{"id":"https://openalex.org/W2108091822","doi":"https://doi.org/10.1093/cvr/cvq400","title":"The endothelium-dependent effect of RTEF-1 in pressure overload cardiac hypertrophy: role of VEGF-B","display_name":"The endothelium-dependent effect of RTEF-1 in pressure overload cardiac hypertrophy: role of VEGF-B","publication_year":2010,"publication_date":"2010-12-17","ids":{"openalex":"https://openalex.org/W2108091822","doi":"https://doi.org/10.1093/cvr/cvq400","mag":"2108091822","pmid":"https://pubmed.ncbi.nlm.nih.gov/21169295","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078796"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvq400","doi":"https://doi.org/10.1093/cvr/cvq400","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvq400","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/90/2/325/17199740/cvq400.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cardiovascres/article-pdf/90/2/325/17199740/cvq400.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069404017","display_name":"Ming Guo Xu","orcid":"https://orcid.org/0000-0001-5234-2203","observed_orcids":["https://orcid.org/0000-0001-5234-2203"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ming Xu","raw_affiliation_strings":["Department of Physiology, Fourth Military Medical University, Xi'an, China","Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I9916479"]},{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063726925","display_name":"Yi Jin","orcid":"https://orcid.org/0000-0001-9704-973X","observed_orcids":["https://orcid.org/0000-0001-9704-973X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Jin","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109012733","display_name":"Qinhui Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinhui Song","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089229323","display_name":"Jia\u2010Ping Wu","orcid":"https://orcid.org/0000-0001-5392-3392","observed_orcids":["https://orcid.org/0000-0001-5392-3392"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiaping Wu","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032251042","display_name":"Melissa J. Philbrick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa J. Philbrick","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000353838","display_name":"Brittany L. Cully","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany L. Cully","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108476427","display_name":"Xiaojin An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojin An","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Guo","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Feng Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Gao","raw_affiliation_strings":["Department of Physiology, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402534","display_name":"Jian Li","orcid":"https://orcid.org/0000-0002-7521-8798","observed_orcids":["https://orcid.org/0000-0002-7521-8798","https://orcid.org/0009-0008-3313-6162"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jian Li","raw_affiliation_strings":["Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, CLS-909, 3 Blackfan Circle, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100402534"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":1.7122,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.85016475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"90","issue":"2","first_page":"325","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.23720000684261322,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vegf-b","display_name":"VEGF-B","score":0.9710000157356262},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.9800000190734863},{"id":"https://openalex.org/keywords/transverse-aortic-constriction","display_name":"transverse aortic constriction","score":0.7950000166893005},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4545650780200958},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.4470837712287903},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4199836254119873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39692118763923645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37330156564712524},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.338703989982605},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33485427498817444},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3284896910190582},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21823757886886597}],"mesh":[{"descriptor_ui":"D000091262","descriptor_name":"TEA Domain Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099152","descriptor_name":"Cadherin 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006332","descriptor_name":"Cardiomegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009124","descriptor_name":"Muscle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015820","descriptor_name":"Cadherins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032446","descriptor_name":"Myoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042561","descriptor_name":"Vascular Endothelial Growth Factor B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D042561","descriptor_name":"Vascular Endothelial Growth Factor B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/cvr/cvq400","doi":"https://doi.org/10.1093/cvr/cvq400","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvq400","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/90/2/325/17199740/cvq400.