{"id":"https://openalex.org/W2107973099","doi":"https://doi.org/10.1093/humupd/dmp040","title":"Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis","display_name":"Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis","publication_year":2009,"publication_date":"2009-10-08","ids":{"openalex":"https://openalex.org/W2107973099","doi":"https://doi.org/10.1093/humupd/dmp040","mag":"2107973099","pmid":"https://pubmed.ncbi.nlm.nih.gov/19815573"},"language":"en","primary_location":{"id":"doi:10.1093/humupd/dmp040","doi":"https://doi.org/10.1093/humupd/dmp040","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humupd/dmp040","pdf_url":null,"source":{"id":"https://openalex.org/S19450991","display_name":"Human Reproduction Update","issn_l":"1355-4786","issn":["1355-4786","1362-4946","1460-2369"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction Update","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112826544","display_name":"Joakim Huber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"J. Huber","raw_affiliation_strings":["Department of Gynaecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103115330","display_name":"Martin Imhof","orcid":"https://orcid.org/0000-0003-1233-9768","observed_orcids":["https://orcid.org/0000-0003-1233-9768"]},"institutions":[{"id":"https://openalex.org/I4210129948","display_name":"Landesklinikum Korneuburg","ror":"https://ror.org/03n0q0765","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210129948"]},{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"M. Imhof","raw_affiliation_strings":["Department of Gynaecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria","Department of Gynaecology and Obstetrics, Teaching Hospital, Korneuburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynaecologic Endocrinology and Reproductive Medicine, Medical University Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Department of Gynaecology and Obstetrics, Teaching Hospital, Korneuburg, Austria","institution_ids":["https://openalex.org/I4210129948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103072836","display_name":"Mathias Schmidt","orcid":"https://orcid.org/0000-0002-4488-4026","observed_orcids":["https://orcid.org/0000-0002-4488-4026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Schmidt","raw_affiliation_strings":["Isoflavone Research Initiative, Wartbergweg 15, D-86874 Mattsies, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Isoflavone Research Initiative, Wartbergweg 15, D-86874 Mattsies, Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3973,"currency":"EUR","value_usd":4490},"apc_paid":null,"fwci":0.156,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.18427518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"16","issue":"1","first_page":"110","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soy-protein","display_name":"soy protein","score":0.8970000147819519},{"id":"https://openalex.org/keywords/isoflavones","display_name":"isoflavones","score":0.9729999899864197},{"id":"https://openalex.org/keywords/soy-products","display_name":"soy products","score":0.722000002861023},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9520000219345093},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.8479999899864197},{"id":"https://openalex.org/keywords/estrone-sulfate","display_name":"estrone sulfate","score":0.9860000014305115},{"id":"https://openalex.org/keywords/breast-cancer-risk","display_name":"breast cancer risk","score":0.906000018119812},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8799999952316284},{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.7774484157562256},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.7760483026504517},{"id":"https://openalex.org/C2910376424","wikidata":"https://www.wikidata.org/wiki/Q11006","display_name":"SOY ISOFLAVONES","level":3,"score":0.7171530723571777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5933800935745239},{"id":"https://openalex.org/C3020703477","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Post menopausal","level":3,"score":0.5001325607299805},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.48874831199645996},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.47740307450294495},{"id":"https://openalex.org/C3018603563","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Postmenopausal