{"id":"https://openalex.org/W2108047366","doi":null,"title":"Gene expression in colorectal cancer.","display_name":"Gene expression in colorectal cancer.","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W2108047366","mag":"2108047366","pmid":"https://pubmed.ncbi.nlm.nih.gov/12154040"},"language":"en","primary_location":{"id":"pmid:12154040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12154040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007467209","display_name":"Karin Birkenkamp\u2010Demtr\u00f6der","orcid":"https://orcid.org/0000-0001-8057-6277","observed_orcids":["https://orcid.org/0000-0001-8057-6277"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Karin Birkenkamp-Demtroder","raw_affiliation_strings":["Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, DK-8200 Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Diagnostic Laboratory, Department of Clinical Biochemistry, Aarhus University Hospital, DK-8200 Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103540099","display_name":"Lise Lotte Christensen","orcid":"https://orcid.org/0000-0001-5622-3068","observed_orcids":["https://orcid.org/0000-0001-5622-3068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lise Lotte Christensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001867937","display_name":"S.H. Olesen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanne Harder Olesen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085180599","display_name":"Casper M\u00f8ller Frederiksen","orcid":"https://orcid.org/0009-0006-6074-1769","observed_orcids":["https://orcid.org/0009-0006-6074-1769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Casper M Frederiksen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023095371","display_name":"P\u00e4ivi Laiho","orcid":"https://orcid.org/0009-0004-3302-4321","observed_orcids":["https://orcid.org/0009-0004-3302-4321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P\u00e4ivi Laiho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028725974","display_name":"Lauri A. Aaltonen","orcid":"https://orcid.org/0000-0001-6839-4286","observed_orcids":["https://orcid.org/0000-0001-6839-4286"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauri A Aaltonen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081693607","display_name":"S\u00f8ren Laurberg","orcid":"https://orcid.org/0000-0001-7158-1998","observed_orcids":["https://orcid.org/0000-0001-7158-1998"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S\u00f8ren Laurberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038413672","display_name":"Flemming Brandt S\u00f8rensen","orcid":"https://orcid.org/0000-0002-5446-1035","observed_orcids":["https://orcid.org/0000-0002-5446-1035"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flemming B S\u00f8rensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895666","display_name":"Rikke Hagemann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rikke Hagemann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111763107","display_name":"Torben Falck Orntoft","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Torben F \u00d8Rntoft","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.82,"has_fulltext":false,"cited_by_count":226,"citation_normalized_percentile":{"value":0.98897811,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"62","issue":"15","first_page":"4352","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.041200000792741776,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.9490000009536743},{"id":"https://openalex.org/keywords/expressed-sequence-tags","display_name":"expressed sequence tags","score":0.828000009059906},{"id":"https://openalex.org/keywords/dukes-stage","display_name":"Dukes stage","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.8090000152587891},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mitochondrial-proteins","display_name":"mitochondrial proteins","score":0.6549999713897705},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/chromosome-15q25","display_name":"chromosome 15q25","score":0.9200000166893005},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7584925889968872},{"id":"https://openalex.org/C149034497","wikidata":"https://www.wikidata.org/wiki/Q1384835","display_name":"Expressed sequence tag","level":4,"score":0.6649726033210754},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6550945043563843},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.5805099606513977},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5296794176101685},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.5293387174606323},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4961751401424408},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45792776346206665},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4361228942871094},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.421478807926178},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3385188579559326},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002894","descriptor_name":"Chromosomes, Human, Pair 