{"id":"https://openalex.org/W2108042998","doi":"https://doi.org/10.1002/wsbm.1310","title":"Integrative biomarker discovery in neurodegenerative diseases","display_name":"Integrative biomarker discovery in neurodegenerative diseases","publication_year":2015,"publication_date":"2015-07-02","ids":{"openalex":"https://openalex.org/W2108042998","doi":"https://doi.org/10.1002/wsbm.1310","mag":"2108042998","pmid":"https://pubmed.ncbi.nlm.nih.gov/26136395"},"language":"en","primary_location":{"id":"doi:10.1002/wsbm.1310","doi":"https://doi.org/10.1002/wsbm.1310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wsbm.1310","pdf_url":null,"source":{"id":"https://openalex.org/S113440077","display_name":"WIREs Systems Biology and Medicine","issn_l":"1939-005X","issn":["1939-005X","1939-5094"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Systems Biology and Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084185357","display_name":"Andr\u00e9 V. Carreiro","orcid":"https://orcid.org/0000-0002-4234-5336","observed_orcids":["https://orcid.org/0000-0002-4234-5336"]},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]},{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 V. Carreiro","raw_affiliation_strings":["INESC\u2010ID Lisbon and Instituto Superior T\u00e9cnico Universidade de Lisboa  Lisboa Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INESC\u2010ID Lisbon and Instituto Superior T\u00e9cnico Universidade de Lisboa  Lisboa Portugal","institution_ids":["https://openalex.org/I121345201","https://openalex.org/I141596103","https://openalex.org/I4387152517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039110327","display_name":"Alexandre de Mendon\u00e7a","orcid":"https://orcid.org/0000-0002-0488-1453","observed_orcids":["https://orcid.org/0000-0002-0488-1453"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Alexandre Mendon\u00e7a","raw_affiliation_strings":["Dementia Clinics, Institute of Molecular Medicine and Faculty of Medicine, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Clinics, Institute of Molecular Medicine and Faculty of Medicine, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040831166","display_name":"Mamede A. de Carvalho","orcid":"https://orcid.org/0000-0001-7556-0158","observed_orcids":["https://orcid.org/0000-0001-7556-0158"]},"institutions":[{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4392738257","display_name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes","ror":"https://ror.org/019g8w217","country_code":"PT","type":"facility","lineage":["https://openalex.org/I141596103","https://openalex.org/I4392738257","https://openalex.org/I4405252639"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Mamede de Carvalho","raw_affiliation_strings":["Translational Clinical Physiology Unit, Institute of Molecular Medicine and Faculty of Medicine, Universidade de Lisboa, Lisboa, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Clinical Physiology Unit, Institute of Molecular Medicine and Faculty of Medicine, Universidade de Lisboa, Lisboa, Portugal","institution_ids":["https://openalex.org/I141596103","https://openalex.org/I4392738257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089809829","display_name":"Sara Cordeiro Madeira","orcid":"https://orcid.org/0000-0002-1459-8096","observed_orcids":["https://orcid.org/0000-0002-1459-8096"]},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]},{"id":"https://openalex.org/I141596103","display_name":"University of Lisbon","ror":"https://ror.org/01c27hj86","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103"]},{"id":"https://openalex.org/I4387152517","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/03db2by73","country_code":"PT","type":"education","lineage":["https://openalex.org/I141596103","https://openalex.org/I4387152517"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Sara C. Madeira","raw_affiliation_strings":["INESC\u2010ID Lisbon and Instituto Superior T\u00e9cnico Universidade de Lisboa  Lisboa Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INESC\u2010ID Lisbon and Instituto Superior T\u00e9cnico Universidade de Lisboa  Lisboa Portugal","institution_ids":["https://openalex.org/I121345201","https://openalex.org/I141596103","https://openalex.org/I4387152517"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089809829"],"corresponding_institution_ids":["https://openalex.org/I121345201","https://openalex.org/I141596103","https://openalex.org/I4387152517"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.1553,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.09437004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"6","first_page":"357","last_page":"379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.9369999766349792},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.972000002861023},{"id":"https://openalex.org/keywords/data-integration","display_name":"data integration","score":0.6890000104904175},{"id":"https://openalex.org/keywords/multi-omics-data","display_name":"multi-omics