{"id":"https://openalex.org/W2108159727","doi":"https://doi.org/10.1152/jappl.1999.87.1.74","title":"Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits","display_name":"Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2108159727","doi":"https://doi.org/10.1152/jappl.1999.87.1.74","mag":"2108159727","pmid":"https://pubmed.ncbi.nlm.nih.gov/10409559"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1999.87.1.74","doi":"https://doi.org/10.1152/jappl.1999.87.1.74","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1999.87.1.74","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040279086","display_name":"Thomas Michael Best","orcid":"https://orcid.org/0000-0003-2836-161X","observed_orcids":["https://orcid.org/0000-0003-2836-161X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas M. Best","raw_affiliation_strings":["Biomedical Engineering, and","Departments of Family Medicine,","Kinesiology,","Orthopedic Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, and","institution_ids":[]},{"raw_affiliation_string":"Departments of Family Medicine,","institution_ids":[]},{"raw_affiliation_string":"Kinesiology,","institution_ids":[]},{"raw_affiliation_string":"Orthopedic Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108503661","display_name":"Russel Fiebig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Russel Fiebig","raw_affiliation_strings":["Kinesiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kinesiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081421697","display_name":"David T. Corr","orcid":"https://orcid.org/0000-0002-4059-8591","observed_orcids":["https://orcid.org/0000-0002-4059-8591"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Corr","raw_affiliation_strings":["Mechanical Engineering, University of Wisconsin, Madison, Wisconsin 53711","Orthopedic Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical Engineering, University of Wisconsin, Madison, Wisconsin 53711","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Orthopedic Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109117486","display_name":"Stacey L. Brickson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacey Brickson","raw_affiliation_strings":["Kinesiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kinesiology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011479283","display_name":"Lili Ji","orcid":"https://orcid.org/0000-0001-6159-2626","observed_orcids":["https://orcid.org/0000-0001-6159-2626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lili Ji","raw_affiliation_strings":["Kinesiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kinesiology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7866,"has_fulltext":false,"cited_by_count":134,"citation_normalized_percentile":{"value":0.96326837,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"87","issue":"1","first_page":"74","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12117","display_name":"Muscle and Compartmental Disorders","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/free-radical-production","display_name":"free radical generation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9629999995231628},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glutathione-reductase","display_name":"glutathione reductase","score":1.0},{"id":"https://openalex.org/keywords/reduced-glutathione","display_name":"reduced glutathione","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.878000020980835},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9850000143051147},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocyte-infiltration","display_name":"polymorphonuclear leukocyte infiltration","score":0.8820000290870667},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.722000002861023},{"id":"https://openalex.org/keywords/acute-muscle-injury","display_name":"acute muscle injury","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7436800599098206},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.7418673038482666},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5523003339767456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5481474995613098},{"id":"https://openalex.org/C28212737","wikidata":"https://www.wikidata.org/wiki/Q5381543","display_name":"Enzyme