{"id":"https://openalex.org/W2108010791","doi":"https://doi.org/10.1186/1472-6882-12-s1-p8","title":"P01.08. Acupuncture alleviates affective dimension of pain in a rat model of inflammatory hyperalgesia","display_name":"P01.08. Acupuncture alleviates affective dimension of pain in a rat model of inflammatory hyperalgesia","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2108010791","doi":"https://doi.org/10.1186/1472-6882-12-s1-p8","mag":"2108010791"},"language":"en","primary_location":{"id":"doi:10.1186/1472-6882-12-s1-p8","doi":"https://doi.org/10.1186/1472-6882-12-s1-p8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6882-12-s1-p8","pdf_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-12-S1-P8","source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-12-S1-P8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015198590","display_name":"Lixing Lao","orcid":"https://orcid.org/0000-0003-0198-9714","observed_orcids":["https://orcid.org/0000-0003-0198-9714"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"L Lao","raw_affiliation_strings":["Center for Integrative Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, Baltimore, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040385179","display_name":"Yunfei Zhang","orcid":"https://orcid.org/0000-0002-9865-7670","observed_orcids":["https://orcid.org/0000-0002-9865-7670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Zhang","raw_affiliation_strings":["Center for Integrative Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, Baltimore, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114230635","display_name":"Xiang-Nan Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"X Shen","raw_affiliation_strings":["Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112945174","display_name":"Anqi Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Li","raw_affiliation_strings":["Center for Integrative Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, Baltimore, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113157242","display_name":"Jiajun Xin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Xin","raw_affiliation_strings":["Center for Integrative Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, Baltimore, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049567539","display_name":"Brian Berman","orcid":"https://orcid.org/0000-0001-6610-4863","observed_orcids":["https://orcid.org/0000-0001-6610-4863"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Berman","raw_affiliation_strings":["Center for Integrative Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, Baltimore, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"M Tan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tan","raw_affiliation_strings":["Center for Integrative Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, Baltimore, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100631971","display_name":"Ke Ren","orcid":"https://orcid.org/0000-0002-6485-1619","observed_orcids":["https://orcid.org/0000-0002-6485-1619"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K Ren","raw_affiliation_strings":["Dept. of Neural and Pain Sciences, Dental Sch., Univ. of Maryland, Baltimore, USA","Department of Neural and Pain Sciences; Dental School; University of Maryland; Baltimore USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Neural and Pain Sciences, Dental Sch., Univ. of Maryland, Baltimore, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Department of Neural and Pain Sciences; Dental School; University of Maryland; Baltimore USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061281490","display_name":"R Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Zhang","raw_affiliation_strings":["Center for Integrative Medicine, Baltimore, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Integrative Medicine, Baltimore, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015198590"],"corresponding_institution_ids":[],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":1.5589,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.86582898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acupuncture","display_name":"acupuncture","score":0.9169999957084656},{"id":"https://openalex.org/keywords/affective-pain","display_name":"affective pain","score":0.9729999899864197},{"id":"https://openalex.org/keywords/inflammatory-hyperalgesia","display_name":"inflammatory hyperalgesia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/conditioned-place-avoidance","display_name":"conditioned place avoidance","score":0.9110000133514404},{"id":"https://openalex.org/keywords/complete-freund-s-adjuvant","display_name":"complete Freund's adjuvant","score":0.9459999799728394},{"id":"https://openalex.org/keywords/intrathecal-morphine","display_name":"intrathecal morphine","score":0.8130000233650208},{"id":"https://openalex.org/keywords/opioid-receptors","display_name":"opioid receptors","score":0.7929999828338623},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":0.8420000076293945},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/rostral-anterior-cingulate-cortex","display_name":"rostral anterior cingulate