{"id":"https://openalex.org/W2107960040","doi":"https://doi.org/10.2967/jnumed.113.131508","title":"Radioiodine Therapy for Thyroid Cancer in the Era of Risk Stratification and Alternative Targeted Therapies","display_name":"Radioiodine Therapy for Thyroid Cancer in the Era of Risk Stratification and Alternative Targeted Therapies","publication_year":2014,"publication_date":"2014-08-11","ids":{"openalex":"https://openalex.org/W2107960040","doi":"https://doi.org/10.2967/jnumed.113.131508","mag":"2107960040","pmid":"https://pubmed.ncbi.nlm.nih.gov/25134528"},"language":"en","primary_location":{"id":"doi:10.2967/jnumed.113.131508","doi":"https://doi.org/10.2967/jnumed.113.131508","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.113.131508","pdf_url":"http://jnm.snmjournals.org/content/55/9/1485.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://jnm.snmjournals.org/content/55/9/1485.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074054064","display_name":"Daniel A. Pryma","orcid":"https://orcid.org/0000-0001-8978-4419","observed_orcids":["https://orcid.org/0000-0001-8978-4419"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel A. Pryma","raw_affiliation_strings":["Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and daniel.pryma@uphs.upenn.edu","Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and daniel.pryma@uphs.upenn.edu","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111630451","display_name":"Susan J. Mandel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan J. Mandel","raw_affiliation_strings":["Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.6354,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.50772082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"55","issue":"9","first_page":"1485","last_page":"1491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radioactive-iodine-therapy","display_name":"radioiodine therapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/differentiated-thyroid-cancer","display_name":"differentiated thyroid cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9319999814033508},{"id":"https://openalex.org/keywords/remnant-ablation","display_name":"remnant ablation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/radioiodine-refractory-thyroid-cancer","display_name":"radioiodine-refractory thyroid cancer","score":0.8180000185966492},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/treatment-dose-optimization","display_name":"treatment dose optimization","score":0.5170000195503235},{"id":"https://openalex.org/keywords/risk-of-recurrence","display_name":"recurrence risk","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8547477722167969},{"id":"https://openalex.org/C3018694869","wikidata":"https://www.wikidata.org/wiki/Q927316","display_name":"Radioiodine therapy","level":4,"score":0.6532076597213745},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.640370786190033},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.5263001918792725},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4839909076690674},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.477762371301651},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.47149011492729187},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.467795193195343},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4427315592765808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40764909982681274},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3200954794883728},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2486027479171753}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2967/jnumed.113.131508","doi":"https://doi.org/10.2967/jnumed.113.131508","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.113.131508","pdf_url":"http://jnm.snmjournals.org/content/55/9/1485.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},{"id":"pmid:25134528","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25134528","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1015.9245","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1015.9245","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/early/2014/08/13/jnumed.113.131508.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1034.850","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1034.850","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnm.snmjournals.org/content/55/9/1485.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2967/jnumed.113.131508","doi":"https://doi.org/10.2967/jnumed.113.131508","is_oa":true,"landing_page_url":"https://doi.org/10.2967/jnumed.113.131508","pdf_url":"http://jnm.snmjournals.org/content/55/9/1485.full.pdf","source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nuclear Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308966","display_name":"Society of Nuclear Medicine and Molecular Imaging","ror":"https://ror.org/02k5gcb44"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107960040.pdf","grobid_xml":"https://content.openalex.org/works/W2107960040.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W67903475","https://openalex.org/W1872904947","https://openalex.org/W1951127742","https://openalex.org/W1971053717","https://openalex.org/W1975344814","https://openalex.org/W1985430208","https://openalex.org/W1987593186","https://openalex.org/W1997533142","https://openalex.org/W1997842432","https://openalex.org/W1998065903","https://openalex.org/W1999758442","https://openalex.org/W2009492047","https://openalex.org/W2010541126","https://openalex.org/W2011043467","https://openalex.org/W2011479095","https://openalex.org/W2019778065","https://openalex.org/W2033751426","https://openalex.org/W2048672579","https://openalex.org/W2052364346","https://openalex.org/W2059336644","https://openalex.org/W2090764107","https://openalex.org/W2096748063","https://openalex.org/W2097112996","https://openalex.org/W2104182459","https://openalex.org/W2105853795","https://openalex.org/W2107717011","https://openalex.org/W2112027306","https://openalex.org/W2112129582","https://openalex.org/W2113637323","https://openalex.org/W2116542352","https://openalex.org/W2116667413","https://openalex.org/W2118868641","https://openalex.org/W2118928366","https://openalex.org/W2120976880","https://openalex.org/W2121348024","https://openalex.org/W2127385754","https://openalex.org/W2135364685","https://openalex.org/W2137605317","https://openalex.org/W2139213909","https://openalex.org/W2140578526","https://openalex.org/W2187505264","https://openalex.org/W2236417624","https://openalex.org/W2301375938","https://openalex.org/W2320378887","https://openalex.org/W2326512026","https://openalex.org/W2409794844","https://openalex.org/W2616027747","https://openalex.org/W4238492599","https://openalex.org/W4248196291","https://openalex.org/W6639678548","https://openalex.org/W6675595345","https://openalex.org/W6686929234"],"related_works":["https://openalex.org/W2016564237","https://openalex.org/W2794659782","https://openalex.org/W3178794390","https://openalex.org/W3017250567","https://openalex.org/W4295297418","https://openalex.org/W4385559770","https://openalex.org/W2592338677","https://openalex.org/W1992455215","https://openalex.org/W2914228108","https://openalex.org/W4409526665"],"abstract_inverted_index":{"Differentiated":[0],"thyroid":[1],"cancers":[2],"are":[3,56,86,94,113],"typically":[4],"iodine-avid":[5],"and":[6,25,54,78,108],"can":[7,41],"be":[8,32,42],"effectively":[9],"treated":[10],"with":[11,59,66,101,123],"radioiodine.":[12,124],"In":[13],"most":[14,63],"patients,":[15],"radioiodine":[16,80],"treatment":[17,65],"is":[18],"done":[19,43],"for":[20,82],"ablation":[21],"of":[22,48],"residual":[23],"tissue,":[24],"in":[26,91,121],"these":[27],"cases":[28],"the":[29,35,46,67,106],"focus":[30],"should":[31],"on":[33,74],"using":[34],"minimum":[36],"effective":[37],"dose.":[38,69],"Adjuvant":[39],"therapy":[40],"to":[44,97,115],"reduce":[45],"risk":[47],"recurrence,":[49],"but":[50],"optimal":[51],"patient":[52,76],"selection":[53,77],"dose":[55],"unclear.":[57],"Patients":[58],"advanced":[60],"disease":[61],"benefit":[62],"from":[64],"maximum-tolerated":[68],"Recent":[70],"research":[71],"has":[72],"focused":[73],"better":[75],"reduced":[79],"doses":[81],"remnant":[83],"ablation.":[84],"There":[85],"emerging":[87],"targeted":[88,117],"therapeutic":[89],"approaches":[90],"patients":[92],"who":[93],"appropriately":[95],"shown":[96],"have":[98],"iodine-refractory":[99],"disease,":[100],"1":[102],"drug":[103],"approved":[104],"by":[105],"Food":[107],"Drug":[109],"Administration.":[110],"Numerous":[111],"trials":[112],"ongoing":[114],"assess":[116],"therapeutics":[118],"alone":[119],"or":[120],"combination":[122]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}