assay","level":3,"score":0.4364665150642395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40134498476982117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3307352364063263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27097582817077637}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005980","descriptor_name":"Glutathione Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007596","descriptor_name":"Joints","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/jappl.1999.87.1.74","doi":"https://doi.org/10.1152/jappl.1999.87.1.74","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1999.87.1.74","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:10409559","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10409559","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W147755979","https://openalex.org/W191793640","https://openalex.org/W1595582953","https://openalex.org/W1607459610","https://openalex.org/W1821750781","https://openalex.org/W1830780748","https://openalex.org/W1869547913","https://openalex.org/W1923982214","https://openalex.org/W1936590366","https://openalex.org/W1964773537","https://openalex.org/W1965261878","https://openalex.org/W1972221909","https://openalex.org/W1976663715","https://openalex.org/W1981888057","https://openalex.org/W1982167041","https://openalex.org/W1984379354","https://openalex.org/W1994948154","https://openalex.org/W2010716981","https://openalex.org/W2019583769","https://openalex.org/W2029417227","https://openalex.org/W2031881999","https://openalex.org/W2039242151","https://openalex.org/W2041134161","https://openalex.org/W2041272135","https://openalex.org/W2053054955","https://openalex.org/W2053264179","https://openalex.org/W2076092450","https://openalex.org/W2079446490","https://openalex.org/W2090389306","https://openalex.org/W2093939923","https://openalex.org/W2105415988","https://openalex.org/W2108791332","https://openalex.org/W2111555485","https://openalex.org/W2112442880","https://openalex.org/W2113864795","https://openalex.org/W2135638650","https://openalex.org/W2148950581","https://openalex.org/W2149625033","https://openalex.org/W2152555940","https://openalex.org/W2168198016","https://openalex.org/W2177605649","https://openalex.org/W2227174102","https://openalex.org/W2257350329","https://openalex.org/W2277618733","https://openalex.org/W2337079132","https://openalex.org/W2407509315","https://openalex.org/W2505713911","https://openalex.org/W4293103701","https://openalex.org/W4293222920"],"related_works":["https://openalex.org/W2006448120","https://openalex.org/W2044550814","https://openalex.org/W6894125828","https://openalex.org/W2052408492","https://openalex.org/W2112442880","https://openalex.org/W2375264114","https://openalex.org/W2337079132","https://openalex.org/W4391191601","https://openalex.org/W2019954935","https://openalex.org/W2421336425"],"abstract_inverted_index":{"The":[0],"present":[1],"study":[2],"investigated":[3],"changes":[4],"in":[5,27,38,42,67,71,175],"rate":[6],"of":[7,120,158],"free":[8,39,68,88,177],"radical":[9,40,69,89,178],"production,":[10],"antioxidant":[11],"enzyme":[12,92,186],"activity,":[13],"and":[14,19,81,100,110,141,150,187],"glutathione":[15,105,111,137,143,188],"status":[16],"immediately":[17,49],"after":[18,22,50,183],"24":[20,59,163,181],"h":[21,60,164,182],"acute":[23,169],"muscle":[24,127,171],"stretch":[25,172],"injury":[26,51,173],"18":[28],"male":[29],"New":[30],"Zealand":[31],"White":[32],"rabbits.":[33],"There":[34,116],"was":[35,63,77,117],"no":[36,118],"change":[37],"production":[41,70,179],"injured":[43,73],"muscles,":[44],"compared":[45],"with":[46],"noninjured":[47],"controls,":[48],"(time":[52,80],"0;":[53],"P":[54],"=":[55,85,108,114,139,145],"0.782).":[56],"However,":[57],"at":[58,162],"postinjury,":[61],"there":[62,76],"a":[64,95],"25%":[65],"increase":[66],"the":[72,159],"muscles.":[74],"Overall,":[75],"an":[78],"interaction":[79,101,131],"treatment)":[82],"effect":[83,102,132],"(P":[84,107,113,138,144],"0.005)":[86],"for":[87,103,134],"production.":[90],"Antioxidant":[91,185],"activity":[93],"demonstrated":[94],"treatment":[96],"(injured":[97],"vs.":[98],"control)":[99],"both":[104,135],"peroxidase":[106],"0.015)":[109],"reductase":[112],"0.041).":[115],"evidence":[119],"lipid":[121],"peroxidation":[122],"damage,":[123],"as":[124],"measured":[125],"by":[126],"malondialdehyde":[128],"content.":[129],"An":[130],"occurred":[133],"reduced":[136],"0.008)":[140],"total":[142],"0.015).":[146],"Morphological":[147],"analysis":[148],"(hematoxylin":[149],"eosin":[151],"staining)":[152],"showed":[153],"significant":[154],"polymorphonuclear":[155],"cell":[156],"infiltration":[157],"damaged":[160],"region":[161],"postinjury.":[165],"We":[166],"conclude":[167],"that":[168],"mechanical":[170],"results":[174],"increased":[176],"within":[180],"injury.":[184],"systems":[189],"also":[190],"appear":[191],"to":[192],"be":[193],"affected":[194],"during":[195],"this":[196],"early":[197],"postinjury":[198],"period.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}