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2344225","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3078796","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:21169295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21169295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3078796","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3078796/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/cvr/cvq400","doi":"https://doi.org/10.1093/cvr/cvq400","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvq400","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/90/2/325/17199740/cvq400.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3268289625","display_name":"The Role of RTEF-1 in Angiogenesis and Myocardial Ischemia","funder_award_id":"R01HL082837","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G712346948","display_name":null,"funder_award_id":"HLR01082837","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320308605","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108091822.pdf","grobid_xml":"https://content.openalex.org/works/W2108091822.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W77187653","https://openalex.org/W1970104310","https://openalex.org/W1976736471","https://openalex.org/W1979363352","https://openalex.org/W1995150248","https://openalex.org/W2003801328","https://openalex.org/W2018183883","https://openalex.org/W2018822308","https://openalex.org/W2025885726","https://openalex.org/W2029813220","https://openalex.org/W2029915133","https://openalex.org/W2039601123","https://openalex.org/W2046650653","https://openalex.org/W2064808936","https://openalex.org/W2067121396","https://openalex.org/W2076234186","https://openalex.org/W2106098568","https://openalex.org/W2106592406","https://openalex.org/W2108359758","https://openalex.org/W2113242413","https://openalex.org/W2114182764","https://openalex.org/W2119439780","https://openalex.org/W2121202595","https://openalex.org/W2130472669","https://openalex.org/W2131262959","https://openalex.org/W2134761503","https://openalex.org/W2145314868","https://openalex.org/W2146361868","https://openalex.org/W2149818824","https://openalex.org/W2164683872","https://openalex.org/W2169835977","https://openalex.org/W2171952998","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1965772466","https://openalex.org/W4241400026","https://openalex.org/W4395075806","https://openalex.org/W2145314868","https://openalex.org/W2020100678","https://openalex.org/W171814863","https://openalex.org/W2078925902","https://openalex.org/W2092615147","https://openalex.org/W2106098568","https://openalex.org/W4388452774"],"abstract_inverted_index":{"AIMS:":[0],"Related":[1],"transcription":[2],"enhancer":[3],"factor-1":[4],"(RTEF-1)":[5],"has":[6,35],"previously":[7],"been":[8,37],"demonstrated":[9,190],"to":[10,69,202],"play":[11],"an":[12,63,218],"important":[13,219],"role":[14,220],"in":[15,26,99,108,123,150,194,206,221],"both":[16],"endothelial":[17,90,100,109,162,195],"cells":[18,101,110,163,196],"and":[19,79,116,128,145,160,181,226],"cardiomyocytes.":[20,207],"However,":[21],"the":[22,27,161,174,212,224],"function":[23],"of":[24,66,82,88,164,215],"RTEF-1":[25,47,113,120,134,193],"communication":[28,222],"between":[29,223],"these":[30],"two":[31],"adjacent":[32],"cell":[33],"types":[34],"not":[36],"elucidated.":[38],"METHODS":[39],"AND":[40],"RESULTS:":[41],"We":[42],"have":[43],"found":[44,132],"that":[45,133,152,191,211],"endothelium-specific":[46],"transgenic":[48],"mice":[49],"(VE-Cad/RTEF-1)":[50],"developed":[51],"significant":[52],"cardiac":[53],"hypertrophy":[54],"after":[55],"transverse":[56],"aortic":[57],"constriction":[58],"surgery,":[59],"as":[60,105,107],"evidenced":[61],"by":[62,172],"increased":[64,98,135,192],"ratio":[65],"heart":[67],"weight":[68],"tibia":[70],"length,":[71],"enlarged":[72],"cardiomyocyte":[73],"size,":[74],"thickened":[75],"left":[76],"ventricular":[77],"wall":[78],"elevated":[80],"expression":[81,114],"hypertrophic":[83,204],"gene":[84],"markers,":[85],"with":[86,111,155,176],"up-regulation":[87],"vascular":[89],"growth":[91],"factor":[92],"B":[93],"(VEGF-B).":[94],"Additionally,":[95],"VEGF-B":[96,136,177,216],"was":[97,121],"from":[102,158],"VE-Cad/RTEF-1":[103,165],"mice,":[104],"well":[106],"forced":[112],"(HMEC-1/RTEF-1),":[115],"coincidentally":[117],"decreased":[118],"when":[119],"deficient":[122],"HMEC-1.":[124],"Using":[125],"chromatin":[126],"immunoprecipitation":[127],"luciferase":[129],"assays,":[130],"we":[131],"promoter":[137],"activity":[138],"through":[139],"a":[140],"direct":[141],"interaction.":[142],"Hypertrophy-associated":[143],"genes":[144,205],"protein":[146],"synthesis":[147],"were":[148,153],"up-regulated":[149],"cardiomyocytes":[151],"incubated":[154],"conditioned":[156],"medium":[157],"HMEC-1/RTEF-1":[159],"mice.":[166],"This":[167],"effect":[168],"could":[169],"be":[170],"abrogated":[171],"treating":[173],"myocytes":[175],"small":[178],"interfering":[179],"RNA":[180],"extracellular":[182],"signal-regulated":[183],"kinase":[184],"1/2":[185],"inhibitor.":[186],"CONCLUSION:":[187],"Our":[188],"data":[189],"upregulates":[197],"VEGF-B,":[198],"which":[199],"is":[200],"able":[201],"stimulate":[203],"These":[208],"results":[209],"suggest":[210],"RTEF-1-driven":[213],"increase":[214],"plays":[217],"endothelium":[225],"myocardium.":[227]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}