{"id":"https://openalex.org/W2107989274","doi":"https://doi.org/10.1242/jcs.017913","title":"Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivo","display_name":"Direct interaction of tyrosinase with Tyrp1 to form heterodimeric complexes in vivo","publication_year":2007,"publication_date":"2007-11-28","ids":{"openalex":"https://openalex.org/W2107989274","doi":"https://doi.org/10.1242/jcs.017913","mag":"2107989274","pmid":"https://pubmed.ncbi.nlm.nih.gov/18042623"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.017913","doi":"https://doi.org/10.1242/jcs.017913","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.017913","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101690849","display_name":"Takeshi Kobayashi","orcid":"https://orcid.org/0000-0002-4372-5285","observed_orcids":["https://orcid.org/0000-0002-4372-5285"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takeshi Kobayashi","raw_affiliation_strings":["Department of Physiology, Nagoya University, Graduate School of Medicine, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Nagoya University, Graduate School of Medicine, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107446295","display_name":"Vincent J. Hearing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vincent J. Hearing","raw_affiliation_strings":["Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101690849","https://openalex.org/A5107446295"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I60134161"],"apc_list":null,"apc_paid":null,"fwci":1.3794,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.77759336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"120","issue":"24","first_page":"4261","last_page":"4268"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":1.0},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/discrete-cosine-transform","display_name":"discrete cosine transform","score":0.7860000133514404},{"id":"https://openalex.org/keywords/heterodimer-formation","display_name":"heterodimer formation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/melanocytes","display_name":"melanocytes","score":0.671999990940094},{"id":"https://openalex.org/keywords/melanosomes","display_name":"melanosomes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/enzyme-stability","display_name":"enzyme stability","score":0.7950000166893005},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7990000247955322},{"id":"https://openalex.org/keywords/hypopigmentation","display_name":"hypopigmentation","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.8506147265434265},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.8157446384429932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7902746796607971},{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.6754621267318726},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6306055784225464},{"id":"https://openalex.org/C94435474","wikidata":"https://www.wikidata.org/wiki/Q1065756","display_name":"Melanosome","level":3,"score":0.6072429418563843},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5714761018753052},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5483742356300354},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5280885100364685},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41998639702796936},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3575730323791504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14839202165603638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10971146821975708}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019746","descriptor_name":"Intramolecular Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020460","descriptor_name":"Melanosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058951","descriptor_name":"gp100 Melanoma Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058951","descriptor_name":"gp100 Melanoma Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058951","descriptor_name":"gp100 Melanoma Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/jcs.017913","doi":"https://doi.org/10.1242/jcs.017913","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.017913","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:18042623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18042623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W33734488","https://openalex.org/W110122724","https://openalex.org/W1498389773","https://openalex.org/W1523767921","https://openalex.org/W1534717671","https://openalex.org/W1536967003","https://openalex.org/W1591346049","https://openalex.org/W1644644959","https://openalex.org/W1816737769","https://openalex.org/W1894166022","https://openalex.org/W1923508075","https://openalex.org/W1961488282","https://openalex.org/W1966640804","https://openalex.org/W1968266715","https://openalex.org/W1971966238","https://openalex.org/W1972452275","https://openalex.org/W2002964171","https://openalex.org/W2003382727","https://openalex.org/W2028785121","https://openalex.org/W2034657285","https://openalex.org/W2043581327","https://openalex.org/W2046624325","https://openalex.org/W2048747800","https://openalex.org/W2049657352","https://openalex.org/W2050291486","https://openalex.org/W2051648246","https://openalex.org/W2059157403","https://openalex.org/W2063844101","https://openalex.org/W2074553285","https://openalex.org/W2077174989","https://openalex.org/W2077887830","https://openalex.org/W2080429461","https://openalex.org/W2081500438","https://openalex.org/W2094247809","https://openalex.org/W2100409705","https://openalex.org/W2100837269","https://openalex.org/W2106782182","https://openalex.org/W2114351721","https://openalex.org/W2121189749","https://openalex.org/W2147898185","https://openalex.org/W2148135961","https://openalex.org/W2148586815","https://openalex.org/W2162306347","https://openalex.org/W2165367433","https://openalex.org/W2167344112","https://openalex.org/W2345480393"],"related_works":["https://openalex.org/W2059157403","https://openalex.org/W2944105732","https://openalex.org/W2003382727","https://openalex.org/W2114351721","https://openalex.org/W33734488","https://openalex.org/W2998253412","https://openalex.org/W1990649171","https://openalex.org/W2148586815","https://openalex.org/W4391345910","https://openalex.org/W2766588016"],"abstract_inverted_index":{"Mutations":[0],"of":[1,13,61,88,135,169,193],"the":[2,14,59,133,189],"critical":[3],"and":[4,17,24,35,43,50,84,103,158,171,191,196],"rate-limiting":[5],"melanogenic":[6,194],"enzyme":[7],"tyrosinase":[8],"(Tyr)":[9],"result":[10],"in":[11,30,47,51,58,74,80,108,120,127,153,156,161,184],"hypopigmentation":[12],"hair,":[15],"skin":[16],"eyes.":[18],"Two":[19],"other":[20,46,138],"related":[21],"enzymes,":[22],"Tyrp1":[23,34,62,76,82,104,119,179],"Dct,":[25,149],"catalyze":[26],"distinct":[27],"post-Tyr":[28],"reactions":[29],"melanin":[31],"biosynthesis.":[32],"Tyr,":[33],"Dct":[36],"have":[37,105],"been":[38,106],"proposed":[39],"to":[40,131],"interact":[41],"with":[42,96,118,137,151,182],"stabilize":[44,132],"each":[45],"multi-enzyme":[48],"complexes,":[49],"vitro,":[52,109],"Tyr":[53,69,89,102,116,136,152,170,183],"activity":[54],"is":[55,70,111],"more":[56,72,159],"stable":[57],"presence":[60],"and/or":[63],"Dct.":[64],"We":[65],"recently":[66],"reported":[67],"that":[68,85,145,178],"degraded":[71],"quickly":[73],"mutant":[75],"mouse":[77],"melanocytes":[78,155],"than":[79],"wild-type":[81,97],"melanocytes,":[83],"decreased":[86],"stability":[87,190],"can":[90],"be":[91],"partly":[92],"rescued":[93],"by":[94],"infection":[95],"Tyrp1.":[98,172],"Although":[99],"interactions":[100],"between":[101],"demonstrated":[107],"there":[110],"no":[112],"direct":[113],"evidence":[114],"for":[115],"interaction":[117],"vivo.":[121],"In":[122],"this":[123],"study,":[124],"we":[125],"use":[126],"vivo":[128],"chemical":[129],"crosslinking":[130],"association":[134],"cellular":[139],"proteins.":[140],"Western":[141],"blot":[142],"analysis":[143,165],"revealed":[144],"Tyrp1,":[146],"but":[147],"not":[148],"associates":[150],"murine":[154],"vivo,":[157,185],"specifically,":[160],"melanosomes.":[162],"Two-dimensional":[163],"SDS-PAGE":[164],"detected":[166],"heterodimeric":[167],"species":[168],"Taken":[173],"together,":[174],"these":[175],"data":[176],"demonstrate":[177],"interacts":[180],"directly":[181],"which":[186],"may":[187],"regulate":[188],"trafficking":[192],"enzymes":[195],"thus":[197],"pigment":[198],"synthesis.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}