4838","issn":["1058-4838","1537-6591"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108178787.pdf","grobid_xml":"https://content.openalex.org/works/W2108178787.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1505568786","https://openalex.org/W1520365933","https://openalex.org/W1995744610","https://openalex.org/W1999900107","https://openalex.org/W2002572303","https://openalex.org/W2011560892","https://openalex.org/W2013425197","https://openalex.org/W2038486513","https://openalex.org/W2045807962","https://openalex.org/W2046783872","https://openalex.org/W2059740732","https://openalex.org/W2064044173","https://openalex.org/W2083829960","https://openalex.org/W2086853614","https://openalex.org/W2087166943","https://openalex.org/W2087413579","https://openalex.org/W2096356210","https://openalex.org/W2098596185","https://openalex.org/W2104375616","https://openalex.org/W2116258000","https://openalex.org/W2121922797","https://openalex.org/W2122483069","https://openalex.org/W2129319296","https://openalex.org/W2144136875","https://openalex.org/W2145564764","https://openalex.org/W2151273566","https://openalex.org/W2157339124","https://openalex.org/W2158000594","https://openalex.org/W2160978572","https://openalex.org/W2169348402","https://openalex.org/W2322682607","https://openalex.org/W2499758804","https://openalex.org/W2723795096","https://openalex.org/W6603344254"],"related_works":["https://openalex.org/W7097065118","https://openalex.org/W2914234121","https://openalex.org/W4239457118","https://openalex.org/W2104375616","https://openalex.org/W1996123235","https://openalex.org/W2292154306","https://openalex.org/W3116055976","https://openalex.org/W2171372754","https://openalex.org/W4221119825","https://openalex.org/W2040950036"],"abstract_inverted_index":{"BACKGROUND.":[0],"The":[1,41],"Toll-like":[2],"receptor":[3],"4":[4,91],"(TLR4)":[5],"is":[6],"an":[7,160],"essential":[8],"component":[9],"of":[10,28,43,57,69,119,144,165,174,184,189],"the":[11,20,26,67,80,102,108,132,140,163,172],"innate":[12],"immune":[13],"response":[14],"to":[15,66],"various":[16,70],"microorganisms.":[17],"We":[18],"investigated":[19],"association":[21,161],"between":[22,162],"TLR4":[23,44,166],"polymorphism":[24],"and":[25,46,62,105,168,171],"risk":[27],"acquiring":[29],"severe":[30],"infections,":[31],"in":[32,54,64,139,177],"patients":[33,61,76,84,180],"with":[34,113,128,181],"human":[35],"immunodeficiency":[36],"virus":[37],"(HIV)-1":[38],"infection.":[39],"METHODS.":[40],"presence":[42,164],"Asp299Gly":[45,103,167],"Thr399Ile":[47,109,169],"single":[48],"nucleotide":[49],"polymorphisms":[50,170],"(SNPs)":[51],"was":[52,99],"determined":[53],"a":[55,114,136,182],"cohort":[56],"199":[58],"HIV-1":[59,178],"infected":[60,179],"evaluated":[63],"relation":[65],"occurrence":[68,173],"infections.":[71],"RESULTS.":[72],"One":[73],"hundred":[74],"seventy-two":[75],"were":[77,86,92],"homozygous":[78,106],"for":[79,88,94,101,107],"wild-type":[81,133],"genotype;":[82],"22":[83],"(11%)":[85],"heterozygous":[87,93,100],"both":[89,125],"SNPs;":[90],"1":[95,97],"polymorphism;":[96],"patient":[98],"SNP":[104],"SNP.":[110],"Of":[111],"individuals":[112],"nadir":[115,185],"CD4":[116,186],"cell":[117,187],"count":[118,188],"<100":[120,190],"cells/mm(3),":[121],"those":[122,129],"who":[123,130],"carried":[124,131],"SNPs,":[126],"compared":[127],"genotype,":[134],"demonstrated":[135],">3-fold":[137],"increase":[138],"odds":[141],"ratio":[142],"(OR)":[143],"any":[145],"serious":[146,175],"infection":[147],"(OR,":[148],"6.33":[149],"vs":[150],"OR,":[151],"1.83,":[152],"P":[153],"=":[154],".043).":[155],"CONCLUSIONS.":[156],"This":[157],"study":[158],"suggests":[159],"infections":[176],"history":[183],"cells/mm(3).":[191]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}