cortex","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8077735900878906},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.7596797943115234},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.7077016830444336},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.686698853969574},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.49822044372558594},{"id":"https://openalex.org/C2779351315","wikidata":"https://www.wikidata.org/wiki/Q627524","display_name":"Freund's adjuvant","level":3,"score":0.46456873416900635},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46368923783302307},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45590656995773315},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43959394097328186},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.3671945333480835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2442304491996765},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1233322024345398},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07929959893226624},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/1472-6882-12-s1-p8","doi":"https://doi.org/10.1186/1472-6882-12-s1-p8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6882-12-s1-p8","pdf_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-12-S1-P8","source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2379247","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3373929","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3373929","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3373929","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complement Altern Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fa009ec491be4a83931245e3307e26b9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa009ec491be4a83931245e3307e26b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Complementary and Alternative Medicine, Vol 12, Iss Suppl 1, p P8 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1472-6882-12-s1-p8","doi":"https://doi.org/10.1186/1472-6882-12-s1-p8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1472-6882-12-s1-p8","pdf_url":"https://bmccomplementmedtherapies.biomedcentral.com/counter/pdf/10.1186/1472-6882-12-S1-P8","source":{"id":"https://openalex.org/S163220592","display_name":"BMC Complementary and Alternative Medicine","issn_l":"1472-6882","issn":["1472-6882"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2108010791.pdf","grobid_xml":"https://content.openalex.org/works/W2108010791.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2082634609","https://openalex.org/W1811629491","https://openalex.org/W2056521145","https://openalex.org/W2012809459","https://openalex.org/W4280609701","https://openalex.org/W2013343597","https://openalex.org/W3135414218","https://openalex.org/W2146817254","https://openalex.org/W1497087883","https://openalex.org/W7162906900"],"abstract_inverted_index":{"An":[0,119],"inflammatory":[1],"pain":[2,156,233],"rat":[3,53,70],"model,":[4],"produced":[5],"by":[6,34,87,104,159],"a":[7,23,44,109,116,179],"complete":[8],"Freund":[9],"adjuvant":[10],"(CFA)":[11],"injection":[12],"into":[13],"the":[14,35,57,66,75,84,88,128,149,165,189,194,220,228,243,246],"hind":[15],"paw":[16],"of":[17,39,56,122,127,137,148,170,200,214,219,249],"each":[18,38,52,69,91],"rat,":[19],"was":[20,47,71,93,172],"combined":[21],"with":[22],"conditioned":[24],"place":[25,99],"avoidance":[26],"(CPA)":[27],"test.":[28,118,181],"On":[29,49,81],"day":[30,50,82],"one,":[31],"time":[32,85,107],"spent":[33,86],"rats":[36,89,97],"in":[37,90,108,227],"two":[40],"distinct":[41],"compartments":[42,59],"during":[43,115],"10-min":[45],"period":[46],"recorded.":[48],"two,":[51],"explored":[54],"one":[55],"conditioning":[58,113,176],"for":[60,78,241],"30":[61,79],"min.":[62,80],"Two":[63],"hours":[64],"after":[65,112],"CFA":[67],"injection,":[68],"allowed":[72],"to":[73,188,230],"explore":[74],"second":[76],"compartment":[77,92,111],"three,":[83],"recorded":[94],"again.":[95],"The":[96,168],"showed":[98,185],"aversion":[100,187],"(i.e.":[101],"affective":[102,150,155,221,232,247],"pain)":[103],"spending":[105],"less":[106],"pain-paired":[110,175,190],"than":[114],"preconditioning":[117],"analgesic":[120],"dose":[121],"intrathecal":[123],"morphine":[124,143],"inhibited":[125,144],"acquisition":[126,145,197,215],"aversive":[129],"response":[130],"but":[131],"had":[132],"no":[133,186],"effect":[134,169],"on":[135],"display":[136,147,199],"an":[138,238],"established":[139],"one;":[140],"systemic":[141],"non-analgesic":[142],"and":[146,177,198,203,209,216,234,245],"reaction.":[151],"This":[152],"suggests":[153],"that":[154,193],"is":[157],"underpinned":[158],"mechanisms":[160],"different":[161],"from":[162],"those":[163],"governing":[164],"sensory":[166,244],"dimension.":[167,222],"EA":[171,184,212,223,235],"evaluated":[173],"before":[174,178],"post-conditioning":[180],"Rats":[182],"given":[183],"compartment,":[191],"indicating":[192],"treatment":[195],"inhibits":[196],"affect.":[201],"Mu":[202],"kappa":[204],"opioid":[205,225],"receptor":[206],"antagonists":[207],"(CTOP":[208],"nor-BNI)":[210],"blocked":[211],"inhibition":[213],"display,":[217],"respectively,":[218],"activates":[224],"receptors":[226],"rACC":[229],"inhibit":[231],"may":[236],"be":[237],"effective":[239],"therapy":[240],"both":[242],"dimensions":[248],"pain.":[250]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}