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12154040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12154040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/04067fa0-0dc7-11dc-bee9-02004c4f4f50","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/04067fa0-0dc7-11dc-bee9-02004c4f4f50","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Birkenkamp-Demtr\u00f6der, K, Christensen, L L, Olesen, S K H, Frederiksen, C M, Laiho, P, Aaltonen, L, S\u00f8rensen, F B, Laurberg, S, Hagemann, R & \u00d8rntoft, T F 2002, 'Gene expression in colorectal cancer', Cancer Research, vol. 62, pp. 4352-4363. < http://cancerres.aacrjournals.org/cgi/content/full/62/15/4352 >","raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2108047366","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12154040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1273980183","https://openalex.org/W1485336702","https://openalex.org/W1497255723","https://openalex.org/W1497974883","https://openalex.org/W1520825092","https://openalex.org/W1540649941","https://openalex.org/W1656339735","https://openalex.org/W1767090291","https://openalex.org/W1973800266","https://openalex.org/W1974932231","https://openalex.org/W1975993620","https://openalex.org/W1976730154","https://openalex.org/W1977920690","https://openalex.org/W1987112135","https://openalex.org/W1992682395","https://openalex.org/W1996449685","https://openalex.org/W2021013870","https://openalex.org/W2030191755","https://openalex.org/W2064499068","https://openalex.org/W2065531843","https://openalex.org/W2075300416","https://openalex.org/W2082270474","https://openalex.org/W2090437258","https://openalex.org/W2092870862","https://openalex.org/W2102034297","https://openalex.org/W2113745932","https://openalex.org/W2120574072","https://openalex.org/W2121357228","https://openalex.org/W2122580718","https://openalex.org/W2126122220","https://openalex.org/W2147151486","https://openalex.org/W2150926065","https://openalex.org/W2156672262","https://openalex.org/W2166564595","https://openalex.org/W2167112977","https://openalex.org/W2168909179","https://openalex.org/W2323734269"],"related_works":["https://openalex.org/W2772399200","https://openalex.org/W2062800766","https://openalex.org/W2162640453","https://openalex.org/W2120574072","https://openalex.org/W2442628423","https://openalex.org/W2037852680","https://openalex.org/W2031189778","https://openalex.org/W2036250355","https://openalex.org/W2025471963","https://openalex.org/W2604383666"],"abstract_inverted_index":{"Understanding":[0],"molecular":[1],"alterations":[2],"in":[3,42,109,189,234],"colorectal":[4,51],"cancer":[5],"(CRC)":[6],"is":[7],"needed":[8],"to":[9,20,39,57,65,81,96,167],"define":[10],"new":[11,238],"biomarkers":[12],"and":[13,29,68,73,91,140,151,174,177,213,231],"treatment":[14],"targets.":[15],"We":[16,53,191],"used":[17],"oligonucleotide":[18],"microarrays":[19],"monitor":[21],"gene":[22],"expression":[23],"of":[24,45,104,111,117,147,157,170,198,207,225,227,253],"about":[25],"6,800":[26],"known":[27,71,89,105,149],"genes":[28,72,90,106,150,165,230],"35,000":[30],"expressed":[31],"sequence":[32],"tags":[33],"(ESTs)":[34],"on":[35,85,217],"five":[36],"pools":[37],"(four":[38],"six":[40],"samples":[41],"each":[43],"pool)":[44],"total":[46],"RNA":[47],"from":[48,60,79],"left-sided":[49],"sporadic":[50],"carcinomas.":[52],"compared":[54],"normal":[55,80,128],"tissue":[56,59,129],"carcinoma":[58],"Dukes'":[61,132,135,138,142],"stages":[62],"A-D":[63],"(noninvasive":[64],"distant":[66],"metastasis)":[67],"identified":[69,192],"908":[70],"4,155":[74],"ESTs":[75,93,153,232],"that":[76],"changed":[77],"remarkably":[78],"tumor":[82,204,240],"tissue.":[83],"Based":[84],"intensive":[86],"filtering":[87],"226":[88],"157":[92],"were":[94,186],"found":[95],"be":[97],"highly":[98],"relevant":[99],"for":[100,249],"CRC.":[101,190,254],"The":[102,161,229],"alteration":[103],"was":[107],"confirmed":[108],">70%":[110],"the":[112,158],"cases":[113],"by":[114],"array":[115],"analysis":[116,126],"25":[118],"single":[119],"samples.":[120],"Two-way":[121],"hierarchical":[122],"average":[123],"linkage":[124],"cluster":[125],"clustered":[127,134,141],"together":[130],"with":[131,137,196,221],"A,":[133],"B":[136],"C,":[139],"D":[143],"separately.":[144],"Real-time":[145],"PCR":[146],"10":[148],"5":[152],"demonstrated":[154],"excellent":[155],"reproducibility":[156],"array-based":[159],"findings.":[160],"most":[162],"frequently":[163],"altered":[164],"belonged":[166],"functional":[168],"categories":[169],"metabolism":[171],"(22%),":[172],"transcription":[173],"translation":[175],"(11%),":[176],"cellular":[178],"processes":[179],"(9%).":[180],"Fifteen":[181],"nuclear":[182],"encoded":[183],"mitochondrial":[184],"proteins":[185],"all":[187],"down-regulated":[188],"several":[193],"chromosomal":[194],"locations":[195],"clusters":[197],"either":[199],"potential":[200,203,239,245],"oncogenes":[201],"or":[202,251],"suppressors.":[205],"Some":[206],"these,":[208],"such":[209],"as":[210,242,244],"aminopeptidase":[211],"N/CD13":[212],"sigma":[214],"B3":[215],"protein":[216],"chromosome":[218],"15q25,":[219],"coincided":[220],"a":[222],"high":[223],"frequency":[224],"loss":[226],"heterozygosity.":[228],"presented":[233],"this":[235],"study":[236],"encode":[237],"markers":[241],"well":[243],"novel":[246],"therapeutic":[247],"targets":[248],"prevention":[250],"therapy":[252]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