data","score":0.7879999876022339},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7900000214576721},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":1.0},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/pathway-analysis","display_name":"pathway analysis","score":0.699999988079071},{"id":"https://openalex.org/keywords/composite-biomarker","display_name":"composite biomarker","score":0.7960000038146973},{"id":"https://openalex.org/keywords/predictive-model","display_name":"prediction model","score":0.6850000023841858},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.7494752407073975},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5930728912353516},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5705194473266602},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.514754056930542},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.5098151564598083},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5033614039421082},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4441908597946167},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4431711435317993},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4175827205181122},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.4173758625984192},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.41152215003967285},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3468361496925354},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32087117433547974},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2823584973812103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21497726440429688},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.18142291903495789},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12326279282569885},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11162140965461731},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.07483324408531189},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/wsbm.1310","doi":"https://doi.org/10.1002/wsbm.1310","is_oa":false,"landing_page_url":"https://doi.org/10.1002/wsbm.1310","pdf_url":null,"source":{"id":"https://openalex.org/S113440077","display_name":"WIREs Systems Biology and Medicine","issn_l":"1939-005X","issn":["1939-005X","1939-5094"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1","poland-100"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"WIREs Systems Biology and Medicine","raw_type":"journal-article"},{"id":"pmid:26136395","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26136395","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wiley interdisciplinary reviews. Systems biology and medicine","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.ulisboa.pt:10451/48740","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10451/48740","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G309696157","display_name":"Instituto de Engenharia de Sistemas e Computadores, Investiga\u00e7\u00e3o e Desenvolvimento em Lisboa","funder_award_id":"UID/CEC/50021/2013","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":131,"referenced_works":["https://openalex.org/W16196038","https://openalex.org/W91108901","https://openalex.org/W344840588","https://openalex.org/W1012257715","https://openalex.org/W1507990444","https://openalex.org/W1513946098","https://openalex.org/W1514308014","https://openalex.org/W1563013603","https://openalex.org/W1703126929","https://openalex.org/W1966844917","https://openalex.org/W1967737804","https://openalex.org/W1969959732","https://openalex.org/W1974037244","https://openalex.org/W1975001104","https://openalex.org/W1979477211","https://openalex.org/W1980991473","https://openalex.org/W1981509058","https://openalex.org/W1984558721","https://openalex.org/W1986310139","https://openalex.org/W1992257573","https://openalex.org/W1994424078","https://openalex.org/W1996347851","https://openalex.org/W2001745832","https://openalex.org/W2002777949","https://openalex.org/W2004910511","https://openalex.org/W2009169574","https://openalex.org/W2009405916","https://openalex.org/W2012739537","https://openalex.org/W2016314802","https://openalex.org/W2019338032","https://openalex.org/W2019373590","https://openalex.org/W2020883789","https://openalex.org/W2021506434","https://openalex.org/W2021787519","https://openalex.org/W2022928211","https://openalex.org/W2025927109","https://openalex.org/W2026980091","https://openalex.org/W2034166503","https://openalex.org/W2039421157","https://openalex.org/W2040316493","https://openalex.org/W2042514731","https://openalex.org/W2045993126","https://openalex.org/W2048207814","https://openalex.org/W2048296798","https://openalex.org/W2054093987","https://openalex.org/W2055456084","https://openalex.org/W2058401000","https://openalex.org/W2059274090","https://openalex.org/W2059416562","https://openalex.org/W2059597342","https://openalex.org/W2061620618","https://openalex.org/W2062533676","https://openalex.org/W2062661728","https://openalex.org/W2063414869","https://openalex.org/W2064563684","https://openalex.org/W2066828509","https://openalex.org/W2072673462","https://openalex.org/W2074086501","https://openalex.org/W2084172837","https://openalex.org/W2088309143","https://openalex.org/W2089427018","https://openalex.