women","level":2,"score":0.44249674677848816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4067779779434204},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3138073682785034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18843230605125427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09056761860847473}],"mesh":[{"descriptor_ui":"D000078202","descriptor_name":"Systematic Reviews as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014674","descriptor_name":"Plant Proteins, Dietary","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015201","descriptor_name":"Meta-Analysis as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017697","descriptor_name":"Premenopause","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045730","descriptor_name":"Soy Foods","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/humupd/dmp040","doi":"https://doi.org/10.1093/humupd/dmp040","is_oa":false,"landing_page_url":"https://doi.org/10.1093/humupd/dmp040","pdf_url":null,"source":{"id":"https://openalex.org/S19450991","display_name":"Human Reproduction Update","issn_l":"1355-4786","issn":["1355-4786","1362-4946","1460-2369"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Reproduction Update","raw_type":"journal-article"},{"id":"pmid:19815573","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19815573","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human reproduction update","raw_type":"Letter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1511930757","https://openalex.org/W1586699954","https://openalex.org/W1593442063","https://openalex.org/W1972638371","https://openalex.org/W2043652943","https://openalex.org/W2048640572","https://openalex.org/W2102416184","https://openalex.org/W2102930722","https://openalex.org/W2109925394","https://openalex.org/W2111178814","https://openalex.org/W2117120389","https://openalex.org/W2119237938","https://openalex.org/W2121198301","https://openalex.org/W2121822533","https://openalex.org/W2137019373","https://openalex.org/W2140124320","https://openalex.org/W2144921993","https://openalex.org/W2169710277"],"related_works":["https://openalex.org/W4253639346","https://openalex.org/W7095548935","https://openalex.org/W2111178814","https://openalex.org/W4214880159","https://openalex.org/W82782142","https://openalex.org/W1673057815","https://openalex.org/W7101043650","https://openalex.org/W7217122844","https://openalex.org/W2393056701","https://openalex.org/W2059253709"],"abstract_inverted_index":{"Sir,":[0],"We":[1],"greatly":[2],"appreciate":[3],"the":[4,42,46,86,106,115],"meta-analysis":[5,72],"by":[6,41,73],"Hooper":[7,66],"et":[8,67,75,140,160,164,168,185,203],"al.":[9,68,76],"(2009)":[10,69],"which":[11],"found":[12],"that":[13,45,78,82,113],"there":[14],"were":[15,124],"minor":[16],"changes":[17],"in":[18,23,27,52,56,85,114,129],"circulating":[19,53,91],"reproductive":[20],"hormone":[21],"levels":[22,93,123,151,173,201],"pre-and":[24],"post-menopausal":[25,57,149],"women":[26,58],"response":[28],"to":[29,134,190],"isoflavone":[30,35],"exposure":[31],"from":[32],"soyfoods":[33],"and":[34,120],"supplements.":[36],"However,":[37],"we":[38],"are":[39,174],"troubled":[40],"author's":[43],"concern":[44],"small":[47],"(\u223c14%)":[48],"non-statistically":[49],"significant":[50],"increase":[51,179],"estradiol":[54,92,138,200],"concentrations":[55],"might":[59],"represent":[60],"an":[61,178],"increased":[62],"breast":[63,100,130,157,182,196],"cancer":[64,101,131,158,197],"risk.":[65],"cite":[70],"a":[71,97,153,192],"Key":[74],"(2002)":[77],"included":[79],"nine":[80],"studies":[81],"showed":[83],"being":[84],"top":[87],"quintile":[88],"of":[89,99,180,195],"total":[90],"was":[94],"associated":[95,126,176],"with":[96,105,127,177],"doubling":[98],"risk":[102,154],"when":[103],"compared":[104],"bottom":[107],"quintile.":[108],"Not":[109],"mentioned,":[110],"however,":[111],"is":[112],"same":[116],"analysis":[117],"higher":[118,148],"estrone":[119,121,150,172],"sulfate":[122],"also":[125,146,175],"increases":[128],"risk,":[132],"similar":[133],"those":[135],"reported":[136],"for":[137,156],"(Key":[139],"al.,":[141,161,165,169,186,204],"2002).":[142],"Other":[143],"investigators":[144],"have":[145],"identified":[147],"as":[152],"factor":[155],"(Gruber":[159],"2002;":[162],"Kaaks":[163],"2005;":[166],"Neilson":[167],"2009);":[170],"elevated":[171],"mammographic":[181],"density":[183],"(Crandall":[184],"2008)\u2014a":[187],"parameter":[188],"considered":[189],"be":[191],"better":[193],"predictor":[194],"than":[198],"serum":[199],"(Cummings":[202],"2009).":[205]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