org/W2090048853","https://openalex.org/W2091791257","https://openalex.org/W2092403294","https://openalex.org/W2095377654","https://openalex.org/W2097524044","https://openalex.org/W2097698606","https://openalex.org/W2097994458","https://openalex.org/W2098513839","https://openalex.org/W2099571503","https://openalex.org/W2101340322","https://openalex.org/W2104430436","https://openalex.org/W2105890305","https://openalex.org/W2109133215","https://openalex.org/W2111104903","https://openalex.org/W2113142309","https://openalex.org/W2113613985","https://openalex.org/W2115779804","https://openalex.org/W2116312873","https://openalex.org/W2117513900","https://openalex.org/W2117906150","https://openalex.org/W2117996813","https://openalex.org/W2119412782","https://openalex.org/W2120083974","https://openalex.org/W2120338495","https://openalex.org/W2120539430","https://openalex.org/W2121820194","https://openalex.org/W2122047581","https://openalex.org/W2124490243","https://openalex.org/W2127648506","https://openalex.org/W2129030910","https://openalex.org/W2133111499","https://openalex.org/W2133868311","https://openalex.org/W2135610921","https://openalex.org/W2136194794","https://openalex.org/W2136195493","https://openalex.org/W2137596615","https://openalex.org/W2138908151","https://openalex.org/W2139558707","https://openalex.org/W2141566528","https://openalex.org/W2141645735","https://openalex.org/W2142064395","https://openalex.org/W2143717335","https://openalex.org/W2144273481","https://openalex.org/W2144544802","https://openalex.org/W2145210308","https://openalex.org/W2145362263","https://openalex.org/W2146089088","https://openalex.org/W2149356014","https://openalex.org/W2152493933","https://openalex.org/W2154945114","https://openalex.org/W2155221045","https://openalex.org/W2158562257","https://openalex.org/W2159482845","https://openalex.org/W2161737267","https://openalex.org/W2162772535","https://openalex.org/W2163485494","https://openalex.org/W2165840723","https://openalex.org/W2166354081","https://openalex.org/W2166736844","https://openalex.org/W2167101736","https://openalex.org/W2167840686","https://openalex.org/W2511246053","https://openalex.org/W2913609543","https://openalex.org/W2919268190","https://openalex.org/W3140207494","https://openalex.org/W3216731846","https://openalex.org/W4213411560","https://openalex.org/W4230005705","https://openalex.org/W4237174028","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4382753232","https://openalex.org/W4386742155","https://openalex.org/W4386022828","https://openalex.org/W4415935405","https://openalex.org/W3129461178","https://openalex.org/W2977084993","https://openalex.org/W2034442997","https://openalex.org/W7096191350","https://openalex.org/W2147615494","https://openalex.org/W2174421297"],"abstract_inverted_index":{"Data":[0,65],"mining":[1],"has":[2,32],"been":[3],"widely":[4],"applied":[5],"in":[6,10,21,48,60,79,120,124,146],"biomarker":[7],"discovery":[8,126],"resulting":[9],"significant":[11],"findings":[12],"of":[13,30,57,127],"different":[14,139],"clinical":[15],"and":[16,63,87,106,165,173],"biological":[17,61],"biomarkers.":[18],"With":[19],"developments":[20],"technology,":[22],"from":[23,66,138],"genomics":[24],"to":[25,71,115],"proteomics":[26],"analysis,":[27],"a":[28,96],"deluge":[29],"data":[31,39,105,111,137],"become":[33],"available,":[34],"as":[35,37,76],"well":[36],"standardized":[38],"repositories.":[40],"Nonetheless,":[41],"researchers":[42],"are":[43,113],"still":[44],"facing":[45],"important":[46],"challenges":[47],"analyzing":[49],"the":[50,55,93,125],"data,":[51],"especially":[52],"when":[53],"considering":[54],"complexity":[56],"pathways":[58],"involved":[59,78],"processes":[62],"diseases.":[64],"single":[67],"sources":[68],"appear":[69],"unable":[70],"explain":[72],"complex":[73],"processes,":[74],"such":[75,143],"those":[77],"brain\u2010related":[80],"disorders,":[81],"including":[82],"Alzheimer's":[83],"disease,":[84],"Parkinson's":[85],"disease":[86],"amyotrophic":[88],"lateral":[89],"sclerosis,":[90],"thus":[91],"raising":[92],"need":[94],"for":[95],"more":[97,147],"comprehensive":[98],"perspective.":[99],"A":[100],"possible":[101],"solution":[102],"relies":[103],"on":[104],"model":[107],"integration,":[108],"where":[109],"several":[110],"types":[112],"combined":[114],"provide":[116],"complementary":[117],"views.":[118],"This":[119,159],"turn":[121],"can":[122],"result":[123],"previously":[128],"unknown":[129],"biomarkers":[130,145],"by":[131],"unraveling":[132],"otherwise":[133],"hidden":[134],"relationships":[135],"between":[136],"sources,":[140],"and/or":[141],"validate":[142],"composite":[144],"powerful":[148],"predictive":[149],"models.":[150],"WIREs":[151],"Syst":[152],"Biol":[153],"Med":[154],"2015,":[155],"7:357\u2013379.":[156],"doi:":[157],"10.1002/wsbm.1310":[158],"article":[160],"is":[161],"categorized":[162],"under:":[163],"Analytical":[164],"Computational":[166,169],"Methods":[167,170],">":[168,176],"Translational,":[171],"Genomic,":[172],"Systems":[174],"Medicine":[175,178],"Translational":[177]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}